YPR065W / ROX1

Heme-dependent repressor of hypoxic genes; mediates aerobic transcriptional repression of hypoxia induced genes such as COX5b and CYC7; repressor function regulated through decreased promoter occupancy in response to oxidative stress; contains an HMG domain that is responsible for DNA bending activity; involved in the hyperosmotic stress resistance

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR065W / ROX1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.41|P-value:7.95E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:4.58|P-value:3.71E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:7.59|P-value:5.29E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:4.43|P-value:7.16E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:7.05|P-value:2.53E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:9.99|P-value:6.86E-23 ID:SGTC_91|Compound:0417-1751|FD-Score:3.17|P-value:9.48E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.90|P-value:3.01E-42 ID:SGTC_138|Compound:0850-0259|FD-Score:7.69|P-value:2.67E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:18.60|P-value:2.90E-74 ID:SGTC_158|Compound:k038-0087|FD-Score:11.50|P-value:9.82E-30 ID:SGTC_161|Compound:4065-0411|FD-Score:4.11|P-value:2.90E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:9.31|P-value:4.10E-20 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.63|P-value:1.88E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.81|P-value:9.69E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:10.30|P-value:4.86E-24 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.93|P-value:6.01E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:9.43|P-value:1.41E-20 ID:SGTC_293|Compound:4049-0273|FD-Score:3.17|P-value:9.45E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.44|P-value:3.84E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.59|P-value:5.57E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-8.62|P-value:1.57E-17 ID:SGTC_354|Compound:2783-3500|FD-Score:4.22|P-value:1.79E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.98|P-value:4.96E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.65|P-value:1.57E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-4.08|P-value:3.26E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.59|P-value:2.21E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.27|P-value:6.85E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.28|P-value:1.37E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.56|P-value:2.59E-8 ID:SGTC_701|Compound:4424-0219|FD-Score:3.52|P-value:2.86E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.51|P-value:3.00E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:15.70|P-value:1.64E-53 ID:SGTC_837|Compound:0091-0265|FD-Score:3.38|P-value:4.77E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.20|P-value:1.96E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.39|P-value:4.55E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.60|P-value:2.13E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:6.50|P-value:9.73E-11 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.52|P-value:4.83E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.46|P-value:3.51E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.66|P-value:1.73E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.40|P-value:8.16E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-4.21|P-value:1.87E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:8.70|P-value:8.00E-18 ID:SGTC_1630|Compound:st005209|FD-Score:3.71|P-value:1.43E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.70|P-value:1.49E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.35|P-value:5.19E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.64|P-value:2.74E-6 ID:SGTC_1691|Compound:st019933|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.56|P-value:4.05E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.86|P-value:7.88E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.60|P-value:2.10E-8 ID:SGTC_1845|Compound:st056753|FD-Score:-3.24|P-value:7.64E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.47|P-value:3.47E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.30|P-value:6.23E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.63|P-value:2.98E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.35|P-value:5.23E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_1919|Compound:st067113|FD-Score:6.49|P-value:1.05E-10 ID:SGTC_1941|Compound:st076221|FD-Score:5.54|P-value:2.92E-8 ID:SGTC_1956|Compound:st077085|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.21|P-value:8.53E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.31|P-value:6.03E-4 ID:SGTC_1974|Compound:st069448|FD-Score:4.06|P-value:3.55E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.53|P-value:4.64E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.64|P-value:1.83E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.27|P-value:6.78E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:9.02E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.61|P-value:3.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.08|P-value:3.30E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.59|P-value:2.24E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.01|P-value:4.26E-5 ID:SGTC_2360|Compound:9040895|FD-Score:-3.32|P-value:5.86E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.43|P-value:3.89E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.16|P-value:9.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.55|P-value:2.55E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.34|P-value:1.10E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.89|P-value:6.94E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.30|P-value:6.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.24|P-value:6.71E-13 ID:SGTC_2896|Compound:9052656|FD-Score:-8.83|P-value:2.68E-18 ID:SGTC_2971|Compound:9092186|FD-Score:-3.22|P-value:8.11E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.15|P-value:2.37E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-3.38|P-value:4.77E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.41|P-value:7.95E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:4.58|P-value:3.71E-6 ID:SGTC_36|Compound:0335-0881|FD-Score:7.59|P-value:5.29E-14 ID:SGTC_64|Compound:000l-0018|FD-Score:4.43|P-value:7.16E-6 ID:SGTC_67|Compound:0335-0847|FD-Score:7.05|P-value:2.53E-12 ID:SGTC_86|Compound:0417-1630|FD-Score:9.99|P-value:6.86E-23 ID:SGTC_91|Compound:0417-1751|FD-Score:3.17|P-value:9.48E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:13.90|P-value:3.01E-42 ID:SGTC_138|Compound:0850-0259|FD-Score:7.69|P-value:2.67E-14 ID:SGTC_142|Compound:0335-0849|FD-Score:18.60|P-value:2.90E-74 ID:SGTC_158|Compound:k038-0087|FD-Score:11.50|P-value:9.82E-30 ID:SGTC_161|Compound:4065-0411|FD-Score:4.11|P-value:2.90E-5 ID:SGTC_165|Compound:k038-0023|FD-Score:9.31|P-value:4.10E-20 ID:SGTC_190|Compound:3970-0790|FD-Score:-3.63|P-value:1.88E-4 ID:SGTC_197|Compound:4544-0043|FD-Score:-3.81|P-value:9.69E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:10.30|P-value:4.86E-24 ID:SGTC_208|Compound:k072-0098|FD-Score:-3.93|P-value:6.01E-5 ID:SGTC_216|Compound:k038-0035|FD-Score:9.43|P-value:1.41E-20 ID:SGTC_293|Compound:4049-0273|FD-Score:3.17|P-value:9.45E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.44|P-value:3.84E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:6.59|P-value:5.57E-11 ID:SGTC_343|Compound:4130-2827|FD-Score:3.58|P-value:2.28E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-8.62|P-value:1.57E-17 ID:SGTC_354|Compound:2783-3500|FD-Score:4.22|P-value:1.79E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:3.98|P-value:4.96E-5 ID:SGTC_435|Compound:c-PAF|FD-Score:5.65|P-value:1.57E-8 ID:SGTC_438|Compound:sphingosine|FD-Score:3.62|P-value:1.96E-4 ID:SGTC_480|Compound:am 92016|FD-Score:-4.08|P-value:3.26E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.49|P-value:3.22E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:3.59|P-value:2.21E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.27|P-value:6.85E-4 ID:SGTC_583|Compound:1488-1091|FD-Score:3.77|P-value:1.10E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:-4.28|P-value:1.37E-5 ID:SGTC_676|Compound:falcarinol|FD-Score:3.26|P-value:7.08E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:5.56|P-value:2.59E-8 ID:SGTC_701|Compound:4424-0219|FD-Score:3.52|P-value:2.86E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.51|P-value:3.00E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:15.70|P-value:1.64E-53 ID:SGTC_837|Compound:0091-0265|FD-Score:3.38|P-value:4.77E-4 ID:SGTC_846|Compound:0335-0850|FD-Score:4.20|P-value:1.96E-5 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_921|Compound:1561-0023|FD-Score:-3.39|P-value:4.55E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:3.45|P-value:3.64E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.60|P-value:2.13E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:6.50|P-value:9.73E-11 ID:SGTC_1054|Compound:3429-0080|FD-Score:-4.52|P-value:4.83E-6 ID:SGTC_1127|Compound:asiatic acid|FD-Score:-3.46|P-value:3.51E-4 ID:SGTC_1204|Compound:4049-0315|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:3.69|P-value:1.55E-4 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.66|P-value:1.73E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.34|P-value:5.47E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:4.40|P-value:8.16E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-4.21|P-value:1.87E-5 ID:SGTC_1598|Compound:3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin|FD-Score:8.70|P-value:8.00E-18 ID:SGTC_1630|Compound:st005209|FD-Score:3.71|P-value:1.43E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.70|P-value:1.49E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:3.35|P-value:5.19E-4 ID:SGTC_1658|Compound:st012944|FD-Score:4.64|P-value:2.74E-6 ID:SGTC_1691|Compound:st019933|FD-Score:3.32|P-value:5.72E-4 ID:SGTC_1733|Compound:st037357|FD-Score:4.56|P-value:4.05E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-3.86|P-value:7.88E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.60|P-value:2.10E-8 ID:SGTC_1845|Compound:st056753|FD-Score:-3.24|P-value:7.64E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:3.47|P-value:3.47E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.30|P-value:6.23E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-4.63|P-value:2.98E-6 ID:SGTC_1913|Compound:st060213|FD-Score:-3.35|P-value:5.23E-4 ID:SGTC_1917|Compound:st066507|FD-Score:3.83|P-value:8.91E-5 ID:SGTC_1919|Compound:st067113|FD-Score:6.49|P-value:1.05E-10 ID:SGTC_1941|Compound:st076221|FD-Score:5.54|P-value:2.92E-8 ID:SGTC_1956|Compound:st077085|FD-Score:4.20|P-value:2.00E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.21|P-value:8.53E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.31|P-value:6.03E-4 ID:SGTC_1974|Compound:st069448|FD-Score:4.06|P-value:3.55E-5 ID:SGTC_2019|Compound:4016004|FD-Score:3.20|P-value:8.75E-4 ID:SGTC_2023|Compound:5144124|FD-Score:4.17|P-value:2.26E-5 ID:SGTC_2100|Compound:5377183|FD-Score:4.53|P-value:4.64E-6 ID:SGTC_2157|Compound:5649910|FD-Score:3.64|P-value:1.83E-4 ID:SGTC_2163|Compound:5671233|FD-Score:3.27|P-value:6.78E-4 ID:SGTC_2190|Compound:6049624|FD-Score:-3.19|P-value:9.02E-4 ID:SGTC_2238|Compound:6671620|FD-Score:4.61|P-value:3.27E-6 ID:SGTC_2241|Compound:6772625|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_2248|Compound:tofa|FD-Score:4.08|P-value:3.30E-5 ID:SGTC_2345|Compound:9052315|FD-Score:3.59|P-value:2.24E-4 ID:SGTC_2350|Compound:9023895|FD-Score:4.01|P-value:4.26E-5 ID:SGTC_2360|Compound:9040895|FD-Score:-3.32|P-value:5.86E-4 ID:SGTC_2395|Compound:5646831|FD-Score:3.43|P-value:3.89E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.16|P-value:9.96E-4 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:-3.55|P-value:2.55E-4 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.34|P-value:1.10E-5 ID:SGTC_2551|Compound:apiole|FD-Score:3.89|P-value:6.94E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.55|P-value:2.57E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:3.30|P-value:6.17E-4 ID:SGTC_2858|Compound:9025781|FD-Score:7.24|P-value:6.71E-13 ID:SGTC_2896|Compound:9052656|FD-Score:-8.83|P-value:2.68E-18 ID:SGTC_2971|Compound:9092186|FD-Score:-3.22|P-value:8.11E-4 ID:SGTC_2973|Compound:9094665|FD-Score:5.15|P-value:2.37E-7 ID:SGTC_3152|Compound:9099253|FD-Score:-3.38|P-value:4.77E-4

Top fitness defect scores for YPR065W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_142 0335-0849 18.60 62.7 µM 2.90E-74 ubiquinone biosynthesis & proteasome 7 2.02E-77
2 SGTC_794 k038-0031 15.70 316.0 µM 1.64E-53 ubiquinone biosynthesis & proteasome 3 9.16E-56
3 SGTC_137 0438-0332 13.90 85.4 µM 3.01E-42 ubiquinone biosynthesis & proteasome 16 5.22E-44
4 SGTC_158 k038-0087 11.50 26.4 µM 9.82E-30 ubiquinone biosynthesis & proteasome 26 5.97E-31
5 SGTC_200 k038-0079 10.30 37.5 µM 4.86E-24 ubiquinone biosynthesis & proteasome 5 5.22E-25
6 SGTC_86 0417-1630 9.99 471.9 µM 6.86E-23 ubiquinone biosynthesis & proteasome 39 8.26E-24
7 SGTC_216 k038-0035 9.43 28.4 µM 1.41E-20 ubiquinone biosynthesis & proteasome 8 2.13E-21
8 SGTC_165 k038-0023 9.31 64.4 µM 4.10E-20 ubiquinone biosynthesis & proteasome 8 6.51E-21
9 SGTC_1598 3(2'-chlorophenyl)-7-hydroxy-4-phenylcoumarin 8.70 19.1 µM 8.00E-18 1 1.60E-18
10 SGTC_138 0850-0259 7.69 40.9 µM 2.67E-14 cell wall 66 7.56E-15
11 SGTC_36 0335-0881 7.59 14.2 µM 5.29E-14 ubiquinone biosynthesis & proteasome 39 1.54E-14
12 SGTC_2858 9025781 7.24 9.0 µM 6.71E-13 sphingolipid biosynthesis & PDR1 35 2.19E-13
13 SGTC_67 0335-0847 7.05 266.0 µM 2.53E-12 ubiquinone biosynthesis & proteasome 49 8.72E-13
14 SGTC_340 k038-0059 6.59 454.0 µM 5.57E-11 ubiquinone biosynthesis & proteasome 15 2.19E-11
15 SGTC_1052 3253-3998 6.50 198.0 µM 9.73E-11 2 3.92E-11
16 SGTC_1919 st067113 6.49 52.3 µM 1.05E-10 TSC3-RPN4 7 4.25E-11
17 SGTC_435 c-PAF 5.65 6.7 µM 1.57E-8 11 7.85E-9
18 SGTC_1844 rapamycin 5.60 4.0 nM 2.10E-8 97 1.06E-8
19 SGTC_690 glyoxal 5.56 20.3 µM 2.59E-8 52 1.33E-8
20 SGTC_1941 st076221 5.54 61.8 µM 2.92E-8 sphingolipid biosynthesis & PDR1 35 1.50E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.571 6.71E-290 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.567 5.22E-285 YPR064W_d YPR064W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.526 6.20E-238 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.473 5.80E-187 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.455 2.86E-171 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.446 1.44E-163 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.445 4.99E-163 YNL111C CYB5 hom Cytochrome b5, involved in the sterol and lipid biosynthesis pathways; acts as an electron donor to support sterol C5-6 desaturation
0.440 4.92E-159 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.433 4.22E-153 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.433 3.86E-153 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.428 1.23E-149 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance
0.423 6.39E-146 YPR146C_d YPR146C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.421 2.81E-144 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.419 9.06E-143 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.416 6.92E-141 YGR255C COQ6 hom Putative flavin-dependent monooxygenase; involved in ubiquinone (Coenzyme Q) biosynthesis; localizes to the matrix face of the mitochondrial inner membrane in a large complex with other ubiquinone biosynthetic enzymes; human COX6 can rescue a yeast cox6 mutant and is implicated in steroid-resistant nephrotic syndrome (SRNS)