YPR070W / MED1

Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR070W / MED1

Click on Significant Values for Screen Details ID:SGTC_85|Compound:0868-0259|FD-Score:3.96|P-value:2.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.05|P-value:1.63E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.82|P-value:9.78E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.49|P-value:3.36E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.91|P-value:2.67E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.66|P-value:1.78E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:3.67|P-value:5.75E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.13|P-value:2.72E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.54|P-value:8.58E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.53|P-value:2.93E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:10.80|P-value:3.74E-22 ID:SGTC_686|Compound:1319-0111|FD-Score:4.47|P-value:3.73E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.63|P-value:6.46E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.67|P-value:5.74E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:5.87|P-value:9.54E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:5.35|P-value:1.03E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:4.44|P-value:4.06E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.72|P-value:4.91E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.16|P-value:1.11E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.18|P-value:1.07E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.48|P-value:3.60E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.96|P-value:2.22E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.61|P-value:2.15E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.57|P-value:7.80E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:7.17|P-value:1.04E-10 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.58|P-value:7.49E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.65|P-value:6.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.22|P-value:7.52E-11 ID:SGTC_1687|Compound:st020778|FD-Score:9.92|P-value:7.17E-19 ID:SGTC_1712|Compound:st032288|FD-Score:7.03|P-value:2.27E-10 ID:SGTC_1754|Compound:st042065|FD-Score:4.88|P-value:7.52E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.52|P-value:4.94E-7 ID:SGTC_1780|Compound:st038448|FD-Score:3.90|P-value:2.75E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.77|P-value:1.16E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.61|P-value:6.84E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.96|P-value:2.26E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.22|P-value:8.99E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.76|P-value:4.26E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.01|P-value:4.41E-6 ID:SGTC_1943|Compound:st076331|FD-Score:4.81|P-value:1.02E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-4.46|P-value:3.83E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-4.15|P-value:1.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.15|P-value:1.18E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.83|P-value:3.38E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.43|P-value:5.95E-9 ID:SGTC_2175|Compound:5807670|FD-Score:-3.66|P-value:5.84E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.99|P-value:2.00E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.66|P-value:1.81E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.78|P-value:3.95E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.93|P-value:2.47E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.08|P-value:1.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.51|P-value:9.38E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.94|P-value:2.37E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.36|P-value:5.59E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-5.38|P-value:9.15E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-4.04|P-value:1.70E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.96|P-value:2.25E-4 ID:SGTC_86|Compound:0417-1630|FD-Score:4.05|P-value:1.63E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:4.82|P-value:9.78E-6 ID:SGTC_115|Compound:0527-0192|FD-Score:4.49|P-value:3.36E-5 ID:SGTC_149|Compound:3970-0822|FD-Score:3.91|P-value:2.67E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.66|P-value:1.78E-9 ID:SGTC_227|Compound:fluconazole|FD-Score:3.67|P-value:5.75E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:5.13|P-value:2.72E-6 ID:SGTC_562|Compound:3772-2733|FD-Score:3.54|P-value:8.58E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:4.53|P-value:2.93E-5 ID:SGTC_682|Compound:0kpi-0099|FD-Score:10.80|P-value:3.74E-22 ID:SGTC_686|Compound:1319-0111|FD-Score:4.47|P-value:3.73E-5 ID:SGTC_706|Compound:4262-0057|FD-Score:3.63|P-value:6.46E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.67|P-value:5.74E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:5.87|P-value:9.54E-8 ID:SGTC_788|Compound:1182-0090|FD-Score:5.35|P-value:1.03E-6 ID:SGTC_789|Compound:1309-1135|FD-Score:4.44|P-value:4.06E-5 ID:SGTC_876|Compound:0720-0963|FD-Score:-3.72|P-value:4.91E-4 ID:SGTC_960|Compound:1222-0186|FD-Score:4.16|P-value:1.11E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.18|P-value:1.07E-4 ID:SGTC_1069|Compound:diphenylcyclopropenone|FD-Score:4.48|P-value:3.60E-5 ID:SGTC_1160|Compound:4092-0570|FD-Score:3.96|P-value:2.22E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.61|P-value:2.15E-5 ID:SGTC_1451|Compound:4152-0210|FD-Score:-3.57|P-value:7.80E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:7.17|P-value:1.04E-10 ID:SGTC_1511|Compound:0906-3109|FD-Score:3.58|P-value:7.49E-4 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:3.65|P-value:6.13E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:7.22|P-value:7.52E-11 ID:SGTC_1687|Compound:st020778|FD-Score:9.92|P-value:7.17E-19 ID:SGTC_1712|Compound:st032288|FD-Score:7.03|P-value:2.27E-10 ID:SGTC_1754|Compound:st042065|FD-Score:4.88|P-value:7.52E-6 ID:SGTC_1760|Compound:st045453|FD-Score:5.52|P-value:4.94E-7 ID:SGTC_1780|Compound:st038448|FD-Score:3.90|P-value:2.75E-4 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.77|P-value:1.16E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.61|P-value:6.84E-4 ID:SGTC_1801|Compound:st050089|FD-Score:3.96|P-value:2.26E-4 ID:SGTC_1803|Compound:st050068|FD-Score:4.22|P-value:8.99E-5 ID:SGTC_1860|Compound:st056228|FD-Score:3.76|P-value:4.26E-4 ID:SGTC_1877|Compound:wortmannin|FD-Score:5.01|P-value:4.41E-6 ID:SGTC_1943|Compound:st076331|FD-Score:4.81|P-value:1.02E-5 ID:SGTC_1948|Compound:st076329|FD-Score:-4.46|P-value:3.83E-5 ID:SGTC_1954|Compound:st077032|FD-Score:-4.15|P-value:1.19E-4 ID:SGTC_2021|Compound:4019055|FD-Score:4.15|P-value:1.18E-4 ID:SGTC_2036|Compound:5160441|FD-Score:3.83|P-value:3.38E-4 ID:SGTC_2165|Compound:5727197|FD-Score:6.43|P-value:5.95E-9 ID:SGTC_2175|Compound:5807670|FD-Score:-3.66|P-value:5.84E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.99|P-value:2.00E-4 ID:SGTC_2366|Compound:9070441|FD-Score:4.66|P-value:1.81E-5 ID:SGTC_2429|Compound:5902844|FD-Score:3.78|P-value:3.95E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.93|P-value:2.47E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:4.08|P-value:1.50E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.51|P-value:9.38E-4 ID:SGTC_2636|Compound:apigenin dimethyl ether|FD-Score:-3.94|P-value:2.37E-4 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.67|P-value:5.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:4.36|P-value:5.59E-5 ID:SGTC_2991|Compound:9074669|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-5.38|P-value:9.15E-7 ID:SGTC_3205|Compound:9113483|FD-Score:-3.62|P-value:6.64E-4 ID:SGTC_3347|Compound:9188721|FD-Score:-4.04|P-value:1.70E-4

Top fitness defect scores for YPR070W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_682 0kpi-0099 10.80 17.0 µM 3.74E-22 5 1.16E-27
2 SGTC_1687 st020778 9.92 55.4 µM 7.17E-19 50 1.71E-23
3 SGTC_1597 7-benzyloxygramine 7.22 47.5 µM 7.52E-11 calcium & mitochondrial duress 33 2.53E-13
4 SGTC_1465 k213-0056 7.17 144.0 µM 1.04E-10 DNA intercalators 2 3.83E-13
5 SGTC_1712 st032288 7.03 53.4 µM 2.27E-10 calcium & mitochondrial duress 55 1.02E-12
6 SGTC_178 4092-0806 6.66 87.5 µM 1.78E-9 ergosterol depletion effects on membrane 30 1.39E-11
7 SGTC_2165 5727197 6.43 32.1 µM 5.95E-9 8 6.39E-11
8 SGTC_762 1165-0429 5.87 115.0 µM 9.54E-8 TSC3-RPN4 2 2.13E-9
9 SGTC_1760 st045453 5.52 10.4 µM 4.94E-7 NEO1-PIK1 94 1.70E-8
10 SGTC_788 1182-0090 5.35 188.0 µM 1.03E-6 endomembrane recycling 46 4.32E-8
11 SGTC_528 3492-0019 5.13 172.0 µM 2.72E-6 calcium & mitochondrial duress 150 1.46E-7
12 SGTC_1877 wortmannin 5.01 25.0 µM 4.41E-6 63 2.69E-7
13 SGTC_1754 st042065 4.88 16.1 µM 7.52E-6 NEO1-PIK1 133 5.28E-7
14 SGTC_94 0334-0113 4.82 514.8 µM 9.78E-6 9 7.35E-7
15 SGTC_1943 st076331 4.81 65.2 µM 1.02E-5 6 7.71E-7
16 SGTC_1788 fluconazole 4.77 20.0 µM 1.16E-5 azole & statin 46 9.08E-7
17 SGTC_2366 9070441 4.66 60.6 µM 1.81E-5 17 1.59E-6
18 SGTC_1304 1165-0502 4.61 251.0 µM 2.15E-5 48 1.98E-6
19 SGTC_582 0987-0078 4.53 156.0 µM 2.93E-5 calcium & mitochondrial duress 47 2.93E-6
20 SGTC_115 0527-0192 4.49 112.0 µM 3.36E-5 51 3.48E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.368 5.00E-108 YIL170W HXT12 hom Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.301 4.69E-71 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.277 3.77E-60 YGL035C MIG1 hom Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.271 1.18E-57 YLR020C YEH2 hom Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.262 8.80E-54 YPL042C SSN3 hom Cyclin-dependent protein kinase, component of RNA polymerase II holoenzyme; involved in phosphorylation of the RNA polymerase II C-terminal domain; involved in glucose repression
0.261 1.53E-53 YPL145C KES1 hom One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.245 2.88E-47 YPR091C NVJ2 hom Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.242 6.10E-46 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.240 5.09E-45 YLR204W QRI5 hom Mitochondrial inner membrane protein, required for accumulation of spliced COX1 mRNA; may have an additional role in translation of COX1 mRNA
0.231 7.15E-42 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.231 7.49E-42 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.221 1.59E-38 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.221 2.28E-38 YMR031W-A_d YMR031W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; null mutant displays shortened telomeres; partially overlaps the uncharacterized ORF YMR031C
0.218 1.79E-37 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.218 2.42E-37 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton