YPR071W_p

Putative membrane protein; YPR071W is not an essential gene; YPR071W has paralog YIL029C

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR071W / YPR071W

Click on Significant Values for Screen Details ID:SGTC_105|Compound:0111-0055|FD-Score:4.53|P-value:2.63E-6 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.34|P-value:2.92E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.43|P-value:2.96E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.98|P-value:2.75E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:3.34|P-value:4.18E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.67|P-value:1.31E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.62|P-value:1.42E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.71|P-value:9.93E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.53|P-value:2.02E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.84|P-value:5.78E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.23|P-value:6.13E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.97|P-value:3.42E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_1608|Compound:st001473|FD-Score:7.46|P-value:2.63E-14 ID:SGTC_1915|Compound:st067105|FD-Score:3.46|P-value:2.63E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.69|P-value:1.08E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.17|P-value:5.48E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.64|P-value:8.77E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.96|P-value:3.49E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.18|P-value:5.20E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.07|P-value:2.20E-5 ID:SGTC_3023|Compound:9089636|FD-Score:3.13|P-value:8.60E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.38|P-value:3.52E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-4.08|P-value:1.39E-5 ID:SGTC_105|Compound:0111-0055|FD-Score:4.53|P-value:2.63E-6 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:-3.34|P-value:2.92E-4 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.02|P-value:9.13E-4 ID:SGTC_302|Compound:1094-0063|FD-Score:3.43|P-value:2.96E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.68|P-value:1.13E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:4.98|P-value:2.75E-7 ID:SGTC_536|Compound:3852-0578|FD-Score:3.34|P-value:4.18E-4 ID:SGTC_538|Compound:2922-0838|FD-Score:4.67|P-value:1.31E-6 ID:SGTC_774|Compound:k060-0086|FD-Score:3.70|P-value:1.05E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:3.62|P-value:1.42E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.71|P-value:9.93E-5 ID:SGTC_1054|Compound:3429-0080|FD-Score:3.40|P-value:3.28E-4 ID:SGTC_1067|Compound:clotrimazole|FD-Score:3.53|P-value:2.02E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.16|P-value:7.82E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.84|P-value:5.78E-5 ID:SGTC_1205|Compound:4161-2785|FD-Score:3.23|P-value:6.13E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.50|P-value:2.29E-4 ID:SGTC_1289|Compound:0976-0073|FD-Score:3.97|P-value:3.42E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.11|P-value:9.47E-4 ID:SGTC_1608|Compound:st001473|FD-Score:7.46|P-value:2.63E-14 ID:SGTC_1915|Compound:st067105|FD-Score:3.46|P-value:2.63E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.69|P-value:1.08E-4 ID:SGTC_2321|Compound:7390090|FD-Score:-3.17|P-value:5.48E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.64|P-value:8.77E-5 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:3.96|P-value:3.49E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:-3.18|P-value:5.20E-4 ID:SGTC_2781|Compound:5567276|FD-Score:3.29|P-value:5.04E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.07|P-value:2.20E-5 ID:SGTC_3023|Compound:9089636|FD-Score:3.13|P-value:8.60E-4 ID:SGTC_3032|Compound:9089427|FD-Score:3.59|P-value:1.61E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.38|P-value:3.52E-4 ID:SGTC_3341|Compound:9147222|FD-Score:-4.08|P-value:1.39E-5

Top fitness defect scores for YPR071W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1608 st001473 7.46 40.5 µM 2.63E-14 9 4.44E-14
2 SGTC_376 3970-0862 4.98 59.1 µM 2.75E-7 9 3.20E-7
3 SGTC_538 2922-0838 4.67 53.3 µM 1.31E-6 Golgi 18 1.48E-6
4 SGTC_105 0111-0055 4.53 734.8 µM 2.63E-6 2 2.93E-6
5 SGTC_2849 9019321 4.07 13.0 µM 2.20E-5 28 2.35E-5
6 SGTC_1289 0976-0073 3.97 69.1 µM 3.42E-5 12 3.62E-5
7 SGTC_2392 N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide 3.96 200.0 µM 3.49E-5 13 3.69E-5
8 SGTC_1202 1988-0068 3.84 29.6 µM 5.78E-5 RNA processing & uracil transport 29 6.06E-5
9 SGTC_1018 4259-0013 3.71 28.1 µM 9.93E-5 29 1.03E-4
10 SGTC_774 k060-0086 3.70 136.0 µM 1.05E-4 23 1.09E-4
11 SGTC_2289 7946404 3.69 165.1 µM 1.08E-4 102 1.12E-4
12 SGTC_373 0844-0104 3.68 25.9 µM 1.13E-4 ERAD & cell cycle 57 1.17E-4
13 SGTC_880 0833-0487 3.62 87.2 µM 1.42E-4 mitochondrial processes 20 1.46E-4
14 SGTC_3032 9089427 3.59 49.5 µM 1.61E-4 60S ribosome export 22 1.66E-4
15 SGTC_1067 clotrimazole 3.53 1.4 µM 2.02E-4 azole & statin 53 2.07E-4
16 SGTC_1243 0416-0003 3.50 5.7 µM 2.29E-4 PDR1 44 2.34E-4
17 SGTC_1915 st067105 3.46 30.6 µM 2.63E-4 RNA pol III & RNase P/MRP 66 2.68E-4
18 SGTC_302 1094-0063 3.43 18.9 µM 2.96E-4 21 3.02E-4
19 SGTC_1054 3429-0080 3.40 167.0 µM 3.28E-4 42 3.33E-4
20 SGTC_3134 9127454 3.38 49.5 µM 3.52E-4 23 3.58E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.105 1.11E-9 YPR159C-A_p YPR159C-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.102 2.90E-9 YDL028C MPS1 het Dual-specificity kinase; required for spindle pole body (SPB) duplication and spindle checkpoint function; substrates include SPB proteins Spc42p, Spc110p, and Spc98p, mitotic exit network protein Mob1p, kinetochore protein Cnn1p, and checkpoint protein Mad1p
0.099 9.81E-9 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.096 2.86E-8 YFL051C_p YFL051C_p hom Putative protein of unknown function; YFL051C is not an essential gene
0.087 4.22E-7 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.086 5.89E-7 YCL034W LSB5 hom Protein of unknown function; binds Las17p, which is a homolog of human Wiskott-Aldrich Syndrome protein involved in actin patch assembly and actin polymerization; may mediate disassembly of the Pan1 complex from the endocytic coat
0.086 6.20E-7 YJL047C-A_p YJL047C-A_p hom Putative protein of unknown function
0.085 8.30E-7 YKL050C YKL050C hom Protein of unknown function; the YKL050W protein is a target of the SCFCdc4 ubiquitin ligase complex and YKL050W transcription is regulated by Azf1p
0.084 1.26E-6 YNL090W RHO2 hom Non-essential small GTPase of the Rho/Rac subfamily of Ras-like proteins, involved in the establishment of cell polarity and in microtubule assembly
0.083 1.68E-6 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.081 2.64E-6 YOR095C RKI1 het Ribose-5-phosphate ketol-isomerase, catalyzes the interconversion of ribose 5-phosphate and ribulose 5-phosphate in the pentose phosphate pathway; participates in pyridoxine biosynthesis
0.081 2.75E-6 YNR002C ATO2 hom Putative transmembrane protein involved in export of ammonia; ammonia is a starvation signal that promotes cell death in aging colonies; phosphorylated in mitochondria; member of the TC 9.B.33 YaaH family; homolog of Y. lipolytica Gpr1p; ATO2 has a paralog, ADY2, that arose from the whole genome duplication
0.075 1.26E-5 YGL170C SPO74 hom Component of the meiotic outer plaque of the spindle pole body, involved in modifying the meiotic outer plaque that is required prior to prospore membrane formation
0.075 1.49E-5 YHL028W WSC4 hom ER membrane protein involved in the translocation of soluble secretory proteins and insertion of membrane proteins into the ER membrane; may also have a role in the stress response but has only partial functional overlap with WSC1-3
0.075 1.50E-5 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly