YPR078C_p

Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR078C / YPR078C

Click on Significant Values for Screen Details ID:SGTC_72|Compound:0744-0168|FD-Score:-3.87|P-value:7.51E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.88|P-value:7.25E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.88|P-value:8.78E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.67|P-value:2.47E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:4.61|P-value:1.59E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.39|P-value:7.44E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.68|P-value:1.90E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.45|P-value:6.82E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.00|P-value:4.73E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.43|P-value:7.55E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.99|P-value:4.08E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.85|P-value:8.07E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.94|P-value:5.84E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.20|P-value:1.69E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.50|P-value:5.41E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:2.27E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.97|P-value:5.65E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.87|P-value:8.99E-6 ID:SGTC_2162|Compound:5663267|FD-Score:2.86|P-value:7.78E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.25|P-value:1.60E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.64|P-value:1.33E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.25|P-value:1.65E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:2.90|P-value:6.74E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:3.93E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.35|P-value:1.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.20|P-value:1.71E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.65|P-value:1.29E-7 ID:SGTC_2932|Compound:9016711|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.07|P-value:3.46E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.86|P-value:3.52E-8 ID:SGTC_3080|Compound:9117754|FD-Score:2.84|P-value:8.42E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.16|P-value:2.37E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.36|P-value:8.24E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.29|P-value:1.13E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.78|P-value:4.42E-8 ID:SGTC_3209|Compound:9113616|FD-Score:4.83|P-value:4.22E-8 ID:SGTC_3312|Compound:9133330|FD-Score:2.87|P-value:7.54E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:-3.87|P-value:7.51E-6 ID:SGTC_260|Compound:nsc-65238|FD-Score:2.88|P-value:7.25E-4 ID:SGTC_345|Compound:1362-0200|FD-Score:3.88|P-value:8.78E-6 ID:SGTC_348|Compound:k064-0012|FD-Score:-3.00|P-value:3.80E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.67|P-value:2.47E-5 ID:SGTC_381|Compound:3461-2219|FD-Score:4.61|P-value:1.59E-7 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.39|P-value:7.44E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-3.68|P-value:1.90E-5 ID:SGTC_521|Compound:r062-0005|FD-Score:3.45|P-value:6.82E-5 ID:SGTC_657|Compound:3534-0529|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:4.00|P-value:4.73E-6 ID:SGTC_1233|Compound:0325-0408|FD-Score:3.43|P-value:7.55E-5 ID:SGTC_1249|Compound:0481-0015|FD-Score:-2.99|P-value:4.08E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:2.85|P-value:8.07E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:2.94|P-value:5.84E-4 ID:SGTC_1623|Compound:st003709|FD-Score:-3.20|P-value:1.69E-4 ID:SGTC_1736|Compound:st036774|FD-Score:3.50|P-value:5.41E-5 ID:SGTC_1908|Compound:st060353|FD-Score:3.69|P-value:2.27E-5 ID:SGTC_1973|Compound:st070275|FD-Score:3.97|P-value:5.65E-6 ID:SGTC_1976|Compound:st070609|FD-Score:3.03|P-value:4.02E-4 ID:SGTC_2159|Compound:5658611|FD-Score:3.87|P-value:8.99E-6 ID:SGTC_2162|Compound:5663267|FD-Score:2.86|P-value:7.78E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.25|P-value:1.60E-4 ID:SGTC_2511|Compound:berberine|FD-Score:4.64|P-value:1.33E-7 ID:SGTC_2514|Compound:salinomycin|FD-Score:3.25|P-value:1.65E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:2.90|P-value:6.74E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.04|P-value:3.93E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.35|P-value:1.04E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.35|P-value:1.06E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.20|P-value:1.71E-4 ID:SGTC_2849|Compound:9019321|FD-Score:4.65|P-value:1.29E-7 ID:SGTC_2932|Compound:9016711|FD-Score:2.91|P-value:6.38E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.06|P-value:3.66E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.07|P-value:3.46E-4 ID:SGTC_3015|Compound:9080845|FD-Score:4.86|P-value:3.52E-8 ID:SGTC_3080|Compound:9117754|FD-Score:2.84|P-value:8.42E-4 ID:SGTC_3165|Compound:9101544|FD-Score:3.16|P-value:2.37E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-3.36|P-value:8.24E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-3.29|P-value:1.13E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.78|P-value:4.42E-8 ID:SGTC_3209|Compound:9113616|FD-Score:4.83|P-value:4.22E-8 ID:SGTC_3312|Compound:9133330|FD-Score:2.87|P-value:7.54E-4

Top fitness defect scores for YPR078C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3015 9080845 4.86 49.5 µM 3.52E-8 2 5.78E-7
2 SGTC_3209 9113616 4.83 49.5 µM 4.22E-8 10 6.69E-7
3 SGTC_2849 9019321 4.65 13.0 µM 1.29E-7 20 1.67E-6
4 SGTC_2511 berberine 4.64 10.5 µM 1.33E-7 60S ribosome export 11 1.70E-6
5 SGTC_381 3461-2219 4.61 42.7 µM 1.59E-7 copper-dependent oxidative stress 13 1.98E-6
6 SGTC_1227 3909-8010 4.00 46.6 µM 4.73E-6 14 3.17E-5
7 SGTC_1973 st070275 3.97 50.2 µM 5.65E-6 9 3.66E-5
8 SGTC_345 1362-0200 3.88 395.0 µM 8.78E-6 19 5.25E-5
9 SGTC_2159 5658611 3.87 73.8 µM 8.99E-6 12 5.36E-5
10 SGTC_1908 st060353 3.69 56.5 µM 2.27E-5 RPP1 & pyrimidine depletion 47 1.14E-4
11 SGTC_374 0880-0231 3.67 82.3 µM 2.47E-5 iron homeostasis 28 1.23E-4
12 SGTC_1736 st036774 3.50 51.0 µM 5.41E-5 50 2.33E-4
13 SGTC_521 r062-0005 3.45 13.8 µM 6.82E-5 24 2.82E-4
14 SGTC_1233 0325-0408 3.43 14.2 µM 7.55E-5 35 3.07E-4
15 SGTC_2798 7813637 3.35 45.5 µM 1.04E-4 53 4.01E-4
16 SGTC_2811 7967822 3.35 32.5 µM 1.06E-4 33 4.05E-4
17 SGTC_2343 7990716 3.25 14.8 µM 1.60E-4 41 5.69E-4
18 SGTC_2514 salinomycin 3.25 42.7 µM 1.65E-4 88 5.83E-4
19 SGTC_3165 9101544 3.16 49.5 µM 2.37E-4 30 7.88E-4
20 SGTC_3014 9081533 3.07 49.5 µM 3.46E-4 33 0.00107

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.143 9.53E-17 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.117 1.30E-11 YOR277C_d YOR277C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene CAF20
0.116 2.03E-11 YOR143C THI80 het Thiamine pyrophosphokinase, phosphorylates thiamine to produce the coenzyme thiamine pyrophosphate (thiamine diphosphate)
0.114 3.06E-11 YDR252W BTT1 hom Beta3 subunit of the heterotrimeric nascent polypeptide-associated complex which binds ribosomes via its beta-subunits in close proximity to nascent polypeptides; interacts with Caf130p of the CCR4-NOT complex; similar to human BTF3
0.104 1.50E-9 YDR521W_d YDR521W_d hom Dubious ORF that overlaps YDR520C; mutant increases expression of PIS1 and RPL3 in glycerol
0.102 2.99E-9 YOL062C APM4 hom Mu2-like subunit of the clathrin associated protein complex (AP-2); involved in vesicle transport
0.099 8.45E-9 YIR004W DJP1 hom Cytosolic J-domain-containing protein, required for peroxisomal protein import and involved in peroxisome assembly, homologous to E. coli DnaJ
0.098 1.28E-8 YJR094C IME1 hom Master regulator of meiosis that is active only during meiotic events, activates transcription of early meiotic genes through interaction with Ume6p, degraded by the 26S proteasome following phosphorylation by Ime2p
0.094 4.94E-8 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.092 9.04E-8 YDL154W MSH5 hom Protein of the MutS family, forms a dimer with Msh4p that facilitates crossovers between homologs during meiosis; msh5-Y823H mutation confers tolerance to DNA alkylating agents; homologs present in C. elegans and humans
0.090 1.98E-7 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.088 3.24E-7 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.087 5.05E-7 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.086 7.00E-7 YLR137W RKM5 hom Protein lysine methyltransferase; monomethylates Lys-46 of the ribosomal large subunit Rpl1a/Rpl1b; member of the seven beta-strand methyltransferase superfamily; orthologs only found among fungal species
0.084 1.23E-6 YGL159W_p YGL159W_p hom Putative protein of unknown function; deletion mutant has no detectable phenotype