YPR088C / SRP54

Signal recognition particle (SRP) subunit (homolog of mammalian SRP54); contains the signal sequence-binding activity of SRP, interacts with the SRP RNA, and mediates binding of SRP to signal receptor; contains GTPase domain

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR088C / SRP54

Click on Significant Values for Screen Details ID:SGTC_14|Compound:0354-0009|FD-Score:3.03|P-value:7.07E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.02|P-value:7.24E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-5.91|P-value:7.71E-11 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.11|P-value:3.52E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.04|P-value:1.96E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:3.88|P-value:2.05E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:-3.08|P-value:3.83E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.35|P-value:2.00E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.71|P-value:2.84E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:-6.63|P-value:3.65E-13 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.09|P-value:4.47E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-14.70|P-value:2.31E-56 ID:SGTC_894|Compound:0960-0238|FD-Score:-5.39|P-value:2.56E-9 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.91|P-value:1.04E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.41|P-value:1.03E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-7.46|P-value:3.70E-16 ID:SGTC_1090|Compound:efavirenz|FD-Score:-2.89|P-value:7.90E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.62|P-value:2.70E-7 ID:SGTC_1187|Compound:1391-0724|FD-Score:-2.94|P-value:6.60E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.12|P-value:4.95E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.49|P-value:7.24E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-4.24|P-value:2.05E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.01|P-value:5.00E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-5.70|P-value:3.27E-10 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.03|P-value:4.78E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-4.06|P-value:4.99E-6 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.60|P-value:6.96E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.52|P-value:9.98E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:5.40|P-value:4.69E-9 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.13|P-value:4.79E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.12|P-value:2.79E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.32|P-value:2.28E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.59|P-value:7.43E-5 ID:SGTC_1819|Compound:st053448|FD-Score:2.94|P-value:9.83E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.44|P-value:1.37E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.77|P-value:3.30E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.56|P-value:5.22E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.00|P-value:7.85E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.64|P-value:6.01E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.14|P-value:3.01E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.45|P-value:1.17E-6 ID:SGTC_2307|Compound:7538926|FD-Score:4.56|P-value:6.54E-7 ID:SGTC_2316|Compound:5844804|FD-Score:-3.04|P-value:4.58E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.26|P-value:1.87E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:1.02E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.08|P-value:7.93E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.07|P-value:7.97E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.20|P-value:2.46E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.31|P-value:2.33E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-2.95|P-value:6.29E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.06|P-value:6.27E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.85|P-value:1.42E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.44|P-value:6.99E-7 ID:SGTC_2747|Compound:doxorubicin|FD-Score:-3.42|P-value:9.70E-5 ID:SGTC_2748|Compound:diazoxide|FD-Score:-3.09|P-value:3.73E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.84|P-value:2.44E-5 ID:SGTC_3042|Compound:9091578|FD-Score:-3.59|P-value:4.57E-5 ID:SGTC_3058|Compound:9093861|FD-Score:2.95|P-value:9.27E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.39|P-value:1.09E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.10|P-value:3.03E-8 ID:SGTC_3108|Compound:9121785|FD-Score:4.09|P-value:7.32E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-4.25|P-value:1.94E-6 ID:SGTC_3353|Compound:9151644|FD-Score:3.51|P-value:1.05E-4 ID:SGTC_14|Compound:0354-0009|FD-Score:3.03|P-value:7.07E-4 ID:SGTC_24|Compound:0417-1663|FD-Score:3.02|P-value:7.24E-4 ID:SGTC_30|Compound:5-(2-thienylidene)-Rhodanine|FD-Score:-5.91|P-value:7.71E-11 ID:SGTC_135|Compound:0933-0004|FD-Score:-3.11|P-value:3.52E-4 ID:SGTC_137|Compound:0438-0332|FD-Score:3.08|P-value:5.92E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-8.04|P-value:1.96E-18 ID:SGTC_173|Compound:1273-0061|FD-Score:3.88|P-value:2.05E-5 ID:SGTC_218|Compound:alverine citrate|FD-Score:-3.08|P-value:3.83E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:4.03|P-value:1.00E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:3.35|P-value:2.00E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:4.71|P-value:2.84E-7 ID:SGTC_864|Compound:0469-0573|FD-Score:-6.63|P-value:3.65E-13 ID:SGTC_875|Compound:0709-0210|FD-Score:-4.09|P-value:4.47E-6 ID:SGTC_893|Compound:0958-0369|FD-Score:-14.70|P-value:2.31E-56 ID:SGTC_894|Compound:0960-0238|FD-Score:-5.39|P-value:2.56E-9 ID:SGTC_1086|Compound:cerivastatin|FD-Score:-3.91|P-value:1.04E-5 ID:SGTC_1088|Compound:bifonazole|FD-Score:-3.41|P-value:1.03E-4 ID:SGTC_1089|Compound:terbinafine|FD-Score:-7.46|P-value:3.70E-16 ID:SGTC_1090|Compound:efavirenz|FD-Score:-2.89|P-value:7.90E-4 ID:SGTC_1091|Compound:telmisartan|FD-Score:-4.62|P-value:2.70E-7 ID:SGTC_1187|Compound:1391-0724|FD-Score:-2.94|P-value:6.60E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.12|P-value:4.95E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.49|P-value:7.24E-5 ID:SGTC_1324|Compound:1418-0026|FD-Score:-4.24|P-value:2.05E-6 ID:SGTC_1331|Compound:1472-0049|FD-Score:-3.01|P-value:5.00E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-5.70|P-value:3.27E-10 ID:SGTC_1417|Compound:3966-0327|FD-Score:-3.03|P-value:4.78E-4 ID:SGTC_1428|Compound:4049-0204|FD-Score:-4.06|P-value:4.99E-6 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.60|P-value:6.96E-5 ID:SGTC_1545|Compound:lovastatin|FD-Score:3.52|P-value:9.98E-5 ID:SGTC_1550|Compound:gossypolone|FD-Score:5.40|P-value:4.69E-9 ID:SGTC_1551|Compound:6-bromo-3'-methylflavone|FD-Score:3.13|P-value:4.79E-4 ID:SGTC_1564|Compound:D-Arginine|FD-Score:5.12|P-value:2.79E-8 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:3.49|P-value:1.15E-4 ID:SGTC_1639|Compound:Lupinine o-methylbenzoicacid ester hydrochloride|FD-Score:-3.25|P-value:2.00E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.32|P-value:2.28E-4 ID:SGTC_1766|Compound:st045414|FD-Score:3.59|P-value:7.43E-5 ID:SGTC_1819|Compound:st053448|FD-Score:2.94|P-value:9.83E-4 ID:SGTC_1865|Compound:st057639|FD-Score:3.44|P-value:1.37E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.34|P-value:2.13E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.77|P-value:3.30E-5 ID:SGTC_1956|Compound:st077085|FD-Score:-3.56|P-value:5.22E-5 ID:SGTC_1970|Compound:st070122|FD-Score:3.00|P-value:7.85E-4 ID:SGTC_2044|Compound:5102272|FD-Score:3.64|P-value:6.01E-5 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.14|P-value:3.01E-4 ID:SGTC_2306|Compound:7482397|FD-Score:4.45|P-value:1.17E-6 ID:SGTC_2307|Compound:7538926|FD-Score:4.56|P-value:6.54E-7 ID:SGTC_2316|Compound:5844804|FD-Score:-3.04|P-value:4.58E-4 ID:SGTC_2380|Compound:9035439|FD-Score:-3.26|P-value:1.87E-4 ID:SGTC_2392|Compound:N-(3-chlorophenyl)-6-oxo-1H-pyridine-3-carboxamide|FD-Score:-3.92|P-value:1.02E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.08|P-value:7.93E-6 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.07|P-value:7.97E-6 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.20|P-value:2.46E-4 ID:SGTC_2512|Compound:diallyl trisulfide|FD-Score:3.31|P-value:2.33E-4 ID:SGTC_2518|Compound:prenyletin|FD-Score:-2.95|P-value:6.29E-4 ID:SGTC_2591|Compound:skatole|FD-Score:3.06|P-value:6.27E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-3.85|P-value:1.42E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-4.44|P-value:6.99E-7 ID:SGTC_2747|Compound:doxorubicin|FD-Score:-3.42|P-value:9.70E-5 ID:SGTC_2748|Compound:diazoxide|FD-Score:-3.09|P-value:3.73E-4 ID:SGTC_2944|Compound:9067346|FD-Score:3.84|P-value:2.44E-5 ID:SGTC_3042|Compound:9091578|FD-Score:-3.59|P-value:4.57E-5 ID:SGTC_3058|Compound:9093861|FD-Score:2.95|P-value:9.27E-4 ID:SGTC_3066|Compound:9117245|FD-Score:-3.39|P-value:1.09E-4 ID:SGTC_3076|Compound:9116187|FD-Score:5.10|P-value:3.03E-8 ID:SGTC_3108|Compound:9121785|FD-Score:4.09|P-value:7.32E-6 ID:SGTC_3193|Compound:9111931|FD-Score:-3.34|P-value:1.36E-4 ID:SGTC_3337|Compound:9144342|FD-Score:-4.25|P-value:1.94E-6 ID:SGTC_3353|Compound:9151644|FD-Score:3.51|P-value:1.05E-4

Top fitness defect scores for YPR088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1550 gossypolone 5.40 36.6 µM 4.69E-9 1 3.26E-8 0.87
2 SGTC_1564 D-Arginine 5.12 115.0 µM 2.79E-8 2 1.57E-7 0.40
3 SGTC_3076 9116187 5.10 49.5 µM 3.03E-8 2 1.68E-7 0.30
4 SGTC_831 k061-1017 4.71 217.0 µM 2.84E-7 translation 4 1.21E-6 0.48
5 SGTC_2307 7538926 4.56 6.3 µM 6.54E-7 15 2.53E-6 0.04
6 SGTC_2306 7482397 4.45 179.5 µM 1.17E-6 RPP1 & pyrimidine depletion 9 4.23E-6 0.41
7 SGTC_3108 9121785 4.09 49.5 µM 7.32E-6 7 2.14E-5 0.03
8 SGTC_2408 sulbentine 4.08 18.4 µM 7.93E-6 31 2.29E-5 0.03
9 SGTC_2409 alverine citrate 4.07 64.0 µM 7.97E-6 11 2.30E-5 0.11
10 SGTC_403 arphamenine a 4.03 50.0 µM 1.00E-5 60S ribosome export 4 2.82E-5 0.23
11 SGTC_173 1273-0061 3.88 2.7 µM 2.05E-5 mitochondrial stress 27 5.31E-5 0.07
12 SGTC_2944 9067346 3.84 25.6 µM 2.44E-5 14 6.20E-5 0.17
13 SGTC_1881 5652484 3.77 16.0 µM 3.30E-5 TRP & mitochondrial translation 6 8.09E-5 0.03
14 SGTC_2044 5102272 3.64 200.0 µM 6.01E-5 12 1.38E-4 0.17
15 SGTC_1539 benzyladenosine 3.60 56.0 µM 6.96E-5 9 1.57E-4 0.13
16 SGTC_1766 st045414 3.59 44.8 µM 7.43E-5 RPP1 & pyrimidine depletion 15 1.66E-4 0.06
17 SGTC_1545 lovastatin 3.52 49.4 µM 9.98E-5 10 2.16E-4 0.07
18 SGTC_3353 9151644 3.51 39.3 µM 1.05E-4 4 2.26E-4 0.12
19 SGTC_1565 sinapyl alcohol 3.49 95.1 µM 1.15E-4 9 2.45E-4 0.04
20 SGTC_1865 st057639 3.44 52.2 µM 1.37E-4 5 2.87E-4 0.08

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.210 9.94E-35 YAR007C RFA1 het Subunit of heterotrimeric Replication Protein A (RPA), which is a highly conserved single-stranded DNA binding protein involved in DNA replication, repair, and recombination
0.201 4.78E-32 YML025C YML6 het Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L4 ribosomal protein and human mitoribosomal MRP-L4 protein; essential for viability, unlike most other mitoribosomal proteins
0.196 3.00E-30 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.162 2.94E-21 YNL026W SAM50 het Essential component of the Sorting and Assembly Machinery (SAM or TOB complex) of the mitochondrial outer membrane, which binds precursors of beta-barrel proteins and facilitates their outer membrane insertion; homologous to bacterial Omp85
0.146 2.13E-17 YMR301C ATM1 het Mitochondrial inner membrane ATP-binding cassette (ABC) transporter, exports mitochondrially synthesized precursors of iron-sulfur (Fe/S) clusters to the cytosol
0.139 6.44E-16 YKL080W VMA5 hom Subunit C of the eight-subunit V1 peripheral membrane domain of vacuolar H+-ATPase (V-ATPase), an electrogenic proton pump found throughout the endomembrane system; required for the V1 domain to assemble onto the vacuolar membrane
0.122 1.39E-12 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.118 8.89E-12 YOR222W ODC2 hom Mitochondrial inner membrane transporter, exports 2-oxoadipate and 2-oxoglutarate from the mitochondrial matrix to the cytosol for use in lysine and glutamate biosynthesis and in lysine catabolism
0.113 4.50E-11 YJL175W_d YJL175W_d hom Dubious open reading frame unlikely to encode a functional protein; deletion confers resistance to cisplatin, hypersensitivity to 5-fluorouracil, and growth defect at high pH with high calcium; overlaps gene for SWI3 transcription factor
0.113 4.73E-11 YGL058W RAD6 hom Ubiquitin-conjugating enzyme (E2), involved in postreplication repair (as a heterodimer with Rad18p), DSBR and checkpoint control (as a heterodimer with Bre1p), ubiquitin-mediated N-end rule protein degradation (as a heterodimer with Ubr1p
0.110 1.51E-10 YBR039W ATP3 hom Gamma subunit of the F1 sector of mitochondrial F1F0 ATP synthase, which is a large, evolutionarily conserved enzyme complex required for ATP synthesis
0.109 2.70E-10 YOR299W BUD7 hom Member of the ChAPs family (Chs5p-Arf1p-binding proteins); members include Bch1p, Bch2p, Bud7p, and Chs6p; ChAPs family proteins form the exomer complex with Chs5p to mediate export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; BUD7 has a paralog, BCH1, that arose from the whole genome duplication
0.109 2.71E-10 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.108 3.63E-10 YLR117C CLF1 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; homolog of Drosophila crooked neck protein; interacts with U1 snRNP proteins
0.107 6.04E-10 YKL036C_d YKL036C_d het Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the essential gene UGP1 gene and uncharacterized ORF YKL037W