HIPHOP chemogenomics database

YPR089W_p

Protein of unknown function; exhibits genetic interaction with ERG11 and protein-protein interaction with Hsp82p

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR089W / YPR089W

Click on Significant Values for Screen Details

Top fitness defect scores for YPR089W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_768	0384-0033	8.20	77.3 µM	6.14E-16	fatty acid desaturase (OLE1)	22	1.20E-16
2	SGTC_178	4092-0806	7.00	87.5 µM	4.15E-12	ergosterol depletion effects on membrane	27	1.25E-12
3	SGTC_2502	avocadyne acetate	5.56	18.6 µM	2.87E-8		10	1.34E-8
4	SGTC_2049	5262831	5.07	67.2 µM	3.71E-7		10	1.96E-7
5	SGTC_568	1193-0097	4.98	7.5 µM	5.83E-7	ERAD & cell cycle	87	3.15E-7
6	SGTC_2501	sodium tetradecyl sulfate	4.96	13.4 µM	6.45E-7		19	3.50E-7
7	SGTC_686	1319-0111	4.95	510.0 µM	6.93E-7	60S ribosome export	11	3.77E-7
8	SGTC_842	0271-0008	4.81	11.1 µM	1.34E-6	heme biosynthesis & mitochondrial translocase	12	7.54E-7
9	SGTC_2351	9026858	4.75	72.3 µM	1.79E-6	RNA processing & uracil transport	14	1.02E-6
10	SGTC_2250	alverine citrate	4.54	130.0 µM	4.72E-6		122	2.82E-6
11	SGTC_2954	9074818	4.43	52.7 µM	7.63E-6		26	4.66E-6
12	SGTC_1660	st012960	4.42	28.1 µM	8.10E-6	iron homeostasis	25	4.96E-6
13	SGTC_637	1181-0519	4.42	7.3 µM	8.16E-6	fatty acid desaturase (OLE1)	85	5.00E-6
14	SGTC_350	k064-0020	4.10	19.8 µM	3.20E-5	heme requiring	27	2.09E-5
15	SGTC_2056	5235370	4.08	200.0 µM	3.42E-5		36	2.24E-5
16	SGTC_925	2064-1272	4.07	59.6 µM	3.64E-5		22	2.40E-5
17	SGTC_2950	9072895	3.80	21.5 µM	1.04E-4		44	7.17E-5
18	SGTC_312	4092-0653	3.73	6.8 µM	1.37E-4	ergosterol depletion effects on membrane	97	9.58E-5
19	SGTC_3349	9149703	3.68	23.0 µM	1.67E-4		22	1.18E-4
20	SGTC_2325	6158266	3.66	200.0 µM	1.75E-4		34	1.24E-4

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.196	1.98E-30	YKL135C	APL2	hom	Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.181	3.77E-26	YDL133W	SRF1	hom	Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.176	7.95E-25	YDL001W	RMD1	hom	Cytoplasmic protein required for sporulation
0.173	5.72E-24	YGR060W	ERG25	het	C-4 methyl sterol oxidase, catalyzes the first of three steps required to remove two C-4 methyl groups from an intermediate in ergosterol biosynthesis; mutants accumulate the sterol intermediate 4,4-dimethylzymosterol
0.167	1.62E-22	YJR060W	CBF1	hom	Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.159	1.73E-20	YML037C_p	YML037C_p	hom	Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.155	1.49E-19	YMR134W	ERG29	het	Protein of unknown function that may be involved in iron metabolism; mutant bm-8 has a growth defect on iron-limited medium that is complemented by overexpression of Yfh1p; shows localization to the ER; highly conserved in ascomycetes
0.148	8.28E-18	YDR213W	UPC2	hom	Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.144	4.18E-17	YDL226C	GCS1	hom	ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.138	8.28E-16	YFL034W_p	YFL034W_p	hom	Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.138	8.34E-16	YPL259C	APM1	hom	Mu1-like medium subunit of the clathrin-associated protein complex (AP-1); binds clathrin; involved in clathrin-dependent Golgi protein sorting
0.137	1.60E-15	YER031C	YPT31	hom	Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.136	3.14E-15	YLR350W	ORM2	hom	Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.133	8.77E-15	YMR071C	TVP18	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.133	9.95E-15	YHL019C	APM2	hom	Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport