HIPHOP chemogenomics database

YPR092W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain

fixedexpanded
Profile for YPR092W / YPR092W

Click on Significant Values for Screen Details

Top fitness defect scores for YPR092W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1803	st050068	18.20	52.4 µM	5.23E-68	NEO1-PIK1	2	1.69E-74
2	SGTC_1760	st045453	12.40	10.4 µM	9.05E-33	NEO1-PIK1	21	8.53E-36
3	SGTC_2939	9044578	8.36	71.4 µM	7.17E-16		10	3.02E-17
4	SGTC_2021	4019055	7.80	173.0 µM	5.00E-14	endomembrane recycling	24	3.18E-15
5	SGTC_1800	st050079	7.50	29.1 µM	3.99E-13	NEO1-PIK1	18	3.11E-14
6	SGTC_445	e6 berbamine	5.95	66.0 µM	6.74E-9	NEO1-PIK1	33	1.34E-9
7	SGTC_197	4544-0043	5.94	41.6 µM	7.05E-9	endomembrane recycling	16	1.40E-9
8	SGTC_1801	st050089	5.64	28.4 µM	3.67E-8	NEO1-PIK1	53	8.57E-9
9	SGTC_1204	4049-0315	5.49	18.3 µM	8.14E-8		4	2.05E-8
10	SGTC_1006	4099-6547	5.16	255.0 µM	4.26E-7		10	1.26E-7
11	SGTC_2020	4017018	4.85	200.0 µM	1.86E-6		5	6.28E-7
12	SGTC_146	3448-8650	4.78	53.1 µM	2.56E-6	NEO1-PIK1	94	8.93E-7
13	SGTC_2484	5809818	4.77	12.0 µM	2.58E-6		9	9.01E-7
14	SGTC_2424	5537928	4.50	59.2 µM	8.69E-6		24	3.40E-6
15	SGTC_2938	9059746	4.28	27.3 µM	2.22E-5	fatty acid desaturase (OLE1)	34	9.48E-6
16	SGTC_1818	st052136	4.26	56.3 µM	2.34E-5	NEO1-PIK1	38	1.00E-5
17	SGTC_3300	9124615	4.15	50.5 µM	3.75E-5		16	1.68E-5
18	SGTC_2429	5902844	4.05	64.4 µM	5.61E-5		23	2.62E-5
19	SGTC_1754	st042065	4.04	16.1 µM	5.76E-5	NEO1-PIK1	171	2.69E-5
20	SGTC_362	0310-0100	3.91	9.0 µM	9.61E-5	RPP1 & pyrimidine depletion	34	4.71E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.461	4.85E-176	YPR091C	NVJ2	hom	Lipid-binding ER protein, enriched at nucleus-vacuolar junctions (NVJ); may be involved in sterol metabolism or signaling at the NVJ; contains a synaptotagmin-like-mitochondrial- lipid binding protein (SMP) domain; binds phosphatidylinositols and other lipids in a large-scale study; may interact with ribosomes, based on co-purification experiments
0.417	5.78E-141	YDR492W	IZH1	hom	Membrane protein involved in zinc ion homeostasis, member of the four-protein IZH family; transcription is regulated directly by Zap1p, expression induced by zinc deficiency and fatty acids; deletion increases sensitivity to elevated zinc
0.395	1.79E-125	YLR020C	YEH2	hom	Steryl ester hydrolase, catalyzes steryl ester hydrolysis at the plasma membrane; involved in sterol metabolism
0.387	4.65E-120	YDR491C_d	YDR491C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.370	3.24E-109	YML097C	VPS9	hom	A guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport; specifically stimulates the intrinsic guanine nucleotide exchange activity of Vps21p/Rab5: similar to mammalian ras inhibitors; binds ubiquitin
0.360	5.29E-103	YNL267W	PIK1	het	Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.350	5.31E-97	YOR357C	SNX3	hom	Sorting nexin required to maintain late-Golgi resident enzymes in their proper location by recycling molecules from the prevacuolar compartment; contains a PX domain and sequence similarity to human Snx3p
0.342	1.20E-92	YPL145C	KES1	hom	One of seven members of the yeast oxysterol binding protein family; involved in negative regulation of Sec14p-dependent Golgi complex secretory functions, peripheral membrane protein that localizes to the Golgi complex; KES1 has a paralog, HES1, that arose from the whole genome duplication
0.336	6.04E-89	YAR042W	SWH1	hom	Protein similar to mammalian oxysterol-binding protein; contains ankyrin repeats; localizes to the Golgi and the nucleus-vacuole junction
0.327	1.77E-84	YNL183C	NPR1	hom	Protein kinase that stabilizes several plasma membrane amino acid transporters by antagonizing their ubiquitin-mediated degradation; phosphorylates Aly2p; negatively regulates Ldb19p-mediated endocytosis through phosphorylation of Ldb19p, which prevents its association with the plasma membrane; Npr1p activity is negatively regulated via phosphorylation by the TOR complex
0.324	8.27E-83	YGL035C	MIG1	hom	Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion
0.317	2.78E-79	YHR108W	GGA2	hom	Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.308	1.26E-74	YDR084C	TVP23	hom	Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.299	3.14E-70	YIL170W	HXT12	hom	Possible pseudogene in strain S288C; YIL170W/HXT12 and the adjacent ORF, YIL171W, together encode a non-functional member of the hexose transporter family
0.286	4.68E-64	YBR246W	RRT2	hom	Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription