HIPHOP chemogenomics database
YPR104C / FHL1 
Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YPR104C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.452 | 3.92E-168 | YER165W | PAB1 | het | Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G |
| 0.429 | 2.04E-150 | YBR091C | TIM12 | het | Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins |
| 0.404 | 1.22E-131 | YLR321C | SFH1 | het | Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog |
| 0.372 | 3.56E-110 | YJL081C | ARP4 | het | Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes |
| 0.366 | 4.40E-107 | YNR016C | ACC1 | het | Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids; |
| 0.348 | 6.17E-96 | YOR236W | DFR1 | het | Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism |
| 0.341 | 2.82E-92 | YDR172W | SUP35 | het | Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype |
| 0.341 | 6.50E-92 | YBR143C | SUP45 | het | Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p |
| 0.333 | 1.77E-87 | YBL026W | LSM2 | het | Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress |
| 0.314 | 1.42E-77 | YLL043W | FPS1 | hom | Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress |
| 0.310 | 9.91E-76 | YPL242C | IQG1 | het | Essential protein required for determination of budding pattern; promotes localization of axial markers Bud4p and Cdc12p and functionally interacts with Sec3p, localizes to the contractile ring during anaphase, member of the IQGAP family; relocalizes from bud neck to cytoplasm upon DNA replication stress |
| 0.300 | 1.50E-70 | YOL005C | RPB11 | het | RNA polymerase II subunit B12.5; part of central core; similar to Rpc19p and bacterial alpha subunit |
| 0.294 | 7.25E-68 | YBR020W | GAL1 | hom | Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication |
| 0.290 | 6.02E-66 | YFR037C | RSC8 | het | Component of the RSC chromatin remodeling complex; essential for viability and mitotic growth; homolog of SWI/SNF subunit Swi3p, but unlike Swi3p, does not activate transcription of reporters |
| 0.288 | 6.54E-65 | YLR033W | RSC58 | het | Component of the RSC chromatin remodeling complex; RSC functions in transcriptional regulation and elongation, chromosome stability, and establishing sister chromatid cohesion; involved in telomere maintenance |