HIPHOP chemogenomics database
YPR105C / COG4 
Essential component of the conserved oligomeric Golgi complex (Cog1p through Cog8p), a cytosolic tethering complex that functions in protein trafficking to mediate fusion of transport vesicles to Golgi compartments
Zygosity: Heterozygous strain
fixedexpanded
  Click on Significant Values for Screen Details |
Top fitness defect scores for YPR105C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Cofit Genes
Download Cofitness data (tab-delimited text) (excel)| Correlation | pval | ORF | Gene | Zygosity | Description |
|---|---|---|---|---|---|
| 0.136 | 2.30E-15 | YMR260C | TIF11 | het | Translation initiation factor eIF1A, essential protein that forms a complex with Sui1p (eIF1) and the 40S ribosomal subunit and scans for the start codon; C-terminus associates with Fun12p (eIF5B); N terminus interacts with eIF2 and eIF3 |
| 0.110 | 1.79E-10 | YDR189W | SLY1 | het | Hydrophilic protein involved in vesicle trafficking between the ER and Golgi; SM (Sec1/Munc-18) family protein that binds the tSNARE Sed5p and stimulates its assembly into a trans-SNARE membrane-protein complex |
| 0.108 | 3.04E-10 | YOR059C | YOR059C | hom | Lipid particle protein of unknown function; contains a putative lipase serine active site; induced by transcription factor Rpn4p; protein abundance increases in response to DNA replication stress |
| 0.104 | 1.79E-9 | YGL202W | ARO8 | hom | Aromatic aminotransferase I, expression is regulated by general control of amino acid biosynthesis |
| 0.093 | 7.70E-8 | YKR068C | BET3 | het | Hydrophilic protein that acts in conjunction with SNARE proteins in targeting and fusion of ER to Golgi transport vesicles; component of the TRAPP (transport protein particle) complex |
| 0.088 | 2.85E-7 | YDR272W | GLO2 | hom | Cytoplasmic glyoxalase II, catalyzes the hydrolysis of S-D-lactoylglutathione into glutathione and D-lactate |
| 0.087 | 4.80E-7 | YJR082C | EAF6 | hom | Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3 |
| 0.087 | 4.84E-7 | YKR080W | MTD1 | hom | NAD-dependent 5,10-methylenetetrahydrafolate dehydrogenase, plays a catalytic role in oxidation of cytoplasmic one-carbon units; expression is regulated by Bas1p and Bas2p, repressed by adenine, and may be induced by inositol and choline |
| 0.086 | 6.36E-7 | YDR109C_p | YDR109C_p | hom | Putative kinase |
| 0.082 | 1.83E-6 | YMR255W | GFD1 | hom | Coiled-coiled protein of unknown function; identified as a high-copy suppressor of a dbp5 mutation; protein abundance increases in response to DNA replication stress |
| 0.081 | 2.37E-6 | YNR061C | YNR061C | hom | Protein of unknown function; relocalizes from vacuole to cytoplasm upon DNA replication stress |
| 0.079 | 4.24E-6 | YPR031W | NTO1 | hom | Subunit of the NuA3 histone acetyltransferase complex that acetylates histone H3; contains PHD finger domain that interacts with methylated histone H3 |
| 0.078 | 5.90E-6 | YGL090W | LIF1 | hom | Component of the DNA ligase IV complex that mediates nonhomologous end joining in DNA double-strand break repair; physically interacts with Dnl4p and Nej1p; homologous to mammalian XRCC4 protein |
| 0.077 | 8.84E-6 | YBR063C_p | YBR063C_p | hom | Putative protein of unknown function; YBR063C is not an essential gene |
| 0.076 | 1.08E-5 | YPR160W | GPH1 | hom | Non-essential glycogen phosphorylase required for the mobilization of glycogen, activity is regulated by cyclic AMP-mediated phosphorylation, expression is regulated by stress-response elements and by the HOG MAP kinase pathway |