YPR116W / RRG8

Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR116W / RRG8

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.62|P-value:2.05E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.10|P-value:3.15E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.38|P-value:9.80E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.23|P-value:7.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.82|P-value:1.85E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.98|P-value:5.98E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.22|P-value:1.93E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.47|P-value:4.95E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.86|P-value:1.08E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.14|P-value:3.52E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.18|P-value:9.18E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.22|P-value:8.04E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.25|P-value:9.24E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.59|P-value:2.87E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.47|P-value:4.51E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.55|P-value:3.39E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.72|P-value:2.85E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.45|P-value:3.68E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.60|P-value:3.71E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.66|P-value:1.72E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.40|P-value:7.19E-8 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.47|P-value:3.44E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.85|P-value:8.63E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.92|P-value:6.36E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.26|P-value:7.18E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.80|P-value:1.86E-11 ID:SGTC_1916|Compound:st067606|FD-Score:3.20|P-value:8.81E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.33|P-value:7.06E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.24|P-value:9.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.02|P-value:4.40E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.59|P-value:2.95E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.58|P-value:2.31E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.06|P-value:5.80E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.72|P-value:2.89E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.34|P-value:5.54E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.91|P-value:1.41E-11 ID:SGTC_3142|Compound:9086498|FD-Score:-7.87|P-value:1.73E-14 ID:SGTC_3197|Compound:9113331|FD-Score:-3.90|P-value:9.23E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:3.62|P-value:2.05E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:3.73|P-value:1.33E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:4.10|P-value:3.15E-5 ID:SGTC_68|Compound:0986-0284|FD-Score:4.38|P-value:9.80E-6 ID:SGTC_141|Compound:0443-0274|FD-Score:3.23|P-value:7.90E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.82|P-value:1.85E-6 ID:SGTC_173|Compound:1273-0061|FD-Score:4.98|P-value:5.98E-7 ID:SGTC_195|Compound:4234-0266|FD-Score:3.65|P-value:1.79E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:4.22|P-value:1.93E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:5.47|P-value:4.95E-8 ID:SGTC_335|Compound:4077-0256|FD-Score:-3.86|P-value:1.08E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.14|P-value:3.52E-5 ID:SGTC_513|Compound:4245-1575|FD-Score:3.18|P-value:9.18E-4 ID:SGTC_601|Compound:0986-0029|FD-Score:3.69|P-value:1.56E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:3.22|P-value:8.04E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:-3.25|P-value:9.24E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:-3.59|P-value:2.87E-4 ID:SGTC_988|Compound:1497-1057|FD-Score:-3.47|P-value:4.51E-4 ID:SGTC_989|Compound:1501-0895|FD-Score:-3.55|P-value:3.39E-4 ID:SGTC_1000|Compound:4048-0884|FD-Score:-4.72|P-value:2.85E-6 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.22|P-value:8.19E-4 ID:SGTC_1319|Compound:1306-0155|FD-Score:3.45|P-value:3.68E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.17|P-value:9.70E-4 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.60|P-value:3.71E-6 ID:SGTC_1535|Compound:tetrahydropapaveroline hydrobromide|FD-Score:3.66|P-value:1.72E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:5.40|P-value:7.19E-8 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:3.47|P-value:3.44E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.85|P-value:8.63E-5 ID:SGTC_1600|Compound:coumarin 106|FD-Score:3.92|P-value:6.36E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.26|P-value:7.18E-4 ID:SGTC_1912|Compound:st060209|FD-Score:6.80|P-value:1.86E-11 ID:SGTC_1916|Compound:st067606|FD-Score:3.20|P-value:8.81E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.33|P-value:7.06E-4 ID:SGTC_2131|Compound:toluylene red|FD-Score:-3.24|P-value:9.78E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.02|P-value:4.40E-5 ID:SGTC_2314|Compound:7727897|FD-Score:-3.59|P-value:2.95E-4 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.35|P-value:6.62E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:3.58|P-value:2.31E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:4.67|P-value:2.62E-6 ID:SGTC_2777|Compound:climbazole|FD-Score:-5.06|P-value:5.80E-7 ID:SGTC_2778|Compound:tioconazole|FD-Score:-4.72|P-value:2.89E-6 ID:SGTC_2783|Compound:7738165|FD-Score:3.34|P-value:5.54E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-6.91|P-value:1.41E-11 ID:SGTC_3142|Compound:9086498|FD-Score:-7.87|P-value:1.73E-14 ID:SGTC_3197|Compound:9113331|FD-Score:-3.90|P-value:9.23E-5

Top fitness defect scores for YPR116W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1912 st060209 6.80 90.8 µM 1.86E-11 7 5.20E-12
2 SGTC_310 1273-0058 5.47 1.1 µM 4.95E-8 mitochondrial stress 164 2.23E-8
3 SGTC_1536 cytidine-2',3'-monophosphoric acid; 3'-cytidylic acid 5.40 61.9 µM 7.19E-8 3 3.31E-8
4 SGTC_173 1273-0061 4.98 2.7 µM 5.98E-7 mitochondrial stress 150 3.12E-7
5 SGTC_2772 vinpocetine 4.67 57.1 µM 2.62E-6 13 1.49E-6
6 SGTC_1457 k015-0032 4.60 57.3 µM 3.71E-6 22 2.16E-6
7 SGTC_68 0986-0284 4.38 82.8 µM 9.80E-6 49 6.02E-6
8 SGTC_236 1509-0011 4.22 5.3 µM 1.93E-5 368 1.23E-5
9 SGTC_66 0109-0187 4.10 42.4 µM 3.15E-5 36 2.07E-5
10 SGTC_2250 alverine citrate 4.02 130.0 µM 4.40E-5 150 2.94E-5
11 SGTC_1600 coumarin 106 3.92 71.1 µM 6.36E-5 28 4.34E-5
12 SGTC_1583 clindamycin 3.85 39.6 µM 8.63E-5 mitochondrial processes 15 5.99E-5
13 SGTC_63 0099-0242 3.73 26.7 µM 1.33E-4 mitochondrial stress 97 9.45E-5
14 SGTC_601 0986-0029 3.69 62.9 µM 1.56E-4 calcium & mitochondrial duress 46 1.12E-4
15 SGTC_1535 tetrahydropapaveroline hydrobromide 3.66 54.3 µM 1.72E-4 RPP1 & pyrimidine depletion 16 1.24E-4
16 SGTC_195 4234-0266 3.65 16.6 µM 1.79E-4 45 1.30E-4
17 SGTC_58 0957-0393 3.62 9.0 µM 2.05E-4 cell wall 414 1.50E-4
18 SGTC_2626 ethyl orsellinate 3.58 100.0 µM 2.31E-4 45 1.70E-4
19 SGTC_1537 2',6'-dihydroxyflavanone 3.47 78.0 µM 3.44E-4 34 2.58E-4
20 SGTC_1319 1306-0155 3.45 43.7 µM 3.68E-4 43 2.77E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.323 2.24E-82 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.302 1.03E-71 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.302 1.08E-71 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.301 9.34E-71 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.292 1.03E-66 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.291 1.70E-66 YDR194C MSS116 hom DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing
0.290 3.46E-66 YPL183W-A RTC6 hom Protein involved in translation; mutants have defects in biogenesis of nuclear ribosomes; sequence similar to prokaryotic ribosomal protein L36, may be a mitochondrial ribosomal protein; protein abundance increases in response to DNA replication stress
0.287 1.02E-64 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.287 1.28E-64 YMR228W MTF1 hom Mitochondrial RNA polymerase specificity factor; has structural similarity to S-adenosylmethionine-dependent methyltransferases and functional similarity to bacterial sigma-factors; Mtf1p interacts with and stabilizes the Rpo41p-promoter complex, enhancing DNA bending and melting to facilitate pre-initiation open complex formation
0.285 2.11E-63 YMR097C MTG1 hom Putative GTPase peripheral to the mitochondrial inner membrane, essential for respiratory competence, likely functions in assembly of the large ribosomal subunit, has homologs in plants and animals
0.281 8.40E-62 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.280 2.55E-61 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.275 2.33E-59 YMR282C AEP2 hom Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.275 3.05E-59 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.274 1.14E-58 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss