YPR120C / CLB5

B-type cyclin involved in DNA replication during S phase; activates Cdc28p to promote initiation of DNA synthesis; functions in formation of mitotic spindles along with Clb3p and Clb4p; most abundant during late G1 phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR120C / CLB5

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:5.67|P-value:5.49E-8 ID:SGTC_14|Compound:0354-0009|FD-Score:4.30|P-value:2.80E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.31|P-value:1.64E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:3.65E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.61|P-value:3.70E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.88|P-value:2.46E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:8.97|P-value:1.89E-17 ID:SGTC_146|Compound:3448-8650|FD-Score:3.35|P-value:8.79E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.54|P-value:4.74E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:14.20|P-value:5.12E-41 ID:SGTC_177|Compound:1327-0068|FD-Score:4.64|P-value:7.00E-6 ID:SGTC_201|Compound:4262-0159|FD-Score:3.66|P-value:3.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.64|P-value:2.84E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.28|P-value:9.67E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.82|P-value:8.21E-11 ID:SGTC_736|Compound:0958-0254|FD-Score:3.37|P-value:8.22E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:5.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.24|P-value:3.65E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:7.31|P-value:3.65E-12 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.62|P-value:3.58E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.40|P-value:1.90E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.66|P-value:2.68E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.28|P-value:3.70E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.74|P-value:2.38E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.29|P-value:9.35E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.29|P-value:3.56E-7 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.10|P-value:8.99E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.08|P-value:6.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.21|P-value:5.17E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.16|P-value:6.79E-7 ID:SGTC_1915|Compound:st067105|FD-Score:3.77|P-value:2.13E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.93|P-value:1.96E-6 ID:SGTC_1964|Compound:st076914|FD-Score:5.43|P-value:1.83E-7 ID:SGTC_1990|Compound:st072050|FD-Score:3.82|P-value:1.74E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.33|P-value:2.58E-5 ID:SGTC_2040|Compound:5100729|FD-Score:6.21|P-value:2.94E-9 ID:SGTC_2109|Compound:5483026|FD-Score:3.77|P-value:2.10E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.86|P-value:1.32E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.93|P-value:1.60E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.45|P-value:1.54E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.10|P-value:6.18E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.52|P-value:1.14E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.04|P-value:7.86E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.68|P-value:4.88E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-4.62|P-value:6.28E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.52|P-value:4.40E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.53|P-value:1.13E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.60|P-value:7.63E-8 ID:SGTC_2534|Compound:helenine|FD-Score:3.50|P-value:5.37E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:12.40|P-value:1.45E-31 ID:SGTC_2584|Compound:androsterone|FD-Score:6.14|P-value:4.22E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:8.85|P-value:4.95E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.91|P-value:1.50E-8 ID:SGTC_2671|Compound:danthron|FD-Score:3.42|P-value:6.95E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.87|P-value:2.58E-6 ID:SGTC_2889|Compound:9059656|FD-Score:3.56|P-value:4.40E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_2961|Compound:9083290|FD-Score:5.20|P-value:5.47E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.52|P-value:4.35E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.90|P-value:1.30E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.87|P-value:1.48E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:9.63E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.17|P-value:6.28E-7 ID:SGTC_3351|Compound:9150312|FD-Score:6.06|P-value:6.80E-9 ID:SGTC_8|Compound:0354-0001|FD-Score:5.67|P-value:5.49E-8 ID:SGTC_14|Compound:0354-0009|FD-Score:4.30|P-value:2.80E-5 ID:SGTC_18|Compound:0111-0177|FD-Score:6.31|P-value:1.64E-9 ID:SGTC_59|Compound:0330-0160|FD-Score:4.79|P-value:3.65E-6 ID:SGTC_71|Compound:0417-1750|FD-Score:3.61|P-value:3.70E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.88|P-value:2.46E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:8.97|P-value:1.89E-17 ID:SGTC_146|Compound:3448-8650|FD-Score:3.35|P-value:8.79E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.54|P-value:4.74E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:14.20|P-value:5.12E-41 ID:SGTC_177|Compound:1327-0068|FD-Score:4.64|P-value:7.00E-6 ID:SGTC_201|Compound:4262-0159|FD-Score:3.66|P-value:3.13E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-3.64|P-value:2.84E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:4.48|P-value:1.38E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.28|P-value:9.67E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.82|P-value:8.21E-11 ID:SGTC_736|Compound:0958-0254|FD-Score:3.37|P-value:8.22E-4 ID:SGTC_900|Compound:1112-0045|FD-Score:3.48|P-value:5.66E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:4.24|P-value:3.65E-5 ID:SGTC_916|Compound:4466-0038|FD-Score:7.31|P-value:3.65E-12 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.87|P-value:1.26E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.62|P-value:3.58E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:4.40|P-value:1.90E-5 ID:SGTC_1044|Compound:1222-0021|FD-Score:-3.66|P-value:2.68E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:5.28|P-value:3.70E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.74|P-value:2.38E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:-3.29|P-value:9.35E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:5.29|P-value:3.56E-7 ID:SGTC_1352|Compound:1496-0991|FD-Score:5.10|P-value:8.99E-7 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.08|P-value:6.80E-5 ID:SGTC_1712|Compound:st032288|FD-Score:5.21|P-value:5.17E-7 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.16|P-value:6.79E-7 ID:SGTC_1915|Compound:st067105|FD-Score:3.77|P-value:2.13E-4 ID:SGTC_1930|Compound:st074634|FD-Score:4.93|P-value:1.96E-6 ID:SGTC_1964|Compound:st076914|FD-Score:5.43|P-value:1.83E-7 ID:SGTC_1990|Compound:st072050|FD-Score:3.82|P-value:1.74E-4 ID:SGTC_2017|Compound:5132927|FD-Score:4.33|P-value:2.58E-5 ID:SGTC_2040|Compound:5100729|FD-Score:6.21|P-value:2.94E-9 ID:SGTC_2109|Compound:5483026|FD-Score:3.77|P-value:2.10E-4 ID:SGTC_2282|Compound:7944268|FD-Score:-3.86|P-value:1.32E-4 ID:SGTC_2286|Compound:7945697|FD-Score:-4.93|P-value:1.60E-6 ID:SGTC_2319|Compound:6033012|FD-Score:4.45|P-value:1.54E-5 ID:SGTC_2321|Compound:7390090|FD-Score:4.10|P-value:6.18E-5 ID:SGTC_2367|Compound:9070478|FD-Score:4.52|P-value:1.14E-5 ID:SGTC_2408|Compound:sulbentine|FD-Score:4.04|P-value:7.86E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-4.68|P-value:4.88E-6 ID:SGTC_2476|Compound:5806916|FD-Score:-4.62|P-value:6.28E-6 ID:SGTC_2477|Compound:5967686|FD-Score:-3.52|P-value:4.40E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.53|P-value:1.13E-5 ID:SGTC_2532|Compound:xanthone|FD-Score:5.60|P-value:7.63E-8 ID:SGTC_2534|Compound:helenine|FD-Score:3.50|P-value:5.37E-4 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:12.40|P-value:1.45E-31 ID:SGTC_2584|Compound:androsterone|FD-Score:6.14|P-value:4.22E-9 ID:SGTC_2619|Compound:obliquin|FD-Score:8.85|P-value:4.95E-17 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.91|P-value:1.50E-8 ID:SGTC_2671|Compound:danthron|FD-Score:3.42|P-value:6.95E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:4.87|P-value:2.58E-6 ID:SGTC_2889|Compound:9059656|FD-Score:3.56|P-value:4.40E-4 ID:SGTC_2912|Compound:7964298|FD-Score:3.70|P-value:2.67E-4 ID:SGTC_2961|Compound:9083290|FD-Score:5.20|P-value:5.47E-7 ID:SGTC_2964|Compound:9083345|FD-Score:-3.52|P-value:4.35E-4 ID:SGTC_3239|Compound:9133757|FD-Score:3.64|P-value:3.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:3.90|P-value:1.30E-4 ID:SGTC_3321|Compound:9137793|FD-Score:3.87|P-value:1.48E-4 ID:SGTC_3322|Compound:9139058|FD-Score:3.91|P-value:1.27E-4 ID:SGTC_3339|Compound:9145883|FD-Score:-3.28|P-value:9.63E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.17|P-value:6.28E-7 ID:SGTC_3351|Compound:9150312|FD-Score:6.06|P-value:6.80E-9

Top fitness defect scores for YPR120C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_163 1327-0036 14.20 7.5 µM 5.12E-41 7 3.13E-46
2 SGTC_2535 4',4'-dimethoxydalbergione 12.40 51.2 µM 1.45E-31 DNA damage response 1 1.55E-35
3 SGTC_138 0850-0259 8.97 40.9 µM 1.89E-17 cell wall 55 1.45E-19
4 SGTC_2619 obliquin 8.85 87.9 µM 4.95E-17 cell wall 33 4.30E-19
5 SGTC_916 4466-0038 7.31 42.0 nM 3.65E-12 cell wall 15 1.38E-13
6 SGTC_514 4466-0038 6.82 2.6 nM 8.21E-11 cell wall 57 4.66E-12
7 SGTC_18 0111-0177 6.31 500.0 nM 1.64E-9 14 1.37E-10
8 SGTC_2040 5100729 6.21 123.0 µM 2.94E-9 10 2.67E-10
9 SGTC_2584 androsterone 6.14 48.7 µM 4.22E-9 cell wall 55 4.01E-10
10 SGTC_3351 9150312 6.06 21.6 µM 6.80E-9 cell wall 6 6.88E-10
11 SGTC_2651 1327-0036 5.91 5.0 µM 1.50E-8 75 1.68E-9
12 SGTC_8 0354-0001 5.67 70.0 µM 5.49E-8 29 7.30E-9
13 SGTC_2532 xanthone 5.60 78.9 µM 7.63E-8 10 1.06E-8
14 SGTC_1964 st076914 5.43 61.0 µM 1.83E-7 RPP1 & pyrimidine depletion 4 2.85E-8
15 SGTC_1304 1165-0502 5.29 251.0 µM 3.56E-7 41 6.04E-8
16 SGTC_1082 camptothecin 5.28 424.9 nM 3.70E-7 DNA damage response 27 6.31E-8
17 SGTC_1712 st032288 5.21 53.4 µM 5.17E-7 calcium & mitochondrial duress 106 9.22E-8
18 SGTC_2961 9083290 5.20 32.5 µM 5.47E-7 5 9.82E-8
19 SGTC_3350 9150499 5.17 3.6 µM 6.28E-7 cell wall 24 1.15E-7
20 SGTC_1844 rapamycin 5.16 4.0 nM 6.79E-7 111 1.25E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.353 3.40E-99 YIL052C RPL34B hom Ribosomal 60S subunit protein L34B; homologous to mammalian ribosomal protein L34, no bacterial homolog; RPL34B has a paralog, RPL34A, that arose from the whole genome duplication
0.334 5.03E-88 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.302 1.66E-71 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.296 5.08E-69 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.274 5.76E-59 YEL061C CIN8 hom Kinesin motor protein involved in mitotic spindle assembly and chromosome segregation
0.272 6.91E-58 YJR013W GPI14 het Glycosylphosphatidylinositol-alpha 1,4 mannosyltransferase I, involved in GPI anchor biosynthesis, requires Pbn1p for function; homolog of mammalian PIG-M
0.269 8.38E-57 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.264 1.51E-54 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.260 3.95E-53 YGL116W CDC20 het Activator of anaphase-promoting complex/cyclosome (APC/C); APC/C is required for metaphase/anaphase transition; directs ubiquitination of mitotic cyclins, Pds1p, and other anaphase inhibitors; cell-cycle regulated; potential Cdc28p substrate; relative distribution to the nucleus increases upon DNA replication stress
0.244 1.27E-46 YNL239W LAP3 hom Cysteine aminopeptidase with homocysteine-thiolactonase activity; protects cells against homocysteine toxicity; has bleomycin hydrolase activity in vitro; transcription is regulated by galactose via Gal4p; orthologous to human BLMH
0.241 1.29E-45 YNL229C URE2 hom Nitrogen catabolite repression transcriptional regulator that acts by inhibition of GLN3 transcription in good nitrogen source; has glutathione peroxidase activity and can mutate to acquire GST activity; altered form creates [URE3] prion
0.236 1.61E-43 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.232 2.32E-42 YIR008C PRI1 het Subunit of DNA primase, which is required for DNA synthesis and double-strand break repair
0.228 8.64E-41 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.226 4.06E-40 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication