YPR133W-A / TOM5

Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import of all mitochondrially directed proteins; involved in transfer of precursors from the Tom70p and Tom20p receptors to the Tom40p pore

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR133W-A / TOM5

Click on Significant Values for Screen Details ID:SGTC_36|Compound:0335-0881|FD-Score:3.03|P-value:8.48E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.37|P-value:1.32E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.89|P-value:2.03E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.01|P-value:9.20E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:4.60|P-value:9.50E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:3.77|P-value:4.80E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.38|P-value:2.24E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.06|P-value:7.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.76|P-value:1.15E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.41|P-value:2.06E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.87|P-value:3.13E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.11|P-value:6.30E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.19|P-value:6.86E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.12|P-value:9.99E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.91|P-value:2.54E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.62|P-value:9.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:5.30|P-value:2.10E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.47|P-value:1.59E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:3.09|P-value:7.02E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.02|P-value:1.01E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.47|P-value:1.84E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.32|P-value:1.71E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.73|P-value:5.56E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.90|P-value:2.01E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-3.41|P-value:2.00E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.53|P-value:1.28E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.33|P-value:3.46E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.17|P-value:5.06E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.03|P-value:8.23E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.78|P-value:1.06E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.50|P-value:1.57E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.01|P-value:1.05E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.06|P-value:7.66E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.34|P-value:2.70E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.28|P-value:3.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.62|P-value:8.24E-7 ID:SGTC_3210|Compound:9128157|FD-Score:3.57|P-value:1.11E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.11|P-value:6.55E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:3.03|P-value:8.48E-4 ID:SGTC_64|Compound:000l-0018|FD-Score:5.37|P-value:1.32E-8 ID:SGTC_115|Compound:0527-0192|FD-Score:4.89|P-value:2.03E-7 ID:SGTC_158|Compound:k038-0087|FD-Score:3.01|P-value:9.20E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.63|P-value:8.51E-5 ID:SGTC_279|Compound:1273-0055|FD-Score:4.60|P-value:9.50E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:3.77|P-value:4.80E-5 ID:SGTC_304|Compound:1310-0298|FD-Score:3.58|P-value:1.07E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.38|P-value:2.24E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:-3.06|P-value:7.52E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-5.76|P-value:1.15E-9 ID:SGTC_467|Compound:ro 31-8220|FD-Score:3.18|P-value:4.98E-4 ID:SGTC_549|Compound:1661-1316|FD-Score:3.41|P-value:2.06E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:3.87|P-value:3.13E-5 ID:SGTC_619|Compound:1652-1634|FD-Score:-3.11|P-value:6.30E-4 ID:SGTC_629|Compound:3448-6466|FD-Score:-4.19|P-value:6.86E-6 ID:SGTC_637|Compound:1181-0519|FD-Score:4.12|P-value:9.99E-6 ID:SGTC_661|Compound:1304-0007|FD-Score:3.91|P-value:2.54E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.41|P-value:2.09E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:3.62|P-value:9.16E-5 ID:SGTC_743|Compound:1275-0778|FD-Score:5.30|P-value:2.10E-8 ID:SGTC_765|Compound:1319-0117|FD-Score:-3.47|P-value:1.59E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.55|P-value:1.27E-6 ID:SGTC_882|Compound:0843-0131|FD-Score:3.09|P-value:7.02E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:5.02|P-value:1.01E-7 ID:SGTC_1120|Compound:ficusin|FD-Score:3.58|P-value:1.05E-4 ID:SGTC_1317|Compound:1273-0028|FD-Score:4.47|P-value:1.84E-6 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.05|P-value:8.08E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-5.32|P-value:1.71E-8 ID:SGTC_1529|Compound:apigenin|FD-Score:3.50|P-value:1.45E-4 ID:SGTC_1712|Compound:st032288|FD-Score:3.76|P-value:5.01E-5 ID:SGTC_1725|Compound:st036284|FD-Score:3.73|P-value:5.56E-5 ID:SGTC_1728|Compound:st035614|FD-Score:4.90|P-value:2.01E-7 ID:SGTC_1730|Compound:st033808|FD-Score:-3.41|P-value:2.00E-4 ID:SGTC_1734|Compound:st037168|FD-Score:3.23|P-value:4.16E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.53|P-value:1.28E-6 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-4.33|P-value:3.46E-6 ID:SGTC_2083|Compound:5306046|FD-Score:3.04|P-value:8.21E-4 ID:SGTC_2146|Compound:5545642|FD-Score:-3.17|P-value:5.06E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.43|P-value:1.94E-4 ID:SGTC_2464|Compound:5717415|FD-Score:-3.03|P-value:8.23E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:5.78|P-value:1.06E-9 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.50|P-value:1.57E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:5.01|P-value:1.05E-7 ID:SGTC_2605|Compound:digitonin|FD-Score:3.06|P-value:7.66E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:3.34|P-value:2.70E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.28|P-value:3.43E-4 ID:SGTC_2849|Compound:9019321|FD-Score:3.49|P-value:1.53E-4 ID:SGTC_3206|Compound:9114350|FD-Score:-4.62|P-value:8.24E-7 ID:SGTC_3210|Compound:9128157|FD-Score:3.57|P-value:1.11E-4 ID:SGTC_3286|Compound:9117135|FD-Score:3.11|P-value:6.55E-4

Top fitness defect scores for YPR133W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2566 crystal violet carbinol 5.78 226.0 nM 1.06E-9 11 3.64E-9
2 SGTC_64 000l-0018 5.37 272.1 µM 1.32E-8 ubiquinone biosynthesis & proteasome 97 3.84E-8
3 SGTC_743 1275-0778 5.30 158.0 µM 2.10E-8 excess fatty acid 15 5.95E-8
4 SGTC_1012 4112-3522 5.02 18.0 µM 1.01E-7 10 2.56E-7
5 SGTC_2584 androsterone 5.01 48.7 µM 1.05E-7 cell wall 81 2.66E-7
6 SGTC_1728 st035614 4.90 33.8 µM 2.01E-7 25 4.89E-7
7 SGTC_115 0527-0192 4.89 112.0 µM 2.03E-7 37 4.94E-7
8 SGTC_279 1273-0055 4.60 2.9 µM 9.50E-7 azole & statin 28 2.09E-6
9 SGTC_769 0302-0231 4.55 76.0 µM 1.27E-6 24 2.73E-6
10 SGTC_2582 agaric acid 4.50 100.0 µM 1.57E-6 redox potentiating 257 3.35E-6
11 SGTC_1317 1273-0028 4.47 910.0 nM 1.84E-6 azole & statin 38 3.87E-6
12 SGTC_637 1181-0519 4.12 7.3 µM 9.99E-6 fatty acid desaturase (OLE1) 92 1.89E-5
13 SGTC_661 1304-0007 3.91 33.6 µM 2.54E-5 23 4.52E-5
14 SGTC_568 1193-0097 3.87 7.5 µM 3.13E-5 ERAD & cell cycle 157 5.49E-5
15 SGTC_283 0987-0079 3.77 11.7 µM 4.80E-5 31 8.19E-5
16 SGTC_1712 st032288 3.76 53.4 µM 5.01E-5 calcium & mitochondrial duress 202 8.52E-5
17 SGTC_1725 st036284 3.73 20.6 µM 5.56E-5 33 9.40E-5
18 SGTC_163 1327-0036 3.63 7.5 µM 8.51E-5 128 1.40E-4
19 SGTC_690 glyoxal 3.62 20.3 µM 9.16E-5 97 1.50E-4
20 SGTC_1120 ficusin 3.58 1.8 µM 1.05E-4 37 1.71E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.44E-31 YLR324W PEX30 hom Peroxisomal integral membrane protein, involved in negative regulation of peroxisome number; partially functionally redundant with Pex31p; genetic interactions suggest action at a step downstream of steps mediated by Pex28p and Pex29p
0.195 5.31E-30 YNL070W TOM7 hom Component of the TOM (translocase of outer membrane) complex responsible for recognition and initial import steps for all mitochondrially directed proteins; promotes assembly and stability of the TOM complex
0.195 5.91E-30 YJR091C JSN1 hom Member of the Puf family of RNA-binding proteins, interacts with mRNAs encoding membrane-associated proteins; involved in localizing the Arp2/3 complex to mitochondria; overexpression causes increased sensitivity to benomyl
0.192 4.54E-29 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.186 1.60E-27 YMR115W MGR3 hom Subunit of the mitochondrial (mt) i-AAA protease supercomplex, which degrades misfolded mitochondrial proteins; forms a subcomplex with Mgr1p that binds to substrates to facilitate proteolysis; required for growth of cells lacking mtDNA
0.186 2.24E-27 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.183 9.67E-27 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.172 8.33E-24 YBL022C PIM1 hom ATP-dependent Lon protease, involved in degradation of misfolded proteins in mitochondria; required for biogenesis and maintenance of mitochondria
0.171 1.59E-23 YOR158W PET123 hom Mitochondrial ribosomal protein of the small subunit; PET123 exhibits genetic interactions with PET122, which encodes a COX3 mRNA-specific translational activator
0.171 1.80E-23 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.168 9.53E-23 YDL133W SRF1 hom Regulator of phospholipase D (Spo14p); interacts with Spo14p and regulates its catalytic activity; capable of buffering the toxicity of C16:0 platelet activating factor, a lipid that accumulates intraneuronally in Alzheimer's patients
0.163 2.55E-21 YML014W TRM9 hom tRNA methyltransferase; catalyzes modification of wobble bases in tRNA anticodons to 2, 5-methoxycarbonylmethyluridine and 5-methoxycarbonylmethyl-2-thiouridine; may act as part of a complex with Trm112p; deletion mutation increases translational infidelity, including amino acid misincorporation and -1 frameshifting, and also confers resistance to zymocin; null mutant displays activation of stress responses
0.162 5.08E-21 YBL046W PSY4 hom Regulatory subunit of protein phosphatase PP4; presence of Psy4p in the PP4 complex (along with catalytic subunit Pph3p and Psy2p) is required for dephosphorylation of the histone variant H2AX, but not for dephosphorylation of Rad53p, during recovery from the DNA damage checkpoint; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; required for cisplatin resistance; homolog of mammalian R2
0.161 6.68E-21 YCR033W SNT1 hom Subunit of the Set3C deacetylase complex that interacts directly with the Set3C subunit, Sif2p; putative DNA-binding protein; mutant has increased aneuploidy tolerance
0.160 9.51E-21 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress