YPR146C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR146C / YPR146C

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.15|P-value:5.14E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.47|P-value:5.97E-23 ID:SGTC_58|Compound:0957-0393|FD-Score:5.28|P-value:2.16E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:22.00|P-value:6.79E-115 ID:SGTC_67|Compound:0335-0847|FD-Score:14.70|P-value:1.36E-52 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.63|P-value:1.08E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.03|P-value:1.30E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:13.80|P-value:1.43E-46 ID:SGTC_103|Compound:0844-0104|FD-Score:7.69|P-value:8.30E-16 ID:SGTC_107|Compound:0358-0022|FD-Score:5.92|P-value:4.25E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:13.40|P-value:7.02E-44 ID:SGTC_138|Compound:0850-0259|FD-Score:3.76|P-value:4.52E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:13.60|P-value:3.60E-45 ID:SGTC_158|Compound:k038-0087|FD-Score:7.87|P-value:1.85E-16 ID:SGTC_200|Compound:k038-0079|FD-Score:3.53|P-value:1.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.87|P-value:2.89E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.18|P-value:4.51E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.19|P-value:6.62E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.52|P-value:4.99E-9 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.39|P-value:2.78E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.73|P-value:1.38E-9 ID:SGTC_594|Compound:1487-1584|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.25|P-value:3.47E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.40|P-value:2.74E-27 ID:SGTC_829|Compound:1635-0120|FD-Score:3.06|P-value:7.06E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.94|P-value:1.47E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:3.66|P-value:7.01E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.12|P-value:1.27E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-5.55|P-value:6.62E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.86|P-value:3.02E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.81|P-value:2.89E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:11.80|P-value:2.34E-34 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.09|P-value:8.40E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.38|P-value:2.61E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.62|P-value:8.04E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.27|P-value:4.27E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.57|P-value:1.01E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.02|P-value:1.44E-5 ID:SGTC_1750|Compound:st081859|FD-Score:12.20|P-value:9.92E-37 ID:SGTC_1861|Compound:st057647|FD-Score:5.55|P-value:4.29E-9 ID:SGTC_1880|Compound:MG-132|FD-Score:3.75|P-value:4.67E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.24|P-value:4.79E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.74|P-value:6.87E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.60|P-value:8.94E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.85|P-value:4.26E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.36|P-value:2.35E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:2.25E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.13|P-value:5.59E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.22|P-value:5.10E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.37|P-value:2.26E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.82|P-value:4.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.81|P-value:3.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.69|P-value:8.52E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-4.52|P-value:1.92E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.16|P-value:4.30E-8 ID:SGTC_2870|Compound:9038528|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.93|P-value:2.20E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.42|P-value:1.51E-18 ID:SGTC_3060|Compound:1327-0027|FD-Score:9.01|P-value:5.86E-21 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.49|P-value:6.24E-9 ID:SGTC_3072|Compound:9116419|FD-Score:-3.28|P-value:4.20E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.07|P-value:6.71E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.34|P-value:1.53E-8 ID:SGTC_3318|Compound:9139014|FD-Score:3.95|P-value:1.96E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.20|P-value:4.24E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:3.18|P-value:4.65E-4 ID:SGTC_23|Compound:0213-0011|FD-Score:3.15|P-value:5.14E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:9.47|P-value:5.97E-23 ID:SGTC_58|Compound:0957-0393|FD-Score:5.28|P-value:2.16E-8 ID:SGTC_64|Compound:000l-0018|FD-Score:22.00|P-value:6.79E-115 ID:SGTC_67|Compound:0335-0847|FD-Score:14.70|P-value:1.36E-52 ID:SGTC_68|Compound:0986-0284|FD-Score:-3.63|P-value:1.08E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-5.03|P-value:1.30E-7 ID:SGTC_86|Compound:0417-1630|FD-Score:13.80|P-value:1.43E-46 ID:SGTC_103|Compound:0844-0104|FD-Score:7.69|P-value:8.30E-16 ID:SGTC_107|Compound:0358-0022|FD-Score:5.92|P-value:4.25E-10 ID:SGTC_137|Compound:0438-0332|FD-Score:13.40|P-value:7.02E-44 ID:SGTC_138|Compound:0850-0259|FD-Score:3.76|P-value:4.52E-5 ID:SGTC_142|Compound:0335-0849|FD-Score:13.60|P-value:3.60E-45 ID:SGTC_158|Compound:k038-0087|FD-Score:7.87|P-value:1.85E-16 ID:SGTC_200|Compound:k038-0079|FD-Score:3.53|P-value:1.17E-4 ID:SGTC_216|Compound:k038-0035|FD-Score:3.87|P-value:2.89E-5 ID:SGTC_246|Compound:cycloheximide|FD-Score:3.26|P-value:3.39E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:3.18|P-value:4.51E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.16|P-value:4.92E-4 ID:SGTC_340|Compound:k038-0059|FD-Score:4.19|P-value:6.62E-6 ID:SGTC_359|Compound:0081-0058|FD-Score:3.48|P-value:1.47E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:5.52|P-value:4.99E-9 ID:SGTC_464|Compound:bw-b 70c|FD-Score:2.96|P-value:9.92E-4 ID:SGTC_511|Compound:blebbistatin|FD-Score:-3.39|P-value:2.78E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:5.73|P-value:1.38E-9 ID:SGTC_594|Compound:1487-1584|FD-Score:3.38|P-value:2.11E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:3.25|P-value:3.47E-4 ID:SGTC_794|Compound:k038-0031|FD-Score:10.40|P-value:2.74E-27 ID:SGTC_829|Compound:1635-0120|FD-Score:3.06|P-value:7.06E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:4.94|P-value:1.47E-7 ID:SGTC_984|Compound:1492-0255|FD-Score:3.66|P-value:7.01E-5 ID:SGTC_1108|Compound:betulinic acid|FD-Score:-4.12|P-value:1.27E-5 ID:SGTC_1112|Compound:tnp00069|FD-Score:-5.55|P-value:6.62E-9 ID:SGTC_1161|Compound:k007-0610|FD-Score:3.03|P-value:7.77E-4 ID:SGTC_1163|Compound:k060-0048|FD-Score:3.86|P-value:3.02E-5 ID:SGTC_1200|Compound:1643-0193|FD-Score:4.81|P-value:2.89E-7 ID:SGTC_1294|Compound:1000-1494|FD-Score:11.80|P-value:2.34E-34 ID:SGTC_1352|Compound:1496-0991|FD-Score:-3.09|P-value:8.40E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.07|P-value:6.88E-4 ID:SGTC_1498|Compound:4478-3555|FD-Score:4.38|P-value:2.61E-6 ID:SGTC_1567|Compound:st069303|FD-Score:3.41|P-value:1.90E-4 ID:SGTC_1642|Compound:st009582|FD-Score:3.28|P-value:3.20E-4 ID:SGTC_1652|Compound:st011932|FD-Score:3.62|P-value:8.04E-5 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:-3.27|P-value:4.27E-4 ID:SGTC_1740|Compound:st038286|FD-Score:4.57|P-value:1.01E-6 ID:SGTC_1748|Compound:st037455|FD-Score:4.02|P-value:1.44E-5 ID:SGTC_1750|Compound:st081859|FD-Score:12.20|P-value:9.92E-37 ID:SGTC_1861|Compound:st057647|FD-Score:5.55|P-value:4.29E-9 ID:SGTC_1880|Compound:MG-132|FD-Score:3.75|P-value:4.67E-5 ID:SGTC_1883|Compound:5-benzylidenerhodanine|FD-Score:-3.24|P-value:4.79E-4 ID:SGTC_1936|Compound:st074407|FD-Score:-3.74|P-value:6.87E-5 ID:SGTC_1974|Compound:st069448|FD-Score:3.25|P-value:3.55E-4 ID:SGTC_2054|Compound:5233173|FD-Score:3.60|P-value:8.94E-5 ID:SGTC_2276|Compound:7947513|FD-Score:-3.85|P-value:4.26E-5 ID:SGTC_2337|Compound:9009472|FD-Score:3.36|P-value:2.35E-4 ID:SGTC_2408|Compound:sulbentine|FD-Score:3.37|P-value:2.25E-4 ID:SGTC_2429|Compound:5902844|FD-Score:3.13|P-value:5.59E-4 ID:SGTC_2445|Compound:5742597|FD-Score:-3.22|P-value:5.10E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.37|P-value:2.26E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.82|P-value:4.83E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.81|P-value:3.68E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:3.01|P-value:8.47E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-3.69|P-value:8.52E-5 ID:SGTC_2696|Compound:st077691|FD-Score:-4.52|P-value:1.92E-6 ID:SGTC_2782|Compound:7736369|FD-Score:5.16|P-value:4.30E-8 ID:SGTC_2870|Compound:9038528|FD-Score:3.25|P-value:3.59E-4 ID:SGTC_2921|Compound:7974240|FD-Score:3.93|P-value:2.20E-5 ID:SGTC_3004|Compound:9076122|FD-Score:3.24|P-value:3.60E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:8.42|P-value:1.51E-18 ID:SGTC_3060|Compound:1327-0027|FD-Score:9.01|P-value:5.86E-21 ID:SGTC_3063|Compound:1327-0034|FD-Score:5.49|P-value:6.24E-9 ID:SGTC_3072|Compound:9116419|FD-Score:-3.28|P-value:4.20E-4 ID:SGTC_3219|Compound:9131112|FD-Score:3.07|P-value:6.71E-4 ID:SGTC_3282|Compound:9108498|FD-Score:5.34|P-value:1.53E-8 ID:SGTC_3318|Compound:9139014|FD-Score:3.95|P-value:1.96E-5 ID:SGTC_3328|Compound:9140624|FD-Score:3.20|P-value:4.24E-4

Top fitness defect scores for YPR146C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_64 000l-0018 22.00 272.1 µM 6.79E-115 ubiquinone biosynthesis & proteasome 8 5.70E-108
2 SGTC_67 0335-0847 14.70 266.0 µM 1.36E-52 ubiquinone biosynthesis & proteasome 10 2.08E-49
3 SGTC_86 0417-1630 13.80 471.9 µM 1.43E-46 ubiquinone biosynthesis & proteasome 21 9.46E-44
4 SGTC_142 0335-0849 13.60 62.7 µM 3.60E-45 ubiquinone biosynthesis & proteasome 19 1.96E-42
5 SGTC_137 0438-0332 13.40 85.4 µM 7.02E-44 ubiquinone biosynthesis & proteasome 17 3.18E-41
6 SGTC_1750 st081859 12.20 2.4 µM 9.92E-37 endomembrane recycling 30 1.66E-34
7 SGTC_1294 1000-1494 11.80 117.0 µM 2.34E-34 10 2.81E-32
8 SGTC_794 k038-0031 10.40 316.0 µM 2.74E-27 ubiquinone biosynthesis & proteasome 14 1.22E-25
9 SGTC_36 0335-0881 9.47 14.2 µM 5.97E-23 ubiquinone biosynthesis & proteasome 21 1.44E-21
10 SGTC_3060 1327-0027 9.01 12.5 µM 5.86E-21 9 1.07E-19
11 SGTC_3059 1327-0034 8.42 3.0 µM 1.51E-18 17 1.95E-17
12 SGTC_158 k038-0087 7.87 26.4 µM 1.85E-16 ubiquinone biosynthesis & proteasome 50 1.77E-15
13 SGTC_103 0844-0104 7.69 51.8 µM 8.30E-16 ERAD & cell cycle 49 7.26E-15
14 SGTC_107 0358-0022 5.92 2.7 µM 4.25E-10 SWF1 & branched chain AA biosynthesis 16 1.64E-9
15 SGTC_576 1073-0113 5.73 22.7 µM 1.38E-9 redox potentiating 23 4.96E-9
16 SGTC_1861 st057647 5.55 17.4 µM 4.29E-9 3 1.44E-8
17 SGTC_367 0335-0881 5.52 7.1 µM 4.99E-9 ubiquinone biosynthesis & proteasome 29 1.65E-8
18 SGTC_3063 1327-0034 5.49 4.0 µM 6.24E-9 25 2.04E-8
19 SGTC_3282 9108498 5.34 15.5 µM 1.53E-8 11 4.71E-8
20 SGTC_58 0957-0393 5.28 9.0 µM 2.16E-8 cell wall 258 6.54E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.675 0 YFR007W YFH7 hom Putative kinase with similarity to the phosphoribulokinase/uridine kinase/bacterial pantothenate kinase (PRK/URK/PANK) subfamily of P-loop kinases
0.673 0 YDL183C YDL183C hom Mitochondrial inner-membrane protein thought to be involved in the formation of an active mitochondrial K+/H+ exchanger (KHE) system; non-essential gene
0.662 0 YJL155C FBP26 hom Fructose-2,6-bisphosphatase, required for glucose metabolism; protein abundance increases in response to DNA replication stress
0.655 0 YDR537C_d YDR537C_d hom Dubious open reading frame unlikely to encode a protein, almost completely overlaps verified ORF PAD1/YDR538W
0.644 0 YER041W YEN1 hom Holliday junction resolvase; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation; homolog of human GEN1 and has similarity to S. cerevisiae endonuclease Rth1p
0.629 0 YJL193W_p YJL193W_p hom Putative protein of unknown function, predicted to encode a triose phosphate transporter subfamily member based on phylogenetic analysis; similar to YOR307C/SLY41; deletion mutant has a respiratory growth defect
0.599 0 YCL014W BUD3 hom Protein involved in bud-site selection and required for axial budding pattern; localizes with septins to bud neck in mitosis and may constitute an axial landmark for next round of budding
0.575 1.05E-294 YJR129C_p YJR129C_p hom Putative protein of unknown function; predicted S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.555 2.90E-270 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.547 3.14E-261 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.532 1.82E-244 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.518 1.73E-229 YML034C-A_d YML034C-A_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.508 5.27E-220 YJL168C SET2 hom Histone methyltransferase with a role in transcriptional elongation; methylates H3 lysine 36, which suppresses incorporation of acetylated histones and signals for the deacetylation of these histones within transcribed genes; associates with the C-terminal domain of Rpo21p; histone methylation activity is regulated by phosphorylation status of Rpo21p
0.504 8.22E-216 YGL119W COQ8 hom Protein required for ubiquinone biosynthesis and respiratory growth; exhibits genetic interaction with COQ9, suggesting a common function; similar to prokaryotic proteins involved in early steps of ubiquinone biosynthesis; COQ8 has a paralog, YBR230W-A, that arose from the whole genome duplication
0.489 3.76E-201 YML034W SRC1 hom Inner nuclear membrane protein; functions in regulation of subtelomeric genes and is linked to TREX (transcription export) factors; SRC1 produces 2 splice variant proteins with different functions; alternative splicing of SRC1 pre-mRNA is promoted by Hub1p; mutant has aneuploidy tolerance