YPR151C / SUE1

Mitochondrial protein required for degradation of unstable forms of cytochrome c

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR151C / SUE1

Click on Significant Values for Screen Details ID:SGTC_66|Compound:0109-0187|FD-Score:-5.25|P-value:4.22E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.15|P-value:5.96E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.99|P-value:1.50E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.65|P-value:9.44E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.92|P-value:2.58E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.22|P-value:8.10E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.00|P-value:2.22E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:2.66|P-value:9.80E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.56|P-value:1.55E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:2.68|P-value:9.30E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.14|P-value:1.19E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:4.87E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.97|P-value:1.91E-6 ID:SGTC_2001|Compound:4023502|FD-Score:5.13|P-value:1.14E-9 ID:SGTC_2002|Compound:4023503|FD-Score:5.84|P-value:5.23E-12 ID:SGTC_2005|Compound:4024620|FD-Score:-3.43|P-value:3.01E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-2.67|P-value:8.95E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.01|P-value:2.28E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.09|P-value:1.63E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.04|P-value:2.01E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.34|P-value:4.76E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.19|P-value:1.03E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.87|P-value:3.91E-4 ID:SGTC_2814|Compound:7977482|FD-Score:2.75|P-value:6.86E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.13|P-value:1.22E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.56|P-value:1.60E-5 ID:SGTC_3067|Compound:9117431|FD-Score:2.70|P-value:8.55E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.83|P-value:4.57E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.19|P-value:1.06E-4 ID:SGTC_66|Compound:0109-0187|FD-Score:-5.25|P-value:4.22E-10 ID:SGTC_72|Compound:0744-0168|FD-Score:-4.15|P-value:5.96E-7 ID:SGTC_74|Compound:000s-0487|FD-Score:-3.99|P-value:1.50E-6 ID:SGTC_337|Compound:1315-0038|FD-Score:-2.65|P-value:9.44E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.92|P-value:2.58E-6 ID:SGTC_516|Compound:3992-2719|FD-Score:-3.22|P-value:8.10E-5 ID:SGTC_517|Compound:1365-0151|FD-Score:-3.00|P-value:2.22E-4 ID:SGTC_808|Compound:0711-0032|FD-Score:2.66|P-value:9.80E-4 ID:SGTC_926|Compound:2268-1401|FD-Score:-3.56|P-value:1.55E-5 ID:SGTC_965|Compound:1291-5240|FD-Score:2.68|P-value:9.30E-4 ID:SGTC_1374|Compound:2889-5571|FD-Score:-3.14|P-value:1.19E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.33|P-value:4.87E-5 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.97|P-value:1.91E-6 ID:SGTC_2001|Compound:4023502|FD-Score:5.13|P-value:1.14E-9 ID:SGTC_2002|Compound:4023503|FD-Score:5.84|P-value:5.23E-12 ID:SGTC_2005|Compound:4024620|FD-Score:-3.43|P-value:3.01E-5 ID:SGTC_2122|Compound:5258151|FD-Score:-2.67|P-value:8.95E-4 ID:SGTC_2124|Compound:5246320|FD-Score:3.01|P-value:2.28E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:3.09|P-value:1.63E-4 ID:SGTC_2182|Compound:6325192|FD-Score:3.04|P-value:2.01E-4 ID:SGTC_2329|Compound:6138490|FD-Score:-3.34|P-value:4.76E-5 ID:SGTC_2344|Compound:7990960|FD-Score:3.19|P-value:1.03E-4 ID:SGTC_2785|Compound:7756463|FD-Score:-2.87|P-value:3.91E-4 ID:SGTC_2814|Compound:7977482|FD-Score:2.75|P-value:6.86E-4 ID:SGTC_2954|Compound:9074818|FD-Score:-3.13|P-value:1.22E-4 ID:SGTC_3002|Compound:9075603|FD-Score:-3.56|P-value:1.60E-5 ID:SGTC_3067|Compound:9117431|FD-Score:2.70|P-value:8.55E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-2.83|P-value:4.57E-4 ID:SGTC_3098|Compound:9119039|FD-Score:3.19|P-value:1.06E-4

Top fitness defect scores for YPR151C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2002 4023503 5.84 131.0 µM 5.23E-12 mitochondrial processes 8 2.62E-9
2 SGTC_2001 4023502 5.13 57.7 µM 1.14E-9 mitochondrial processes 4 1.42E-7
3 SGTC_1503 4585-0012 3.97 61.3 µM 1.91E-6 13 3.57E-5
4 SGTC_358 0075-0058 3.92 9.4 µM 2.58E-6 65 4.47E-5
5 SGTC_2344 7990960 3.19 77.0 µM 1.03E-4 55 7.09E-4
6 SGTC_3098 9119039 3.19 49.5 µM 1.06E-4 Golgi 66 7.22E-4
7 SGTC_2170 morpholine 3.09 200.0 µM 1.63E-4 33 9.99E-4
8 SGTC_2182 6325192 3.04 200.0 µM 2.01E-4 Golgi 35 0.00117
9 SGTC_2124 5246320 3.01 200.0 µM 2.28E-4 heme biosynthesis & mitochondrial translocase 58 0.00129
10 SGTC_2814 7977482 2.75 43.0 µM 6.86E-4 138 0.00295
11 SGTC_3067 9117431 2.70 49.5 µM 8.55E-4 73 0.00348
12 SGTC_965 1291-5240 2.68 308.0 µM 9.30E-4 93 0.00371
13 SGTC_808 0711-0032 2.66 135.0 µM 9.80E-4 81 0.00386
14 SGTC_1346 1488-2224 2.60 62.4 µM 0.00126 78 0.00467
15 SGTC_2355 9061122 2.56 103.1 µM 0.00144 78 0.00517
16 SGTC_2050 5263056 2.53 171.0 µM 0.00166 fatty acid desaturase (OLE1) 151 0.00576
17 SGTC_1034 k072-0165 2.50 12.7 µM 0.00181 Golgi 119 0.00614
18 SGTC_1747 st037496 2.48 66.6 µM 0.00201 125 0.00664
19 SGTC_1975 st070967 2.46 30.8 µM 0.00211 161 0.00690
20 SGTC_616 4092-0450 2.42 108.0 µM 0.00243 120 0.00766

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 1.11E-46 YJR106W ECM27 hom Putative protein of unknown function; may play a role in cell wall biosynthesis, mutants are hypersensitive to Papulacandin B; null mutants have increased plasmid loss; displays a two-hybrid interaction with Pdr5p
0.238 2.54E-44 YLR237W THI7 hom Plasma membrane transporter responsible for the uptake of thiamine, member of the major facilitator superfamily of transporters; mutation of human ortholog causes thiamine-responsive megaloblastic anemia
0.213 8.48E-36 YLR414C PUN1 hom Plasma membrane protein with a role in cell wall integrity; co-localizes with Sur7p in punctate membrane patches; null mutant displays decreased thermotolerance; transcription induced upon cell wall damage and metal ion stress
0.195 4.96E-30 YGR213C RTA1 hom Protein involved in 7-aminocholesterol resistance; has seven potential membrane-spanning regions; expression is induced under both low-heme and low-oxygen conditions; member of the fungal lipid-translocating exporter (LTE) family of protein
0.191 7.91E-29 YDR312W SSF2 hom Protein required for ribosomal large subunit maturation; functionally redundant with Ssf1p; member of the Brix family; SSF2 has a paralog, SSF1, that arose from the whole genome duplication
0.190 1.18E-28 YDR374C_p YDR374C_p hom Putative protein of unknown function
0.176 9.47E-25 YOR252W TMA16 hom Protein of unknown function that associates with ribosomes
0.170 2.95E-23 YLR405W DUS4 hom Dihydrouridine synthase, member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus3p
0.158 3.43E-20 YDL176W YDL176W hom Protein of unknown function, predicted by computational methods to be involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; interacts with components of the GID complex; YDL176W is not an essential gene
0.156 1.15E-19 YNL013C_d YNL013C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF HEF3/YNL014W
0.155 1.84E-19 YGL004C RPN14 hom Proteasome-interacting protein involved in the assembly of the base subcomplex of the 19S proteasome regulatory particle (RP); null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; interacts with Rpt5p
0.153 4.72E-19 YBR047W_p FMP23_p hom Putative protein of unknown function; proposed to be involved in iron or copper homeostasis; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.153 4.76E-19 YOL071W EMI5 hom Subunit of succinate dehydrogenase, which couples succinate oxidation to ubiquinone reduction; required for FAD cofactor attachment to Sdh1p; mutations in human ortholog PGL2 are associated with neuroendocrine tumors (paraganglioma)
0.152 9.49E-19 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.145 2.71E-17 YGR022C_d YGR022C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps almost completely with the verified ORF MTL1/YGR023W