YPR165W / RHO1

GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YPR165W / RHO1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:12.80|P-value:1.66E-21 ID:SGTC_91|Compound:0417-1751|FD-Score:7.25|P-value:4.55E-8 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.53|P-value:4.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:6.06E-26 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.10|P-value:9.80E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.97|P-value:9.33E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.57|P-value:4.00E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.05|P-value:1.00E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:9.66|P-value:4.81E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:11.10|P-value:9.66E-17 ID:SGTC_351|Compound:caspofungin|FD-Score:4.24|P-value:9.41E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:8.97|P-value:1.74E-11 ID:SGTC_360|Compound:0957-0399|FD-Score:21.00|P-value:9.84E-55 ID:SGTC_369|Compound:0957-0393|FD-Score:4.28|P-value:8.54E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.13|P-value:8.19E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.41|P-value:6.11E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:6.48|P-value:9.15E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:16.20|P-value:2.62E-33 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.47|P-value:1.81E-8 ID:SGTC_483|Compound:fpl-64176|FD-Score:10.80|P-value:8.92E-16 ID:SGTC_486|Compound:niguldipine|FD-Score:5.71|P-value:1.33E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.42|P-value:3.40E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:10.70|P-value:1.32E-15 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.56|P-value:2.98E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.25|P-value:9.14E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.39|P-value:1.27E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.93|P-value:6.25E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:25.40|P-value:2.27E-79 ID:SGTC_591|Compound:4299-0174|FD-Score:5.07|P-value:9.63E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:6.50|P-value:8.31E-7 ID:SGTC_624|Compound:k048-0052|FD-Score:5.18|P-value:7.00E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:9.96|P-value:8.81E-14 ID:SGTC_643|Compound:k048-0106|FD-Score:7.08|P-value:8.94E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:24.60|P-value:7.83E-75 ID:SGTC_673|Compound:1082-0474|FD-Score:6.53|P-value:7.46E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.90|P-value:1.58E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.39|P-value:4.70E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:7.38|P-value:2.65E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:6.37|P-value:1.35E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:5.08|P-value:9.38E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:29.40|P-value:3.57E-106 ID:SGTC_871|Compound:0574-0004|FD-Score:5.99|P-value:5.22E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:18.40|P-value:1.45E-42 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:17.60|P-value:5.53E-39 ID:SGTC_916|Compound:4466-0038|FD-Score:4.80|P-value:2.12E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:21.60|P-value:5.54E-58 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.98|P-value:8.90E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:24.50|P-value:2.27E-74 ID:SGTC_974|Compound:1326-0144|FD-Score:4.80|P-value:2.11E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:14.30|P-value:1.36E-26 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.48|P-value:5.06E-4 ID:SGTC_1115|Compound:galangin|FD-Score:5.87|P-value:7.77E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:5.76|P-value:1.13E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:9.38|P-value:2.14E-12 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.34|P-value:1.52E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.11|P-value:8.64E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.93|P-value:2.05E-11 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.63|P-value:3.42E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.70|P-value:2.76E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.29|P-value:1.82E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.60|P-value:1.05E-10 ID:SGTC_1652|Compound:st011932|FD-Score:4.67|P-value:3.02E-4 ID:SGTC_1672|Compound:st016598|FD-Score:9.48|P-value:1.26E-12 ID:SGTC_1707|Compound:st032323|FD-Score:5.55|P-value:2.23E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.05|P-value:4.25E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:15.10|P-value:2.70E-29 ID:SGTC_1880|Compound:MG-132|FD-Score:7.77|P-value:4.86E-9 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.67|P-value:3.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.81|P-value:2.61E-7 ID:SGTC_2003|Compound:4023581|FD-Score:4.98|P-value:1.25E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.56|P-value:1.30E-10 ID:SGTC_2009|Compound:4012297|FD-Score:10.10|P-value:3.19E-14 ID:SGTC_2017|Compound:5132927|FD-Score:-4.81|P-value:1.45E-4 ID:SGTC_2022|Compound:5136654|FD-Score:7.66|P-value:7.99E-9 ID:SGTC_2024|Compound:5144227|FD-Score:4.27|P-value:8.73E-4 ID:SGTC_2028|Compound:5153890|FD-Score:21.70|P-value:2.39E-58 ID:SGTC_2041|Compound:5107442|FD-Score:4.38|P-value:6.48E-4 ID:SGTC_2057|Compound:5236571|FD-Score:5.65|P-value:1.62E-5 ID:SGTC_2109|Compound:5483026|FD-Score:10.40|P-value:9.68E-15 ID:SGTC_2111|Compound:5486399|FD-Score:5.10|P-value:9.01E-5 ID:SGTC_2124|Compound:5246320|FD-Score:16.50|P-value:1.38E-34 ID:SGTC_2140|Compound:5586273|FD-Score:6.87|P-value:2.03E-7 ID:SGTC_2149|Compound:5554786|FD-Score:15.80|P-value:4.12E-32 ID:SGTC_2160|Compound:5660466|FD-Score:5.45|P-value:3.04E-5 ID:SGTC_2180|Compound:6301957|FD-Score:10.70|P-value:1.01E-15 ID:SGTC_2210|Compound:7115885|FD-Score:7.68|P-value:7.32E-9 ID:SGTC_2248|Compound:tofa|FD-Score:5.72|P-value:1.26E-5 ID:SGTC_2272|Compound:7805186|FD-Score:17.80|P-value:4.96E-40 ID:SGTC_2278|Compound:7948257|FD-Score:4.57|P-value:3.95E-4 ID:SGTC_2289|Compound:7946404|FD-Score:32.60|P-value:5.27E-130 ID:SGTC_2304|Compound:7443016|FD-Score:5.79|P-value:1.03E-5 ID:SGTC_2354|Compound:9060492|FD-Score:5.03|P-value:1.09E-4 ID:SGTC_2367|Compound:9070478|FD-Score:8.14|P-value:9.34E-10 ID:SGTC_2399|Compound:5884133|FD-Score:12.90|P-value:6.13E-22 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.68|P-value:4.24E-7 ID:SGTC_2471|Compound:5466956|FD-Score:5.37|P-value:3.97E-5 ID:SGTC_2475|Compound:5812728|FD-Score:5.74|P-value:1.20E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.44|P-value:5.63E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:8.54|P-value:1.40E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.56|P-value:2.16E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.47|P-value:2.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.49|P-value:2.73E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.10|P-value:8.06E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:15.30|P-value:6.11E-30 ID:SGTC_2610|Compound:ononetin|FD-Score:4.91|P-value:1.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.70|P-value:1.32E-15 ID:SGTC_2619|Compound:obliquin|FD-Score:21.50|P-value:2.41E-57 ID:SGTC_2620|Compound:irigenin|FD-Score:8.31|P-value:4.21E-10 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.60|P-value:5.81E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.55|P-value:4.19E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.49|P-value:2.71E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:4.86|P-value:1.79E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.13|P-value:7.34E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-5.18|P-value:4.85E-5 ID:SGTC_2890|Compound:9046729|FD-Score:5.77|P-value:1.07E-5 ID:SGTC_2912|Compound:7964298|FD-Score:16.10|P-value:2.93E-33 ID:SGTC_2939|Compound:9044578|FD-Score:-4.66|P-value:2.23E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.24|P-value:9.29E-4 ID:SGTC_3122|Compound:9126309|FD-Score:7.65|P-value:8.16E-9 ID:SGTC_3159|Compound:9100096|FD-Score:4.88|P-value:1.67E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.46|P-value:5.35E-4 ID:SGTC_3266|Compound:9136860|FD-Score:17.40|P-value:1.53E-38 ID:SGTC_3279|Compound:9140807|FD-Score:5.78|P-value:1.07E-5 ID:SGTC_3285|Compound:9112818|FD-Score:34.50|P-value:2.44E-145 ID:SGTC_3304|Compound:9125678|FD-Score:6.08|P-value:3.80E-6 ID:SGTC_3311|Compound:9131146|FD-Score:25.90|P-value:1.22E-82 ID:SGTC_3321|Compound:9137793|FD-Score:6.45|P-value:1.02E-6 ID:SGTC_3322|Compound:9139058|FD-Score:23.10|P-value:2.44E-66 ID:SGTC_3331|Compound:9141060|FD-Score:24.50|P-value:3.76E-74 ID:SGTC_3344|Compound:9148862|FD-Score:7.86|P-value:3.26E-9 ID:SGTC_3350|Compound:9150499|FD-Score:24.90|P-value:1.24E-76 ID:SGTC_3351|Compound:9150312|FD-Score:7.91|P-value:2.61E-9 ID:SGTC_3356|Compound:9151811|FD-Score:12.50|P-value:1.45E-20 ID:SGTC_58|Compound:0957-0393|FD-Score:12.80|P-value:1.66E-21 ID:SGTC_91|Compound:0417-1751|FD-Score:7.25|P-value:4.55E-8 ID:SGTC_102|Compound:gallobenzophenone|FD-Score:4.53|P-value:4.41E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:14.10|P-value:6.06E-26 ID:SGTC_159|Compound:3970-0959|FD-Score:-4.10|P-value:9.80E-4 ID:SGTC_175|Compound:3793-3120|FD-Score:-4.97|P-value:9.33E-5 ID:SGTC_181|Compound:1447-1644|FD-Score:4.57|P-value:4.00E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:7.05|P-value:1.00E-7 ID:SGTC_268|Compound:camptothecin|FD-Score:9.66|P-value:4.81E-13 ID:SGTC_304|Compound:1310-0298|FD-Score:11.10|P-value:9.66E-17 ID:SGTC_351|Compound:caspofungin|FD-Score:4.24|P-value:9.41E-4 ID:SGTC_354|Compound:2783-3500|FD-Score:8.97|P-value:1.74E-11 ID:SGTC_360|Compound:0957-0399|FD-Score:21.00|P-value:9.84E-55 ID:SGTC_369|Compound:0957-0393|FD-Score:4.28|P-value:8.54E-4 ID:SGTC_393|Compound:acivicin|FD-Score:5.13|P-value:8.19E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.41|P-value:6.11E-4 ID:SGTC_430|Compound:0958-0115|FD-Score:6.48|P-value:9.15E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:16.20|P-value:2.62E-33 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:7.47|P-value:1.81E-8 ID:SGTC_483|Compound:fpl-64176|FD-Score:10.80|P-value:8.92E-16 ID:SGTC_486|Compound:niguldipine|FD-Score:5.71|P-value:1.33E-5 ID:SGTC_500|Compound:h-89|FD-Score:5.42|P-value:3.40E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:10.70|P-value:1.32E-15 ID:SGTC_517|Compound:1365-0151|FD-Score:-4.56|P-value:2.98E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:4.25|P-value:9.14E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.39|P-value:1.27E-6 ID:SGTC_582|Compound:0987-0078|FD-Score:5.93|P-value:6.25E-6 ID:SGTC_586|Compound:0957-0265|FD-Score:25.40|P-value:2.27E-79 ID:SGTC_591|Compound:4299-0174|FD-Score:5.07|P-value:9.63E-5 ID:SGTC_598|Compound:3937-0236|FD-Score:6.50|P-value:8.31E-7 ID:SGTC_624|Compound:k048-0052|FD-Score:5.18|P-value:7.00E-5 ID:SGTC_642|Compound:0335-0876|FD-Score:9.96|P-value:8.81E-14 ID:SGTC_643|Compound:k048-0106|FD-Score:7.08|P-value:8.94E-8 ID:SGTC_663|Compound:1486-0733|FD-Score:24.60|P-value:7.83E-75 ID:SGTC_673|Compound:1082-0474|FD-Score:6.53|P-value:7.46E-7 ID:SGTC_690|Compound:glyoxal|FD-Score:4.90|P-value:1.58E-4 ID:SGTC_711|Compound:k292-0785|FD-Score:-4.39|P-value:4.70E-4 ID:SGTC_721|Compound:1187-1332|FD-Score:7.38|P-value:2.65E-8 ID:SGTC_837|Compound:0091-0265|FD-Score:6.37|P-value:1.35E-6 ID:SGTC_850|Compound:0388-0143|FD-Score:5.08|P-value:9.38E-5 ID:SGTC_863|Compound:0466-0191|FD-Score:29.40|P-value:3.57E-106 ID:SGTC_871|Compound:0574-0004|FD-Score:5.99|P-value:5.22E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:18.40|P-value:1.45E-42 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:17.60|P-value:5.53E-39 ID:SGTC_916|Compound:4466-0038|FD-Score:4.80|P-value:2.12E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:21.60|P-value:5.54E-58 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.98|P-value:8.90E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:24.50|P-value:2.27E-74 ID:SGTC_974|Compound:1326-0144|FD-Score:4.80|P-value:2.11E-4 ID:SGTC_1053|Compound:3366-3204|FD-Score:14.30|P-value:1.36E-26 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.48|P-value:5.06E-4 ID:SGTC_1115|Compound:galangin|FD-Score:5.87|P-value:7.77E-6 ID:SGTC_1124|Compound:fisetin|FD-Score:5.76|P-value:1.13E-5 ID:SGTC_1162|Compound:k048-0130|FD-Score:9.38|P-value:2.14E-12 ID:SGTC_1239|Compound:0337-0584|FD-Score:6.34|P-value:1.52E-6 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.11|P-value:8.64E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:8.93|P-value:2.05E-11 ID:SGTC_1377|Compound:2944-0135|FD-Score:4.63|P-value:3.42E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:4.70|P-value:2.76E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.29|P-value:1.82E-6 ID:SGTC_1510|Compound:1123-0200|FD-Score:8.60|P-value:1.05E-10 ID:SGTC_1652|Compound:st011932|FD-Score:4.67|P-value:3.02E-4 ID:SGTC_1672|Compound:st016598|FD-Score:9.48|P-value:1.26E-12 ID:SGTC_1707|Compound:st032323|FD-Score:5.55|P-value:2.23E-5 ID:SGTC_1773|Compound:st048542|FD-Score:6.05|P-value:4.25E-6 ID:SGTC_1874|Compound:staurosporine|FD-Score:15.10|P-value:2.70E-29 ID:SGTC_1880|Compound:MG-132|FD-Score:7.77|P-value:4.86E-9 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.67|P-value:3.00E-4 ID:SGTC_1959|Compound:st077091|FD-Score:6.81|P-value:2.61E-7 ID:SGTC_2003|Compound:4023581|FD-Score:4.98|P-value:1.25E-4 ID:SGTC_2007|Compound:4011539|FD-Score:8.56|P-value:1.30E-10 ID:SGTC_2009|Compound:4012297|FD-Score:10.10|P-value:3.19E-14 ID:SGTC_2017|Compound:5132927|FD-Score:-4.81|P-value:1.45E-4 ID:SGTC_2022|Compound:5136654|FD-Score:7.66|P-value:7.99E-9 ID:SGTC_2024|Compound:5144227|FD-Score:4.27|P-value:8.73E-4 ID:SGTC_2028|Compound:5153890|FD-Score:21.70|P-value:2.39E-58 ID:SGTC_2041|Compound:5107442|FD-Score:4.38|P-value:6.48E-4 ID:SGTC_2057|Compound:5236571|FD-Score:5.65|P-value:1.62E-5 ID:SGTC_2109|Compound:5483026|FD-Score:10.40|P-value:9.68E-15 ID:SGTC_2111|Compound:5486399|FD-Score:5.10|P-value:9.01E-5 ID:SGTC_2124|Compound:5246320|FD-Score:16.50|P-value:1.38E-34 ID:SGTC_2140|Compound:5586273|FD-Score:6.87|P-value:2.03E-7 ID:SGTC_2149|Compound:5554786|FD-Score:15.80|P-value:4.12E-32 ID:SGTC_2160|Compound:5660466|FD-Score:5.45|P-value:3.04E-5 ID:SGTC_2180|Compound:6301957|FD-Score:10.70|P-value:1.01E-15 ID:SGTC_2210|Compound:7115885|FD-Score:7.68|P-value:7.32E-9 ID:SGTC_2248|Compound:tofa|FD-Score:5.72|P-value:1.26E-5 ID:SGTC_2272|Compound:7805186|FD-Score:17.80|P-value:4.96E-40 ID:SGTC_2278|Compound:7948257|FD-Score:4.57|P-value:3.95E-4 ID:SGTC_2289|Compound:7946404|FD-Score:32.60|P-value:5.27E-130 ID:SGTC_2304|Compound:7443016|FD-Score:5.79|P-value:1.03E-5 ID:SGTC_2354|Compound:9060492|FD-Score:5.03|P-value:1.09E-4 ID:SGTC_2367|Compound:9070478|FD-Score:8.14|P-value:9.34E-10 ID:SGTC_2399|Compound:5884133|FD-Score:12.90|P-value:6.13E-22 ID:SGTC_2417|Compound:cerulenin|FD-Score:6.68|P-value:4.24E-7 ID:SGTC_2471|Compound:5466956|FD-Score:5.37|P-value:3.97E-5 ID:SGTC_2475|Compound:5812728|FD-Score:5.74|P-value:1.20E-5 ID:SGTC_2495|Compound:cafestol|FD-Score:4.44|P-value:5.63E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:8.54|P-value:1.40E-10 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:5.56|P-value:2.16E-5 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:5.47|P-value:2.84E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.49|P-value:2.73E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:7.10|P-value:8.06E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:15.30|P-value:6.11E-30 ID:SGTC_2610|Compound:ononetin|FD-Score:4.91|P-value:1.56E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.70|P-value:1.32E-15 ID:SGTC_2619|Compound:obliquin|FD-Score:21.50|P-value:2.41E-57 ID:SGTC_2620|Compound:irigenin|FD-Score:8.31|P-value:4.21E-10 ID:SGTC_2648|Compound:atorvastatin|FD-Score:6.60|P-value:5.81E-7 ID:SGTC_2662|Compound:daunorubicin|FD-Score:4.55|P-value:4.19E-4 ID:SGTC_2700|Compound:st077718|FD-Score:5.49|P-value:2.71E-5 ID:SGTC_2743|Compound:auranofin|FD-Score:4.86|P-value:1.79E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:7.13|P-value:7.34E-8 ID:SGTC_2835|Compound:9006588|FD-Score:-5.18|P-value:4.85E-5 ID:SGTC_2890|Compound:9046729|FD-Score:5.77|P-value:1.07E-5 ID:SGTC_2912|Compound:7964298|FD-Score:16.10|P-value:2.93E-33 ID:SGTC_2939|Compound:9044578|FD-Score:-4.66|P-value:2.23E-4 ID:SGTC_3092|Compound:9117248|FD-Score:4.24|P-value:9.29E-4 ID:SGTC_3122|Compound:9126309|FD-Score:7.65|P-value:8.16E-9 ID:SGTC_3159|Compound:9100096|FD-Score:4.88|P-value:1.67E-4 ID:SGTC_3165|Compound:9101544|FD-Score:4.46|P-value:5.35E-4 ID:SGTC_3266|Compound:9136860|FD-Score:17.40|P-value:1.53E-38 ID:SGTC_3279|Compound:9140807|FD-Score:5.78|P-value:1.07E-5 ID:SGTC_3285|Compound:9112818|FD-Score:34.50|P-value:2.44E-145 ID:SGTC_3304|Compound:9125678|FD-Score:6.08|P-value:3.80E-6 ID:SGTC_3311|Compound:9131146|FD-Score:25.90|P-value:1.22E-82 ID:SGTC_3321|Compound:9137793|FD-Score:6.45|P-value:1.02E-6 ID:SGTC_3322|Compound:9139058|FD-Score:23.10|P-value:2.44E-66 ID:SGTC_3331|Compound:9141060|FD-Score:24.50|P-value:3.76E-74 ID:SGTC_3344|Compound:9148862|FD-Score:7.86|P-value:3.26E-9 ID:SGTC_3350|Compound:9150499|FD-Score:24.90|P-value:1.24E-76 ID:SGTC_3351|Compound:9150312|FD-Score:7.91|P-value:2.61E-9 ID:SGTC_3356|Compound:9151811|FD-Score:12.50|P-value:1.45E-20

Top fitness defect scores for YPR165W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3285 9112818 34.50 20.9 µM 2.44E-145 cell wall 1 8.55E-262 25.10
2 SGTC_2289 7946404 32.60 165.1 µM 5.27E-130 1 4.91E-234 18.00
3 SGTC_863 0466-0191 29.40 129.0 µM 3.57E-106 cell wall 1 6.81E-191 10.70
4 SGTC_3311 9131146 25.90 2.9 µM 1.22E-82 cell wall 1 2.73E-148 10.80
5 SGTC_586 0957-0265 25.40 8.2 µM 2.27E-79 cell wall 2 2.27E-142 8.48
6 SGTC_3350 9150499 24.90 3.6 µM 1.24E-76 cell wall 1 2.05E-137 14.40
7 SGTC_663 1486-0733 24.60 13.9 µM 7.83E-75 cell wall signaling 1 3.72E-134 14.00
8 SGTC_964 1287-0107 24.50 19.4 µM 2.27E-74 cell wall 1 2.55E-133 15.30
9 SGTC_3331 9141060 24.50 2.0 µM 3.76E-74 cell wall 1 6.36E-133 18.00
10 SGTC_3322 9139058 23.10 2.1 µM 2.44E-66 cell wall 1 8.88E-119 17.10
11 SGTC_2028 5153890 21.70 36.4 µM 2.39E-58 cell wall signaling 1 2.59E-104 12.40
12 SGTC_951 1171-0579 21.60 82.7 µM 5.54E-58 cell wall 1 1.18E-103 6.71
13 SGTC_2619 obliquin 21.50 87.9 µM 2.41E-57 cell wall 2 1.69E-102 5.21
14 SGTC_360 0957-0399 21.00 1.0 µM 9.84E-55 cell wall 1 9.04E-98 15.00
15 SGTC_883 0850-0245 18.40 24.6 µM 1.45E-42 cell wall 1 9.63E-76 12.90
16 SGTC_2272 7805186 17.80 180.0 µM 4.96E-40 cell wall signaling 1 3.70E-71 12.80
17 SGTC_905 2-aminofluorene 17.60 215.0 µM 5.53E-39 cell wall signaling 1 2.91E-69 12.10
18 SGTC_3266 9136860 17.40 49.5 µM 1.53E-38 cell wall 1 1.82E-68 7.90
19 SGTC_2124 5246320 16.50 200.0 µM 1.38E-34 heme biosynthesis & mitochondrial translocase 1 2.62E-61 2.35
20 SGTC_450 aminopyrene 16.20 156.0 nM 2.62E-33 1 5.40E-59 11.50

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.437 8.26E-157 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.418 1.03E-141 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions
0.417 2.91E-140 YHR030C SLT2 hom Serine/threonine MAP kinase; involved in regulating maintenance of cell wall integrity, progression through the cell cycle, and nuclear mRNA retention in heat shock; required for mitophagy and pexophagy; affects recruitment of mitochondria to the phagophore assembly site (PAS); regulated by the PKC1-mediated signaling pathway
0.407 5.16E-134 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.390 1.79E-122 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.388 1.14E-120 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.387 4.07E-120 YJL095W BCK1 hom Mitogen-activated protein (MAP) kinase kinase kinase acting in the protein kinase C signaling pathway, which controls cell integrity; upon activation by Pkc1p phosphorylates downstream kinases Mkk1p and Mkk2p
0.385 3.56E-119 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.372 1.30E-110 YOR008C SLG1 hom Sensor-transducer of the stress-activated PKC1-MPK1 kinase pathway; involved in maintenance of cell wall integrity; required for mitophagy; involved in organization of the actin cytoskeleton; secretory pathway Wsc1p is required for the arrest of secretion response
0.367 8.78E-108 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress
0.334 5.28E-88 YKL114C APN1 hom Major apurinic/apyrimidinic endonuclease, 3'-repair diesterase involved in repair of DNA damage by oxidation and alkylating agents; also functions as a 3'-5' exonuclease to repair 7,8-dihydro-8-oxodeoxyguanosine
0.333 1.08E-87 YLR371W ROM2 hom GDP/GTP exchange factor (GEF) for Rho1p and Rho2p; mutations are synthetically lethal with mutations in rom1, which also encodes a GEF; Rom2p localization to the bud surface is dependent on Ack1p
0.325 1.62E-83 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.318 1.08E-79 YLR332W MID2 hom O-glycosylated plasma membrane protein that acts as a sensor for cell wall integrity signaling and activates the pathway; interacts with Rom2p, a guanine nucleotide exchange factor for Rho1p, and with cell integrity pathway protein Zeo1p
0.316 7.48E-79 YGR056W RSC1 hom Component of the RSC chromatin remodeling complex; required for expression of mid-late sporulation-specific genes; contains two essential bromodomains, a bromo-adjacent homology (BAH) domain, and an AT hook