YPR185W / ATG13

Regulatory subunit of the Atg1p signaling complex; stimulates Atg1p kinase activity; required for vesicle formation during autophagy and the cytoplasm-to-vacuole targeting (Cvt) pathway; involved in Atg9p, Atg23p, and Atg27p cycling

Zygosity: Homozygous strain
fixedexpanded
Profile for YPR185W / ATG13

Click on Significant Values for Screen Details ID:SGTC_108|Compound:0509-0257|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.04|P-value:5.93E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.83|P-value:2.22E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.16|P-value:4.58E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:3.22|P-value:2.99E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.16|P-value:3.76E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.69|P-value:4.06E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.99|P-value:5.04E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.67|P-value:4.45E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.92|P-value:1.46E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:5.07|P-value:3.13E-8 ID:SGTC_1410|Compound:3909-8106|FD-Score:5.65|P-value:8.05E-10 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.99|P-value:7.06E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.71|P-value:2.48E-7 ID:SGTC_1591|Compound:genipin|FD-Score:4.59|P-value:4.77E-7 ID:SGTC_2376|Compound:9072922|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.88|P-value:9.87E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.71|P-value:2.47E-7 ID:SGTC_2828|Compound:7998861|FD-Score:4.31|P-value:2.14E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.47|P-value:1.08E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.38|P-value:1.46E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.18|P-value:3.46E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.12|P-value:3.20E-11 ID:SGTC_3240|Compound:9133527|FD-Score:3.35|P-value:1.75E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-6.33|P-value:5.98E-12 ID:SGTC_108|Compound:0509-0257|FD-Score:-3.13|P-value:3.83E-4 ID:SGTC_113|Compound:0099-0221|FD-Score:3.04|P-value:5.93E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:3.83|P-value:2.22E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:3.19|P-value:3.38E-4 ID:SGTC_740|Compound:k014-0057|FD-Score:3.90|P-value:1.60E-5 ID:SGTC_749|Compound:1000-0129|FD-Score:4.16|P-value:4.58E-6 ID:SGTC_978|Compound:1416-0512|FD-Score:3.22|P-value:2.99E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.33|P-value:1.90E-4 ID:SGTC_1105|Compound:epirubicin|FD-Score:3.16|P-value:3.76E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.69|P-value:4.06E-5 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.99|P-value:5.04E-8 ID:SGTC_1213|Compound:1315-0166|FD-Score:3.67|P-value:4.45E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:3.92|P-value:1.46E-5 ID:SGTC_1356|Compound:1502-0781|FD-Score:5.07|P-value:3.13E-8 ID:SGTC_1410|Compound:3909-8106|FD-Score:5.65|P-value:8.05E-10 ID:SGTC_1418|Compound:3966-3099|FD-Score:2.99|P-value:7.06E-4 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:4.71|P-value:2.48E-7 ID:SGTC_1591|Compound:genipin|FD-Score:4.59|P-value:4.77E-7 ID:SGTC_2376|Compound:9072922|FD-Score:-3.26|P-value:2.34E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:-3.40|P-value:1.31E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:-2.88|P-value:9.87E-4 ID:SGTC_2825|Compound:7998094|FD-Score:4.71|P-value:2.47E-7 ID:SGTC_2828|Compound:7998861|FD-Score:4.31|P-value:2.14E-6 ID:SGTC_2919|Compound:7978188|FD-Score:3.47|P-value:1.08E-4 ID:SGTC_2988|Compound:9073640|FD-Score:-3.39|P-value:1.36E-4 ID:SGTC_2990|Compound:9074105|FD-Score:-3.38|P-value:1.46E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.18|P-value:3.46E-4 ID:SGTC_3202|Compound:9113761|FD-Score:6.12|P-value:3.20E-11 ID:SGTC_3240|Compound:9133527|FD-Score:3.35|P-value:1.75E-4 ID:SGTC_3331|Compound:9141060|FD-Score:-6.33|P-value:5.98E-12

Top fitness defect scores for YPR185W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3202 9113761 6.12 49.5 µM 3.20E-11 12 4.79E-10
2 SGTC_1410 3909-8106 5.65 77.9 µM 8.05E-10 3 8.12E-9
3 SGTC_1356 1502-0781 5.07 85.8 µM 3.13E-8 fatty acid desaturase (OLE1) 6 2.02E-7
4 SGTC_1161 k007-0610 4.99 110.0 µM 5.04E-8 ERAD & cell cycle 82 3.07E-7
5 SGTC_2825 7998094 4.71 58.4 µM 2.47E-7 fatty acid desaturase (OLE1) 18 1.24E-6
6 SGTC_1532 4',5'-dihydroxyflavone 4.71 78.7 µM 2.48E-7 Golgi 14 1.25E-6
7 SGTC_1591 genipin 4.59 88.4 µM 4.77E-7 mitochondrial processes 5 2.22E-6
8 SGTC_2828 7998861 4.31 71.4 µM 2.14E-6 9 8.29E-6
9 SGTC_749 1000-0129 4.16 128.0 µM 4.58E-6 amide catabolism 17 1.62E-5
10 SGTC_1272 0839-0021 3.92 27.0 µM 1.46E-5 18 4.51E-5
11 SGTC_740 k014-0057 3.90 261.0 µM 1.60E-5 27 4.88E-5
12 SGTC_121 0557-0495 3.83 61.3 µM 2.22E-5 calcium & mitochondrial duress 63 6.50E-5
13 SGTC_1136 pergolide 3.69 1.1 µM 4.06E-5 48 1.11E-4
14 SGTC_1213 1315-0166 3.67 115.0 µM 4.45E-5 39 1.20E-4
15 SGTC_2919 7978188 3.47 46.4 µM 1.08E-4 38 2.63E-4
16 SGTC_3240 9133527 3.35 49.5 µM 1.75E-4 27 4.02E-4
17 SGTC_1002 4049-0206 3.33 172.0 µM 1.90E-4 71 4.33E-4
18 SGTC_978 1416-0512 3.22 87.4 µM 2.99E-4 redox potentiating 56 6.46E-4
19 SGTC_727 3032-0951 3.19 202.0 µM 3.38E-4 54 7.20E-4
20 SGTC_3026 9090633 3.18 49.5 µM 3.46E-4 49 7.35E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.154 4.10E-19 YOR291W YPK9 hom Vacuolar protein with a possible role in sequestering heavy metals; has similarity to the type V P-type ATPase Spf1p; homolog of human ATP13A2 (PARK9), mutations in which are associated with Parkinson disease and Kufor-Rakeb syndrome
0.131 2.47E-14 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.114 3.29E-11 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.105 1.10E-9 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences
0.102 3.08E-9 YBR130C SHE3 hom Protein that acts as an adaptor between Myo4p and the She2p-mRNA complex; part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud; also required for cortical ER inheritance
0.099 8.85E-9 YLR380W CSR1 hom Phosphatidylinositol transfer protein; has a potential role in regulating lipid and fatty acid metabolism under heme-depleted conditions; interacts specifically with thioredoxin peroxidase; may have a role in oxidative stress resistance; protein abundance increases in response to DNA replication stress
0.099 9.13E-9 YBR138C_p YBR138C_p hom Cytoplasmic protein of unknown function, potentially phosphorylated by Cdc28p; YBR138C is not an essential gene
0.097 1.66E-8 YIL114C POR2 hom Putative mitochondrial porin (voltage-dependent anion channel); not required for mitochondrial membrane permeability or mitochondrial osmotic stability; POR2 has a paralog, POR1, that arose from the whole genome duplication
0.095 3.79E-8 YLR120C YPS1 hom Aspartic protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; attached to the plasma membrane via a glycosylphosphatidylinositol (GPI) anchor
0.094 4.42E-8 YMR188C MRPS17 hom Mitochondrial ribosomal protein of the small subunit
0.094 4.40E-8 YNL082W PMS1 hom ATP-binding protein required for mismatch repair in mitosis and meiosis; functions as a heterodimer with Mlh1p, binds double- and single-stranded DNA via its N-terminal domain, similar to E. coli MutL
0.093 6.48E-8 YDR023W SES1 het Cytosolic seryl-tRNA synthetase, class II aminoacyl-tRNA synthetase that aminoacylates tRNA(Ser), displays tRNA-dependent amino acid recognition which enhances discrimination of the serine substrate, interacts with peroxin Pex21p
0.093 6.68E-8 YOR230W WTM1 hom Transcriptional modulator involved in regulation of meiosis, silencing, and expression of RNR genes; required for nuclear localization of the ribonucleotide reductase small subunit Rnr2p and Rnr4p; contains WD repeats
0.090 1.68E-7 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.090 2.01E-7 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element