YAL004W_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene SSA1/YAL005C

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL004W / YAL004W

Click on Significant Values for Screen Details ID:SGTC_20|Compound:0481-0013|FD-Score:4.05|P-value:9.51E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.80|P-value:2.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.15|P-value:1.03E-6 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.56|P-value:4.80E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.48|P-value:6.82E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.01|P-value:1.10E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.15|P-value:6.71E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.73|P-value:2.76E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.43|P-value:7.35E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.87|P-value:1.84E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.47|P-value:1.72E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.52|P-value:5.96E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.40|P-value:8.75E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.07|P-value:1.49E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.44|P-value:7.61E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.74|P-value:2.86E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.40|P-value:2.55E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.46|P-value:1.96E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.71|P-value:3.21E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.95|P-value:1.37E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-9.82|P-value:5.30E-20 ID:SGTC_2783|Compound:7738165|FD-Score:4.51|P-value:1.60E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-5.54|P-value:1.50E-7 ID:SGTC_2906|Compound:7926292|FD-Score:-3.73|P-value:2.70E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.34|P-value:9.81E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.40|P-value:8.73E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.62|P-value:4.25E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.63|P-value:4.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.54|P-value:5.52E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.84|P-value:1.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:-3.34|P-value:9.67E-4 ID:SGTC_20|Compound:0481-0013|FD-Score:4.05|P-value:9.51E-5 ID:SGTC_364|Compound:0083-0097|FD-Score:3.80|P-value:2.36E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:5.15|P-value:1.03E-6 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.56|P-value:4.80E-4 ID:SGTC_744|Compound:1594-0068|FD-Score:3.81|P-value:2.22E-4 ID:SGTC_747|Compound:3448-8087|FD-Score:3.48|P-value:6.82E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:4.01|P-value:1.10E-4 ID:SGTC_995|Compound:3931-2021|FD-Score:4.15|P-value:6.71E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.73|P-value:2.76E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:-3.43|P-value:7.35E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.87|P-value:1.84E-4 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-4.47|P-value:1.72E-5 ID:SGTC_1234|Compound:0326-0494|FD-Score:3.52|P-value:5.96E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.40|P-value:8.75E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:5.07|P-value:1.49E-6 ID:SGTC_1527|Compound:coumarin|FD-Score:3.44|P-value:7.61E-4 ID:SGTC_1740|Compound:st038286|FD-Score:3.74|P-value:2.86E-4 ID:SGTC_1878|Compound:temozolomide|FD-Score:4.40|P-value:2.55E-5 ID:SGTC_1939|Compound:st074455|FD-Score:4.46|P-value:1.96E-5 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.71|P-value:3.21E-4 ID:SGTC_2469|Compound:5655019|FD-Score:3.95|P-value:1.37E-4 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:-9.82|P-value:5.30E-20 ID:SGTC_2783|Compound:7738165|FD-Score:4.51|P-value:1.60E-5 ID:SGTC_2786|Compound:7743617|FD-Score:-5.54|P-value:1.50E-7 ID:SGTC_2906|Compound:7926292|FD-Score:-3.73|P-value:2.70E-4 ID:SGTC_2911|Compound:7942208|FD-Score:-3.34|P-value:9.81E-4 ID:SGTC_2959|Compound:9079155|FD-Score:3.40|P-value:8.73E-4 ID:SGTC_2986|Compound:9022445|FD-Score:3.62|P-value:4.25E-4 ID:SGTC_3044|Compound:9093193|FD-Score:3.63|P-value:4.21E-4 ID:SGTC_3127|Compound:9126946|FD-Score:3.54|P-value:5.52E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.84|P-value:1.86E-4 ID:SGTC_3225|Compound:9130819|FD-Score:-3.34|P-value:9.67E-4

Top fitness defect scores for YAL004W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_568 1193-0097 5.15 7.5 µM 1.03E-6 ERAD & cell cycle 81 1.29E-7
2 SGTC_1450 4112-4260 5.07 37.6 µM 1.49E-6 calcium & mitochondrial duress 13 1.99E-7
3 SGTC_2783 7738165 4.51 71.4 µM 1.60E-5 18 3.18E-6
4 SGTC_1939 st074455 4.46 53.6 µM 1.96E-5 19 4.02E-6
5 SGTC_1878 temozolomide 4.40 1.0 mM 2.55E-5 5 5.46E-6
6 SGTC_995 3931-2021 4.15 34.6 µM 6.71E-5 RPP1 & pyrimidine depletion 21 1.69E-5
7 SGTC_20 0481-0013 4.05 4.9 µM 9.51E-5 21 2.54E-5
8 SGTC_899 1083-0020 4.01 478.0 µM 1.10E-4 23 3.00E-5
9 SGTC_2469 5655019 3.95 90.8 µM 1.37E-4 22 3.90E-5
10 SGTC_1133 3473-0247 3.87 50.0 µM 1.84E-4 RSC complex & mRNA processing 53 5.48E-5
11 SGTC_744 1594-0068 3.81 283.0 µM 2.22E-4 amide catabolism 32 6.83E-5
12 SGTC_364 0083-0097 3.80 67.7 µM 2.36E-4 28 7.31E-5
13 SGTC_1740 st038286 3.74 13.2 µM 2.86E-4 33 9.15E-5
14 SGTC_2130 NSC 7 3.71 2.5 µM 3.21E-4 copper-dependent oxidative stress 33 1.05E-4
15 SGTC_3044 9093193 3.63 49.5 µM 4.21E-4 37 1.44E-4
16 SGTC_2986 9022445 3.62 71.4 µM 4.25E-4 24 1.45E-4
17 SGTC_3127 9126946 3.54 49.5 µM 5.52E-4 ERG2 26 1.97E-4
18 SGTC_1234 0326-0494 3.52 15.5 µM 5.96E-4 25 2.15E-4
19 SGTC_747 3448-8087 3.48 38.7 µM 6.82E-4 39 2.52E-4
20 SGTC_1527 coumarin 3.44 137.0 µM 7.61E-4 38 2.86E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.255 7.38E-51 YER066W_p RRT13_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with decreased levels of rDNA transcription
0.237 5.28E-44 YGL146C_p RRT6_p hom Putative protein of unknown function; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription; contains two putative transmembrane spans, but no significant homology to other known proteins
0.208 5.67E-34 YLR395C COX8 hom Subunit VIII of cytochrome c oxidase, which is the terminal member of the mitochondrial inner membrane electron transport chain
0.188 5.73E-28 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.166 3.54E-22 YJL043W_p YJL043W_p hom Putative protein of unknown function; YJL043W is a non-essential gene
0.160 1.49E-20 YCR102W-A_d YCR102W-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.151 1.44E-18 YEL049W PAU2 hom Member of the seripauperin multigene family encoded mainly in subtelomeric regions, active during alcoholic fermentation, regulated by anaerobiosis, negatively regulated by oxygen, repressed by heme
0.151 1.68E-18 YOR300W_d YOR300W_d hom Dubious open reading frame, unlikely to encode a protein; overlaps with verified gene BUD7/YOR299W; mutation affects bipolar budding and bud site selection, though phenotype could be due to the mutation's effects on BUD7
0.145 3.53E-17 YNL220W ADE12 hom Adenylosuccinate synthase, catalyzes the first step in synthesis of adenosine monophosphate from inosine 5'monophosphate during purine nucleotide biosynthesis; exhibits binding to single-stranded autonomously replicating (ARS) core sequence
0.144 4.99E-17 YGL144C ROG1 hom Protein with putative serine active lipase domain; ROG1 has a paralog, YDL109C, that arose from the whole genome duplication
0.144 6.49E-17 YER068W MOT2 hom Ubiquitin-protein ligase subunit of the CCR4-NOT complex; with Ubc4p, ubiquitinates nascent polypeptide-associated complex subunits and histone demethyase Jhd2p; CCR4-NOT has roles in transcription regulation, mRNA degradation, and post-transcriptional modifications
0.141 2.47E-16 YNR067C DSE4 hom Daughter cell-specific secreted protein with similarity to glucanases, degrades cell wall from the daughter side causing daughter to separate from mother
0.136 2.84E-15 YIL115C NUP159 het FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport; regulates ADP release from the ATP-dependent RNA helicase Dbp5p; forms a stable association with Nup82p, Gle2p and two other FG-nucleoporins (Nsp1p and Nup116p)
0.128 1.21E-13 YER071C_p TDA2_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; null mutant is sensitive to expression of the top1-T722A allele
0.123 9.88E-13 YOR166C SWT1 hom RNA endoribonuclease involved in perinuclear mRNP quality control via the turnover of aberrant, unprocessed pre-mRNAs; interacts with subunits of THO/TREX, TREX-2, and RNA polymerase II; contains a PIN (PilT N terminus) domain