YAL017W / PSK1

PAS domain-containing serine/threonine protein kinase; coordinately regulates protein synthesis and carbohydrate metabolism and storage in response to a unknown metabolite that reflects nutritional status; PSK1 has a paralog, PSK2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL017W / PSK1

Click on Significant Values for Screen Details ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.09|P-value:7.58E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.44|P-value:1.69E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.10|P-value:7.49E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.32|P-value:2.74E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.33|P-value:2.62E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.79|P-value:3.90E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.68|P-value:1.76E-9 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.15|P-value:6.16E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:7.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.18|P-value:4.63E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.19|P-value:4.34E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.38|P-value:2.17E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.03|P-value:9.36E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.17|P-value:5.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.62|P-value:8.26E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.04|P-value:9.19E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.99|P-value:2.06E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.15|P-value:6.32E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.23|P-value:4.59E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:3.31|P-value:2.84E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:-3.09|P-value:7.58E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.44|P-value:1.69E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:-3.10|P-value:7.49E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.32|P-value:2.74E-4 ID:SGTC_632|Compound:0781-2353|FD-Score:3.33|P-value:2.62E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:3.79|P-value:3.90E-5 ID:SGTC_938|Compound:3126-1755|FD-Score:3.42|P-value:1.83E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:5.68|P-value:1.76E-9 ID:SGTC_1471|Compound:k673-0312|FD-Score:-3.15|P-value:6.16E-4 ID:SGTC_1523|Compound:st012844|FD-Score:3.32|P-value:2.75E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.06|P-value:7.06E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.24|P-value:3.62E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.18|P-value:4.63E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.21|P-value:4.15E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:3.19|P-value:4.34E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.38|P-value:2.17E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.15|P-value:5.03E-4 ID:SGTC_2333|Compound:9017922|FD-Score:-3.03|P-value:9.36E-4 ID:SGTC_2417|Compound:cerulenin|FD-Score:-3.17|P-value:5.74E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.62|P-value:8.26E-5 ID:SGTC_2694|Compound:st077685|FD-Score:-3.04|P-value:9.19E-4 ID:SGTC_2813|Compound:7971799|FD-Score:-3.99|P-value:2.06E-5 ID:SGTC_2979|Compound:9012552|FD-Score:-3.15|P-value:6.32E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.23|P-value:4.59E-4

Top fitness defect scores for YAL017W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1004 4084-0029 5.68 199.0 µM 1.76E-9 3 6.54E-9
2 SGTC_937 3122-0005 3.79 46.7 µM 3.90E-5 29 7.41E-5
3 SGTC_2583 asiatic acid 3.62 100.0 µM 8.26E-5 46 1.49E-4
4 SGTC_418 lividomycin a 3.44 100.0 µM 1.69E-4 24 2.91E-4
5 SGTC_938 3126-1755 3.42 342.0 µM 1.83E-4 24 3.14E-4
6 SGTC_2167 5876490 3.38 200.0 µM 2.17E-4 54 3.67E-4
7 SGTC_632 0781-2353 3.33 4.7 µM 2.62E-4 Golgi 71 4.39E-4
8 SGTC_435 c-PAF 3.32 6.7 µM 2.74E-4 75 4.56E-4
9 SGTC_1523 st012844 3.32 44.7 µM 2.75E-4 60S ribosome export 48 4.58E-4
10 SGTC_219 mitoxanthrone 3.31 164.4 µM 2.84E-4 DNA intercalators 70 4.72E-4
11 SGTC_1636 st007707 3.24 68.9 µM 3.62E-4 79 5.93E-4
12 SGTC_2084 5306078 3.21 60.6 µM 4.15E-4 44 6.73E-4
13 SGTC_2130 NSC 7 3.19 2.5 µM 4.34E-4 copper-dependent oxidative stress 72 7.02E-4
14 SGTC_1851 st056236 3.18 18.9 µM 4.63E-4 44 7.46E-4
15 SGTC_2329 6138490 3.15 200.0 µM 5.03E-4 72 8.05E-4
16 SGTC_1630 st005209 3.06 31.3 µM 7.06E-4 67 0.00110
17 SGTC_2096 5468907 2.93 200.0 µM 0.00112 38 0.00170
18 SGTC_3207 9114163 2.91 49.5 µM 0.00119 87 0.00180
19 SGTC_102 gallobenzophenone 2.82 83.6 µM 0.00161 redox potentiating 95 0.00238
20 SGTC_353 1988-1175 2.74 58.3 µM 0.00214 unfolded protein response 94 0.00311

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.135 4.46E-15 YBR129C OPY1 hom Protein of unknown function, overproduction blocks cell cycle arrest in the presence of mating pheromone; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.134 6.41E-15 YMR164C MSS11 hom Transcription factor involved in regulation of invasive growth and starch degradation; controls the activation of FLO11 and STA2 in response to nutritional signals
0.130 4.38E-14 YIL111W COX5B hom Subunit Vb of cytochrome c oxidase; cytochrome c oxidase is the terminal member of the mitochondrial inner membrane electron transport chain; Cox5Bp is predominantly expressed during anaerobic growth while its isoform Va (Cox5Ap) is expressed during aerobic growth; COX5B has a paralog, COX5A, that arose from the whole genome duplication
0.117 1.31E-11 YGL178W MPT5 hom mRNA-binding protein of the PUF family; binds to the 3' UTR of specific mRNAs, including those involved in mating type switching, cell wall integrity, chronological lifespan, chromatin modification, and spindle pole body architecture; recruits the CCR4-NOT deadenylase complex to mRNAs along with Dhh1p and Dcp1p to promote deadenylation, decapping, and decay; also interacts with the Caf20p translational initiation repressor, affecting its mRNA target specificity
0.116 1.73E-11 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.112 7.35E-11 YMR283C RIT1 hom 2'-O-ribosyl phosphate transferase, modifies the initiator methionine tRNA at position 64 to distinguish it from elongator methionine tRNA
0.111 1.07E-10 YOR292C_p YOR292C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; YOR292C is not an essential gene
0.111 1.35E-10 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.108 3.09E-10 YDR193W_d YDR193W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.108 3.64E-10 YIL062C ARC15 het Subunit of the ARP2/3 complex, which is required for the motility and integrity of cortical actin patches; has mRNA binding activity
0.100 6.07E-9 YJR116W_p TDA4_p hom Putative protein of unknown function; null mutant is sensitive to expression of the top1-T722A allele
0.100 6.15E-9 YDR534C FIT1 hom Mannoprotein that is incorporated into the cell wall via a glycosylphosphatidylinositol (GPI) anchor, involved in the retention of siderophore-iron in the cell wall
0.100 6.58E-9 YKR024C DBP7 hom Putative ATP-dependent RNA helicase of the DEAD-box family involved in ribosomal biogenesis; essential for growth under anaerobic conditions
0.100 7.08E-9 YAL028W FRT2 hom Tail-anchored ER membrane protein of unknown function; interacts with homolog Frt1p; promotes growth in conditions of high Na+, alkaline pH, or cell wall stress, possibly via a role in posttranslational translocation; potential Cdc28p substrate; FRT2 has a paralog, FRT1, that arose from the whole genome duplication
0.098 1.47E-8 YHL010C ETP1 hom Putative protein of unknown function that is required for growth on ethanol; contains a zinc finger region and has homology to human BRAP2, which is a cytoplasmic protein that binds nuclear localization sequences