YAL030W / SNC1

Vesicle membrane receptor protein (v-SNARE); involved in the fusion between Golgi-derived secretory vesicles with the plasma membrane; proposed to be involved in endocytosis; member of the synaptobrevin/VAMP family of R-type v-SNARE proteins; SNC1 has a paralog, SNC2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL030W / SNC1

Click on Significant Values for Screen Details ID:SGTC_90|Compound:0870-0863|FD-Score:-2.97|P-value:6.94E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.48|P-value:9.05E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.29|P-value:1.99E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.20|P-value:2.90E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.64|P-value:4.57E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.92|P-value:8.49E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.35|P-value:4.22E-9 ID:SGTC_684|Compound:1140-0066|FD-Score:3.04|P-value:5.26E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-4.19|P-value:3.32E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:6.54|P-value:1.02E-12 ID:SGTC_925|Compound:2064-1272|FD-Score:5.30|P-value:6.07E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:7.83|P-value:1.77E-17 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.69|P-value:3.57E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.14|P-value:4.15E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.17|P-value:3.25E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.27|P-value:2.19E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.94|P-value:7.85E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.21|P-value:2.98E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.63|P-value:4.71E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.08|P-value:4.66E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.94|P-value:1.12E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1748|Compound:st037455|FD-Score:5.04|P-value:2.97E-8 ID:SGTC_1977|Compound:st070720|FD-Score:3.77|P-value:2.51E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-4.19|P-value:3.26E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-2.98|P-value:6.86E-4 ID:SGTC_2295|Compound:7971645|FD-Score:6.57|P-value:7.84E-13 ID:SGTC_2305|Compound:7443522|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.63|P-value:4.66E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.47|P-value:7.36E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-3.03|P-value:5.59E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.20|P-value:3.06E-6 ID:SGTC_2397|Compound:5161689|FD-Score:3.19|P-value:2.93E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.17|P-value:3.19E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.17|P-value:3.29E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.50|P-value:8.31E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.97|P-value:6.58E-11 ID:SGTC_2797|Compound:7859098|FD-Score:3.01|P-value:5.89E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.97|P-value:9.88E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.16|P-value:3.33E-4 ID:SGTC_2884|Compound:9058502|FD-Score:6.87|P-value:7.09E-14 ID:SGTC_2939|Compound:9044578|FD-Score:-4.13|P-value:4.41E-6 ID:SGTC_3089|Compound:9117425|FD-Score:4.52|P-value:5.82E-7 ID:SGTC_90|Compound:0870-0863|FD-Score:-2.97|P-value:6.94E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.48|P-value:9.05E-5 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.29|P-value:1.99E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-3.20|P-value:2.90E-4 ID:SGTC_476|Compound:mead acid|FD-Score:3.64|P-value:4.57E-5 ID:SGTC_491|Compound:tetrandrine|FD-Score:2.92|P-value:8.49E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:5.35|P-value:4.22E-9 ID:SGTC_684|Compound:1140-0066|FD-Score:3.04|P-value:5.26E-4 ID:SGTC_736|Compound:0958-0254|FD-Score:-4.19|P-value:3.32E-6 ID:SGTC_914|Compound:3820-6779|FD-Score:6.54|P-value:1.02E-12 ID:SGTC_925|Compound:2064-1272|FD-Score:5.30|P-value:6.07E-9 ID:SGTC_1082|Compound:camptothecin|FD-Score:7.83|P-value:1.77E-17 ID:SGTC_1221|Compound:2958-7315|FD-Score:3.69|P-value:3.57E-5 ID:SGTC_1272|Compound:0839-0021|FD-Score:4.14|P-value:4.15E-6 ID:SGTC_1276|Compound:0871-0068|FD-Score:-3.17|P-value:3.25E-4 ID:SGTC_1369|Compound:1866-0067|FD-Score:3.37|P-value:1.43E-4 ID:SGTC_1416|Compound:3966-0321|FD-Score:-3.27|P-value:2.19E-4 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.12|P-value:3.89E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:2.94|P-value:7.85E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:4.21|P-value:2.98E-6 ID:SGTC_1534|Compound:6-azauridine|FD-Score:-3.63|P-value:4.71E-5 ID:SGTC_1558|Compound:st069300|FD-Score:3.08|P-value:4.66E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.94|P-value:1.12E-5 ID:SGTC_1746|Compound:st038117|FD-Score:3.39|P-value:1.31E-4 ID:SGTC_1748|Compound:st037455|FD-Score:5.04|P-value:2.97E-8 ID:SGTC_1977|Compound:st070720|FD-Score:3.77|P-value:2.51E-5 ID:SGTC_1979|Compound:st071809|FD-Score:-4.19|P-value:3.26E-6 ID:SGTC_2054|Compound:5233173|FD-Score:-2.98|P-value:6.86E-4 ID:SGTC_2295|Compound:7971645|FD-Score:6.57|P-value:7.84E-13 ID:SGTC_2305|Compound:7443522|FD-Score:3.07|P-value:4.82E-4 ID:SGTC_2306|Compound:7482397|FD-Score:-3.63|P-value:4.66E-5 ID:SGTC_2315|Compound:7733312|FD-Score:4.47|P-value:7.36E-7 ID:SGTC_2377|Compound:9073351|FD-Score:-3.03|P-value:5.59E-4 ID:SGTC_2380|Compound:9035439|FD-Score:4.20|P-value:3.06E-6 ID:SGTC_2397|Compound:5161689|FD-Score:3.19|P-value:2.93E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.40|P-value:1.27E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.37|P-value:1.44E-4 ID:SGTC_2533|Compound:agelasine|FD-Score:3.17|P-value:3.19E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.17|P-value:3.29E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.50|P-value:8.31E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:-3.20|P-value:2.85E-4 ID:SGTC_2716|Compound:st080858|FD-Score:2.90|P-value:9.17E-4 ID:SGTC_2780|Compound:5215298|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_2788|Compound:5282734|FD-Score:5.97|P-value:6.58E-11 ID:SGTC_2797|Compound:7859098|FD-Score:3.01|P-value:5.89E-4 ID:SGTC_2798|Compound:7813637|FD-Score:3.97|P-value:9.88E-6 ID:SGTC_2808|Compound:7946468|FD-Score:3.16|P-value:3.33E-4 ID:SGTC_2884|Compound:9058502|FD-Score:6.87|P-value:7.09E-14 ID:SGTC_2939|Compound:9044578|FD-Score:-4.13|P-value:4.41E-6 ID:SGTC_3089|Compound:9117425|FD-Score:4.52|P-value:5.82E-7

Top fitness defect scores for YAL030W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 7.83 424.9 nM 1.77E-17 DNA damage response 13 2.39E-15
2 SGTC_2884 9058502 6.87 52.0 µM 7.09E-14 2 3.15E-12
3 SGTC_2295 7971645 6.57 200.0 µM 7.84E-13 4 2.53E-11
4 SGTC_914 3820-6779 6.54 408.0 µM 1.02E-12 2 3.17E-11
5 SGTC_2788 5282734 5.97 71.4 µM 6.58E-11 11 1.18E-9
6 SGTC_624 k048-0052 5.35 28.0 µM 4.22E-9 Golgi 7 4.33E-8
7 SGTC_925 2064-1272 5.30 59.6 µM 6.07E-9 5 5.94E-8
8 SGTC_1748 st037455 5.04 53.6 µM 2.97E-8 7 2.36E-7
9 SGTC_3089 9117425 4.52 49.5 µM 5.82E-7 12 3.12E-6
10 SGTC_2315 7733312 4.47 200.0 µM 7.36E-7 15 3.83E-6
11 SGTC_1465 k213-0056 4.21 144.0 µM 2.98E-6 DNA intercalators 17 1.29E-5
12 SGTC_2380 9035439 4.20 200.0 µM 3.06E-6 endomembrane recycling 13 1.32E-5
13 SGTC_1272 0839-0021 4.14 27.0 µM 4.15E-6 13 1.72E-5
14 SGTC_2798 7813637 3.97 45.5 µM 9.88E-6 31 3.66E-5
15 SGTC_1611 st001856 3.94 99.4 µM 1.12E-5 17 4.07E-5
16 SGTC_1977 st070720 3.77 65.3 µM 2.51E-5 12 8.24E-5
17 SGTC_1221 2958-7315 3.69 257.0 µM 3.57E-5 20 1.12E-4
18 SGTC_476 mead acid 3.64 10.0 µM 4.57E-5 7 1.39E-4
19 SGTC_2780 5215298 3.40 71.4 µM 1.25E-4 59 3.33E-4
20 SGTC_2440 5628896 3.40 157.8 µM 1.27E-4 35 3.39E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 6.77E-22 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.139 7.56E-16 YKL099C UTP11 het Subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit
0.119 4.90E-12 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.110 1.48E-10 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.106 8.07E-10 YMR297W PRC1 hom Vacuolar carboxypeptidase Y (proteinase C; CPY), broad-specificity C-terminal exopeptidase involved in non-specific protein degradation in the vacuole; member of the serine carboxypeptidase family
0.105 1.24E-9 YBL088C TEL1 hom Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)
0.098 1.56E-8 YOR038C HIR2 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; recruits Swi-Snf complexes to histone gene promoters; promotes heterochromatic gene silencing with Asf1p
0.094 4.66E-8 YAR035W YAT1 hom Outer mitochondrial carnitine acetyltransferase, minor ethanol-inducible enzyme involved in transport of activated acyl groups from the cytoplasm into the mitochondrial matrix; phosphorylated
0.090 1.79E-7 YCR081W SRB8 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation; involved in glucose repression
0.088 2.94E-7 YNL118C DCP2 het Catalytic subunit of the Dcp1p-Dcp2p decapping enzyme complex; removes the 5' cap structure from mRNAs prior to their degradation; nudix hydrolase family member; forms cytoplasmic foci upon DNA replication stress
0.086 5.31E-7 YBR079C RPG1 het eIF3a subunit of the core complex of translation initiation factor 3 (eIF3), essential for translation; part of a Prt1p-Rpg1p-Nip1p subcomplex that stimulates binding of mRNA and tRNA(i)Met to ribosomes; involved in translation reinitiation
0.086 5.47E-7 YPR019W MCM4 het Essential helicase component of heterohexameric MCM2-7 complexes which bind pre-replication complexes on DNA and melt DNA prior to replication; forms an Mcm4p-6p-7p subcomplex; shows nuclear accumulation in G1; homolog of S. pombe Cdc21p
0.086 5.95E-7 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.084 1.18E-6 YGL010W_p YGL010W_p hom Putative protein of unknown function; YGL010W is not an essential gene
0.082 1.83E-6 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination