YAL036C / RBG1

Member of the DRG family of GTP-binding proteins; associates with translating ribosomes; interacts with Tma46p, Ygr250cp, Gir2p and Yap1p via two-hybrid

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL036C / RBG1

Click on Significant Values for Screen Details ID:SGTC_106|Compound:0092-0003|FD-Score:4.01|P-value:4.12E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-5.02|P-value:4.22E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.68|P-value:1.58E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.31|P-value:5.69E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:9.65E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.78|P-value:1.02E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.86|P-value:7.52E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.43|P-value:3.82E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.35|P-value:5.00E-4 ID:SGTC_1663|Compound:st014140|FD-Score:4.42|P-value:7.27E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.77|P-value:1.45E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:5.11E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.33|P-value:5.45E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.31|P-value:1.14E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.19|P-value:8.73E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.89|P-value:6.82E-5 ID:SGTC_2387|Compound:9077560|FD-Score:-3.29|P-value:6.37E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-4.24|P-value:1.66E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.58|P-value:2.20E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.15|P-value:9.99E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.84|P-value:8.28E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.22|P-value:7.85E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.41|P-value:4.07E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.61|P-value:2.04E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:5.10|P-value:2.75E-7 ID:SGTC_2954|Compound:9074818|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.65|P-value:1.69E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.42|P-value:4.00E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.54|P-value:2.66E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.21|P-value:8.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:7.97E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.29|P-value:6.24E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.67|P-value:2.26E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.78|P-value:1.05E-4 ID:SGTC_106|Compound:0092-0003|FD-Score:4.01|P-value:4.12E-5 ID:SGTC_301|Compound:4119-0100|FD-Score:-5.02|P-value:4.22E-7 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.68|P-value:1.58E-4 ID:SGTC_599|Compound:1935-0052|FD-Score:3.40|P-value:4.22E-4 ID:SGTC_605|Compound:1315-0399|FD-Score:3.31|P-value:5.69E-4 ID:SGTC_656|Compound:4090-1979|FD-Score:3.16|P-value:9.65E-4 ID:SGTC_712|Compound:r015-0009|FD-Score:3.41|P-value:4.03E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_893|Compound:0958-0369|FD-Score:3.78|P-value:1.02E-4 ID:SGTC_974|Compound:1326-0144|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_980|Compound:1473-0395|FD-Score:3.39|P-value:4.44E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:-3.31|P-value:5.95E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:3.86|P-value:7.52E-5 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.43|P-value:3.82E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:-3.76|P-value:1.13E-4 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.35|P-value:5.00E-4 ID:SGTC_1663|Compound:st014140|FD-Score:4.42|P-value:7.27E-6 ID:SGTC_1675|Compound:st018485|FD-Score:3.73|P-value:1.25E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-4.77|P-value:1.45E-6 ID:SGTC_1733|Compound:st037357|FD-Score:-3.35|P-value:5.11E-4 ID:SGTC_1775|Compound:st081588|FD-Score:3.33|P-value:5.45E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.39|P-value:4.39E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.31|P-value:1.14E-5 ID:SGTC_2317|Compound:5986382|FD-Score:3.19|P-value:8.73E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.89|P-value:6.82E-5 ID:SGTC_2387|Compound:9077560|FD-Score:-3.29|P-value:6.37E-4 ID:SGTC_2391|Compound:6285546|FD-Score:-4.24|P-value:1.66E-5 ID:SGTC_2393|Compound:9031399|FD-Score:3.58|P-value:2.20E-4 ID:SGTC_2477|Compound:5967686|FD-Score:3.77|P-value:1.06E-4 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.15|P-value:9.99E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:3.84|P-value:8.28E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.22|P-value:7.85E-4 ID:SGTC_2648|Compound:atorvastatin|FD-Score:3.41|P-value:4.07E-4 ID:SGTC_2671|Compound:danthron|FD-Score:-3.61|P-value:2.04E-4 ID:SGTC_2680|Compound:butyl paraben|FD-Score:5.10|P-value:2.75E-7 ID:SGTC_2954|Compound:9074818|FD-Score:3.65|P-value:1.67E-4 ID:SGTC_2970|Compound:9090938|FD-Score:3.65|P-value:1.69E-4 ID:SGTC_3072|Compound:9116419|FD-Score:-3.42|P-value:4.00E-4 ID:SGTC_3089|Compound:9117425|FD-Score:-3.54|P-value:2.66E-4 ID:SGTC_3116|Compound:9124943|FD-Score:3.21|P-value:8.14E-4 ID:SGTC_3201|Compound:9113999|FD-Score:-3.33|P-value:5.61E-4 ID:SGTC_3203|Compound:9113543|FD-Score:3.22|P-value:7.97E-4 ID:SGTC_3210|Compound:9128157|FD-Score:3.29|P-value:6.24E-4 ID:SGTC_3329|Compound:9141233|FD-Score:4.67|P-value:2.26E-6 ID:SGTC_3335|Compound:9143315|FD-Score:-3.78|P-value:1.05E-4

Top fitness defect scores for YAL036C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2680 butyl paraben 5.10 22.2 µM 2.75E-7 amide catabolism 3 1.68E-7
2 SGTC_3329 9141233 4.67 27.6 µM 2.26E-6 8 1.49E-6
3 SGTC_1663 st014140 4.42 55.4 µM 7.27E-6 60S ribosome export 12 5.02E-6
4 SGTC_2171 5739187 4.31 198.1 µM 1.14E-5 copper-dependent oxidative stress 11 8.00E-6
5 SGTC_106 0092-0003 4.01 11.6 µM 4.12E-5 copper-dependent oxidative stress 15 3.03E-5
6 SGTC_2360 9040895 3.89 200.0 µM 6.82E-5 RPP1 & pyrimidine depletion 16 5.10E-5
7 SGTC_1350 1495-0454 3.86 146.0 µM 7.52E-5 31 5.65E-5
8 SGTC_2605 digitonin 3.84 300.0 nM 8.28E-5 34 6.25E-5
9 SGTC_893 0958-0369 3.78 48.9 µM 1.02E-4 29 7.78E-5
10 SGTC_722 3534-0461 3.77 190.0 µM 1.06E-4 PDR1 42 8.06E-5
11 SGTC_2477 5967686 3.77 25.2 µM 1.06E-4 29 8.07E-5
12 SGTC_1675 st018485 3.73 24.5 µM 1.25E-4 60S ribosome export 33 9.55E-5
13 SGTC_2954 9074818 3.65 52.7 µM 1.67E-4 45 1.29E-4
14 SGTC_2970 9090938 3.65 41.9 µM 1.69E-4 RNA processing & uracil transport 54 1.31E-4
15 SGTC_2393 9031399 3.58 185.9 µM 2.20E-4 RNA processing & uracil transport 41 1.72E-4
16 SGTC_974 1326-0144 3.46 138.0 µM 3.44E-4 ERG2 64 2.74E-4
17 SGTC_1389 3405-0187 3.43 19.0 µM 3.82E-4 30 3.04E-4
18 SGTC_712 r015-0009 3.41 80.6 µM 4.03E-4 36 3.22E-4
19 SGTC_2648 atorvastatin 3.41 78.7 µM 4.07E-4 azole & statin 31 3.25E-4
20 SGTC_599 1935-0052 3.40 86.5 µM 4.22E-4 29 3.38E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.098 1.27E-8 YNL103W MET4 het Leucine-zipper transcriptional activator, responsible for the regulation of the sulfur amino acid pathway, requires different combinations of the auxiliary factors Cbf1p, Met28p, Met31p and Met32p
0.094 5.11E-8 YML099C ARG81 hom Zinc-finger transcription factor of the Zn(2)-Cys(6) binuclear cluster domain type, involved in the regulation of arginine-responsive genes; acts with Arg80p and Arg82p
0.087 4.78E-7 YNL104C LEU4 hom Alpha-isopropylmalate synthase (2-isopropylmalate synthase); the main isozyme responsible for the first step in the leucine biosynthesis pathway; LEU4 has a paralog, LEU9, that arose from the whole genome duplication
0.082 1.83E-6 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.080 3.44E-6 YKL063C_p YKL063C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the Golgi
0.073 2.61E-5 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.072 3.25E-5 YJL037W IRC18 hom Putative protein of unknown function; expression induced in respiratory-deficient cells and in carbon-limited chemostat cultures; similar to adjacent ORF, YJL038C; null mutant displays increased levels of spontaneous Rad52p foci
0.071 3.52E-5 YJR010W MET3 hom ATP sulfurylase, catalyzes the primary step of intracellular sulfate activation, essential for assimilatory reduction of sulfate to sulfide, involved in methionine metabolism
0.071 3.65E-5 YOL094C RFC4 het Subunit of heteropentameric Replication factor C (RF-C), which is a DNA binding protein and ATPase that acts as a clamp loader of the proliferating cell nuclear antigen (PCNA) processivity factor for DNA polymerases delta and epsilon
0.069 5.67E-5 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.066 1.21E-4 YPL160W CDC60 het Cytosolic leucyl tRNA synthetase, ligates leucine to the appropriate tRNA
0.066 1.33E-4 YPR002W PDH1 hom Mitochondrial protein that participates in respiration, induced by diauxic shift; homologous to E. coli PrpD, may take part in the conversion of 2-methylcitrate to 2-methylisocitrate
0.064 2.00E-4 YGL249W ZIP2 hom Meiosis-specific protein; involved in normal synaptonemal complex formation and pairing between homologous chromosomes during meiosis; relocalizes from mitochondrion to cytoplasm upon DNA replication stress
0.063 2.34E-4 YKR077W MSA2 hom Putative transcriptional activator, that interacts with G1-specific transcription factor, MBF and G1-specific promoters; ortholog of Msa2p, an MBF and SBF activator that regulates G1-specific transcription and cell cycle initiation
0.063 2.90E-4 YGR038W ORM1 hom Evolutionarily conserved protein, similar to Orm2p, required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control