YAL037C-A_p

Putative protein of unknown function

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL037C-A / YAL037C-A

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.21|P-value:7.29E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.62|P-value:2.27E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.26|P-value:1.15E-5 ID:SGTC_484|Compound:loperamide|FD-Score:3.88|P-value:5.83E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.33|P-value:4.72E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-5.32|P-value:6.27E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:-5.63|P-value:1.14E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.81|P-value:8.96E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.54|P-value:2.18E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.17|P-value:8.40E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.15|P-value:9.02E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.47|P-value:4.55E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.32|P-value:4.91E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.76|P-value:9.50E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.96|P-value:4.20E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.90|P-value:5.55E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.33|P-value:4.73E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.80|P-value:9.37E-7 ID:SGTC_1975|Compound:st070967|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.01|P-value:3.44E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.60|P-value:1.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.34|P-value:4.57E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.46|P-value:3.03E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.73|P-value:1.03E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.86|P-value:6.41E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.32|P-value:8.88E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-4.82|P-value:8.50E-7 ID:SGTC_2833|Compound:9001315|FD-Score:4.59|P-value:2.61E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-4.96|P-value:4.24E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.26|P-value:6.15E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.66|P-value:1.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.79|P-value:8.37E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.29|P-value:5.54E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.82|P-value:7.47E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:-3.47|P-value:2.78E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.21|P-value:7.29E-4 ID:SGTC_61|Compound:0978-8327|FD-Score:-4.62|P-value:2.27E-6 ID:SGTC_369|Compound:0957-0393|FD-Score:3.26|P-value:6.12E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:-4.26|P-value:1.15E-5 ID:SGTC_484|Compound:loperamide|FD-Score:3.88|P-value:5.83E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:-3.33|P-value:4.72E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-5.32|P-value:6.27E-8 ID:SGTC_796|Compound:1234-0020|FD-Score:-5.63|P-value:1.14E-8 ID:SGTC_800|Compound:3448-7362|FD-Score:-3.35|P-value:4.29E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:4.81|P-value:8.96E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:-3.54|P-value:2.18E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.17|P-value:8.40E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:3.15|P-value:9.02E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.47|P-value:4.55E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.32|P-value:5.03E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.32|P-value:4.91E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:3.76|P-value:9.50E-5 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.96|P-value:4.20E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.90|P-value:5.55E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.33|P-value:4.73E-4 ID:SGTC_1721|Compound:st082152|FD-Score:-4.80|P-value:9.37E-7 ID:SGTC_1975|Compound:st070967|FD-Score:3.38|P-value:4.05E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.61|P-value:1.72E-4 ID:SGTC_2019|Compound:4016004|FD-Score:4.01|P-value:3.44E-5 ID:SGTC_2145|Compound:5634607|FD-Score:3.60|P-value:1.78E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.34|P-value:4.57E-4 ID:SGTC_2502|Compound:avocadyne acetate|FD-Score:-3.50|P-value:2.56E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.46|P-value:3.03E-4 ID:SGTC_2662|Compound:daunorubicin|FD-Score:-3.73|P-value:1.03E-4 ID:SGTC_2674|Compound:ligustilide|FD-Score:3.86|P-value:6.41E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.32|P-value:8.88E-6 ID:SGTC_2829|Compound:7992743|FD-Score:-4.82|P-value:8.50E-7 ID:SGTC_2833|Compound:9001315|FD-Score:4.59|P-value:2.61E-6 ID:SGTC_2834|Compound:9001755|FD-Score:-4.96|P-value:4.24E-7 ID:SGTC_2844|Compound:9010103|FD-Score:3.26|P-value:6.15E-4 ID:SGTC_3047|Compound:9092122|FD-Score:-3.66|P-value:1.40E-4 ID:SGTC_3131|Compound:9127911|FD-Score:3.70|P-value:1.20E-4 ID:SGTC_3224|Compound:9130643|FD-Score:3.79|P-value:8.37E-5 ID:SGTC_3331|Compound:9141060|FD-Score:3.29|P-value:5.54E-4 ID:SGTC_3351|Compound:9150312|FD-Score:-3.82|P-value:7.47E-5

Top fitness defect scores for YAL037C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_855 0428-0020 4.81 25.0 µM 8.96E-7 Golgi 12 7.39E-7
2 SGTC_2833 9001315 4.59 45.5 µM 2.61E-6 amide catabolism 35 2.19E-6
3 SGTC_1058 3448-5425 4.47 97.3 µM 4.55E-6 26 3.84E-6
4 SGTC_2019 4016004 4.01 108.0 µM 3.44E-5 32 3.00E-5
5 SGTC_1512 0259-0544 3.96 12.2 µM 4.20E-5 16 3.67E-5
6 SGTC_1688 st021091 3.90 57.6 µM 5.55E-5 6 4.87E-5
7 SGTC_484 loperamide 3.88 105.0 µM 5.83E-5 4 5.12E-5
8 SGTC_2674 ligustilide 3.86 100.0 µM 6.41E-5 7 5.63E-5
9 SGTC_3224 9130643 3.79 49.5 µM 8.37E-5 RPP1 & pyrimidine depletion 29 7.39E-5
10 SGTC_1448 4255-0083 3.76 152.0 µM 9.50E-5 ERG2 21 8.40E-5
11 SGTC_3131 9127911 3.70 49.5 µM 1.20E-4 36 1.06E-4
12 SGTC_2018 5133068 3.61 143.0 µM 1.72E-4 32 1.54E-4
13 SGTC_2145 5634607 3.60 200.0 µM 1.78E-4 11 1.59E-4
14 SGTC_2569 tetrandrine 3.46 100.0 µM 3.03E-4 38 2.72E-4
15 SGTC_1975 st070967 3.38 30.8 µM 4.05E-4 53 3.66E-4
16 SGTC_1364 1653-0028 3.32 37.6 µM 4.91E-4 45 4.45E-4
17 SGTC_1225 1216-0074 3.32 20.6 µM 5.03E-4 48 4.56E-4
18 SGTC_3331 9141060 3.29 2.0 µM 5.54E-4 cell wall 54 5.02E-4
19 SGTC_369 0957-0393 3.26 4.5 µM 6.12E-4 cell wall signaling 54 5.56E-4
20 SGTC_2844 9010103 3.26 26.0 µM 6.15E-4 58 5.59E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.137 1.76E-15 YJR130C STR2 hom Cystathionine gamma-synthase, converts cysteine into cystathionine
0.128 1.14E-13 YOR090C PTC5 hom Mitochondrial type 2C protein phosphatase (PP2C) involved in regulation of pyruvate dehydrogenase activity by dephosphorylating the serine 133 of the Pda1p subunit; localizes to the intermembrane space and is imported via the presequence pathway and processed by the inner membrane protease (Imp1p-Imp2p); acts in concert with kinases Pkp1p and Pkp2p and phosphatase Ptc6p
0.128 1.25E-13 YNR028W CPR8 hom Peptidyl-prolyl cis-trans isomerase (cyclophilin), catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; similarity to Cpr4p suggests a potential role in the secretory pathway
0.127 1.79E-13 YKL202W_d YKL202W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.116 1.62E-11 YLR457C NBP1 het Spindle pole body (SPB) component; required for the insertion of the duplication plaque into the nuclear membrane during SPB duplication; essential for bipolar spindle formation; component of the Mps2p-Bbp1p complex; NBP1 has a paralog, YPR174C, that arose from the whole genome duplication
0.102 2.74E-9 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.100 6.07E-9 YMR012W CLU1 hom eIF3 component of unknown function; deletion causes defects in mitochondrial organization but not in growth or translation initiation, can rescue cytokinesis and mitochondrial organization defects of the Dictyostelium cluA- mutant
0.099 8.57E-9 YLL054C_p YLL054C_p hom Putative protein of unknown function with similarity to Pip2p, an oleate-specific transcriptional activator of peroxisome proliferation; YLL054C is not an essential gene
0.081 2.50E-6 YDR302W GPI11 het ER membrane protein involved in a late step of glycosylphosphatidylinositol (GPI) anchor assembly; involved in the addition of phosphoethanolamine to the multiply mannosylated GPI intermediate; human PIG-Fp is a functional homolog
0.080 3.13E-6 YLR269C_d YLR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.077 8.77E-6 YDR056C_p YDR056C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; YDR056C is not an essential protein
0.076 9.34E-6 YDL212W SHR3 het Endoplasmic reticulum packaging chaperone, required for incorporation of amino acid permeases into COPII coated vesicles for transport to the cell surface
0.075 1.35E-5 YHL012W_p YHL012W_p hom Putative UTP glucose-1-phosphate uridylyltransferase; YHL012W has a paralog, UGP1, that arose from the whole genome duplication
0.074 1.62E-5 YDR428C BNA7 hom Formylkynurenine formamidase, involved in the de novo biosynthesis of NAD from tryptophan via kynurenine
0.074 1.97E-5 YJL119C_d YJL119C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data