YAL041W / CDC24

Guanine nucleotide exchange factor for Cdc42p; also known as a GEF or GDP-release factor; required for polarity establishment and maintenance, and mutants have morphological defects in bud formation and shmooing; relocalizes from nucleus to cytoplasm upon DNA replication stress

Zygosity: Heterozygous strain
fixedexpanded
Profile for YAL041W / CDC24

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.67|P-value:2.81E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.59|P-value:3.47E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.31|P-value:2.64E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.45|P-value:5.51E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.29|P-value:9.28E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.49|P-value:4.93E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-4.45|P-value:1.33E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.85|P-value:2.41E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.52|P-value:4.45E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.37|P-value:7.79E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.83|P-value:2.20E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:6.47|P-value:6.09E-10 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.55|P-value:4.02E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.41|P-value:6.49E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.80|P-value:1.65E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.94|P-value:1.09E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.65|P-value:2.88E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:5.74|P-value:3.49E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:4.93|P-value:1.78E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.80|P-value:1.80E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.24|P-value:3.78E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:3.60|P-value:3.69E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.58|P-value:8.59E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.94|P-value:1.08E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.79|P-value:1.73E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.17|P-value:4.44E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.53|P-value:4.58E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.06|P-value:7.01E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.83|P-value:2.87E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.51|P-value:4.95E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.73|P-value:2.35E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.61|P-value:3.26E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.16|P-value:3.51E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.60|P-value:3.67E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.44|P-value:6.27E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.36|P-value:2.11E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-4.00|P-value:7.83E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.39|P-value:6.84E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.52|P-value:4.70E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.99|P-value:8.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.11|P-value:5.69E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.12|P-value:5.58E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.45|P-value:1.49E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.49|P-value:5.34E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.22|P-value:3.67E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.38|P-value:7.62E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.89|P-value:2.18E-6 ID:SGTC_2277|Compound:7947813|FD-Score:5.74|P-value:3.45E-8 ID:SGTC_2286|Compound:7945697|FD-Score:4.17|P-value:4.51E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.69|P-value:2.71E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.57|P-value:7.37E-8 ID:SGTC_2459|Compound:5811157|FD-Score:-4.29|P-value:2.55E-5 ID:SGTC_2469|Compound:5655019|FD-Score:-3.41|P-value:6.45E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.28|P-value:2.93E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.51|P-value:1.15E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.97|P-value:1.48E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.31|P-value:8.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.70|P-value:5.17E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.39|P-value:7.24E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.92|P-value:1.06E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:2.65E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.35|P-value:8.36E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.07|P-value:6.68E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.31|P-value:9.64E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:7.82E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-5.30|P-value:2.85E-7 ID:SGTC_3264|Compound:9137442|FD-Score:-3.75|P-value:2.00E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.61|P-value:3.46E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.67|P-value:2.81E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:-3.59|P-value:3.47E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:4.31|P-value:2.64E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:-3.45|P-value:5.51E-4 ID:SGTC_284|Compound:0988-0104|FD-Score:-3.29|P-value:9.28E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-3.49|P-value:4.93E-4 ID:SGTC_318|Compound:1488-0629|FD-Score:-4.45|P-value:1.33E-5 ID:SGTC_428|Compound:3448-4153|FD-Score:-4.85|P-value:2.41E-6 ID:SGTC_438|Compound:sphingosine|FD-Score:-3.52|P-value:4.45E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:3.37|P-value:7.79E-4 ID:SGTC_589|Compound:1227-0070|FD-Score:5.83|P-value:2.20E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:6.47|P-value:6.09E-10 ID:SGTC_612|Compound:0302-0167|FD-Score:-3.55|P-value:4.02E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:-3.41|P-value:6.49E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.80|P-value:1.65E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:3.94|P-value:1.09E-4 ID:SGTC_701|Compound:4424-0219|FD-Score:-3.65|P-value:2.88E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:5.74|P-value:3.49E-8 ID:SGTC_747|Compound:3448-8087|FD-Score:4.93|P-value:1.78E-6 ID:SGTC_849|Compound:0386-0493|FD-Score:3.80|P-value:1.80E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:-5.24|P-value:3.78E-7 ID:SGTC_859|Compound:0439-0102|FD-Score:3.60|P-value:3.69E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.58|P-value:8.59E-6 ID:SGTC_951|Compound:1171-0579|FD-Score:3.94|P-value:1.08E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.66|P-value:2.95E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.79|P-value:1.73E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:4.17|P-value:4.44E-5 ID:SGTC_1239|Compound:0337-0584|FD-Score:3.53|P-value:4.58E-4 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.89|P-value:1.29E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:4.06|P-value:7.01E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:4.83|P-value:2.87E-6 ID:SGTC_1423|Compound:4048-0112|FD-Score:3.51|P-value:4.95E-4 ID:SGTC_1445|Compound:4239-0156|FD-Score:3.73|P-value:2.35E-4 ID:SGTC_1511|Compound:0906-3109|FD-Score:-3.61|P-value:3.26E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.16|P-value:3.51E-9 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.60|P-value:3.67E-4 ID:SGTC_1606|Compound:st000094|FD-Score:3.44|P-value:6.27E-4 ID:SGTC_1608|Compound:st001473|FD-Score:4.36|P-value:2.11E-5 ID:SGTC_1620|Compound:st003704|FD-Score:-4.00|P-value:7.83E-5 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.39|P-value:6.84E-4 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.52|P-value:4.70E-4 ID:SGTC_1799|Compound:st045822|FD-Score:3.99|P-value:8.87E-5 ID:SGTC_1871|Compound:st057448|FD-Score:4.11|P-value:5.69E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:4.12|P-value:5.58E-5 ID:SGTC_2041|Compound:5107442|FD-Score:4.45|P-value:1.49E-5 ID:SGTC_2047|Compound:4141938|FD-Score:3.49|P-value:5.34E-4 ID:SGTC_2128|Compound:5255449|FD-Score:4.22|P-value:3.67E-5 ID:SGTC_2164|Compound:5685496|FD-Score:3.38|P-value:7.62E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.89|P-value:2.18E-6 ID:SGTC_2277|Compound:7947813|FD-Score:5.74|P-value:3.45E-8 ID:SGTC_2286|Compound:7945697|FD-Score:4.17|P-value:4.51E-5 ID:SGTC_2426|Compound:5582046|FD-Score:3.69|P-value:2.71E-4 ID:SGTC_2457|Compound:5731572|FD-Score:-5.57|P-value:7.37E-8 ID:SGTC_2459|Compound:5811157|FD-Score:-4.29|P-value:2.55E-5 ID:SGTC_2469|Compound:5655019|FD-Score:-3.41|P-value:6.45E-4 ID:SGTC_2472|Compound:5377652|FD-Score:4.28|P-value:2.93E-5 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.51|P-value:1.15E-5 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.97|P-value:1.48E-6 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.31|P-value:8.80E-4 ID:SGTC_2698|Compound:st077697|FD-Score:4.70|P-value:5.17E-6 ID:SGTC_2749|Compound:bexarotene|FD-Score:3.39|P-value:7.24E-4 ID:SGTC_2758|Compound:dehydroepiandrosterone|FD-Score:3.43|P-value:6.45E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-3.92|P-value:1.06E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.67|P-value:2.65E-4 ID:SGTC_3045|Compound:9092950|FD-Score:3.35|P-value:8.36E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.07|P-value:6.68E-5 ID:SGTC_3130|Compound:9127414|FD-Score:3.47|P-value:5.60E-4 ID:SGTC_3200|Compound:9114385|FD-Score:3.31|P-value:9.64E-4 ID:SGTC_3202|Compound:9113761|FD-Score:3.37|P-value:7.82E-4 ID:SGTC_3243|Compound:9134147|FD-Score:-5.30|P-value:2.85E-7 ID:SGTC_3264|Compound:9137442|FD-Score:-3.75|P-value:2.00E-4 ID:SGTC_3293|Compound:9120939|FD-Score:3.61|P-value:3.46E-4

Top fitness defect scores for YAL041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_605 1315-0399 6.47 119.0 µM 6.09E-10 Golgi 2 5.00E-11 1.27
2 SGTC_1525 8-methoxypsoralen 6.16 92.5 µM 3.51E-9 DNA damage response 5 3.60E-10 0.99
3 SGTC_589 1227-0070 5.83 34.1 µM 2.20E-8 3 2.85E-9 0.31
4 SGTC_2277 7947813 5.74 106.9 µM 3.45E-8 RSC complex & mRNA processing 7 4.73E-9 0.08
5 SGTC_738 1315-0003 5.74 72.4 µM 3.49E-8 1 4.79E-9 0.55
6 SGTC_2622 2-methoxyxanthone 4.97 59.9 µM 1.48E-6 1 3.27E-7 0.89
7 SGTC_747 3448-8087 4.93 38.7 µM 1.78E-6 3 4.01E-7 0.02
8 SGTC_2229 7354935 4.89 190.0 µM 2.18E-6 RSC complex & mRNA processing 16 5.03E-7 0.95
9 SGTC_1374 2889-5571 4.83 141.0 µM 2.87E-6 RSC complex & mRNA processing 30 6.87E-7 0.01
10 SGTC_2698 st077697 4.70 67.5 µM 5.17E-6 4 1.33E-6 0.41
11 SGTC_934 2950-0684 4.58 338.0 µM 8.59E-6 2 2.36E-6 0.60
12 SGTC_2612 dictamnine 4.51 15.5 µM 1.15E-5 RNA pol III & RNase P/MRP 22 3.26E-6 0.03
13 SGTC_2041 5107442 4.45 45.3 µM 1.49E-5 RSC complex & mRNA processing 22 4.39E-6 0.01
14 SGTC_1608 st001473 4.36 40.5 µM 2.11E-5 2 6.47E-6 0.32
15 SGTC_93 0109-0045 4.31 59.2 µM 2.64E-5 DNA damage response 19 8.34E-6 0.04
16 SGTC_2472 5377652 4.28 49.4 µM 2.93E-5 TRP & mitochondrial translation 7 9.37E-6 0.18
17 SGTC_2128 5255449 4.22 168.5 µM 3.67E-5 6 1.21E-5 0.38
18 SGTC_1155 4088-0394 4.17 48.2 µM 4.44E-5 3 1.49E-5 0.25
19 SGTC_2286 7945697 4.17 125.0 µM 4.51E-5 9 1.52E-5 0.19
20 SGTC_1873 rapamycin 4.12 2.0 nM 5.58E-5 16 1.93E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.136 2.53E-15 YDR404C RPB7 het RNA polymerase II subunit B16; forms two subunit dissociable complex with Rpb4p; involved in recruitment of 3'-end processing factors to transcribing RNA polymerase II complex and in export of mRNA to cytoplasm under stress conditions; also involved in translation initiation
0.116 1.38E-11 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.097 1.76E-8 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.090 1.60E-7 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.086 5.77E-7 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.083 1.30E-6 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.082 2.13E-6 YBL026W LSM2 het Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; relocalizes from nucleus to cytoplasmic foci upon DNA replication stress
0.082 2.22E-6 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.080 3.41E-6 YML127W RSC9 het Component of the RSC chromatin remodeling complex; DNA-binding protein involved in the synthesis of rRNA and in transcriptional repression and activation of genes regulated by the Target of Rapamycin (TOR) pathway
0.079 4.78E-6 YJL004C SYS1 hom Integral membrane protein of the Golgi required for targeting of the Arf-like GTPase Arl3p to the Golgi; multicopy suppressor of ypt6 null mutation
0.078 5.44E-6 YPR034W ARP7 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.077 9.03E-6 YML031W NDC1 het Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication; homologous to human NDC1
0.076 1.01E-5 YGR265W_d YGR265W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF MES1/YGR264C, which encodes methionyl-tRNA synthetase
0.076 1.08E-5 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.076 1.12E-5 YHR143W-A RPC10 het RNA polymerase subunit ABC10-alpha, found in RNA pol I, II, and III; relocalizes from nucleolus to cytoplasm upon DNA replication stress