YAL058W / CNE1

Calnexin; integral membrane ER chaperone involved in folding and quality control of glycoproteins; chaperone activity is inhibited by Mpd1p, with which Cne1p interacts; 24% identical to mammalian calnexin; Ca+ binding not yet shown in yeast

Zygosity: Homozygous strain
fixedexpanded
Profile for YAL058W / CNE1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:8.48|P-value:1.77E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.19|P-value:5.77E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.03|P-value:9.20E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.84|P-value:3.96E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:6.21|P-value:9.45E-11 ID:SGTC_532|Compound:1548-0774|FD-Score:3.19|P-value:5.16E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.16|P-value:3.16E-17 ID:SGTC_663|Compound:1486-0733|FD-Score:5.59|P-value:4.94E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:9.44|P-value:1.98E-22 ID:SGTC_741|Compound:4582-0002|FD-Score:3.13|P-value:6.42E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.61|P-value:1.18E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.53|P-value:1.13E-18 ID:SGTC_830|Compound:4076-0286|FD-Score:4.20|P-value:8.14E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:5.18|P-value:5.37E-8 ID:SGTC_880|Compound:0833-0487|FD-Score:3.02|P-value:9.31E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.55|P-value:1.49E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-4.03|P-value:2.00E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.31|P-value:3.82E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.12|P-value:6.76E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.19|P-value:5.19E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.15|P-value:6.25E-8 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.03|P-value:9.13E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.18|P-value:5.36E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.02|P-value:9.32E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.63|P-value:1.11E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.31|P-value:5.66E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.34|P-value:2.99E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.34|P-value:3.44E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.44|P-value:1.99E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.32|P-value:4.67E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.97|P-value:2.59E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-5.52|P-value:9.13E-9 ID:SGTC_2007|Compound:4011539|FD-Score:9.12|P-value:4.60E-21 ID:SGTC_2009|Compound:4012297|FD-Score:5.32|P-value:2.33E-8 ID:SGTC_2017|Compound:5132927|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.72|P-value:2.17E-9 ID:SGTC_2054|Compound:5233173|FD-Score:-4.09|P-value:1.52E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.15|P-value:6.86E-4 ID:SGTC_2176|Compound:5809774|FD-Score:4.33|P-value:4.28E-6 ID:SGTC_2272|Compound:7805186|FD-Score:4.97|P-value:1.69E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-3.12|P-value:7.61E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.72|P-value:1.25E-15 ID:SGTC_2319|Compound:6033012|FD-Score:3.33|P-value:3.13E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.04|P-value:8.94E-4 ID:SGTC_2399|Compound:5884133|FD-Score:8.26|P-value:1.22E-17 ID:SGTC_2485|Compound:5633444|FD-Score:5.41|P-value:1.46E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.33|P-value:3.13E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.24|P-value:4.88E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.66|P-value:8.38E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.13|P-value:7.22E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.31|P-value:3.31E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.92|P-value:2.23E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.44|P-value:2.36E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.86|P-value:3.64E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.44|P-value:1.20E-8 ID:SGTC_2997|Compound:9067075|FD-Score:3.47|P-value:1.80E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-8.99|P-value:2.15E-20 ID:SGTC_3166|Compound:9102297|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.13|P-value:6.42E-4 ID:SGTC_16|Compound:erodoxin|FD-Score:8.48|P-value:1.77E-18 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.19|P-value:5.77E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:3.03|P-value:9.20E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:3.32|P-value:3.16E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.15|P-value:6.08E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.84|P-value:3.96E-5 ID:SGTC_531|Compound:3788-1495|FD-Score:6.21|P-value:9.45E-11 ID:SGTC_532|Compound:1548-0774|FD-Score:3.19|P-value:5.16E-4 ID:SGTC_625|Compound:k213-0058|FD-Score:8.16|P-value:3.16E-17 ID:SGTC_663|Compound:1486-0733|FD-Score:5.59|P-value:4.94E-9 ID:SGTC_708|Compound:3448-5400|FD-Score:9.44|P-value:1.98E-22 ID:SGTC_741|Compound:4582-0002|FD-Score:3.13|P-value:6.42E-4 ID:SGTC_793|Compound:0488-0545|FD-Score:-3.61|P-value:1.18E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:8.53|P-value:1.13E-18 ID:SGTC_830|Compound:4076-0286|FD-Score:4.20|P-value:8.14E-6 ID:SGTC_868|Compound:0527-0199|FD-Score:5.18|P-value:5.37E-8 ID:SGTC_880|Compound:0833-0487|FD-Score:3.02|P-value:9.31E-4 ID:SGTC_942|Compound:3253-1115|FD-Score:-3.55|P-value:1.49E-4 ID:SGTC_1025|Compound:k007-0731|FD-Score:-4.03|P-value:2.00E-5 ID:SGTC_1030|Compound:k029-0042|FD-Score:-3.31|P-value:3.82E-4 ID:SGTC_1038|Compound:k292-0204|FD-Score:3.12|P-value:6.76E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:3.19|P-value:5.19E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:5.15|P-value:6.25E-8 ID:SGTC_1324|Compound:1418-0026|FD-Score:3.03|P-value:9.13E-4 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.18|P-value:5.36E-4 ID:SGTC_1690|Compound:st023502|FD-Score:3.02|P-value:9.32E-4 ID:SGTC_1726|Compound:st035556|FD-Score:-3.63|P-value:1.11E-4 ID:SGTC_1728|Compound:st035614|FD-Score:3.65|P-value:8.95E-5 ID:SGTC_1730|Compound:st033808|FD-Score:3.13|P-value:6.46E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.31|P-value:5.66E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.34|P-value:2.99E-4 ID:SGTC_1772|Compound:st048439|FD-Score:-3.34|P-value:3.44E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.44|P-value:1.99E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:4.32|P-value:4.67E-6 ID:SGTC_1923|Compound:st058458|FD-Score:3.19|P-value:5.28E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.97|P-value:2.59E-5 ID:SGTC_1929|Compound:genistein trimethyl ether|FD-Score:4.14|P-value:1.04E-5 ID:SGTC_1930|Compound:st074634|FD-Score:-5.52|P-value:9.13E-9 ID:SGTC_2007|Compound:4011539|FD-Score:9.12|P-value:4.60E-21 ID:SGTC_2009|Compound:4012297|FD-Score:5.32|P-value:2.33E-8 ID:SGTC_2017|Compound:5132927|FD-Score:-3.09|P-value:8.48E-4 ID:SGTC_2036|Compound:5160441|FD-Score:5.72|P-value:2.17E-9 ID:SGTC_2054|Compound:5233173|FD-Score:-4.09|P-value:1.52E-5 ID:SGTC_2056|Compound:5235370|FD-Score:-3.15|P-value:6.86E-4 ID:SGTC_2176|Compound:5809774|FD-Score:4.33|P-value:4.28E-6 ID:SGTC_2272|Compound:7805186|FD-Score:4.97|P-value:1.69E-7 ID:SGTC_2277|Compound:7947813|FD-Score:-3.12|P-value:7.61E-4 ID:SGTC_2289|Compound:7946404|FD-Score:7.72|P-value:1.25E-15 ID:SGTC_2319|Compound:6033012|FD-Score:3.33|P-value:3.13E-4 ID:SGTC_2359|Compound:9039622|FD-Score:3.04|P-value:8.94E-4 ID:SGTC_2399|Compound:5884133|FD-Score:8.26|P-value:1.22E-17 ID:SGTC_2485|Compound:5633444|FD-Score:5.41|P-value:1.46E-8 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.33|P-value:3.13E-4 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:-3.24|P-value:4.88E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.66|P-value:8.38E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.13|P-value:7.22E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.31|P-value:3.31E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:4.92|P-value:2.23E-7 ID:SGTC_2766|Compound:oltipraz|FD-Score:-3.44|P-value:2.36E-4 ID:SGTC_2772|Compound:vinpocetine|FD-Score:-4.86|P-value:3.64E-7 ID:SGTC_2825|Compound:7998094|FD-Score:5.44|P-value:1.20E-8 ID:SGTC_2997|Compound:9067075|FD-Score:3.47|P-value:1.80E-4 ID:SGTC_3155|Compound:9099265|FD-Score:-8.99|P-value:2.15E-20 ID:SGTC_3166|Compound:9102297|FD-Score:3.02|P-value:9.54E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.13|P-value:6.42E-4

Top fitness defect scores for YAL058W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_708 3448-5400 9.44 146.0 µM 1.98E-22 2 1.88E-21
2 SGTC_2007 4011539 9.12 71.8 µM 4.60E-21 cell wall signaling 14 3.78E-20
3 SGTC_800 3448-7362 8.53 155.0 µM 1.13E-18 translation 13 7.23E-18
4 SGTC_16 erodoxin 8.48 22.8 µM 1.77E-18 unfolded protein response 14 1.11E-17
5 SGTC_2399 5884133 8.26 200.0 µM 1.22E-17 cell wall signaling 15 7.02E-17
6 SGTC_625 k213-0058 8.16 121.0 µM 3.16E-17 translation 10 1.74E-16
7 SGTC_2289 7946404 7.72 165.1 µM 1.25E-15 17 5.84E-15
8 SGTC_531 3788-1495 6.21 174.0 µM 9.45E-11 unfolded protein response 9 2.64E-10
9 SGTC_2036 5160441 5.72 105.0 µM 2.17E-9 NEO1 45 5.24E-9
10 SGTC_663 1486-0733 5.59 13.9 µM 4.94E-9 cell wall signaling 23 1.15E-8
11 SGTC_2825 7998094 5.44 58.4 µM 1.20E-8 fatty acid desaturase (OLE1) 12 2.69E-8
12 SGTC_2485 5633444 5.41 17.8 µM 1.46E-8 redox potentiating 19 3.23E-8
13 SGTC_2009 4012297 5.32 12.1 µM 2.33E-8 cell wall signaling 32 5.05E-8
14 SGTC_868 0527-0199 5.18 213.0 µM 5.37E-8 fatty acid desaturase (OLE1) 11 1.12E-7
15 SGTC_1264 0783-0040 5.15 158.0 µM 6.25E-8 8 1.30E-7
16 SGTC_2272 7805186 4.97 180.0 µM 1.69E-7 cell wall signaling 11 3.36E-7
17 SGTC_2763 lisinopril 4.92 49.3 µM 2.23E-7 4 4.37E-7
18 SGTC_2176 5809774 4.33 34.0 µM 4.28E-6 mitochondrial processes 8 7.31E-6
19 SGTC_1874 staurosporine 4.32 7.6 µM 4.67E-6 cell wall signaling 21 7.96E-6
20 SGTC_830 4076-0286 4.20 57.8 µM 8.14E-6 translation 48 1.35E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.431 2.03E-151 YAL056C-A_d YAL056C-A_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.430 3.02E-151 YOR085W OST3 hom Gamma subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins; Ost3p is important for N-glycosylation of a subset of proteins
0.411 6.23E-137 YNL322C KRE1 hom Cell wall glycoprotein involved in beta-glucan assembly; serves as a K1 killer toxin membrane receptor
0.305 4.80E-73 YMR200W ROT1 het Molecular chaperone involved in protein folding in the ER; mutation causes defects in cell wall synthesis and in lysis of autophagic bodies, suppresses tor2 mutations, and is synthetically lethal with kar2-1 and with rot2 mutations; involved in N-linked glycosylation and O-mannosylation
0.300 6.91E-71 YBR260C RGD1 hom GTPase-activating protein (RhoGAP) for Rho3p and Rho4p, possibly involved in control of actin cytoskeleton organization
0.297 5.93E-69 YDL096C_d OPI6_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PMT1/YDL095W; YDL096C is not essential
0.256 4.00E-51 YGR196C FYV8 hom Protein of unknown function, required for survival upon exposure to K1 killer toxin
0.236 1.12E-43 YBR229C ROT2 hom Glucosidase II catalytic subunit required for normal cell wall synthesis; mutations in rot2 suppress tor2 mutations, and are synthetically lethal with rot1 mutations
0.234 4.41E-43 YKL096C-B_p YKL096C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.231 9.07E-42 YAL053W FLC2 hom Putative FAD transporter; required for uptake of FAD into endoplasmic reticulum; involved in cell wall maintenance; FLC2 has a paralog, YOR365C, that arose from the whole genome duplication
0.221 2.23E-38 YJR075W HOC1 hom Alpha-1,6-mannosyltransferase involved in cell wall mannan biosynthesis; subunit of a Golgi-localized complex that also contains Anp1p, Mnn9p, Mnn11p, and Mnn10p; identified as a suppressor of a cell lysis sensitive pkc1-371 allele
0.217 6.08E-37 YGR166W TRS65 hom Subunit of TRAPPII, a multimeric guanine nucleotide-exchange factor for Ypt1p; involved in intra-Golgi traffic and the retrograde pathway from the endosome to Golgi; role in cell wall beta-glucan biosynthesis and the stress response
0.207 9.75E-34 YDL095W PMT1 hom Protein O-mannosyltransferase of the ER membrane; transfers mannose from dolichyl phosphate-D-mannose to protein serine and threonine residues; 1 of 7 related proteins involved in O-glycosylation which is essential for cell wall rigidity; involved in ER quality control; amino terminus faces cytoplasm, carboxyl terminus faces ER lumen
0.201 9.05E-32 YOR002W ALG6 hom Alpha 1,3 glucosyltransferase, involved in transfer of oligosaccharides from dolichyl pyrophosphate to asparagine residues of proteins during N-linked protein glycosylation; mutations in human ortholog are associated with disease
0.195 5.43E-30 YJL139C YUR1 hom Mannosyltransferase involved in protein N-glycosylation; member of the KTR1 family; located in the Golgi apparatus; YUR1 has a paralog, KTR2, that arose from the whole genome duplication