YAR035C-A_p

Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching; predicted to have a role in cell budding based on computational guilt by association analysis

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR035C-A / YAR035C-A

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-3.32|P-value:1.74E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.22|P-value:2.46E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.25|P-value:2.15E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.90|P-value:1.23E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.97|P-value:6.53E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.17|P-value:3.02E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.15|P-value:3.20E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:2.88|P-value:9.15E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.92|P-value:1.11E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:5.57|P-value:8.44E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:2.89|P-value:8.68E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.05|P-value:5.69E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.08|P-value:4.32E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:9.26|P-value:6.38E-24 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.57|P-value:5.95E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.98|P-value:8.03E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.92|P-value:8.13E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:7.91|P-value:6.10E-18 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.88|P-value:9.10E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.95|P-value:9.43E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.75|P-value:1.35E-7 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.32|P-value:1.65E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.27|P-value:1.96E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.16|P-value:3.24E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.99|P-value:7.79E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.32|P-value:1.45E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_1690|Compound:st023502|FD-Score:2.98|P-value:6.28E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.94|P-value:1.00E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.74|P-value:2.55E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.20|P-value:2.81E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.91|P-value:8.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.67|P-value:3.55E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.02|P-value:6.81E-6 ID:SGTC_1934|Compound:st074720|FD-Score:5.25|P-value:6.63E-9 ID:SGTC_1959|Compound:st077091|FD-Score:3.87|P-value:1.38E-5 ID:SGTC_1980|Compound:st071811|FD-Score:6.37|P-value:2.80E-12 ID:SGTC_1981|Compound:st071826|FD-Score:3.18|P-value:2.86E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.68|P-value:3.39E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.60|P-value:4.87E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.00|P-value:5.71E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.66|P-value:3.73E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.93|P-value:1.03E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.66|P-value:3.74E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.26|P-value:2.07E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.93|P-value:7.52E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:2.88|P-value:8.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:8.82E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:2.88|P-value:9.00E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.21|P-value:2.57E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.99|P-value:7.75E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.10|P-value:4.51E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.14|P-value:3.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.18|P-value:2.91E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-2.96|P-value:6.98E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.86|P-value:7.05E-8 ID:SGTC_3189|Compound:9110682|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.72|P-value:2.96E-5 ID:SGTC_3243|Compound:9134147|FD-Score:2.87|P-value:9.28E-4 ID:SGTC_38|Compound:0929-0051|FD-Score:-3.32|P-value:1.74E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.22|P-value:2.46E-6 ID:SGTC_134|Compound:0269-0018|FD-Score:4.25|P-value:2.15E-6 ID:SGTC_236|Compound:1509-0011|FD-Score:3.88|P-value:1.33E-5 ID:SGTC_414|Compound:piperonyl butoxide|FD-Score:3.90|P-value:1.23E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:2.97|P-value:6.53E-4 ID:SGTC_456|Compound:gingerol|FD-Score:3.17|P-value:3.02E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:3.15|P-value:3.20E-4 ID:SGTC_591|Compound:4299-0174|FD-Score:2.88|P-value:9.15E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.92|P-value:1.11E-5 ID:SGTC_654|Compound:1124-0271|FD-Score:5.57|P-value:8.44E-10 ID:SGTC_669|Compound:0108-0021|FD-Score:3.43|P-value:1.03E-4 ID:SGTC_688|Compound:0527-0193|FD-Score:2.89|P-value:8.68E-4 ID:SGTC_934|Compound:2950-0684|FD-Score:4.05|P-value:5.69E-6 ID:SGTC_949|Compound:1165-0505|FD-Score:3.08|P-value:4.32E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:9.26|P-value:6.38E-24 ID:SGTC_992|Compound:3909-8734|FD-Score:-3.57|P-value:5.95E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:3.98|P-value:8.03E-6 ID:SGTC_1164|Compound:k060-0068|FD-Score:-2.92|P-value:8.13E-4 ID:SGTC_1184|Compound:1269-1718|FD-Score:7.91|P-value:6.10E-18 ID:SGTC_1298|Compound:1079-1278|FD-Score:2.88|P-value:9.10E-4 ID:SGTC_1331|Compound:1472-0049|FD-Score:3.95|P-value:9.43E-6 ID:SGTC_1368|Compound:1852-0141|FD-Score:4.75|P-value:1.35E-7 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:3.32|P-value:1.65E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:3.27|P-value:1.96E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-3.16|P-value:3.24E-4 ID:SGTC_1673|Compound:st016611|FD-Score:3.99|P-value:7.79E-6 ID:SGTC_1680|Compound:diphenhydramine|FD-Score:4.32|P-value:1.45E-6 ID:SGTC_1686|Compound:st019653|FD-Score:3.34|P-value:1.52E-4 ID:SGTC_1690|Compound:st023502|FD-Score:2.98|P-value:6.28E-4 ID:SGTC_1691|Compound:st019933|FD-Score:3.94|P-value:1.00E-5 ID:SGTC_1695|Compound:st026914|FD-Score:3.74|P-value:2.55E-5 ID:SGTC_1859|Compound:st055998|FD-Score:-3.20|P-value:2.81E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:2.91|P-value:8.02E-4 ID:SGTC_1921|Compound:5740136|FD-Score:3.67|P-value:3.55E-5 ID:SGTC_1924|Compound:st058459|FD-Score:3.41|P-value:1.09E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:4.02|P-value:6.81E-6 ID:SGTC_1934|Compound:st074720|FD-Score:5.25|P-value:6.63E-9 ID:SGTC_1959|Compound:st077091|FD-Score:3.87|P-value:1.38E-5 ID:SGTC_1980|Compound:st071811|FD-Score:6.37|P-value:2.80E-12 ID:SGTC_1981|Compound:st071826|FD-Score:3.18|P-value:2.86E-4 ID:SGTC_1994|Compound:st072947|FD-Score:3.68|P-value:3.39E-5 ID:SGTC_2064|Compound:5220758|FD-Score:3.60|P-value:4.87E-5 ID:SGTC_2175|Compound:5807670|FD-Score:3.42|P-value:1.07E-4 ID:SGTC_2185|Compound:6113692|FD-Score:3.00|P-value:5.71E-4 ID:SGTC_2188|Compound:6126565|FD-Score:3.20|P-value:2.70E-4 ID:SGTC_2281|Compound:7943571|FD-Score:3.66|P-value:3.73E-5 ID:SGTC_2425|Compound:5628681|FD-Score:3.93|P-value:1.03E-5 ID:SGTC_2428|Compound:5615643|FD-Score:3.66|P-value:3.74E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.26|P-value:2.07E-4 ID:SGTC_2480|Compound:5767542|FD-Score:3.36|P-value:1.38E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.93|P-value:7.52E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:2.88|P-value:8.98E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:3.79|P-value:2.04E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.48|P-value:8.82E-5 ID:SGTC_2645|Compound:abamectin|FD-Score:2.88|P-value:9.00E-4 ID:SGTC_2759|Compound:disulfiram|FD-Score:3.21|P-value:2.57E-4 ID:SGTC_2815|Compound:7968870|FD-Score:-3.22|P-value:2.58E-4 ID:SGTC_2821|Compound:7996764|FD-Score:3.41|P-value:1.12E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.99|P-value:7.75E-6 ID:SGTC_2844|Compound:9010103|FD-Score:4.10|P-value:4.51E-6 ID:SGTC_2849|Compound:9019321|FD-Score:3.14|P-value:3.30E-4 ID:SGTC_2882|Compound:9058044|FD-Score:3.18|P-value:2.91E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-2.96|P-value:6.98E-4 ID:SGTC_3089|Compound:9117425|FD-Score:4.86|P-value:7.05E-8 ID:SGTC_3189|Compound:9110682|FD-Score:3.32|P-value:1.64E-4 ID:SGTC_3203|Compound:9113543|FD-Score:-3.72|P-value:2.96E-5 ID:SGTC_3243|Compound:9134147|FD-Score:2.87|P-value:9.28E-4

Top fitness defect scores for YAR035C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_966 1300-0360 9.26 30.2 µM 6.38E-24 heme requiring 1 9.97E-21
2 SGTC_1184 1269-1718 7.91 139.0 µM 6.10E-18 2 1.33E-15
3 SGTC_1980 st071811 6.37 45.7 µM 2.80E-12 RPP1 & pyrimidine depletion 1 9.55E-11
4 SGTC_654 1124-0271 5.57 80.9 µM 8.44E-10 4 1.28E-8
5 SGTC_1934 st074720 5.25 32.6 µM 6.63E-9 23 7.53E-8
6 SGTC_3089 9117425 4.86 49.5 µM 7.05E-8 8 5.75E-7
7 SGTC_1368 1852-0141 4.75 284.0 µM 1.35E-7 ERG2 24 1.00E-6
8 SGTC_1680 diphenhydramine 4.32 100.0 µM 1.45E-6 NEO1 21 7.74E-6
9 SGTC_134 0269-0018 4.25 6.9 µM 2.15E-6 122 1.09E-5
10 SGTC_58 0957-0393 4.22 9.0 µM 2.46E-6 cell wall 351 1.22E-5
11 SGTC_2844 9010103 4.10 26.0 µM 4.51E-6 32 2.06E-5
12 SGTC_934 2950-0684 4.05 338.0 µM 5.69E-6 20 2.51E-5
13 SGTC_1928 4'-methoxychalcone 4.02 40.3 µM 6.81E-6 10 2.93E-5
14 SGTC_2829 7992743 3.99 58.4 µM 7.75E-6 36 3.27E-5
15 SGTC_1673 st016611 3.99 27.3 µM 7.79E-6 43 3.29E-5
16 SGTC_1087 pterostilbene 3.98 9.1 µM 8.03E-6 24 3.38E-5
17 SGTC_1331 1472-0049 3.95 76.2 µM 9.43E-6 18 3.88E-5
18 SGTC_1691 st019933 3.94 84.6 µM 1.00E-5 14 4.09E-5
19 SGTC_2425 5628681 3.93 7.8 µM 1.03E-5 25 4.18E-5
20 SGTC_627 1391-0720 3.92 175.0 µM 1.11E-5 14 4.46E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.139 5.72E-16 YJL062W-A COA3 hom Mitochondrial inner membrane protein that participates in regulation of COX1 translation, Cox1p stabilization, and cytochrome oxidase assembly
0.137 1.40E-15 YNR045W PET494 hom Mitochondrial translational activator specific for the COX3 mRNA, acts together with Pet54p and Pet122p; located in the mitochondrial inner membrane
0.131 2.25E-14 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.128 1.10E-13 YHL038C CBP2 hom Required for splicing of the group I intron bI5 of the COB pre-mRNA; nuclear-encoded mitochondrial protein that binds to the RNA to promote splicing; also involved in but not essential for splicing of the COB bI2 intron and the intron in the 21S rRNA gene
0.128 1.25E-13 YDR231C COX20 hom Mitochondrial inner membrane protein, required for proteolytic processing of Cox2p and its assembly into cytochrome c oxidase
0.127 1.27E-13 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.121 1.65E-12 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.121 1.76E-12 YGL107C RMD9 hom Mitochondrial protein required for respiratory growth; mutant phenotype and genetic interactions suggest a role in delivering mt mRNAs to ribosomes; located on matrix face of the inner membrane and loosely associated with mitoribosomes
0.118 6.69E-12 YDL107W MSS2 hom Peripherally bound inner membrane protein of the mitochondrial matrix involved in membrane insertion of C-terminus of Cox2p, interacts genetically and physically with Cox18p
0.118 7.66E-12 YGR012W YGR012W hom Putative cysteine synthase, localized to the mitochondrial outer membrane
0.117 8.48E-12 YER058W PET117 hom Protein required for assembly of cytochrome c oxidase
0.117 1.23E-11 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.117 1.30E-11 YGR223C HSV2 hom Phosphatidylinositol 3,5-bisphosphate-binding protein, plays a role in micronucleophagy; belongs to the PROPPIN family of proteins; predicted to fold as a seven-bladed beta-propeller; displays punctate cytoplasmic localization
0.112 7.25E-11 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.110 1.57E-10 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit