YAR047C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR047C / YAR047C

Click on Significant Values for Screen Details ID:SGTC_96|Compound:0929-0093|FD-Score:3.05|P-value:6.07E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.89|P-value:1.74E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.50|P-value:9.78E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.83|P-value:2.39E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.03|P-value:6.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.11|P-value:4.91E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.23|P-value:3.11E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.14|P-value:5.64E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:4.12|P-value:6.15E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.00|P-value:7.09E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.80|P-value:2.82E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.83|P-value:2.40E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.10|P-value:5.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.02|P-value:6.80E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.25|P-value:3.19E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.80|P-value:1.70E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-2.93|P-value:8.94E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.35|P-value:1.92E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.13|P-value:4.46E-4 ID:SGTC_1667|Compound:st014849|FD-Score:2.94|P-value:8.98E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:2.99|P-value:7.64E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.55|P-value:7.80E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.01|P-value:6.88E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.68|P-value:8.10E-10 ID:SGTC_2144|Compound:5628481|FD-Score:5.16|P-value:2.12E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.00|P-value:7.29E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.01|P-value:6.76E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.95|P-value:7.60E-8 ID:SGTC_2172|Compound:5754775|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.01|P-value:1.05E-5 ID:SGTC_2177|Compound:5811945|FD-Score:4.80|P-value:1.74E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.44|P-value:1.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.09|P-value:3.30E-8 ID:SGTC_2268|Compound:7933382|FD-Score:5.90|P-value:1.92E-10 ID:SGTC_2332|Compound:7982454|FD-Score:3.62|P-value:6.13E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.93|P-value:1.50E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.92|P-value:9.44E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.15|P-value:4.23E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.33|P-value:1.97E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.22|P-value:3.21E-4 ID:SGTC_96|Compound:0929-0093|FD-Score:3.05|P-value:6.07E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.89|P-value:1.74E-5 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.50|P-value:9.78E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:3.83|P-value:2.39E-5 ID:SGTC_401|Compound:neomycin|FD-Score:3.03|P-value:6.64E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.11|P-value:4.91E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:3.23|P-value:3.11E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.34|P-value:1.99E-4 ID:SGTC_604|Compound:1000-0114|FD-Score:4.14|P-value:5.64E-6 ID:SGTC_796|Compound:1234-0020|FD-Score:4.12|P-value:6.15E-6 ID:SGTC_824|Compound:1304-0008|FD-Score:-3.00|P-value:7.09E-4 ID:SGTC_885|Compound:0865-0106|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_1064|Compound:honokiol|FD-Score:3.80|P-value:2.82E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:3.83|P-value:2.40E-5 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.10|P-value:5.02E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.02|P-value:6.80E-4 ID:SGTC_1332|Compound:1480-0653|FD-Score:4.25|P-value:3.19E-6 ID:SGTC_1414|Compound:3917-0015|FD-Score:3.12|P-value:4.73E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:4.80|P-value:1.70E-7 ID:SGTC_1506|Compound:4226-2149|FD-Score:3.63|P-value:5.83E-5 ID:SGTC_1514|Compound:1189-1591|FD-Score:-3.29|P-value:2.32E-4 ID:SGTC_1568|Compound:digitonin|FD-Score:-2.93|P-value:8.94E-4 ID:SGTC_1576|Compound:erythromycin ethylsuccinate|FD-Score:3.35|P-value:1.92E-4 ID:SGTC_1657|Compound:st012939|FD-Score:3.13|P-value:4.46E-4 ID:SGTC_1667|Compound:st014849|FD-Score:2.94|P-value:8.98E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:2.99|P-value:7.64E-4 ID:SGTC_1911|Compound:st060208|FD-Score:-3.55|P-value:7.80E-5 ID:SGTC_1914|Compound:st062367|FD-Score:-3.01|P-value:6.88E-4 ID:SGTC_1917|Compound:st066507|FD-Score:5.68|P-value:8.10E-10 ID:SGTC_2144|Compound:5628481|FD-Score:5.16|P-value:2.12E-8 ID:SGTC_2160|Compound:5660466|FD-Score:3.29|P-value:2.40E-4 ID:SGTC_2164|Compound:5685496|FD-Score:3.00|P-value:7.29E-4 ID:SGTC_2167|Compound:5876490|FD-Score:-3.01|P-value:6.76E-4 ID:SGTC_2169|Compound:5-(ethoxymethyl)quinolin-8-ol|FD-Score:4.95|P-value:7.60E-8 ID:SGTC_2172|Compound:5754775|FD-Score:3.10|P-value:5.05E-4 ID:SGTC_2175|Compound:5807670|FD-Score:4.01|P-value:1.05E-5 ID:SGTC_2177|Compound:5811945|FD-Score:4.80|P-value:1.74E-7 ID:SGTC_2243|Compound:6634756|FD-Score:3.44|P-value:1.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:5.09|P-value:3.30E-8 ID:SGTC_2268|Compound:7933382|FD-Score:5.90|P-value:1.92E-10 ID:SGTC_2332|Compound:7982454|FD-Score:3.62|P-value:6.13E-5 ID:SGTC_2403|Compound:6032726|FD-Score:3.93|P-value:1.50E-5 ID:SGTC_2535|Compound:4',4'-dimethoxydalbergione|FD-Score:-2.92|P-value:9.44E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:2.99|P-value:7.54E-4 ID:SGTC_2711|Compound:st079103|FD-Score:3.15|P-value:4.23E-4 ID:SGTC_2712|Compound:st079126|FD-Score:-3.33|P-value:1.97E-4 ID:SGTC_2808|Compound:7946468|FD-Score:3.22|P-value:3.21E-4

Top fitness defect scores for YAR047C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2268 7933382 5.90 153.8 µM 1.92E-10 10 1.85E-9
2 SGTC_1917 st066507 5.68 28.5 µM 8.10E-10 Golgi 14 6.65E-9
3 SGTC_2144 5628481 5.16 200.0 µM 2.12E-8 ERG2 8 1.21E-7
4 SGTC_2246 7293507 5.09 91.6 µM 3.30E-8 17 1.80E-7
5 SGTC_2169 5-(ethoxymethyl)quinolin-8-ol 4.95 49.5 µM 7.60E-8 8 3.78E-7
6 SGTC_1451 4152-0210 4.80 104.0 µM 1.70E-7 9 7.75E-7
7 SGTC_2177 5811945 4.80 192.0 µM 1.74E-7 14 7.92E-7
8 SGTC_1332 1480-0653 4.25 17.5 µM 3.19E-6 TSC3-RPN4 11 1.05E-5
9 SGTC_604 1000-0114 4.14 314.0 µM 5.64E-6 15 1.75E-5
10 SGTC_796 1234-0020 4.12 70.7 µM 6.15E-6 SWF1 & branched chain AA biosynthesis 23 1.89E-5
11 SGTC_2175 5807670 4.01 165.3 µM 1.05E-5 21 3.04E-5
12 SGTC_2403 6032726 3.93 181.2 µM 1.50E-5 39 4.20E-5
13 SGTC_290 2043-6722 3.83 48.1 µM 2.39E-5 12 6.36E-5
14 SGTC_1164 k060-0068 3.83 93.7 µM 2.40E-5 27 6.37E-5
15 SGTC_1064 honokiol 3.80 6.8 µM 2.82E-5 30 7.36E-5
16 SGTC_1506 4226-2149 3.63 212.0 µM 5.83E-5 37 1.41E-4
17 SGTC_2332 7982454 3.62 138.9 µM 6.13E-5 65 1.47E-4
18 SGTC_2243 6634756 3.44 200.0 µM 1.30E-4 34 2.88E-4
19 SGTC_1576 erythromycin ethylsuccinate 3.35 23.2 µM 1.92E-4 37 4.08E-4
20 SGTC_529 4076-0302 3.34 30.3 µM 1.99E-4 mitochondrial processes 34 4.21E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.32E-10 YBR089C-A NHP6B hom High-mobility group (HMG) protein, binds to and remodels nucleosomes; involved in recruiting FACT and other chromatin remodelling complexes to the chromosomes; functionally redundant with Nhp6Ap; homologous to mammalian HMGB1 and HMGB2; NHP6B has a paralog, NHP6A, that arose from the whole genome duplication
0.094 5.13E-8 YNL148C ALF1 hom Alpha-tubulin folding protein, similar to mammalian cofactor B; Alf1p-GFP localizes to cytoplasmic microtubules; required for the folding of alpha-tubulin and may play an additional role in microtubule maintenance
0.090 1.65E-7 YOR386W PHR1 hom DNA photolyase involved in photoreactivation, repairs pyrimidine dimers in the presence of visible light; induced by DNA damage; regulated by transcriptional repressor Rph1p
0.085 7.81E-7 YOR257W CDC31 het Calcium-binding component of the spindle pole body (SPB) half-bridge, required for SPB duplication in mitosis and meiosis II; homolog of mammalian centrin; binds multiubiquitinated proteins and is involved in proteasomal protein degradation
0.084 1.01E-6 YJL197W UBP12 hom Ubiquitin-specific protease; cleaves ubiquitin from ubiquitinated proteins; present in the nucleus and cytoplasm
0.083 1.41E-6 YLR043C TRX1 hom Cytoplasmic thioredoxin isoenzyme; part of the thioredoxin system which protects cells against oxidative and reductive stress; forms LMA1 complex with Pbi2p; acts as a cofactor for Tsa1p, required for ER-Golgi transport and vacuole inheritance; protein abundance increases in response to DNA replication stress
0.081 2.37E-6 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein
0.080 3.20E-6 YHR095W_d YHR095W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.080 3.67E-6 YKL181W PRS1 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes
0.079 4.08E-6 YOL152W FRE7 hom Putative ferric reductase with similarity to Fre2p; expression induced by low copper levels
0.079 4.49E-6 YIL047C SYG1 hom Plasma membrane protein of unknown function; truncation and overexpression suppresses lethality of G-alpha protein deficiency
0.079 5.01E-6 YHL014C YLF2 hom Protein of unknown function, has weak similarity to E. coli GTP-binding protein gtp1; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.075 1.48E-5 YOR323C PRO2 hom Gamma-glutamyl phosphate reductase, catalyzes the second step in proline biosynthesis
0.075 1.51E-5 YER103W SSA4 hom Heat shock protein that is highly induced upon stress; plays a role in SRP-dependent cotranslational protein-membrane targeting and translocation; member of the HSP70 family; cytoplasmic protein that concentrates in nuclei upon starvation; SSA4 has a paralog, SSA3, that arose from the whole genome duplication
0.072 3.18E-5 YFL046W_p FMP32_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies