YAR050W / FLO1

Lectin-like protein involved in flocculation, cell wall protein that binds to mannose chains on the surface of other cells, confers floc-forming ability that is chymotrypsin sensitive and heat resistant; similar to Flo5p

Zygosity: Homozygous strain
fixedexpanded
Profile for YAR050W / FLO1

Click on Significant Values for Screen Details ID:SGTC_129|Compound:0088-0017|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:1.51E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.24|P-value:3.75E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.45|P-value:6.31E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.94|P-value:1.30E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.34|P-value:9.06E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.58|P-value:4.53E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.84|P-value:1.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.35|P-value:8.86E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.49|P-value:6.04E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.73|P-value:2.50E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.67|P-value:3.32E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.44|P-value:6.62E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.50|P-value:1.70E-7 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.48|P-value:6.39E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.50|P-value:5.96E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.33|P-value:2.92E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.82|P-value:1.83E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.47|P-value:5.98E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.73|P-value:5.23E-8 ID:SGTC_2306|Compound:7482397|FD-Score:3.54|P-value:5.17E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.63|P-value:3.49E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.71|P-value:5.54E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.55|P-value:4.64E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.37|P-value:9.05E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.31|P-value:6.00E-15 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.67|P-value:3.36E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.97|P-value:1.14E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.41|P-value:7.90E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.60|P-value:4.31E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.73|P-value:2.44E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.39|P-value:8.50E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.57|P-value:4.25E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.81|P-value:1.85E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.42|P-value:7.59E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:3.83|P-value:1.94E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.90|P-value:1.51E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:-3.97|P-value:1.04E-4 ID:SGTC_194|Compound:1486-1323|FD-Score:-4.24|P-value:3.75E-5 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.45|P-value:6.31E-4 ID:SGTC_485|Compound:niflumic acid|FD-Score:3.94|P-value:1.30E-4 ID:SGTC_522|Compound:1273-0010|FD-Score:-3.34|P-value:9.06E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.58|P-value:4.53E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:-3.84|P-value:1.68E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:-3.35|P-value:8.86E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:3.49|P-value:6.04E-4 ID:SGTC_770|Compound:0389-1121|FD-Score:-3.73|P-value:2.50E-4 ID:SGTC_991|Compound:3996-0057|FD-Score:3.67|P-value:3.32E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:-3.44|P-value:6.62E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:5.50|P-value:1.70E-7 ID:SGTC_1090|Compound:efavirenz|FD-Score:3.48|P-value:6.39E-4 ID:SGTC_1276|Compound:0871-0068|FD-Score:3.50|P-value:5.96E-4 ID:SGTC_1729|Compound:st035615|FD-Score:4.33|P-value:2.92E-5 ID:SGTC_1733|Compound:st037357|FD-Score:-3.82|P-value:1.83E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.47|P-value:5.98E-4 ID:SGTC_2092|Compound:5303694|FD-Score:5.73|P-value:5.23E-8 ID:SGTC_2306|Compound:7482397|FD-Score:3.54|P-value:5.17E-4 ID:SGTC_2312|Compound:7706453|FD-Score:-3.63|P-value:3.49E-4 ID:SGTC_2378|Compound:9074213|FD-Score:-4.71|P-value:5.54E-6 ID:SGTC_2387|Compound:9077560|FD-Score:-3.55|P-value:4.64E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.37|P-value:9.05E-4 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:8.31|P-value:6.00E-15 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.67|P-value:3.36E-4 ID:SGTC_2607|Compound:solasodine|FD-Score:3.97|P-value:1.14E-4 ID:SGTC_2653|Compound:dihydrofissinolide|FD-Score:3.41|P-value:7.90E-4 ID:SGTC_2666|Compound:tannic acid|FD-Score:3.60|P-value:4.31E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-3.73|P-value:2.44E-4 ID:SGTC_2883|Compound:9059145|FD-Score:3.39|P-value:8.50E-4 ID:SGTC_2927|Compound:9011802|FD-Score:-3.57|P-value:4.25E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.45|P-value:6.28E-4 ID:SGTC_3127|Compound:9126946|FD-Score:-3.81|P-value:1.85E-4 ID:SGTC_3194|Compound:9111903|FD-Score:3.42|P-value:7.59E-4

Top fitness defect scores for YAR050W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2566 crystal violet carbinol 8.31 226.0 nM 6.00E-15 6 4.89E-17
2 SGTC_2092 5303694 5.73 80.7 µM 5.23E-8 TSC3-RPN4 5 5.01E-9
3 SGTC_1042 0350-0096 5.50 82.0 µM 1.70E-7 TSC3-RPN4 7 1.95E-8
4 SGTC_1729 st035615 4.33 46.0 µM 2.92E-5 25 7.33E-6
5 SGTC_2607 solasodine 3.97 47.4 µM 1.14E-4 59 3.52E-5
6 SGTC_485 niflumic acid 3.94 177.0 µM 1.30E-4 12 4.10E-5
7 SGTC_151 3013-0144 3.90 2.3 µM 1.51E-4 iron homeostasis 30 4.86E-5
8 SGTC_129 0088-0017 3.83 176.6 µM 1.94E-4 66 6.48E-5
9 SGTC_991 3996-0057 3.67 64.7 µM 3.32E-4 25 1.20E-4
10 SGTC_2577 2',4'-dihydroxy-4-methoxychalcone 3.67 15.3 µM 3.36E-4 44 1.22E-4
11 SGTC_2666 tannic acid 3.60 100.0 µM 4.31E-4 iron homeostasis 52 1.62E-4
12 SGTC_536 3852-0578 3.58 10.6 µM 4.53E-4 42 1.72E-4
13 SGTC_2306 7482397 3.54 179.5 µM 5.17E-4 RPP1 & pyrimidine depletion 34 2.00E-4
14 SGTC_1276 0871-0068 3.50 94.2 µM 5.96E-4 29 2.35E-4
15 SGTC_762 1165-0429 3.49 115.0 µM 6.04E-4 TSC3-RPN4 32 2.39E-4
16 SGTC_1090 efavirenz 3.48 20.7 µM 6.39E-4 36 2.55E-4
17 SGTC_3194 9111903 3.42 49.5 µM 7.59E-4 40 3.11E-4
18 SGTC_2653 dihydrofissinolide 3.41 100.0 µM 7.90E-4 10 3.25E-4
19 SGTC_2883 9059145 3.39 45.5 µM 8.50E-4 20 3.54E-4
20 SGTC_2405 ticlatone 3.37 3.5 µM 9.05E-4 95 3.80E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.111 1.34E-10 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.096 2.58E-8 YJR023C_d YJR023C_d het Putative protein of unknown function; open reading frame overlaps LSM8/YJR022W encoding an essential snRNP protein required for RNA processing and splicing
0.089 2.50E-7 YOR308C SNU66 hom Component of the U4/U6.U5 snRNP complex involved in pre-mRNA splicing via spliceosome; also required for pre-5S rRNA processing and may act in concert with Rnh70p; has homology to human SART-1
0.087 4.86E-7 YER009W NTF2 het Nuclear envelope protein, interacts with GDP-bound Gsp1p and with proteins of the nuclear pore to transport Gsp1p into the nucleus where it is an essential player in nucleocytoplasmic transport
0.087 5.01E-7 YLL024C SSA2 hom ATP binding protein involved in protein folding and vacuolar import of proteins; member of heat shock protein 70 (HSP70) family; associated with the chaperonin-containing T-complex; present in the cytoplasm, vacuolar membrane and cell wall; 98% identical with paralog Ssa1p, but subtle differences between the two proteins provide functional specificity with respect to propagation of yeast [URE3] prions and vacuolar-mediated degradations of gluconeogenesis enzymes
0.086 6.44E-7 YNL102W POL1 het Catalytic subunit of the DNA polymerase I alpha-primase complex, required for the initiation of DNA replication during mitotic DNA synthesis and premeiotic DNA synthesis
0.086 6.79E-7 YPR199C ARR1 hom Transcriptional activator of the basic leucine zipper (bZIP) family, required for transcription of genes involved in resistance to arsenic compounds
0.085 9.31E-7 YCL001W-B_p YCL001W-B_p hom Putative protein of unknown function; present in a region duplicated between chromosomes XIV and III; YCL001W-B has a paralog, DOM34, that arose from the whole genome duplication
0.082 1.82E-6 YJR045C SSC1 het Hsp70 family ATPase; constituent of the import motor component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); involved in protein translocation and folding; subunit of SceI endonuclease; SSC1 has a paralog, ECM10, that arose from the whole genome duplication
0.081 2.47E-6 YGR274C TAF1 het TFIID subunit (145 kDa), involved in RNA polymerase II transcription initiation; possesses in vitro histone acetyltransferase activity but its role in vivo appears to be minor; involved in promoter binding and G1/S progression
0.078 5.59E-6 YER053C-A YER053C-A hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress
0.076 9.93E-6 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.074 2.05E-5 YBL018C POP8 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.073 2.35E-5 YNL137C NAM9 het Mitochondrial ribosomal component of the small subunit
0.071 3.73E-5 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data