YBL049W / MOH1

Protein of unknown function, has homology to kinase Snf7p; not required for growth on nonfermentable carbon sources; essential for survival in stationary phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL049W / MOH1

Click on Significant Values for Screen Details ID:SGTC_54|Compound:0159-0055|FD-Score:4.05|P-value:1.24E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.86|P-value:5.49E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:4.19|P-value:7.70E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:3.48|P-value:8.34E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.45|P-value:9.19E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.58|P-value:1.73E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.80|P-value:7.28E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.76|P-value:8.48E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.06|P-value:1.13E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:7.99|P-value:2.48E-13 ID:SGTC_848|Compound:0368-0089|FD-Score:3.72|P-value:3.95E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.44|P-value:8.93E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.71|P-value:1.03E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.83|P-value:2.66E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.64|P-value:4.72E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.12|P-value:9.04E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-5.25|P-value:9.26E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.50|P-value:2.40E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.04|P-value:1.29E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.61|P-value:5.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.16|P-value:1.57E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:-4.44|P-value:2.70E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:4.17|P-value:8.34E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:6.31|P-value:5.85E-9 ID:SGTC_1629|Compound:st005085|FD-Score:4.51|P-value:2.30E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.77|P-value:3.30E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.76|P-value:4.80E-10 ID:SGTC_1770|Compound:st043884|FD-Score:3.48|P-value:8.43E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.55|P-value:6.80E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.47|P-value:2.71E-5 ID:SGTC_1961|Compound:st076550|FD-Score:7.34|P-value:1.52E-11 ID:SGTC_2037|Compound:5169046|FD-Score:4.28|P-value:5.49E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.89|P-value:2.18E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.36|P-value:4.10E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.58|P-value:6.06E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:8.51E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.17|P-value:8.22E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.57|P-value:6.33E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.58|P-value:6.04E-4 ID:SGTC_2337|Compound:9009472|FD-Score:5.73|P-value:1.08E-7 ID:SGTC_2463|Compound:5473429|FD-Score:5.56|P-value:2.54E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.13|P-value:1.50E-8 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.93|P-value:1.91E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.19|P-value:7.65E-5 ID:SGTC_2709|Compound:st078560|FD-Score:4.22|P-value:6.77E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:5.95|P-value:3.65E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.41|P-value:3.35E-5 ID:SGTC_2782|Compound:7736369|FD-Score:6.04|P-value:2.36E-8 ID:SGTC_2789|Compound:5281112|FD-Score:6.16|P-value:1.26E-8 ID:SGTC_2791|Compound:5663188|FD-Score:5.38|P-value:5.64E-7 ID:SGTC_2795|Compound:7780010|FD-Score:5.61|P-value:1.96E-7 ID:SGTC_2897|Compound:9048598|FD-Score:3.97|P-value:1.70E-4 ID:SGTC_2914|Compound:7968218|FD-Score:5.48|P-value:3.66E-7 ID:SGTC_2921|Compound:7974240|FD-Score:3.59|P-value:5.84E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.94|P-value:1.84E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.80|P-value:2.98E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.09|P-value:1.10E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.83|P-value:2.69E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.96|P-value:1.75E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.58|P-value:6.04E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.73|P-value:3.44E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.46|P-value:8.88E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.52|P-value:7.40E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:4.05|P-value:1.24E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:4.86|P-value:5.49E-6 ID:SGTC_147|Compound:4466-0538|FD-Score:4.19|P-value:7.70E-5 ID:SGTC_155|Compound:k072-0202|FD-Score:3.48|P-value:8.34E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:3.45|P-value:9.19E-4 ID:SGTC_333|Compound:3486-0131|FD-Score:4.58|P-value:1.73E-5 ID:SGTC_588|Compound:3970-1144|FD-Score:4.80|P-value:7.28E-6 ID:SGTC_595|Compound:3909-8003|FD-Score:4.76|P-value:8.48E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:-4.06|P-value:1.13E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:7.99|P-value:2.48E-13 ID:SGTC_848|Compound:0368-0089|FD-Score:3.72|P-value:3.95E-4 ID:SGTC_907|Compound:3448-6986|FD-Score:-3.44|P-value:8.93E-4 ID:SGTC_914|Compound:3820-6779|FD-Score:4.64|P-value:1.38E-5 ID:SGTC_1021|Compound:4476-0760|FD-Score:4.71|P-value:1.03E-5 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.83|P-value:2.66E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.64|P-value:4.72E-4 ID:SGTC_1261|Compound:0712-0010|FD-Score:-4.12|P-value:9.04E-5 ID:SGTC_1348|Compound:1493-0373|FD-Score:-5.25|P-value:9.26E-7 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.50|P-value:2.40E-5 ID:SGTC_1357|Compound:1503-1303|FD-Score:4.04|P-value:1.29E-4 ID:SGTC_1402|Compound:3909-7673|FD-Score:3.61|P-value:5.61E-4 ID:SGTC_1469|Compound:k284-2957|FD-Score:5.16|P-value:1.57E-6 ID:SGTC_1475|Compound:4092-1048|FD-Score:-4.44|P-value:2.70E-5 ID:SGTC_1540|Compound:guanosine|FD-Score:4.17|P-value:8.34E-5 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:6.31|P-value:5.85E-9 ID:SGTC_1629|Compound:st005085|FD-Score:4.51|P-value:2.30E-5 ID:SGTC_1675|Compound:st018485|FD-Score:3.77|P-value:3.30E-4 ID:SGTC_1726|Compound:st035556|FD-Score:6.76|P-value:4.80E-10 ID:SGTC_1770|Compound:st043884|FD-Score:3.48|P-value:8.43E-4 ID:SGTC_1791|Compound:st048313|FD-Score:3.55|P-value:6.80E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.47|P-value:2.71E-5 ID:SGTC_1961|Compound:st076550|FD-Score:7.34|P-value:1.52E-11 ID:SGTC_2037|Compound:5169046|FD-Score:4.28|P-value:5.49E-5 ID:SGTC_2046|Compound:4110841|FD-Score:3.89|P-value:2.18E-4 ID:SGTC_2066|Compound:5222451|FD-Score:4.36|P-value:4.10E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.58|P-value:6.06E-4 ID:SGTC_2239|Compound:6685329|FD-Score:3.47|P-value:8.51E-4 ID:SGTC_2255|Compound:7941087|FD-Score:4.17|P-value:8.22E-5 ID:SGTC_2260|Compound:7964312|FD-Score:3.57|P-value:6.33E-4 ID:SGTC_2291|Compound:7917025|FD-Score:3.58|P-value:6.04E-4 ID:SGTC_2337|Compound:9009472|FD-Score:5.73|P-value:1.08E-7 ID:SGTC_2463|Compound:5473429|FD-Score:5.56|P-value:2.54E-7 ID:SGTC_2634|Compound:4'-methoxyflavone|FD-Score:6.13|P-value:1.50E-8 ID:SGTC_2664|Compound:lyso-paf C-16|FD-Score:3.93|P-value:1.91E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.19|P-value:7.65E-5 ID:SGTC_2709|Compound:st078560|FD-Score:4.22|P-value:6.77E-5 ID:SGTC_2724|Compound:maprotiline|FD-Score:5.95|P-value:3.65E-8 ID:SGTC_2729|Compound:fluphenazine|FD-Score:4.41|P-value:3.35E-5 ID:SGTC_2782|Compound:7736369|FD-Score:6.04|P-value:2.36E-8 ID:SGTC_2789|Compound:5281112|FD-Score:6.16|P-value:1.26E-8 ID:SGTC_2791|Compound:5663188|FD-Score:5.38|P-value:5.64E-7 ID:SGTC_2795|Compound:7780010|FD-Score:5.61|P-value:1.96E-7 ID:SGTC_2897|Compound:9048598|FD-Score:3.97|P-value:1.70E-4 ID:SGTC_2914|Compound:7968218|FD-Score:5.48|P-value:3.66E-7 ID:SGTC_2921|Compound:7974240|FD-Score:3.59|P-value:5.84E-4 ID:SGTC_2931|Compound:9014674|FD-Score:3.94|P-value:1.84E-4 ID:SGTC_2999|Compound:9069765|FD-Score:3.80|P-value:2.98E-4 ID:SGTC_3001|Compound:9076041|FD-Score:4.09|P-value:1.10E-4 ID:SGTC_3006|Compound:9075424|FD-Score:3.67|P-value:4.65E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.83|P-value:2.69E-4 ID:SGTC_3026|Compound:9090633|FD-Score:3.96|P-value:1.75E-4 ID:SGTC_3072|Compound:9116419|FD-Score:3.58|P-value:6.04E-4 ID:SGTC_3076|Compound:9116187|FD-Score:-3.73|P-value:3.44E-4 ID:SGTC_3292|Compound:9120825|FD-Score:3.46|P-value:8.88E-4 ID:SGTC_3315|Compound:9136395|FD-Score:3.52|P-value:7.40E-4

Top fitness defect scores for YBL049W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_784 4579-0127 7.99 173.0 µM 2.48E-13 1 6.97E-16
2 SGTC_1961 st076550 7.34 68.7 µM 1.52E-11 1 1.03E-13
3 SGTC_1726 st035556 6.76 14.6 µM 4.80E-10 9 6.86E-12
4 SGTC_1544 7-methoxy-4-methylcoumarin 6.31 105.0 µM 5.85E-9 3 1.43E-10
5 SGTC_2789 5281112 6.16 71.4 µM 1.26E-8 4 3.62E-10
6 SGTC_2634 4'-methoxyflavone 6.13 100.0 µM 1.50E-8 6 4.50E-10
7 SGTC_2782 7736369 6.04 71.4 µM 2.36E-8 6 7.78E-10
8 SGTC_2724 maprotiline 5.95 69.6 µM 3.65E-8 ERG2 3 1.32E-9
9 SGTC_2337 9009472 5.73 200.0 µM 1.08E-7 7 4.95E-9
10 SGTC_2795 7780010 5.61 54.5 µM 1.96E-7 4 1.01E-8
11 SGTC_2463 5473429 5.56 200.0 µM 2.54E-7 ERG2 5 1.39E-8
12 SGTC_2914 7968218 5.48 45.3 µM 3.66E-7 5 2.16E-8
13 SGTC_2791 5663188 5.38 71.4 µM 5.64E-7 RPP1 & pyrimidine depletion 2 3.65E-8
14 SGTC_1469 k284-2957 5.16 126.0 µM 1.57E-6 1 1.27E-7
15 SGTC_70 0141-0289 4.86 43.3 µM 5.49E-6 mitochondrial stress 116 5.76E-7
16 SGTC_588 3970-1144 4.80 52.9 µM 7.28E-6 13 8.11E-7
17 SGTC_595 3909-8003 4.76 73.7 µM 8.48E-6 4 9.75E-7
18 SGTC_1021 4476-0760 4.71 85.3 µM 1.03E-5 11 1.23E-6
19 SGTC_914 3820-6779 4.64 408.0 µM 1.38E-5 11 1.76E-6
20 SGTC_333 3486-0131 4.58 40.1 µM 1.73E-5 amide catabolism 4 2.31E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.089 2.59E-7 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.088 3.31E-7 YMR240C CUS1 het Protein required for assembly of U2 snRNP into the spliceosome, forms a complex with Hsh49p and Hsh155p
0.085 9.59E-7 YOR178C GAC1 hom Regulatory subunit for Glc7p type-1 protein phosphatase (PP1), tethers Glc7p to Gsy2p glycogen synthase, binds Hsf1p heat shock transcription factor, required for induction of some HSF-regulated genes under heat shock
0.084 1.10E-6 YMR199W CLN1 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)
0.078 6.61E-6 YER039C-A_p YER039C-A_p hom Putative protein of unknown function; YER039C-A is not an essential gene
0.073 2.60E-5 YDR509W_d YDR509W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.072 3.22E-5 YBR220C_p YBR220C_p hom Putative protein of unknown function; YBR220C is not an essential gene
0.071 4.03E-5 YER175W-A_p YER175W-A_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.071 4.11E-5 YCR046C IMG1 hom Mitochondrial ribosomal protein of the large subunit, required for respiration and for maintenance of the mitochondrial genome
0.071 4.26E-5 YIL026C IRR1 het Subunit of the cohesin complex, which is required for sister chromatid cohesion during mitosis and meiosis and interacts with centromeres and chromosome arms, essential for viability
0.068 7.48E-5 YGR050C_p YGR050C_p hom Protein of unknown function; mRNA identified as translated by ribosome profiling data
0.068 8.55E-5 YJL104W PAM16 het Constituent of the import motor (PAM complex) component of the Translocase of the Inner Mitochondrial membrane (TIM23 complex); forms a 1:1 subcomplex with Pam18p and inhibits its cochaperone activity; contains a J-like domain
0.067 9.72E-5 YER045C ACA1 hom ATF/CREB family basic leucine zipper (bZIP) transcription factor; binds as a homodimer to the ATF/CREB consensus sequence TGACGTCA; important for carbon source utilization; target genes include GRE2 and COS8; ACA1 has a paralog, CST6, that arose from the whole genome duplication
0.067 9.73E-5 YHR098C SFB3 hom Component of the Sec23p-Sfb3p heterodimer of the COPII vesicle coat, required for cargo selection during vesicle formation in ER to Golgi transport; homologous to Sec24p and Sfb2p
0.066 1.37E-4 YPL256C CLN2 hom G1 cyclin involved in regulation of the cell cycle; activates Cdc28p kinase to promote the G1 to S phase transition; late G1 specific expression depends on transcription factor complexes, MBF (Swi6p-Mbp1p) and SBF (Swi6p-Swi4p)