YBL088C / TEL1

Protein kinase primarily involved in telomere length regulation; contributes to cell cycle checkpoint control in response to DNA damage; functionally redundant with Mec1p; regulates P-body formation induced by replication stress; homolog of human ataxia-telangiectasia mutated (ATM) gene, the gene responsible for ataxia telangiectasia (AT) (OMIM 607585)

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL088C / TEL1

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.36|P-value:2.90E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.79|P-value:8.48E-16 ID:SGTC_408|Compound:cantharidin|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.33|P-value:3.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.29|P-value:3.79E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.88|P-value:3.60E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.85|P-value:4.14E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.84|P-value:7.98E-20 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.02|P-value:1.96E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.07|P-value:8.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.03|P-value:9.69E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.00|P-value:1.60E-7 ID:SGTC_1853|Compound:st056710|FD-Score:3.11|P-value:7.42E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-4.06|P-value:1.65E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.30|P-value:3.71E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.27|P-value:4.01E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.92|P-value:3.04E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.54|P-value:1.46E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.65|P-value:9.43E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.18|P-value:9.82E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.53|P-value:1.53E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.53|P-value:1.79E-6 ID:SGTC_3022|Compound:9087993|FD-Score:3.80|P-value:5.07E-5 ID:SGTC_3036|Compound:9090181|FD-Score:5.14|P-value:7.49E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.05|P-value:9.27E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.05|P-value:9.09E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-4.78|P-value:4.97E-7 ID:SGTC_3247|Compound:9135149|FD-Score:4.32|P-value:5.13E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:3.23|P-value:4.82E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:-3.36|P-value:2.90E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.79|P-value:8.48E-16 ID:SGTC_408|Compound:cantharidin|FD-Score:3.17|P-value:5.90E-4 ID:SGTC_446|Compound:go6976|FD-Score:3.33|P-value:3.35E-4 ID:SGTC_451|Compound:chloral hydrate|FD-Score:3.29|P-value:3.79E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.30|P-value:3.68E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:3.88|P-value:3.60E-5 ID:SGTC_850|Compound:0388-0143|FD-Score:3.85|P-value:4.14E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:8.84|P-value:7.98E-20 ID:SGTC_1119|Compound:parthenolide|FD-Score:-4.02|P-value:1.96E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:4.13|P-value:1.23E-5 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.07|P-value:8.42E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:3.03|P-value:9.69E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.00|P-value:2.11E-5 ID:SGTC_1783|Compound:st039459|FD-Score:5.00|P-value:1.60E-7 ID:SGTC_1853|Compound:st056710|FD-Score:3.11|P-value:7.42E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-4.06|P-value:1.65E-5 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.30|P-value:3.71E-4 ID:SGTC_2018|Compound:5133068|FD-Score:3.15|P-value:6.31E-4 ID:SGTC_2027|Compound:5150920|FD-Score:-3.27|P-value:4.01E-4 ID:SGTC_2117|Compound:5521686|FD-Score:3.92|P-value:3.04E-5 ID:SGTC_2279|Compound:7948423|FD-Score:3.60|P-value:1.17E-4 ID:SGTC_2412|Compound:st077135|FD-Score:3.54|P-value:1.46E-4 ID:SGTC_2482|Compound:5981709|FD-Score:3.65|P-value:9.43E-5 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:4.18|P-value:9.82E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.53|P-value:1.53E-4 ID:SGTC_2834|Compound:9001755|FD-Score:-4.53|P-value:1.79E-6 ID:SGTC_3022|Compound:9087993|FD-Score:3.80|P-value:5.07E-5 ID:SGTC_3036|Compound:9090181|FD-Score:5.14|P-value:7.49E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.05|P-value:9.27E-4 ID:SGTC_3157|Compound:9099274|FD-Score:-3.05|P-value:9.09E-4 ID:SGTC_3179|Compound:9107801|FD-Score:-4.78|P-value:4.97E-7 ID:SGTC_3247|Compound:9135149|FD-Score:4.32|P-value:5.13E-6 ID:SGTC_3294|Compound:9122953|FD-Score:3.15|P-value:6.31E-4

Top fitness defect scores for YBL088C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1082 camptothecin 8.84 424.9 nM 7.98E-20 DNA damage response 10 4.92E-19
2 SGTC_268 camptothecin 7.79 39.6 µM 8.48E-16 DNA damage response 15 3.48E-15
3 SGTC_3036 9090181 5.14 49.5 µM 7.49E-8 2 1.39E-7
4 SGTC_1783 st039459 5.00 87.5 µM 1.60E-7 Golgi 11 2.88E-7
5 SGTC_3247 9135149 4.32 49.5 µM 5.13E-6 DNA damage response 19 7.98E-6
6 SGTC_2580 diallyl disulphide 4.18 81.4 µM 9.82E-6 19 1.49E-5
7 SGTC_1129 3453-1384 4.13 223.0 µM 1.23E-5 35 1.85E-5
8 SGTC_1707 st032323 4.00 6.3 µM 2.11E-5 DNA damage response 55 3.10E-5
9 SGTC_2117 5521686 3.92 200.0 µM 3.04E-5 13 4.39E-5
10 SGTC_638 3970-0837 3.88 4.1 µM 3.60E-5 42 5.16E-5
11 SGTC_850 0388-0143 3.85 75.9 µM 4.14E-5 13 5.90E-5
12 SGTC_3022 9087993 3.80 49.5 µM 5.07E-5 9 7.17E-5
13 SGTC_2482 5981709 3.65 142.7 µM 9.43E-5 PDR1 46 1.30E-4
14 SGTC_2279 7948423 3.60 32.9 µM 1.17E-4 21 1.60E-4
15 SGTC_2412 st077135 3.54 33.4 µM 1.46E-4 38 1.97E-4
16 SGTC_2754 granisetron 3.53 64.0 µM 1.53E-4 46 2.07E-4
17 SGTC_446 go6976 3.33 132.0 µM 3.35E-4 32 4.38E-4
18 SGTC_563 tetrahydrosecaminediol 3.30 614.0 µM 3.68E-4 amide catabolism 31 4.79E-4
19 SGTC_1879 gemcitabine 3.30 100.0 µM 3.71E-4 40 4.84E-4
20 SGTC_451 chloral hydrate 3.29 100.0 µM 3.79E-4 91 4.92E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.325 3.44E-83 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.294 5.67E-68 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.285 7.53E-64 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.264 2.42E-54 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.249 1.05E-48 YPR066W UBA3 hom Protein that acts together with Ula1p to activate Rub1p before its conjugation to proteins (neddylation), which may play a role in protein degradation; GFP-fusion protein localizes to the cytoplasm in a punctate pattern
0.243 2.49E-46 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.224 1.61E-39 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.171 1.68E-23 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.169 6.00E-23 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.163 1.90E-21 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.157 5.75E-20 YLR135W SLX4 hom Endonuclease involved in processing DNA; acts during recombination and repair; cleaves branched structures in a complex with Slx1p; involved interstrand cross-link repair and in Rad1p/Rad10p-dependent removal of 3'-nonhomologous tails during DSBR via single-strand annealing; relative distribution to nuclear foci increases upon DNA replication stress
0.154 2.78E-19 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.148 8.60E-18 YJL077W-B_p YJL077W-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.143 7.54E-17 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.142 1.43E-16 YJL047C RTT101 hom Cullin subunit of a Roc1p-dependent E3 ubiquitin ligase complex with a role in anaphase progression; implicated in Mms22-dependent DNA repair; involved with Mms1p in nonfunctional rRNA decay; modified by the ubiquitin-like protein, Rub1p