YBL091C / MAP2

Methionine aminopeptidase, catalyzes the cotranslational removal of N-terminal methionine from nascent polypeptides; function is partially redundant with that of Map1p

Zygosity: Homozygous strain
fixedexpanded
Profile for YBL091C / MAP2

Click on Significant Values for Screen Details ID:SGTC_53|Compound:0973-0023|FD-Score:-3.88|P-value:3.77E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-4.15|P-value:1.13E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.54|P-value:2.06E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.15|P-value:6.61E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:4.47|P-value:2.87E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.35|P-value:3.44E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.09|P-value:8.02E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.42|P-value:2.61E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:5.72|P-value:3.14E-9 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.20|P-value:5.84E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.34|P-value:3.24E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.86|P-value:4.47E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.95|P-value:2.58E-7 ID:SGTC_1940|Compound:st075990|FD-Score:-4.02|P-value:2.02E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.15|P-value:6.45E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.13|P-value:9.59E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.07|P-value:8.52E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.28|P-value:4.03E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.57|P-value:1.32E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.22|P-value:9.11E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.13|P-value:7.01E-4 ID:SGTC_2744|Compound:captopril|FD-Score:6.51|P-value:1.89E-11 ID:SGTC_3065|Compound:9113888|FD-Score:5.12|P-value:1.02E-7 ID:SGTC_3128|Compound:9127691|FD-Score:3.80|P-value:5.90E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.48|P-value:2.09E-4 ID:SGTC_53|Compound:0973-0023|FD-Score:-3.88|P-value:3.77E-5 ID:SGTC_62|Compound:0180-0423|FD-Score:3.64|P-value:1.13E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:-4.15|P-value:1.13E-5 ID:SGTC_444|Compound:curcumin|FD-Score:3.63|P-value:1.17E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:3.50|P-value:1.97E-4 ID:SGTC_710|Compound:3448-4187|FD-Score:4.54|P-value:2.06E-6 ID:SGTC_757|Compound:1066-0008|FD-Score:-3.15|P-value:6.61E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:4.47|P-value:2.87E-6 ID:SGTC_936|Compound:3005-4620|FD-Score:3.35|P-value:3.44E-4 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.09|P-value:8.02E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:3.60|P-value:1.31E-4 ID:SGTC_1197|Compound:1601-0112|FD-Score:3.42|P-value:2.61E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:5.72|P-value:3.14E-9 ID:SGTC_1444|Compound:4112-3581|FD-Score:3.62|P-value:1.19E-4 ID:SGTC_1474|Compound:0330-0125|FD-Score:3.20|P-value:5.84E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.34|P-value:3.24E-4 ID:SGTC_1920|Compound:st075728|FD-Score:3.64|P-value:1.10E-4 ID:SGTC_1933|Compound:st074711|FD-Score:3.86|P-value:4.47E-5 ID:SGTC_1934|Compound:st074720|FD-Score:4.95|P-value:2.58E-7 ID:SGTC_1940|Compound:st075990|FD-Score:-4.02|P-value:2.02E-5 ID:SGTC_2283|Compound:7944793|FD-Score:-3.15|P-value:6.45E-4 ID:SGTC_2299|Compound:7976368|FD-Score:5.13|P-value:9.59E-8 ID:SGTC_2483|Compound:5729050|FD-Score:-3.07|P-value:8.52E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.28|P-value:4.03E-4 ID:SGTC_2593|Compound:nobiletin|FD-Score:-3.57|P-value:1.32E-4 ID:SGTC_2687|Compound:chenodiol|FD-Score:4.22|P-value:9.11E-6 ID:SGTC_2707|Compound:st078556|FD-Score:3.49|P-value:2.01E-4 ID:SGTC_2713|Compound:st079149|FD-Score:-3.13|P-value:7.01E-4 ID:SGTC_2744|Compound:captopril|FD-Score:6.51|P-value:1.89E-11 ID:SGTC_3065|Compound:9113888|FD-Score:5.12|P-value:1.02E-7 ID:SGTC_3128|Compound:9127691|FD-Score:3.80|P-value:5.90E-5 ID:SGTC_3129|Compound:9127257|FD-Score:3.43|P-value:2.56E-4 ID:SGTC_3209|Compound:9113616|FD-Score:3.48|P-value:2.09E-4

Top fitness defect scores for YBL091C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2744 captopril 6.51 92.0 µM 1.89E-11 60S ribosome export 1 3.72E-11
2 SGTC_1299 1079-1439 5.72 3.7 µM 3.14E-9 TSC3-RPN4 2 5.28E-9
3 SGTC_2299 7976368 5.13 114.9 µM 9.59E-8 13 1.45E-7
4 SGTC_3065 9113888 5.12 49.5 µM 1.02E-7 10 1.54E-7
5 SGTC_1934 st074720 4.95 32.6 µM 2.58E-7 29 3.79E-7
6 SGTC_710 3448-4187 4.54 58.0 µM 2.06E-6 fatty acid desaturase (OLE1) 36 2.84E-6
7 SGTC_877 0771-0151 4.47 33.1 µM 2.87E-6 11 3.91E-6
8 SGTC_2687 chenodiol 4.22 100.0 µM 9.11E-6 17 1.20E-5
9 SGTC_1933 st074711 3.86 15.9 µM 4.47E-5 46 5.62E-5
10 SGTC_3128 9127691 3.80 49.5 µM 5.90E-5 25 7.35E-5
11 SGTC_1920 st075728 3.64 45.7 µM 1.10E-4 33 1.35E-4
12 SGTC_62 0180-0423 3.64 3.2 µM 1.13E-4 60S ribosome export 29 1.38E-4
13 SGTC_444 curcumin 3.63 90.4 µM 1.17E-4 iron homeostasis 35 1.43E-4
14 SGTC_1444 4112-3581 3.62 28.0 µM 1.19E-4 18 1.46E-4
15 SGTC_1050 3232-1156 3.60 69.3 µM 1.31E-4 RSC complex & mRNA processing 31 1.59E-4
16 SGTC_567 1080-0542 3.50 68.4 µM 1.97E-4 26 2.37E-4
17 SGTC_2707 st078556 3.49 66.6 µM 2.01E-4 20 2.42E-4
18 SGTC_3209 9113616 3.48 49.5 µM 2.09E-4 47 2.51E-4
19 SGTC_3129 9127257 3.43 49.5 µM 2.56E-4 39 3.05E-4
20 SGTC_1197 1601-0112 3.42 267.0 µM 2.61E-4 37 3.12E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 4.94E-9 YMR174C PAI3 hom Cytoplasmic proteinase A (Pep4p) inhibitor, dependent on Pbs2p and Hog1p protein kinases for osmotic induction; intrinsically unstructured, N-terminal half becomes ordered in the active site of proteinase A upon contact
0.094 4.33E-8 YMR234W RNH1 hom Ribonuclease H1; able to bind double-stranded RNAs and RNA-DNA hybrids; associates with RNAse polymerase I; the homolog of mammalian RNAse HII (the S. cerevisiae homolog of mammalian RNAse HI is RNH201)
0.094 5.06E-8 YJL173C RFA3 het Subunit of heterotrimeric Replication Protein A (RPA); RPA is a highly conserved single-stranded DNA binding protein complex involved in DNA replication, repair, and recombination; protein abundance increases in response to DNA replication stress
0.093 6.23E-8 YGL089C MF(ALPHA)2 hom Mating pheromone alpha-factor, made by alpha cells; interacts with mating type a cells to induce cell cycle arrest and other responses leading to mating; also encoded by MF(ALPHA)1, which is more highly expressed than MF(ALPHA)2
0.090 1.74E-7 YBR128C ATG14 hom Autophagy-specific subunit of phosphatidylinositol 3-kinase complex I (with Vps34/15/30p); Atg14p targets complex I to the phagophore assembly site (PAS); required for localizing additional ATG proteins to the PAS; required for overflow degradation of misfolded proteins when ERAD is saturated; homolog of human Barkor
0.085 8.55E-7 YOR027W STI1 hom Hsp90 cochaperone, interacts with the Ssa group of the cytosolic Hsp70 chaperones and activates Ssa1p ATPase activity; interacts with Hsp90 chaperones and inhibits their ATPase activity; homolog of mammalian Hop
0.083 1.35E-6 YNL093W YPT53 hom Rab family GTPase; similar to Ypt51p and Ypt52p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; YPT53 has a paralog, VPS21, that arose from the whole genome duplication
0.081 2.55E-6 YCR085W_d YCR085W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.079 5.28E-6 YIR001C SGN1 hom Cytoplasmic RNA-binding protein, contains an RNA recognition motif (RRM); may have a role in mRNA translation, as suggested by genetic interactions with genes encoding proteins involved in translational initiation
0.078 6.59E-6 YPL096C-A ERI1 hom Endoplasmic reticulum membrane protein that binds to and inhibits GTP-bound Ras2p at the ER; component of the GPI-GnT complex which catalyzes the first step in GPI-anchor biosynthesis; probable homolog of mammalian PIG-Y protein
0.078 6.53E-6 YBR121C GRS1 het Cytoplasmic and mitochondrial glycyl-tRNA synthase; ligates glycine to the cognate anticodon-bearing tRNA; transcription termination factor that may interact with the 3'-end of pre-mRNA to promote 3'-end formation; GRS1 has a paralog, GRS2, that arose from the whole genome duplication
0.075 1.39E-5 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.075 1.53E-5 YGR276C RNH70 hom 3'-5' exoribonuclease; required for maturation of 3' ends of 5S rRNA and tRNA-Arg3 from dicistronic transcripts
0.074 1.76E-5 YGR015C_p YGR015C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion
0.073 2.19E-5 YHR035W_p YHR035W_p hom Putative protein of unknown function; not an essential gene