YBR014C / GRX7

Cis-golgi localized monothiol glutaredoxin; more similar in activity to dithiol than other monothiol glutaredoxins; involved in the oxidative stress response; does not bind metal ions; GRX7 has a paralog, GRX6, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR014C / GRX7

Click on Significant Values for Screen Details ID:SGTC_42|Compound:0133-0086|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.61|P-value:6.95E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:5.00|P-value:6.62E-8 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.10|P-value:6.36E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.88|P-value:2.13E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.13|P-value:5.74E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.69|P-value:9.48E-13 ID:SGTC_572|Compound:0960-0087|FD-Score:6.12|P-value:5.92E-11 ID:SGTC_754|Compound:3474-0146|FD-Score:4.22|P-value:4.27E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.25|P-value:2.92E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.48|P-value:1.11E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-9.94|P-value:1.35E-25 ID:SGTC_881|Compound:0833-0569|FD-Score:3.35|P-value:2.02E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.32|P-value:2.24E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.59|P-value:9.27E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.34|P-value:2.09E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.05|P-value:6.18E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.92|P-value:9.97E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.21|P-value:3.38E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.29|P-value:3.08E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.58|P-value:7.61E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.97|P-value:8.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.73|P-value:4.15E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.87|P-value:2.22E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.89|P-value:1.99E-5 ID:SGTC_1836|Compound:st055642|FD-Score:-3.24|P-value:3.79E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.98|P-value:8.08E-4 ID:SGTC_2006|Compound:4011487|FD-Score:7.50|P-value:1.52E-15 ID:SGTC_2007|Compound:4011539|FD-Score:3.19|P-value:3.72E-4 ID:SGTC_2031|Compound:5180455|FD-Score:2.95|P-value:8.84E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.57|P-value:8.23E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.82|P-value:2.69E-5 ID:SGTC_2448|Compound:5185112|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.01|P-value:1.14E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.51|P-value:9.64E-7 ID:SGTC_2692|Compound:st077426|FD-Score:3.13|P-value:4.65E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.84|P-value:2.49E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.11|P-value:9.36E-6 ID:SGTC_3182|Compound:9108849|FD-Score:5.17|P-value:2.52E-8 ID:SGTC_3272|Compound:9137413|FD-Score:2.97|P-value:8.42E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.44|P-value:1.73E-4 ID:SGTC_42|Compound:0133-0086|FD-Score:3.47|P-value:1.25E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:2.97|P-value:8.31E-4 ID:SGTC_85|Compound:0868-0259|FD-Score:3.61|P-value:6.95E-5 ID:SGTC_113|Compound:0099-0221|FD-Score:5.00|P-value:6.62E-8 ID:SGTC_114|Compound:0364-0001|FD-Score:-3.10|P-value:6.36E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.88|P-value:2.13E-5 ID:SGTC_459|Compound:nigericin|FD-Score:-3.13|P-value:5.74E-4 ID:SGTC_518|Compound:1021-0119|FD-Score:6.69|P-value:9.48E-13 ID:SGTC_572|Compound:0960-0087|FD-Score:6.12|P-value:5.92E-11 ID:SGTC_754|Compound:3474-0146|FD-Score:4.22|P-value:4.27E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:3.25|P-value:2.92E-4 ID:SGTC_779|Compound:1360-0071|FD-Score:4.48|P-value:1.11E-6 ID:SGTC_853|Compound:0419-0306|FD-Score:-9.94|P-value:1.35E-25 ID:SGTC_881|Compound:0833-0569|FD-Score:3.35|P-value:2.02E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:3.32|P-value:2.24E-4 ID:SGTC_899|Compound:1083-0020|FD-Score:-3.59|P-value:9.27E-5 ID:SGTC_910|Compound:3454-3003|FD-Score:3.25|P-value:2.98E-4 ID:SGTC_970|Compound:1315-0089|FD-Score:3.34|P-value:2.09E-4 ID:SGTC_1095|Compound:3-[3,5-dibromo-4-hydroxybenzoyl]-2-ethylbenzofuran|FD-Score:3.05|P-value:6.18E-4 ID:SGTC_1119|Compound:parthenolide|FD-Score:2.92|P-value:9.97E-4 ID:SGTC_1125|Compound:tnp00248|FD-Score:3.21|P-value:3.38E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:-3.29|P-value:3.08E-4 ID:SGTC_1149|Compound:3909-7961|FD-Score:3.58|P-value:7.61E-5 ID:SGTC_1203|Compound:3992-3522|FD-Score:2.97|P-value:8.30E-4 ID:SGTC_1463|Compound:k081-0032|FD-Score:3.73|P-value:4.15E-5 ID:SGTC_1468|Compound:k284-1086|FD-Score:3.87|P-value:2.22E-5 ID:SGTC_1736|Compound:st036774|FD-Score:3.89|P-value:1.99E-5 ID:SGTC_1836|Compound:st055642|FD-Score:-3.24|P-value:3.79E-4 ID:SGTC_1967|Compound:st070177|FD-Score:2.98|P-value:8.08E-4 ID:SGTC_2006|Compound:4011487|FD-Score:7.50|P-value:1.52E-15 ID:SGTC_2007|Compound:4011539|FD-Score:3.19|P-value:3.72E-4 ID:SGTC_2031|Compound:5180455|FD-Score:2.95|P-value:8.84E-4 ID:SGTC_2073|Compound:5212005|FD-Score:3.26|P-value:2.88E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.57|P-value:8.23E-5 ID:SGTC_2313|Compound:7726885|FD-Score:3.82|P-value:2.69E-5 ID:SGTC_2448|Compound:5185112|FD-Score:2.93|P-value:9.68E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:-3.30|P-value:3.00E-4 ID:SGTC_2595|Compound:hexamethylquercetagetin|FD-Score:4.01|P-value:1.14E-5 ID:SGTC_2601|Compound:securinine|FD-Score:3.37|P-value:1.87E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.51|P-value:9.64E-7 ID:SGTC_2692|Compound:st077426|FD-Score:3.13|P-value:4.65E-4 ID:SGTC_2841|Compound:9004761|FD-Score:3.84|P-value:2.49E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-4.11|P-value:9.36E-6 ID:SGTC_3182|Compound:9108849|FD-Score:5.17|P-value:2.52E-8 ID:SGTC_3272|Compound:9137413|FD-Score:2.97|P-value:8.42E-4 ID:SGTC_3322|Compound:9139058|FD-Score:-3.44|P-value:1.73E-4

Top fitness defect scores for YBR014C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2006 4011487 7.50 200.0 µM 1.52E-15 endomembrane recycling 33 3.28E-14
2 SGTC_518 1021-0119 6.69 62.6 µM 9.48E-13 ERG2 9 1.13E-11
3 SGTC_572 0960-0087 6.12 17.7 µM 5.92E-11 4 4.82E-10
4 SGTC_3182 9108849 5.17 49.5 µM 2.52E-8 RPP1 & pyrimidine depletion 4 1.17E-7
5 SGTC_113 0099-0221 5.00 2.5 µM 6.62E-8 10 2.82E-7
6 SGTC_2690 usnic acid 4.51 100.0 µM 9.64E-7 17 3.21E-6
7 SGTC_779 1360-0071 4.48 233.0 µM 1.11E-6 fatty acid desaturase (OLE1) 16 3.65E-6
8 SGTC_754 3474-0146 4.22 171.0 µM 4.27E-6 copper-dependent oxidative stress 22 1.24E-5
9 SGTC_2595 hexamethylquercetagetin 4.01 100.0 µM 1.14E-5 22 3.03E-5
10 SGTC_1736 st036774 3.89 51.0 µM 1.99E-5 35 5.00E-5
11 SGTC_119 0121-0043 3.88 24.8 µM 2.13E-5 mitochondrial stress 120 5.32E-5
12 SGTC_1468 k284-1086 3.87 134.0 µM 2.22E-5 DNA intercalators 41 5.53E-5
13 SGTC_2841 9004761 3.84 39.0 µM 2.49E-5 amide catabolism 33 6.13E-5
14 SGTC_2313 7726885 3.82 200.0 µM 2.69E-5 RPP1 & pyrimidine depletion 38 6.58E-5
15 SGTC_1463 k081-0032 3.73 34.1 µM 4.15E-5 8 9.75E-5
16 SGTC_85 0868-0259 3.61 160.1 µM 6.95E-5 60S ribosome export 17 1.56E-4
17 SGTC_1149 3909-7961 3.58 23.3 µM 7.61E-5 32 1.69E-4
18 SGTC_2198 6589944 3.57 200.0 µM 8.23E-5 23 1.82E-4
19 SGTC_42 0133-0086 3.47 60.6 µM 1.25E-4 44 2.65E-4
20 SGTC_2601 securinine 3.37 100.0 µM 1.87E-4 49 3.82E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.134 5.91E-15 YDR084C TVP23 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.129 5.78E-14 YDR258C HSP78 hom Oligomeric mitochondrial matrix chaperone that cooperates with Ssc1p in mitochondrial thermotolerance after heat shock; able to prevent the aggregation of misfolded proteins as well as resolubilize protein aggregates
0.122 1.39E-12 YER005W YND1 hom Apyrase with wide substrate specificity, helps prevent inhibition of glycosylation by hydrolyzing nucleoside tri- and diphosphates that inhibit glycotransferases; partially redundant with Gda1p; mediates adenovirus E4orf4-induced toxicity
0.105 1.04E-9 YKR051W_p YKR051W_p hom Putative protein of unknown function
0.100 7.42E-9 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.099 1.06E-8 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.098 1.18E-8 YMR192W GYL1 hom Putative GTPase activating protein (GAP) with a role in exocytosis; stimulates Gyp5p GAP activity on Ypt1p, colocalizes with Gyp5p at sites of polarized growth; interacts with Gyp5p, Rvs161p, and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; increases in abundance and relocalizes from bud neck to cytoplasm upon DNA replication stress
0.088 3.30E-7 YMR153W NUP53 hom FG-nucleoporin component of central core of nuclear pore complex (NPC); also part of the NPC nuclear basket; contributes directly to nucleocytoplasmic transport; involved in regulation of transcription and mitosis; induces membrane tubulation, which may contribute to nuclear pore assembly; NUP53 has a paralog, ASM4, that arose from the whole genome duplication
0.086 6.48E-7 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.085 8.54E-7 YGL199C_d YGL199C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF YIP4/YGL198W
0.084 1.13E-6 YER097W_d YER097W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.083 1.65E-6 YJL106W IME2 hom Serine/threonine protein kinase involved in activation of meiosis, associates with Ime1p and mediates its stability, activates Ndt80p; IME2 expression is positively regulated by Ime1p
0.080 3.62E-6 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.079 4.41E-6 YGL198W YIP4 hom Protein that interacts with Rab GTPases, localized to late Golgi vesicles; computational analysis of large-scale protein-protein interaction data suggests a possible role in vesicle-mediated transport
0.078 6.30E-6 YEL026W SNU13 het RNA binding protein, part of U3 snoRNP involved in rRNA processing, part of U4/U6-U5 tri-snRNP involved in mRNA splicing, similar to human 15.5K protein