YBR019C / GAL10

UDP-glucose-4-epimerase, catalyzes the interconversion of UDP-galactose and UDP-D-glucose in galactose metabolism; also catalyzes the conversion of alpha-D-glucose or alpha-D-galactose to their beta-anomers

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR019C / GAL10

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.74|P-value:4.55E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.72|P-value:4.87E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:4.11|P-value:8.31E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.56|P-value:9.75E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.15|P-value:4.53E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.92|P-value:2.00E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.27|P-value:1.66E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:5.37|P-value:9.33E-9 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.02|P-value:7.39E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.47|P-value:1.30E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.54|P-value:9.59E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.96|P-value:1.70E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.97|P-value:9.30E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.13|P-value:7.72E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.02|P-value:7.94E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.55|P-value:1.00E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.64|P-value:6.91E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.85|P-value:2.73E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.39|P-value:1.95E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.71|P-value:4.71E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-2.95|P-value:9.33E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.40|P-value:7.71E-9 ID:SGTC_1916|Compound:st067606|FD-Score:4.45|P-value:1.57E-6 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:3.08E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.96|P-value:1.71E-5 ID:SGTC_2094|Compound:5332512|FD-Score:-3.38|P-value:1.88E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-2.94|P-value:9.84E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.03|P-value:7.63E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.19|P-value:4.19E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.77|P-value:3.56E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.98|P-value:1.55E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.17|P-value:4.53E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-7.34|P-value:6.21E-15 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.55|P-value:8.57E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.69|P-value:5.15E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.17|P-value:4.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.20|P-value:3.71E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.34|P-value:2.78E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.07|P-value:6.16E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.89|P-value:2.10E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:3.74|P-value:4.55E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.72|P-value:4.87E-5 ID:SGTC_94|Compound:0334-0113|FD-Score:4.11|P-value:8.31E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.67|P-value:5.96E-5 ID:SGTC_147|Compound:4466-0538|FD-Score:3.56|P-value:9.75E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-3.15|P-value:4.53E-4 ID:SGTC_297|Compound:0986-0032|FD-Score:3.92|P-value:2.00E-5 ID:SGTC_367|Compound:0335-0881|FD-Score:5.27|P-value:1.66E-8 ID:SGTC_368|Compound:fentichlor|FD-Score:5.37|P-value:9.33E-9 ID:SGTC_495|Compound:decylubiquinone|FD-Score:3.07|P-value:6.43E-4 ID:SGTC_552|Compound:k242-0005|FD-Score:-3.02|P-value:7.39E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:-3.47|P-value:1.30E-4 ID:SGTC_638|Compound:3970-0837|FD-Score:4.54|P-value:9.59E-7 ID:SGTC_685|Compound:1278-0033|FD-Score:3.21|P-value:3.94E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.25|P-value:3.36E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:3.96|P-value:1.70E-5 ID:SGTC_1215|Compound:3852-0577|FD-Score:2.97|P-value:9.30E-4 ID:SGTC_1217|Compound:1183-1422|FD-Score:4.13|P-value:7.72E-6 ID:SGTC_1225|Compound:1216-0074|FD-Score:3.02|P-value:7.94E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:3.55|P-value:1.00E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:3.64|P-value:6.91E-5 ID:SGTC_1564|Compound:D-Arginine|FD-Score:3.85|P-value:2.73E-5 ID:SGTC_1629|Compound:st005085|FD-Score:3.39|P-value:1.95E-4 ID:SGTC_1781|Compound:st038725|FD-Score:-3.71|P-value:4.71E-5 ID:SGTC_1798|Compound:st045719|FD-Score:-2.95|P-value:9.33E-4 ID:SGTC_1912|Compound:st060209|FD-Score:5.40|P-value:7.71E-9 ID:SGTC_1916|Compound:st067606|FD-Score:4.45|P-value:1.57E-6 ID:SGTC_2047|Compound:4141938|FD-Score:3.27|P-value:3.08E-4 ID:SGTC_2089|Compound:5281248|FD-Score:3.96|P-value:1.71E-5 ID:SGTC_2094|Compound:5332512|FD-Score:-3.38|P-value:1.88E-4 ID:SGTC_2295|Compound:7971645|FD-Score:-2.94|P-value:9.84E-4 ID:SGTC_2441|Compound:5730946|FD-Score:3.22|P-value:3.69E-4 ID:SGTC_2445|Compound:5742597|FD-Score:3.03|P-value:7.63E-4 ID:SGTC_2459|Compound:5811157|FD-Score:3.19|P-value:4.19E-4 ID:SGTC_2467|Compound:5474540|FD-Score:-3.77|P-value:3.56E-5 ID:SGTC_2478|Compound:5763493|FD-Score:3.12|P-value:5.41E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:3.98|P-value:1.55E-5 ID:SGTC_2576|Compound:guaiol|FD-Score:3.17|P-value:4.53E-4 ID:SGTC_2610|Compound:ononetin|FD-Score:-7.34|P-value:6.21E-15 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-4.55|P-value:8.57E-7 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.69|P-value:5.15E-5 ID:SGTC_2802|Compound:7925815|FD-Score:3.39|P-value:1.96E-4 ID:SGTC_2818|Compound:7996756|FD-Score:-3.17|P-value:4.22E-4 ID:SGTC_2947|Compound:9072639|FD-Score:-3.20|P-value:3.71E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.34|P-value:2.78E-6 ID:SGTC_3031|Compound:9088762|FD-Score:-3.07|P-value:6.16E-4 ID:SGTC_3338|Compound:9144300|FD-Score:-3.89|P-value:2.10E-5

Top fitness defect scores for YBR019C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1912 st060209 5.40 90.8 µM 7.71E-9 13 3.39E-8
2 SGTC_368 fentichlor 5.37 4.6 µM 9.33E-9 7 4.03E-8
3 SGTC_367 0335-0881 5.27 7.1 µM 1.66E-8 ubiquinone biosynthesis & proteasome 34 6.83E-8
4 SGTC_638 3970-0837 4.54 4.1 µM 9.59E-7 22 2.75E-6
5 SGTC_1916 st067606 4.45 49.2 µM 1.57E-6 20 4.31E-6
6 SGTC_3027 9089541 4.34 49.5 µM 2.78E-6 fatty acid desaturase (OLE1) 15 7.27E-6
7 SGTC_1217 1183-1422 4.13 255.0 µM 7.72E-6 7 1.85E-5
8 SGTC_94 0334-0113 4.11 514.8 µM 8.31E-6 19 1.97E-5
9 SGTC_2510 benzyl isothiocyanate 3.98 8.3 µM 1.55E-5 16 3.49E-5
10 SGTC_1110 3-hydroxy-3'-methoxyflavone 3.96 1.2 µM 1.70E-5 iron homeostasis 42 3.80E-5
11 SGTC_2089 5281248 3.96 129.7 µM 1.71E-5 superoxide 21 3.81E-5
12 SGTC_297 0986-0032 3.92 24.0 µM 2.00E-5 60S ribosome export 5 4.40E-5
13 SGTC_1564 D-Arginine 3.85 115.0 µM 2.73E-5 30 5.86E-5
14 SGTC_82 0054-0107 3.74 293.8 µM 4.55E-5 12 9.33E-5
15 SGTC_85 0868-0259 3.72 160.1 µM 4.87E-5 60S ribosome export 13 9.92E-5
16 SGTC_145 3737-0113 3.67 38.4 µM 5.96E-5 DNA intercalators 87 1.19E-4
17 SGTC_1316 1272-0050 3.64 65.9 µM 6.91E-5 16 1.37E-4
18 SGTC_147 4466-0538 3.56 29.2 µM 9.75E-5 ergosterol biosynthesis 34 1.87E-4
19 SGTC_1304 1165-0502 3.55 251.0 µM 1.00E-4 79 1.92E-4
20 SGTC_1629 st005085 3.39 44.9 µM 1.95E-4 RPP1 & pyrimidine depletion 57 3.53E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.093 6.60E-8 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.091 1.43E-7 YLR128W DCN1 hom Scaffold-type E3 ligase required for cullin neddylation and ubiquitin ligase activation; contains a ubiquitin-binding domain (UBA) for ubiquitin and Nedd8 (Rub1p) interaction and a PONY domain involved in cullin binding and neddylation
0.090 1.54E-7 YER039C HVG1 hom Protein of unknown function, has homology to Vrg4p
0.090 1.74E-7 YOL013W-A_p YOL013W-A_p hom Putative protein of unknown function; identified by SAGE
0.087 5.12E-7 YPR022C_p YPR022C_p hom Putative transcription factor, as suggested by computational analysis; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.083 1.40E-6 YPR116W RRG8 hom Putative protein of unknown function, required for mitochondrial genome maintenance; null mutation results in a decrease in plasma membrane electron transport
0.082 2.01E-6 YML098W TAF13 het TFIID subunit (19 kDa), involved in RNA polymerase II transcription initiation, similar to histone H4 with atypical histone fold motif of Spt3-like transcription factors
0.080 3.72E-6 YDR043C NRG1 hom Transcriptional repressor; recruits the Cyc8p-Tup1p complex to promoters; mediates glucose repression and negatively regulates a variety of processes including filamentous growth and alkaline pH response; NRG1 has a paralog, NRG2, that arose from the whole genome duplication
0.077 7.21E-6 YPR053C_d YPR053C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene NHP6A/YPR052C
0.076 1.04E-5 YBR066C NRG2 hom Transcriptional repressor; mediates glucose repression and negatively regulates filamentous growth; NRG2 has a paralog, NRG1, that arose from the whole genome duplication
0.075 1.25E-5 YBR142W MAK5 het Essential nucleolar protein, putative DEAD-box RNA helicase required for maintenance of M1 dsRNA virus; involved in biogenesis of large (60S) ribosomal subunits
0.075 1.50E-5 YLR335W NUP2 hom Nucleoporin involved in nucleocytoplasmic transport, binds to either the nucleoplasmic or cytoplasmic faces of the nuclear pore complex depending on Ran-GTP levels; also has a role in chromatin organization
0.073 2.44E-5 YMR292W GOT1 hom Homodimeric protein that is packaged into COPII vesicles and cycles between the ER and Golgi; involved in secretory transport but not directly required for aspects of transport assayed in vitro; may influence membrane composition
0.072 2.94E-5 YLR142W PUT1 hom Proline oxidase, nuclear-encoded mitochondrial protein involved in utilization of proline as sole nitrogen source; PUT1 transcription is induced by Put3p in the presence of proline and the absence of a preferred nitrogen source
0.072 3.10E-5 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p