YBR020W / GAL1

Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR020W / GAL1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:8.57|P-value:2.73E-18 ID:SGTC_81|Compound:0411-0046|FD-Score:4.31|P-value:6.34E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:3.14|P-value:7.09E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.14|P-value:2.93E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.39|P-value:5.82E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.45|P-value:2.95E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.26|P-value:4.78E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.50|P-value:1.90E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:13.60|P-value:2.97E-43 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.31|P-value:4.06E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:3.23|P-value:5.32E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.24|P-value:6.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.88|P-value:4.06E-7 ID:SGTC_816|Compound:0325-0417|FD-Score:3.22|P-value:5.46E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.78|P-value:6.48E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.96|P-value:2.63E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.44|P-value:3.81E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.58|P-value:1.80E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.39|P-value:3.68E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.00|P-value:2.56E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.85|P-value:4.57E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.74|P-value:9.54E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:7.99|P-value:3.67E-16 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.18|P-value:1.15E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.54|P-value:1.67E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.47|P-value:2.19E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.62|P-value:6.83E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.20|P-value:7.12E-8 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.64|P-value:1.12E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:3.35E-10 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.33|P-value:4.45E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.80|P-value:6.06E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.10|P-value:2.15E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.52|P-value:1.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.90|P-value:3.60E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.11|P-value:1.56E-5 ID:SGTC_2396|Compound:5342950|FD-Score:9.06|P-value:3.26E-20 ID:SGTC_2414|Compound:st077232|FD-Score:-3.98|P-value:3.64E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:9.75E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:5.69|P-value:4.36E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.72|P-value:8.80E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:9.78|P-value:3.03E-23 ID:SGTC_2777|Compound:climbazole|FD-Score:3.23|P-value:5.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.07|P-value:2.40E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:6.42E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.04|P-value:2.38E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.21|P-value:1.01E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.71|P-value:8.43E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.70|P-value:1.12E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.37|P-value:6.32E-6 ID:SGTC_3311|Compound:9131146|FD-Score:7.01|P-value:7.42E-13 ID:SGTC_3350|Compound:9150499|FD-Score:3.87|P-value:4.46E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:8.57|P-value:2.73E-18 ID:SGTC_81|Compound:0411-0046|FD-Score:4.31|P-value:6.34E-6 ID:SGTC_91|Compound:0417-1751|FD-Score:3.14|P-value:7.09E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:7.14|P-value:2.93E-13 ID:SGTC_178|Compound:4092-0806|FD-Score:-4.39|P-value:5.82E-6 ID:SGTC_217|Compound:ketoconazole|FD-Score:-3.45|P-value:2.95E-4 ID:SGTC_266|Compound:formosanin C|FD-Score:3.26|P-value:4.78E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.29|P-value:4.20E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.50|P-value:1.90E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:3.25|P-value:4.90E-4 ID:SGTC_468|Compound:gf-109203x|FD-Score:3.18|P-value:6.34E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:13.60|P-value:2.97E-43 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.20|P-value:7.11E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:5.31|P-value:4.06E-8 ID:SGTC_722|Compound:3534-0461|FD-Score:3.23|P-value:5.32E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:-3.24|P-value:6.25E-4 ID:SGTC_769|Compound:0302-0231|FD-Score:4.88|P-value:4.06E-7 ID:SGTC_816|Compound:0325-0417|FD-Score:3.22|P-value:5.46E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:4.78|P-value:6.48E-7 ID:SGTC_839|Compound:0122-0028|FD-Score:4.96|P-value:2.63E-7 ID:SGTC_848|Compound:0368-0089|FD-Score:-3.21|P-value:6.84E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:6.44|P-value:3.81E-11 ID:SGTC_871|Compound:0574-0004|FD-Score:3.45|P-value:2.32E-4 ID:SGTC_916|Compound:4466-0038|FD-Score:4.58|P-value:1.80E-6 ID:SGTC_922|Compound:1866-0035|FD-Score:-3.39|P-value:3.68E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:4.00|P-value:2.56E-5 ID:SGTC_1126|Compound:isoteolin|FD-Score:3.35|P-value:3.39E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:4.85|P-value:4.57E-7 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.74|P-value:9.54E-5 ID:SGTC_1248|Compound:0469-0687|FD-Score:7.99|P-value:3.67E-16 ID:SGTC_1250|Compound:0485-0349|FD-Score:4.18|P-value:1.15E-5 ID:SGTC_1275|Compound:0867-0008|FD-Score:3.54|P-value:1.67E-4 ID:SGTC_1344|Compound:1488-0097|FD-Score:3.47|P-value:2.19E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:5.62|P-value:6.83E-9 ID:SGTC_1374|Compound:2889-5571|FD-Score:5.20|P-value:7.12E-8 ID:SGTC_1470|Compound:k295-0292|FD-Score:3.64|P-value:1.12E-4 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:3.35E-10 ID:SGTC_1600|Compound:coumarin 106|FD-Score:-3.33|P-value:4.45E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.54|P-value:1.69E-4 ID:SGTC_1648|Compound:st011736|FD-Score:3.07|P-value:9.11E-4 ID:SGTC_1707|Compound:st032323|FD-Score:4.80|P-value:6.06E-7 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.10|P-value:2.15E-5 ID:SGTC_2009|Compound:4012297|FD-Score:3.48|P-value:2.10E-4 ID:SGTC_2043|Compound:5101342|FD-Score:3.32|P-value:3.77E-4 ID:SGTC_2241|Compound:6772625|FD-Score:-3.12|P-value:9.48E-4 ID:SGTC_2294|Compound:7971431|FD-Score:3.52|P-value:1.76E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.90|P-value:3.60E-7 ID:SGTC_2348|Compound:9022543|FD-Score:4.11|P-value:1.56E-5 ID:SGTC_2396|Compound:5342950|FD-Score:9.06|P-value:3.26E-20 ID:SGTC_2414|Compound:st077232|FD-Score:-3.98|P-value:3.64E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:8.68|P-value:9.75E-19 ID:SGTC_2584|Compound:androsterone|FD-Score:5.69|P-value:4.36E-9 ID:SGTC_2612|Compound:dictamnine|FD-Score:4.72|P-value:8.80E-7 ID:SGTC_2619|Compound:obliquin|FD-Score:9.78|P-value:3.03E-23 ID:SGTC_2777|Compound:climbazole|FD-Score:3.23|P-value:5.33E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.07|P-value:2.40E-5 ID:SGTC_2797|Compound:7859098|FD-Score:-3.84|P-value:6.42E-5 ID:SGTC_2896|Compound:9052656|FD-Score:-5.04|P-value:2.38E-7 ID:SGTC_2912|Compound:7964298|FD-Score:4.21|P-value:1.01E-5 ID:SGTC_2985|Compound:9022375|FD-Score:3.71|P-value:8.43E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-3.70|P-value:1.12E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.58|P-value:1.42E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-4.37|P-value:6.32E-6 ID:SGTC_3311|Compound:9131146|FD-Score:7.01|P-value:7.42E-13 ID:SGTC_3350|Compound:9150499|FD-Score:3.87|P-value:4.46E-5

Top fitness defect scores for YBR020W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_514 4466-0038 13.60 2.6 nM 2.97E-43 cell wall 12 1.23E-42
2 SGTC_2619 obliquin 9.78 87.9 µM 3.03E-23 cell wall 23 6.87E-23
3 SGTC_2396 5342950 9.06 42.8 µM 3.26E-20 RSC complex & mRNA processing 3 6.71E-20
4 SGTC_2582 agaric acid 8.68 100.0 µM 9.75E-19 redox potentiating 88 1.92E-18
5 SGTC_58 0957-0393 8.57 9.0 µM 2.73E-18 cell wall 110 5.29E-18
6 SGTC_1248 0469-0687 7.99 58.6 µM 3.67E-16 2 6.65E-16
7 SGTC_138 0850-0259 7.14 40.9 µM 2.93E-13 cell wall 73 4.82E-13
8 SGTC_3311 9131146 7.01 2.9 µM 7.42E-13 cell wall 48 1.20E-12
9 SGTC_852 0418-0143 6.44 439.0 µM 3.81E-11 calcium & mitochondrial duress 23 5.83E-11
10 SGTC_1493 4348-0038 6.11 111.0 µM 3.35E-10 RSC complex & mRNA processing 2 4.97E-10
11 SGTC_2584 androsterone 5.69 48.7 µM 4.36E-9 cell wall 65 6.22E-9
12 SGTC_1353 1498-1206 5.62 8.1 µM 6.83E-9 mitochondrial response to ROS 21 9.67E-9
13 SGTC_673 1082-0474 5.31 110.0 µM 4.06E-8 RSC complex & mRNA processing 29 5.60E-8
14 SGTC_1374 2889-5571 5.20 141.0 µM 7.12E-8 RSC complex & mRNA processing 18 9.73E-8
15 SGTC_839 0122-0028 4.96 230.0 µM 2.63E-7 RSC complex & mRNA processing 14 3.52E-7
16 SGTC_2297 7971671 4.90 152.3 µM 3.60E-7 RNA processing & uracil transport 10 4.79E-7
17 SGTC_769 0302-0231 4.88 76.0 µM 4.06E-7 18 5.39E-7
18 SGTC_1133 3473-0247 4.85 50.0 µM 4.57E-7 RSC complex & mRNA processing 27 6.06E-7
19 SGTC_1707 st032323 4.80 6.3 µM 6.06E-7 DNA damage response 37 8.01E-7
20 SGTC_829 1635-0120 4.78 117.0 µM 6.48E-7 DNA damage response 25 8.56E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.485 5.36E-198 YOR091W TMA46 hom Protein of unknown function that associates with translating ribosomes; interacts with GTPase Rbg1p
0.484 2.91E-196 YGL033W HOP2 hom Meiosis-specific protein that localizes to chromosomes, preventing synapsis between nonhomologous chromosomes and ensuring synapsis between homologs; complexes with Mnd1p to promote homolog pairing and meiotic double-strand break repair
0.442 1.01E-160 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.433 2.56E-153 YMR121C RPL15B hom Ribosomal 60S subunit protein L15B; binds to 5.8 S rRNA; homologous to mammalian ribosomal protein L15, no bacterial homolog; RPL15B has a paralog, RPL15A, that arose from the whole genome duplication; relocalizes from nucleus to nucleolus upon DNA replication stress
0.428 3.93E-149 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.421 2.79E-144 YOR051C ETT1 hom Nuclear protein that inhibits replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts; deletion increases stop codon readthrough
0.399 1.51E-128 YPR061C JID1 hom Probable Hsp40p co-chaperone, has a DnaJ-like domain and appears to be involved in ER-associated degradation of misfolded proteins containing a tightly folded cytoplasmic domain; inhibits replication of Brome mosaic virus in S. cerevisiae
0.377 1.75E-113 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.376 4.86E-113 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.358 3.98E-102 YDR172W SUP35 het Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype
0.337 6.75E-90 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.337 1.30E-89 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.332 4.42E-87 YML117W NAB6 hom Putative RNA-binding protein that associates with mRNAs encoding cell wall proteins in high-throughput studies; deletion mutants display increased sensitivity to some cell wall disrupting agents; expression negatively regulated by cAMP
0.327 1.72E-84 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.317 4.19E-79 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria