YBR041W / FAT1

Very long chain fatty acyl-CoA synthetase and long chain fatty acid transporter; activates imported fatty acids with a preference for very long lengths (C20-C26); has a separate function in the transport of long chain fatty acids

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR041W / FAT1

Click on Significant Values for Screen Details ID:SGTC_103|Compound:0844-0104|FD-Score:6.62|P-value:2.36E-10 ID:SGTC_181|Compound:1447-1644|FD-Score:3.58|P-value:4.50E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.41|P-value:7.82E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:8.64|P-value:1.70E-16 ID:SGTC_439|Compound:amiodarone|FD-Score:3.37|P-value:8.99E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.76|P-value:4.24E-6 ID:SGTC_493|Compound:zm226600|FD-Score:-4.27|P-value:1.45E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.38|P-value:2.33E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:3.97|P-value:1.08E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.58|P-value:4.48E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.07|P-value:7.70E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.20|P-value:4.55E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.51|P-value:1.29E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.63|P-value:3.79E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.52|P-value:5.57E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.84|P-value:1.78E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.56|P-value:4.78E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.60|P-value:4.17E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.34|P-value:9.91E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.49|P-value:2.99E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.16|P-value:5.42E-5 ID:SGTC_1730|Compound:st033808|FD-Score:4.23|P-value:4.04E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.41|P-value:7.88E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.20|P-value:8.06E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.74|P-value:2.55E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.98|P-value:4.82E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.36|P-value:9.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.74|P-value:2.58E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.49|P-value:5.17E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.48|P-value:1.57E-10 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.41|P-value:7.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.69|P-value:3.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.59|P-value:2.08E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.86|P-value:7.60E-5 ID:SGTC_3211|Compound:9128781|FD-Score:5.93|P-value:1.27E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-4.05|P-value:3.62E-5 ID:SGTC_3300|Compound:9124615|FD-Score:4.57|P-value:9.87E-6 ID:SGTC_3302|Compound:9125395|FD-Score:4.27|P-value:3.48E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.30|P-value:5.68E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:6.62|P-value:2.36E-10 ID:SGTC_181|Compound:1447-1644|FD-Score:3.58|P-value:4.50E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:3.41|P-value:7.82E-4 ID:SGTC_344|Compound:k064-0035|FD-Score:-3.28|P-value:6.14E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:8.64|P-value:1.70E-16 ID:SGTC_439|Compound:amiodarone|FD-Score:3.37|P-value:8.99E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:4.76|P-value:4.24E-6 ID:SGTC_493|Compound:zm226600|FD-Score:-4.27|P-value:1.45E-5 ID:SGTC_568|Compound:1193-0097|FD-Score:5.38|P-value:2.33E-7 ID:SGTC_652|Compound:0437-0092|FD-Score:3.97|P-value:1.08E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.58|P-value:4.48E-4 ID:SGTC_827|Compound:3253-0474|FD-Score:4.07|P-value:7.70E-5 ID:SGTC_879|Compound:0831-1030|FD-Score:4.20|P-value:4.55E-5 ID:SGTC_881|Compound:0833-0569|FD-Score:4.51|P-value:1.29E-5 ID:SGTC_919|Compound:tnp00227|FD-Score:3.63|P-value:3.79E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.52|P-value:5.57E-4 ID:SGTC_1284|Compound:0929-0043|FD-Score:3.84|P-value:1.78E-4 ID:SGTC_1356|Compound:1502-0781|FD-Score:3.56|P-value:4.78E-4 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.60|P-value:4.17E-4 ID:SGTC_1590|Compound:st077108|FD-Score:3.34|P-value:9.91E-4 ID:SGTC_1620|Compound:st003704|FD-Score:-3.49|P-value:2.99E-4 ID:SGTC_1725|Compound:st036284|FD-Score:4.16|P-value:5.42E-5 ID:SGTC_1730|Compound:st033808|FD-Score:4.23|P-value:4.04E-5 ID:SGTC_1735|Compound:st034310|FD-Score:3.41|P-value:7.88E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.20|P-value:8.06E-4 ID:SGTC_1925|Compound:st057770|FD-Score:3.74|P-value:2.55E-4 ID:SGTC_2023|Compound:5144124|FD-Score:3.77|P-value:2.33E-4 ID:SGTC_2130|Compound:NSC 7|FD-Score:-3.98|P-value:4.82E-5 ID:SGTC_2191|Compound:5911152|FD-Score:3.36|P-value:9.25E-4 ID:SGTC_2302|Compound:7771753|FD-Score:3.74|P-value:2.58E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.45|P-value:1.62E-5 ID:SGTC_2406|Compound:ethylparaben|FD-Score:6.49|P-value:5.17E-10 ID:SGTC_2408|Compound:sulbentine|FD-Score:-6.48|P-value:1.57E-10 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:3.41|P-value:7.80E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:3.59|P-value:4.27E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.69|P-value:3.10E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.59|P-value:2.08E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.86|P-value:7.60E-5 ID:SGTC_3211|Compound:9128781|FD-Score:5.93|P-value:1.27E-8 ID:SGTC_3266|Compound:9136860|FD-Score:-4.05|P-value:3.62E-5 ID:SGTC_3300|Compound:9124615|FD-Score:4.57|P-value:9.87E-6 ID:SGTC_3302|Compound:9125395|FD-Score:4.27|P-value:3.48E-5 ID:SGTC_3308|Compound:9128332|FD-Score:-3.30|P-value:5.68E-4

Top fitness defect scores for YBR041W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_352 k048-0007 8.64 5.1 µM 1.70E-16 ERAD & cell cycle 14 2.70E-18
2 SGTC_103 0844-0104 6.62 51.8 µM 2.36E-10 ERAD & cell cycle 63 1.76E-11
3 SGTC_2406 ethylparaben 6.49 405.7 µM 5.17E-10 8 4.19E-11
4 SGTC_3211 9128781 5.93 49.5 µM 1.27E-8 21 1.48E-9
5 SGTC_568 1193-0097 5.38 7.5 µM 2.33E-7 ERAD & cell cycle 76 3.74E-8
6 SGTC_453 enantio-paf c16 4.76 10.0 µM 4.24E-6 97 9.45E-7
7 SGTC_3300 9124615 4.57 50.5 µM 9.87E-6 10 2.43E-6
8 SGTC_881 0833-0569 4.51 170.0 µM 1.29E-5 15 3.27E-6
9 SGTC_2322 7413319 4.45 38.2 µM 1.62E-5 ERAD & cell cycle 129 4.21E-6
10 SGTC_3302 9125395 4.27 16.4 µM 3.48E-5 4 9.89E-6
11 SGTC_1730 st033808 4.23 45.1 µM 4.04E-5 23 1.17E-5
12 SGTC_879 0831-1030 4.20 162.0 µM 4.55E-5 41 1.33E-5
13 SGTC_1725 st036284 4.16 20.6 µM 5.42E-5 24 1.62E-5
14 SGTC_827 3253-0474 4.07 693.0 µM 7.70E-5 17 2.40E-5
15 SGTC_652 0437-0092 3.97 114.0 µM 1.08E-4 18 3.52E-5
16 SGTC_1284 0929-0043 3.84 16.0 µM 1.78E-4 26 6.12E-5
17 SGTC_2023 5144124 3.77 124.0 µM 2.33E-4 27 8.25E-5
18 SGTC_1925 st057770 3.74 10.1 µM 2.55E-4 TSC3-RPN4 24 9.13E-5
19 SGTC_2302 7771753 3.74 200.0 µM 2.58E-4 48 9.27E-5
20 SGTC_2647 atorvastatin 3.69 60.2 µM 3.10E-4 azole & statin 22 1.14E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 2.06E-29 YER069W ARG5,6 hom Acetylglutamate kinase and N-acetyl-gamma-glutamyl-phosphate reductase; N-acetyl-L-glutamate kinase (NAGK) catalyzes the 2nd and N-acetyl-gamma-glutamyl-phosphate reductase (NAGSA), the 3rd step in arginine biosynthesis; synthesized as a precursor which is processed in the mitochondrion to yield mature NAGK and NAGSA; enzymes form a metabolon complex with Arg2p; NAGK C-terminal domain stabilizes the enzymes, slows catalysis and is involved in feed-back inhibition by arginine
0.190 9.20E-29 YOL002C IZH2 hom Plasma membrane protein involved in zinc homeostasis and osmotin-induced apoptosis; transcription regulated by Zap1p, zinc and fatty acid levels; similar to mammalian adiponectins; deletion increases sensitivity to elevated zinc
0.189 2.57E-28 YMR052C-A_d YMR052C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.186 2.05E-27 YER084W_p YER084W_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.180 8.97E-26 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.178 2.39E-25 YDR199W_d YDR199W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene VPS64; computationally predicted to have thiol-disulfide oxidoreductase activity
0.163 2.05E-21 YOL065C INP54 hom Phosphatidylinositol 4,5-bisphosphate 5-phosphatase with a role in secretion, localizes to the endoplasmic reticulum via the C-terminal tail; lacks the Sac1 domain and proline-rich region found in the other 3 INP proteins
0.155 1.55E-19 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.155 2.11E-19 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.149 3.51E-18 YMR214W SCJ1 hom One of several homologs of bacterial chaperone DnaJ, located in the ER lumen where it cooperates with Kar2p to mediate maturation of proteins
0.149 4.54E-18 YDL122W UBP1 hom Ubiquitin-specific protease that removes ubiquitin from ubiquitinated proteins; cleaves at the C terminus of ubiquitin fusions irrespective of their size; capable of cleaving polyubiquitin chains
0.142 1.44E-16 YMR170C ALD2 hom Cytoplasmic aldehyde dehydrogenase, involved in ethanol oxidation and beta-alanine biosynthesis; uses NAD+ as the preferred coenzyme; expression is stress induced and glucose repressed; very similar to Ald3p
0.141 1.76E-16 YKR014C YPT52 hom Rab family GTPase, similar to Ypt51p and Ypt53p and to mammalian rab5; required for vacuolar protein sorting and endocytosis; protein abundance increases in response to DNA replication stress
0.140 3.06E-16 YMR022W UBC7 hom Ubiquitin conjugating enzyme, involved in the ER-associated protein degradation pathway; requires Cue1p for recruitment to the ER membrane; proposed to be involved in chromatin assembly
0.139 7.40E-16 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance