YBR119W / MUD1

U1 snRNP A protein, homolog of human U1-A; involved in nuclear mRNA splicing

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR119W / MUD1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:4.50|P-value:1.37E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.84|P-value:8.43E-11 ID:SGTC_311|Compound:1315-0136|FD-Score:3.37|P-value:8.85E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.57|P-value:4.51E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.40|P-value:7.89E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.25|P-value:3.80E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.71|P-value:2.82E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.66|P-value:3.36E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.32|P-value:2.89E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.33|P-value:7.85E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.76|P-value:2.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.39|P-value:6.36E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.61|P-value:4.01E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.62|P-value:8.51E-6 ID:SGTC_2100|Compound:5377183|FD-Score:4.35|P-value:2.60E-5 ID:SGTC_2163|Compound:5671233|FD-Score:4.24|P-value:3.95E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.41|P-value:7.78E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.35|P-value:9.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.91|P-value:1.36E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.38|P-value:8.39E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.57|P-value:7.52E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.81|P-value:2.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.57|P-value:1.04E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.85|P-value:2.19E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:3.44|P-value:6.97E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.60|P-value:4.05E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.55|P-value:8.11E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.75|P-value:2.43E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.68|P-value:3.09E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.40|P-value:8.05E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.45|P-value:1.69E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.03|P-value:1.36E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:4.50|P-value:1.37E-5 ID:SGTC_97|Compound:0535-0701|FD-Score:3.85|P-value:1.72E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:6.84|P-value:8.43E-11 ID:SGTC_311|Compound:1315-0136|FD-Score:3.37|P-value:8.85E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:3.57|P-value:4.51E-4 ID:SGTC_489|Compound:paxilline|FD-Score:3.40|P-value:7.89E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:4.25|P-value:3.80E-5 ID:SGTC_550|Compound:4123-0385|FD-Score:3.71|P-value:2.82E-4 ID:SGTC_655|Compound:k060-0012|FD-Score:3.66|P-value:3.36E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.32|P-value:2.89E-5 ID:SGTC_735|Compound:3076-0345|FD-Score:-3.33|P-value:7.85E-4 ID:SGTC_738|Compound:1315-0003|FD-Score:3.76|P-value:2.36E-4 ID:SGTC_871|Compound:0574-0004|FD-Score:-3.39|P-value:6.36E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.61|P-value:4.01E-4 ID:SGTC_1607|Compound:st000305|FD-Score:3.98|P-value:1.05E-4 ID:SGTC_2062|Compound:5245942|FD-Score:4.62|P-value:8.51E-6 ID:SGTC_2100|Compound:5377183|FD-Score:4.35|P-value:2.60E-5 ID:SGTC_2163|Compound:5671233|FD-Score:4.24|P-value:3.95E-5 ID:SGTC_2343|Compound:7990716|FD-Score:3.41|P-value:7.78E-4 ID:SGTC_2349|Compound:9023730|FD-Score:3.35|P-value:9.37E-4 ID:SGTC_2366|Compound:9070441|FD-Score:3.91|P-value:1.36E-4 ID:SGTC_2367|Compound:9070478|FD-Score:3.38|P-value:8.39E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.57|P-value:7.52E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.84|P-value:1.79E-4 ID:SGTC_2750|Compound:bromebric acid|FD-Score:3.81|P-value:2.01E-4 ID:SGTC_2755|Compound:lomerizine|FD-Score:4.57|P-value:1.04E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:-4.85|P-value:2.19E-6 ID:SGTC_2760|Compound:etidronate|FD-Score:3.44|P-value:6.97E-4 ID:SGTC_2919|Compound:7978188|FD-Score:3.60|P-value:4.05E-4 ID:SGTC_2928|Compound:9011484|FD-Score:-4.55|P-value:8.11E-6 ID:SGTC_2952|Compound:9073731|FD-Score:3.75|P-value:2.43E-4 ID:SGTC_3055|Compound:9094636|FD-Score:3.68|P-value:3.09E-4 ID:SGTC_3211|Compound:9128781|FD-Score:3.40|P-value:8.05E-4 ID:SGTC_3311|Compound:9131146|FD-Score:4.45|P-value:1.69E-5 ID:SGTC_3321|Compound:9137793|FD-Score:5.03|P-value:1.36E-6

Top fitness defect scores for YBR119W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_138 0850-0259 6.84 40.9 µM 8.43E-11 cell wall 80 4.03E-12
2 SGTC_3321 9137793 5.03 26.8 µM 1.36E-6 cell wall 42 2.44E-7
3 SGTC_2062 5245942 4.62 200.0 µM 8.51E-6 4 1.95E-6
4 SGTC_2755 lomerizine 4.57 42.7 µM 1.04E-5 17 2.46E-6
5 SGTC_58 0957-0393 4.50 9.0 µM 1.37E-5 cell wall 327 3.36E-6
6 SGTC_3311 9131146 4.45 2.9 µM 1.69E-5 cell wall 97 4.27E-6
7 SGTC_2100 5377183 4.35 190.0 µM 2.60E-5 60S ribosome export 8 6.93E-6
8 SGTC_660 4031-1742 4.32 102.0 µM 2.89E-5 redox potentiating 36 7.81E-6
9 SGTC_502 l-744,832 4.25 89.3 µM 3.80E-5 calcium & mitochondrial duress 33 1.07E-5
10 SGTC_2163 5671233 4.24 125.0 µM 3.95E-5 17 1.12E-5
11 SGTC_1607 st000305 3.98 50.6 µM 1.05E-4 11 3.39E-5
12 SGTC_2366 9070441 3.91 60.6 µM 1.36E-4 30 4.56E-5
13 SGTC_97 0535-0701 3.85 19.1 µM 1.72E-4 60S ribosome export 14 5.93E-5
14 SGTC_2582 agaric acid 3.84 100.0 µM 1.79E-4 redox potentiating 331 6.20E-5
15 SGTC_2750 bromebric acid 3.81 70.2 µM 2.01E-4 35 7.08E-5
16 SGTC_738 1315-0003 3.76 72.4 µM 2.36E-4 27 8.48E-5
17 SGTC_2952 9073731 3.75 13.8 µM 2.43E-4 tubulin folding & SWR complex 51 8.78E-5
18 SGTC_550 4123-0385 3.71 25.7 µM 2.82E-4 TSC3-RPN4 35 1.04E-4
19 SGTC_3055 9094636 3.68 49.5 µM 3.09E-4 14 1.15E-4
20 SGTC_655 k060-0012 3.66 42.0 µM 3.36E-4 21 1.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.277 2.99E-60 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.238 1.36E-44 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.220 4.69E-38 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.207 6.58E-34 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.203 2.18E-32 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.200 1.51E-31 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.198 5.50E-31 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.196 2.33E-30 YPL269W KAR9 hom Karyogamy protein required for correct positioning of the mitotic spindle and for orienting cytoplasmic microtubules, localizes at the shmoo tip in mating cells and at the tip of the growing bud in small-budded cells through anaphase
0.186 1.42E-27 YBL031W SHE1 hom Mitotic spindle protein; interacts with components of the Dam1 (DASH) complex, its effector Sli15p, and microtubule-associated protein Bim1p; also localizes to nuclear microtubules and to the bud neck in a ring-shaped structure; inhibits dynein function
0.185 3.38E-27 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.183 1.35E-26 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.180 6.35E-26 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.180 9.17E-26 YDR351W SBE2 hom Protein involved in the transport of cell wall components from the Golgi to the cell surface; required for bud growth
0.179 1.34E-25 YAL015C NTG1 hom DNA N-glycosylase and apurinic/apyrimidinic (AP) lyase; involved in base excision repair; acts in both nucleus and mitochondrion; creates a double-strand break at mtDNA origins that stimulates replication in response to oxidative stress; NTG1 has a paralog, NTG2, that arose from the whole genome duplication
0.179 1.39E-25 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication