YBR236C / ABD1

Methyltransferase, catalyzes the transfer of a methyl group from S-adenosylmethionine to the GpppN terminus of capped mRNA

Zygosity: Heterozygous strain
fixedexpanded
Profile for YBR236C / ABD1

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:7.13|P-value:2.40E-14 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:2.88E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.16|P-value:3.91E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.65|P-value:3.96E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.33|P-value:2.21E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.63|P-value:6.43E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.78|P-value:3.24E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.68|P-value:4.97E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.61|P-value:6.34E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.10|P-value:3.11E-8 ID:SGTC_779|Compound:1360-0071|FD-Score:3.77|P-value:3.35E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:6.00|P-value:1.13E-10 ID:SGTC_826|Compound:1683-5028|FD-Score:4.13|P-value:6.42E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.22|P-value:3.37E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.16|P-value:4.23E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.17|P-value:5.39E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.99|P-value:7.94E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.94|P-value:9.09E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.12|P-value:6.69E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.68|P-value:5.04E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.62|P-value:6.60E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.66|P-value:5.01E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.93|P-value:1.67E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.42|P-value:1.43E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.04|P-value:6.61E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.35|P-value:2.11E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.89|P-value:1.96E-5 ID:SGTC_2360|Compound:9040895|FD-Score:4.59|P-value:6.20E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.60|P-value:7.32E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.33|P-value:2.22E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.90|P-value:1.74E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.73|P-value:2.67E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.40|P-value:1.62E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.16|P-value:5.51E-6 ID:SGTC_2899|Compound:9053889|FD-Score:2.98|P-value:8.40E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.35|P-value:2.04E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.51|P-value:9.88E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.95|P-value:1.41E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.98|P-value:7.81E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:7.13|P-value:2.40E-14 ID:SGTC_51|Compound:1013-0126|FD-Score:3.81|P-value:2.88E-5 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.16|P-value:3.91E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.65|P-value:3.96E-7 ID:SGTC_124|Compound:0136-0217|FD-Score:3.33|P-value:2.21E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:3.63|P-value:6.43E-5 ID:SGTC_193|Compound:1273-0060|FD-Score:3.78|P-value:3.24E-5 ID:SGTC_473|Compound:2-arachidonoylglycerol|FD-Score:3.68|P-value:4.97E-5 ID:SGTC_626|Compound:0214-0009|FD-Score:-3.61|P-value:6.34E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-5.10|P-value:3.11E-8 ID:SGTC_779|Compound:1360-0071|FD-Score:3.77|P-value:3.35E-5 ID:SGTC_789|Compound:1309-1135|FD-Score:6.00|P-value:1.13E-10 ID:SGTC_826|Compound:1683-5028|FD-Score:4.13|P-value:6.42E-6 ID:SGTC_883|Compound:0850-0245|FD-Score:3.22|P-value:3.37E-4 ID:SGTC_1103|Compound:duloxetine|FD-Score:3.16|P-value:4.23E-4 ID:SGTC_1128|Compound:3448-9350|FD-Score:4.17|P-value:5.39E-6 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.99|P-value:7.94E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:-2.94|P-value:9.09E-4 ID:SGTC_1367|Compound:1812-0510|FD-Score:4.12|P-value:6.69E-6 ID:SGTC_1617|Compound:st002906|FD-Score:3.68|P-value:5.04E-5 ID:SGTC_1688|Compound:st021091|FD-Score:3.62|P-value:6.60E-5 ID:SGTC_1720|Compound:st037298|FD-Score:-3.66|P-value:5.01E-5 ID:SGTC_1724|Compound:st037281|FD-Score:3.93|P-value:1.67E-5 ID:SGTC_1933|Compound:st074711|FD-Score:-3.42|P-value:1.43E-4 ID:SGTC_2085|Compound:5307070|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.04|P-value:6.61E-4 ID:SGTC_2237|Compound:6667747|FD-Score:4.35|P-value:2.11E-6 ID:SGTC_2307|Compound:7538926|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_2329|Compound:6138490|FD-Score:3.89|P-value:1.96E-5 ID:SGTC_2360|Compound:9040895|FD-Score:4.59|P-value:6.20E-7 ID:SGTC_2411|Compound:st077133|FD-Score:3.60|P-value:7.32E-5 ID:SGTC_2476|Compound:5806916|FD-Score:3.33|P-value:2.22E-4 ID:SGTC_2477|Compound:5967686|FD-Score:-3.90|P-value:1.74E-5 ID:SGTC_2484|Compound:5809818|FD-Score:-4.73|P-value:2.67E-7 ID:SGTC_2707|Compound:st078556|FD-Score:3.40|P-value:1.62E-4 ID:SGTC_2710|Compound:st078562|FD-Score:4.16|P-value:5.51E-6 ID:SGTC_2899|Compound:9053889|FD-Score:2.98|P-value:8.40E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.35|P-value:2.04E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.51|P-value:9.88E-5 ID:SGTC_3062|Compound:9077494|FD-Score:-3.95|P-value:1.41E-5 ID:SGTC_3071|Compound:9117417|FD-Score:3.38|P-value:1.82E-4 ID:SGTC_3299|Compound:9121982|FD-Score:-2.98|P-value:7.81E-4

Top fitness defect scores for YBR236C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_47 0149-0135 7.13 24.2 µM 2.40E-14 TSC3-RPN4 1 5.10E-13 1.71
2 SGTC_789 1309-1135 6.00 70.6 µM 1.13E-10 ERG2 1 9.89E-10 1.06
3 SGTC_2360 9040895 4.59 200.0 µM 6.20E-7 RPP1 & pyrimidine depletion 6 2.23E-6 0.54
4 SGTC_2237 6667747 4.35 47.2 µM 2.11E-6 4 6.68E-6 1.09
5 SGTC_1128 3448-9350 4.17 235.0 µM 5.39E-6 4 1.55E-5 0.07
6 SGTC_2710 st078562 4.16 53.7 µM 5.51E-6 4 1.59E-5 0.23
7 SGTC_826 1683-5028 4.13 118.0 µM 6.42E-6 3 1.82E-5 0.12
8 SGTC_1367 1812-0510 4.12 76.9 µM 6.69E-6 6 1.89E-5 0.60
9 SGTC_1724 st037281 3.93 8.3 µM 1.67E-5 14 4.29E-5 0.12
10 SGTC_2329 6138490 3.89 200.0 µM 1.96E-5 12 4.95E-5 0.12
11 SGTC_51 1013-0126 3.81 23.4 µM 2.88E-5 6 7.01E-5 0.35
12 SGTC_193 1273-0060 3.78 1.6 µM 3.24E-5 ergosterol biosynthesis 7 7.79E-5 0.30
13 SGTC_779 1360-0071 3.77 233.0 µM 3.35E-5 fatty acid desaturase (OLE1) 6 8.03E-5 0.35
14 SGTC_473 2-arachidonoylglycerol 3.68 10.0 µM 4.97E-5 6 1.14E-4 0.08
15 SGTC_1617 st002906 3.68 78.0 µM 5.04E-5 3 1.16E-4 0.13
16 SGTC_151 3013-0144 3.63 2.3 µM 6.43E-5 iron homeostasis 15 1.44E-4 0.03
17 SGTC_1688 st021091 3.62 57.6 µM 6.60E-5 4 1.48E-4 0.13
18 SGTC_2411 st077133 3.60 39.9 µM 7.32E-5 RNA pol III & RNase P/MRP 23 1.62E-4 0.07
19 SGTC_2085 5307070 3.50 144.1 µM 1.09E-4 superoxide 12 2.32E-4 0.03
20 SGTC_2307 7538926 3.41 6.3 µM 1.61E-4 30 3.30E-4 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.147 9.81E-18 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.108 3.88E-10 YER127W LCP5 het Essential protein involved in maturation of 18S rRNA; depletion leads to inhibited pre-rRNA processing and reduced polysome levels; localizes primarily to the nucleolus
0.107 4.84E-10 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.104 1.82E-9 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.103 2.48E-9 YJL218W_p YJL218W_p hom Putative acetyltransferase; similar to bacterial galactoside O-acetyltransferases; induced by oleate in an OAF1/PIP2-dependent manner; promoter contains an oleate response element consensus sequence; non-essential gene
0.100 7.52E-9 YNL161W CBK1 het Serine/threonine protein kinase of the the RAM signaling network; Ndr/LATS family member; binds regulatory subunit Mob2p; involved in regulation of cellular morphogenesis, polarized growth, and septum destruction; phosphorylation by Cbk1p regulates localization and activity of Ace2p transcription factor and Ssd1p translational repressor; Cbk1p activity is regulated by both phosphorylation and specific localization; relocalizes to cytoplasm upon DNA replication stress
0.099 7.74E-9 YKL162C-A_d YKL162C-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.44E-9 YDL209C CWC2 het Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2
0.099 9.17E-9 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.096 2.88E-8 YER172C BRR2 het RNA-dependent ATPase RNA helicase (DEIH box); required for disruption of U4/U6 base-pairing in native snRNPs to activate the spliceosome for catalysis; homologous to human U5-200kD
0.094 4.25E-8 YDR531W CAB1 het Pantothenate kinase (ATP:D-pantothenate 4'-phosphotransferase, EC 2.7.1.33); catalyzes the first committed step in the universal biosynthetic pathway for synthesis of coenzyme A (CoA); transcriptionally regulated by Upc2p via a sterol response element
0.094 4.81E-8 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.094 5.70E-8 YKL042W SPC42 het Central plaque component of spindle pole body (SPB); involved in SPB duplication, may facilitate attachment of the SPB to the nuclear membrane
0.094 5.58E-8 YPR135W CTF4 hom Chromatin-associated protein, required for sister chromatid cohesion; interacts with DNA polymerase alpha (Pol1p) and may link DNA synthesis to sister chromatid cohesion
0.093 5.99E-8 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle