YBR285W_p

Putative protein of unknown function; YBR285W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YBR285W / YBR285W

Click on Significant Values for Screen Details ID:SGTC_38|Compound:0929-0051|FD-Score:-4.40|P-value:2.18E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.40|P-value:7.79E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:5.48|P-value:2.18E-7 ID:SGTC_885|Compound:0865-0106|FD-Score:3.60|P-value:4.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.59|P-value:1.15E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:4.28|P-value:3.96E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:7.16|P-value:1.94E-11 ID:SGTC_942|Compound:3253-1115|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.35|P-value:3.91E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:4.99E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.69|P-value:7.55E-8 ID:SGTC_1548|Compound:st061468|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.56|P-value:4.64E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.61|P-value:4.00E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.85|P-value:3.88E-6 ID:SGTC_1782|Compound:st039423|FD-Score:5.01|P-value:1.93E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.60|P-value:4.56E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.95|P-value:1.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.98|P-value:2.17E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.71|P-value:3.16E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.00|P-value:1.02E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-5.37|P-value:3.08E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.06|P-value:9.28E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.62|P-value:4.28E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:1.42E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.96|P-value:1.31E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.60|P-value:4.12E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.20|P-value:5.47E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.48|P-value:6.03E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.75|P-value:2.80E-4 ID:SGTC_3146|Compound:9095609|FD-Score:6.20|P-value:5.36E-9 ID:SGTC_3147|Compound:9097027|FD-Score:7.81|P-value:2.71E-13 ID:SGTC_3154|Compound:9100113|FD-Score:5.77|P-value:4.96E-8 ID:SGTC_3156|Compound:9099931|FD-Score:4.05|P-value:9.50E-5 ID:SGTC_38|Compound:0929-0051|FD-Score:-4.40|P-value:2.18E-5 ID:SGTC_425|Compound:3825-7017|FD-Score:-3.40|P-value:7.79E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:5.48|P-value:2.18E-7 ID:SGTC_885|Compound:0865-0106|FD-Score:3.60|P-value:4.59E-4 ID:SGTC_888|Compound:0916-0002|FD-Score:4.59|P-value:1.15E-5 ID:SGTC_898|Compound:1000-0849|FD-Score:4.28|P-value:3.96E-5 ID:SGTC_929|Compound:2805-0021|FD-Score:7.16|P-value:1.94E-11 ID:SGTC_942|Compound:3253-1115|FD-Score:4.57|P-value:1.24E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.35|P-value:3.91E-7 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.57|P-value:4.99E-4 ID:SGTC_1377|Compound:2944-0135|FD-Score:5.69|P-value:7.55E-8 ID:SGTC_1548|Compound:st061468|FD-Score:3.85|P-value:1.96E-4 ID:SGTC_1578|Compound:josamycin|FD-Score:-3.56|P-value:4.64E-4 ID:SGTC_1730|Compound:st033808|FD-Score:-3.61|P-value:4.00E-4 ID:SGTC_1743|Compound:st037606|FD-Score:4.85|P-value:3.88E-6 ID:SGTC_1782|Compound:st039423|FD-Score:5.01|P-value:1.93E-6 ID:SGTC_1788|Compound:fluconazole|FD-Score:3.60|P-value:4.56E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.95|P-value:1.38E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.98|P-value:2.17E-6 ID:SGTC_2001|Compound:4023502|FD-Score:3.71|P-value:3.16E-4 ID:SGTC_2004|Compound:4023728|FD-Score:-4.00|P-value:1.02E-4 ID:SGTC_2106|Compound:5357045|FD-Score:3.94|P-value:1.42E-4 ID:SGTC_2412|Compound:st077135|FD-Score:-5.37|P-value:3.08E-7 ID:SGTC_2418|Compound:pentamidine|FD-Score:4.06|P-value:9.28E-5 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.62|P-value:4.28E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.91|P-value:1.42E-4 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.96|P-value:1.31E-4 ID:SGTC_2623|Compound:humulene|FD-Score:-3.60|P-value:4.12E-4 ID:SGTC_2624|Compound:nerol|FD-Score:4.20|P-value:5.47E-5 ID:SGTC_2628|Compound:lathosterol|FD-Score:-3.48|P-value:6.03E-4 ID:SGTC_2684|Compound:capsaicin|FD-Score:3.75|P-value:2.80E-4 ID:SGTC_3146|Compound:9095609|FD-Score:6.20|P-value:5.36E-9 ID:SGTC_3147|Compound:9097027|FD-Score:7.81|P-value:2.71E-13 ID:SGTC_3154|Compound:9100113|FD-Score:5.77|P-value:4.96E-8 ID:SGTC_3156|Compound:9099931|FD-Score:4.05|P-value:9.50E-5

Top fitness defect scores for YBR285W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3147 9097027 7.81 49.5 µM 2.71E-13 2 2.81E-15
2 SGTC_929 2805-0021 7.16 398.0 µM 1.94E-11 1 4.11E-13
3 SGTC_3146 9095609 6.20 49.5 µM 5.36E-9 1 2.89E-10
4 SGTC_3154 9100113 5.77 49.5 µM 4.96E-8 8 3.88E-9
5 SGTC_1377 2944-0135 5.69 198.0 µM 7.55E-8 calcium & mitochondrial duress 14 6.32E-9
6 SGTC_628 1636-0253 5.48 16.0 µM 2.18E-7 sphingolipid biosynthesis & PDR1 12 2.18E-8
7 SGTC_1107 amlodipine 5.35 47.0 µM 3.91E-7 8 4.30E-8
8 SGTC_1782 st039423 5.01 80.6 µM 1.93E-6 5 2.76E-7
9 SGTC_1949 st076024 4.98 69.1 µM 2.17E-6 10 3.17E-7
10 SGTC_1743 st037606 4.85 46.4 µM 3.88E-6 10 6.22E-7
11 SGTC_888 0916-0002 4.59 7.0 µM 1.15E-5 NEO1 33 2.20E-6
12 SGTC_942 3253-1115 4.57 227.0 µM 1.24E-5 14 2.41E-6
13 SGTC_898 1000-0849 4.28 28.3 µM 3.96E-5 2 9.29E-6
14 SGTC_2624 nerol 4.20 100.0 µM 5.47E-5 7 1.35E-5
15 SGTC_2418 pentamidine 4.06 31.7 µM 9.28E-5 mitochondrial processes 39 2.50E-5
16 SGTC_3156 9099931 4.05 49.5 µM 9.50E-5 6 2.57E-5
17 SGTC_2622 2-methoxyxanthone 3.96 59.9 µM 1.31E-4 19 3.75E-5
18 SGTC_1914 st062367 3.95 72.6 µM 1.38E-4 20 3.98E-5
19 SGTC_2106 5357045 3.94 167.3 µM 1.42E-4 18 4.10E-5
20 SGTC_1548 st061468 3.85 90.8 µM 1.96E-4 9 5.97E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.153 6.26E-19 YPL012W RRP12 het Protein required for export of the ribosomal subunits; associates with the RNA components of the pre-ribosomes; has a role in nuclear import in association with Pse1p; contains HEAT-repeats
0.152 7.24E-19 YLL049W LDB18 hom Component of the dynactin complex, which is required for dynein activity; null mutant exhibits defects in nuclear migration and spindle orientation and has reduced affinity for alcian blue dye; has homology to mammalian dynactin subunit p24
0.107 4.53E-10 YDR393W SHE9 hom Mitochondrial inner membrane protein required for normal mitochondrial morphology, may be involved in fission of the inner membrane; forms a homo-oligomeric complex
0.102 3.81E-9 YGL120C PRP43 het RNA helicase in the DEAH-box family, functions in both RNA polymerase I and polymerase II transcript metabolism, involved in release of the lariat-intron from the spliceosome
0.094 5.57E-8 YML047C PRM6 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; regulated by Ste12p during mating; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family
0.090 1.74E-7 YMR145C NDE1 hom Mitochondrial external NADH dehydrogenase, a type II NAD(P)H:quinone oxidoreductase that catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p provide cytosolic NADH to the mitochondrial respiratory chain
0.088 3.43E-7 YMR318C ADH6 hom NADPH-dependent medium chain alcohol dehydrogenase; has broad substrate specificity; member of the cinnamyl family of alcohol dehydrogenases; may be involved in fusel alcohol synthesis or in aldehyde tolerance; protein abundance increases in response to DNA replication stress
0.087 4.53E-7 YDR153C ENT5 hom Protein containing an N-terminal epsin-like domain involved in clathrin recruitment and traffic between the Golgi and endosomes; associates with the clathrin adaptor Gga2p, clathrin adaptor complex AP-1, and clathrin
0.084 9.63E-7 YCR101C_p YCR101C_p hom Putative protein of unknown function; localizes to the membrane fraction; YCR101C is not an essential gene
0.083 1.34E-6 YDR087C RRP1 het Essential evolutionarily conserved nucleolar protein necessary for biogenesis of 60S ribosomal subunits and processing of pre-rRNAs to mature rRNAs, associated with several distinct 66S pre-ribosomal particles
0.082 1.81E-6 YKR018C YKR018C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress; YKR018C has a paralog, IML2, that arose from the whole genome duplication
0.080 3.05E-6 YBR159W IFA38 hom Microsomal beta-keto-reductase; contains oleate response element (ORE) sequence in the promoter region; mutants exhibit reduced VLCFA synthesis, accumulate high levels of dihydrosphingosine, phytosphingosine and medium-chain ceramides
0.080 3.18E-6 YGR263C SAY1 hom Sterol deacetylase; component of the sterol acetylation/deacetylation cycle along with Atf2p; integral membrane protein with active site in the ER lumen; green fluorescent protein (GFP)-fusion protein localizes to the endoplasmic reticulum
0.080 3.27E-6 YGR075C PRP38 het Unique component of the U4/U6.U5 tri-snRNP particle, required for conformational changes which result in the catalytic activation of the spliceosome; dispensible for spliceosome assembly
0.079 4.73E-6 YML003W_p YML003W_p hom Putative protein of unknown function