YCR005C / CIT2

Citrate synthase; catalyzes the condensation of acetyl coenzyme A and oxaloacetate to form citrate, peroxisomal isozyme involved in glyoxylate cycle; expression is controlled by Rtg1p and Rtg2p transcription factors; CIT2 has a paralog, CIT1, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR005C / CIT2

Click on Significant Values for Screen Details ID:SGTC_258|Compound:haloperidol|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.05|P-value:7.11E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.21|P-value:3.61E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.28|P-value:2.92E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.89|P-value:2.26E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.51|P-value:1.17E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.10|P-value:5.79E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.00|P-value:8.47E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.25|P-value:3.95E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.54|P-value:9.68E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.94|P-value:9.68E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.01|P-value:1.24E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.10|P-value:5.80E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.40|P-value:1.85E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.97|P-value:9.30E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.42|P-value:1.72E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.43|P-value:1.66E-4 ID:SGTC_2438|Compound:5259590|FD-Score:5.42|P-value:6.65E-9 ID:SGTC_2460|Compound:5552655|FD-Score:-3.14|P-value:4.71E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.91|P-value:2.10E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.73|P-value:4.65E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.19|P-value:3.87E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.04|P-value:1.18E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-4.41|P-value:1.74E-6 ID:SGTC_3044|Compound:9093193|FD-Score:-5.21|P-value:2.10E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.22|P-value:3.67E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.16|P-value:4.44E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.34|P-value:2.15E-4 ID:SGTC_3222|Compound:9128301|FD-Score:2.97|P-value:9.44E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.08|P-value:6.01E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.41|P-value:1.64E-4 ID:SGTC_258|Compound:haloperidol|FD-Score:-3.36|P-value:2.02E-4 ID:SGTC_322|Compound:k048-0136|FD-Score:3.05|P-value:7.11E-4 ID:SGTC_407|Compound:eburnamonine|FD-Score:-3.21|P-value:3.61E-4 ID:SGTC_767|Compound:0929-0023|FD-Score:-3.40|P-value:1.70E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:3.28|P-value:2.92E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.89|P-value:2.26E-5 ID:SGTC_942|Compound:3253-1115|FD-Score:3.51|P-value:1.17E-4 ID:SGTC_944|Compound:3370-0224|FD-Score:3.10|P-value:5.79E-4 ID:SGTC_950|Compound:1165-0508|FD-Score:3.00|P-value:8.47E-4 ID:SGTC_1201|Compound:1889-3372|FD-Score:-4.25|P-value:3.95E-6 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.54|P-value:9.68E-5 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:-2.94|P-value:9.68E-4 ID:SGTC_1610|Compound:st001799|FD-Score:-4.01|P-value:1.24E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.13|P-value:5.20E-4 ID:SGTC_1842|Compound:st055362|FD-Score:3.10|P-value:5.80E-4 ID:SGTC_1914|Compound:st062367|FD-Score:3.22|P-value:3.76E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.33|P-value:2.44E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.40|P-value:1.85E-4 ID:SGTC_2162|Compound:5663267|FD-Score:2.97|P-value:9.30E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.42|P-value:1.72E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.43|P-value:1.66E-4 ID:SGTC_2438|Compound:5259590|FD-Score:5.42|P-value:6.65E-9 ID:SGTC_2460|Compound:5552655|FD-Score:-3.14|P-value:4.71E-4 ID:SGTC_2468|Compound:5987765|FD-Score:3.91|P-value:2.10E-5 ID:SGTC_2695|Compound:st077686|FD-Score:3.73|P-value:4.65E-5 ID:SGTC_2906|Compound:7926292|FD-Score:-3.19|P-value:3.87E-4 ID:SGTC_2978|Compound:9011784|FD-Score:4.04|P-value:1.18E-5 ID:SGTC_2982|Compound:9019404|FD-Score:-4.41|P-value:1.74E-6 ID:SGTC_3044|Compound:9093193|FD-Score:-5.21|P-value:2.10E-8 ID:SGTC_3143|Compound:9086658|FD-Score:3.22|P-value:3.67E-4 ID:SGTC_3196|Compound:9111891|FD-Score:-3.16|P-value:4.44E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-3.34|P-value:2.15E-4 ID:SGTC_3222|Compound:9128301|FD-Score:2.97|P-value:9.44E-4 ID:SGTC_3244|Compound:9134489|FD-Score:-3.08|P-value:6.01E-4 ID:SGTC_3269|Compound:9137823|FD-Score:-3.41|P-value:1.64E-4

Top fitness defect scores for YCR005C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2438 5259590 5.42 200.0 µM 6.65E-9 7 2.97E-8
2 SGTC_2978 9011784 4.04 43.0 µM 1.18E-5 26 2.73E-5
3 SGTC_2468 5987765 3.91 72.9 µM 2.10E-5 17 4.61E-5
4 SGTC_940 3232-1287 3.89 54.8 µM 2.26E-5 NEO1 41 4.92E-5
5 SGTC_2695 st077686 3.73 52.0 µM 4.65E-5 44 9.53E-5
6 SGTC_942 3253-1115 3.51 227.0 µM 1.17E-4 44 2.22E-4
7 SGTC_2437 5741531 3.43 144.2 µM 1.66E-4 59 3.05E-4
8 SGTC_2165 5727197 3.42 32.1 µM 1.72E-4 53 3.15E-4
9 SGTC_1956 st077085 3.40 54.0 µM 1.85E-4 36 3.37E-4
10 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 3.33 70.1 µM 2.44E-4 58 4.33E-4
11 SGTC_908 3448-7491 3.28 47.7 µM 2.92E-4 mitochondrial stress 177 5.10E-4
12 SGTC_3143 9086658 3.22 49.5 µM 3.67E-4 91 6.30E-4
13 SGTC_1914 st062367 3.22 72.6 µM 3.76E-4 45 6.45E-4
14 SGTC_1744 st037937 3.13 38.9 µM 5.20E-4 58 8.67E-4
15 SGTC_944 3370-0224 3.10 231.0 µM 5.79E-4 66 9.57E-4
16 SGTC_1842 st055362 3.10 61.2 µM 5.80E-4 45 9.58E-4
17 SGTC_322 k048-0136 3.05 19.3 µM 7.11E-4 RSC & ERG11 43 0.00115
18 SGTC_950 1165-0508 3.00 94.1 µM 8.47E-4 66 0.00135
19 SGTC_2162 5663267 2.97 200.0 µM 9.30E-4 40 0.00148
20 SGTC_3222 9128301 2.97 49.5 µM 9.44E-4 60S ribosome export 67 0.00150

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.156 1.17E-19 YPL123C RNY1 hom Vacuolar RNase of the T(2) family, relocalizes to the cytosol where it cleaves tRNAs upon oxidative or stationary phase stress; promotes apoptosis under stress conditions and this function is independent of its catalytic activity
0.124 5.15E-13 YLL042C ATG10 hom Conserved E2-like conjugating enzyme that mediates formation of the Atg12p-Atg5p conjugate, which is a critical step in autophagy
0.121 2.22E-12 YMR148W OSW5 hom Protein of unknown function that may play a role in spore wall assembly; predicted to contain an N-terminal transmembrane domain; osw5 null mutant spores exhibit increased spore wall permeability and sensitivity to beta-glucanase digestion
0.094 5.56E-8 YOL014W_p YOL014W_p hom Putative protein of unknown function
0.093 6.16E-8 YNL053W MSG5 hom Dual-specificity protein phosphatase; exists in 2 isoforms; required for maintenance of a low level of signaling through the cell integrity pathway, adaptive response to pheromone; regulates and is regulated by Slt2p; dephosphorylates Fus3p
0.088 3.01E-7 YLL052C AQY2 hom Water channel that mediates the transport of water across cell membranes, only expressed in proliferating cells, controlled by osmotic signals, may be involved in freeze tolerance; disrupted by a stop codon in many S. cerevisiae strains
0.088 5.59E-7 YKR099W BAS1 hom Myb-related transcription factor involved in regulating basal and induced expression of genes of the purine and histidine biosynthesis pathways; also involved in regulation of meiotic recombination at specific genes
0.087 5.03E-7 YHR156C LIN1 hom Non-essential component of U5 snRNP; nuclear protein; physically interacts with Irr1p of cohesin complex; may link together proteins involved in chromosome segregation, mRNA splicing and DNA replication
0.086 6.66E-7 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.086 6.80E-7 YOR152C_p YOR152C_p hom Putative protein of unknown function; YOR152C is not an essential gene
0.085 9.20E-7 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.082 1.92E-6 YMR106C YKU80 hom Subunit of the telomeric Ku complex (Yku70p-Yku80p), involved in telomere length maintenance, structure and telomere position effect; relocates to sites of double-strand cleavage to promote nonhomologous end joining during DSB repair
0.082 2.05E-6 YDL225W SHS1 hom Component of the septin ring that is required for cytokinesis; septins are GTP-binding proteins that assemble into rod-like hetero-oligomers that can associate with other rods to form filaments; septin rings at the mother-bud neck act as scaffolds for recruiting cell division factors and as barriers to prevent diffusion of specific proteins; undergoes sumoylation and phosphorylation during mitosis; protein abundance increases in response to DNA replication stress
0.082 2.21E-6 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.080 3.62E-6 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)