YCR036W / RBK1

Putative ribokinase

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR036W / RBK1

Click on Significant Values for Screen Details ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.63|P-value:7.59E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.80|P-value:9.54E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.97|P-value:5.92E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.45|P-value:1.39E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.71|P-value:5.91E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.85|P-value:8.24E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.11|P-value:3.62E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.31|P-value:1.96E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.91|P-value:6.99E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.68|P-value:1.61E-10 ID:SGTC_592|Compound:k241-0073|FD-Score:4.02|P-value:5.07E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:5.03|P-value:1.98E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.93|P-value:2.74E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.89|P-value:3.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.04|P-value:1.91E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.80|P-value:4.31E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:5.58|P-value:2.52E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.30|P-value:7.28E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.49|P-value:1.21E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.49|P-value:1.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.97|P-value:5.93E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.84|P-value:8.59E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.06|P-value:4.55E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.43|P-value:1.48E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.12|P-value:3.81E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-4.42|P-value:1.37E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.46|P-value:1.34E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.40|P-value:1.62E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.03|P-value:4.96E-4 ID:SGTC_2449|Compound:5812982|FD-Score:5.38|P-value:5.35E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:6.47|P-value:5.99E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.92|P-value:2.90E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.98|P-value:5.78E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.16|P-value:3.37E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.70|P-value:1.59E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.79|P-value:9.93E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.24|P-value:2.66E-4 ID:SGTC_2923|Compound:7992654|FD-Score:6.36|P-value:9.70E-8 ID:SGTC_2940|Compound:9060638|FD-Score:-4.48|P-value:1.12E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.82|P-value:8.44E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.68|P-value:1.70E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-6.32|P-value:1.01E-7 ID:SGTC_2979|Compound:9012552|FD-Score:3.91|P-value:6.97E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.13|P-value:3.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.63|P-value:7.57E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.36|P-value:1.82E-4 ID:SGTC_28|Compound:pentachloropyridine N-oxide|FD-Score:4.63|P-value:7.59E-5 ID:SGTC_88|Compound:0180-0332|FD-Score:3.80|P-value:9.54E-4 ID:SGTC_94|Compound:0334-0113|FD-Score:3.97|P-value:5.92E-4 ID:SGTC_206|Compound:4546-0025|FD-Score:4.45|P-value:1.39E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:4.71|P-value:5.91E-5 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.85|P-value:8.24E-4 ID:SGTC_435|Compound:c-PAF|FD-Score:-4.11|P-value:3.62E-4 ID:SGTC_452|Compound:diindolylmethane|FD-Score:-4.31|P-value:1.96E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:3.91|P-value:6.99E-4 ID:SGTC_562|Compound:3772-2733|FD-Score:7.68|P-value:1.61E-10 ID:SGTC_592|Compound:k241-0073|FD-Score:4.02|P-value:5.07E-4 ID:SGTC_737|Compound:1950-0117|FD-Score:5.03|P-value:1.98E-5 ID:SGTC_753|Compound:1322-0200|FD-Score:4.93|P-value:2.74E-5 ID:SGTC_838|Compound:0109-0203|FD-Score:4.89|P-value:3.16E-5 ID:SGTC_1107|Compound:amlodipine|FD-Score:5.04|P-value:1.91E-5 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.80|P-value:4.31E-5 ID:SGTC_1152|Compound:3909-8331|FD-Score:5.58|P-value:2.52E-6 ID:SGTC_1176|Compound:0848-0131|FD-Score:5.30|P-value:7.28E-6 ID:SGTC_1199|Compound:1638-0010|FD-Score:4.49|P-value:1.21E-4 ID:SGTC_1281|Compound:0884-0031|FD-Score:4.49|P-value:1.21E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:3.97|P-value:5.93E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.84|P-value:8.59E-4 ID:SGTC_1492|Compound:4158-0558|FD-Score:4.06|P-value:4.55E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.43|P-value:1.48E-4 ID:SGTC_1744|Compound:st037937|FD-Score:4.12|P-value:3.81E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-4.42|P-value:1.37E-4 ID:SGTC_1833|Compound:st055984|FD-Score:4.46|P-value:1.34E-4 ID:SGTC_2163|Compound:5671233|FD-Score:4.40|P-value:1.62E-4 ID:SGTC_2379|Compound:9035213|FD-Score:4.03|P-value:4.96E-4 ID:SGTC_2449|Compound:5812982|FD-Score:5.38|P-value:5.35E-6 ID:SGTC_2496|Compound:diffractaic acid|FD-Score:6.47|P-value:5.99E-8 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:4.92|P-value:2.90E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:3.98|P-value:5.78E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:4.16|P-value:3.37E-4 ID:SGTC_2762|Compound:leflunomide|FD-Score:5.70|P-value:1.59E-6 ID:SGTC_2775|Compound:cyproheptadine|FD-Score:3.79|P-value:9.93E-4 ID:SGTC_2851|Compound:9015922|FD-Score:4.24|P-value:2.66E-4 ID:SGTC_2923|Compound:7992654|FD-Score:6.36|P-value:9.70E-8 ID:SGTC_2940|Compound:9060638|FD-Score:-4.48|P-value:1.12E-4 ID:SGTC_2962|Compound:9082311|FD-Score:-3.82|P-value:8.44E-4 ID:SGTC_2963|Compound:9082507|FD-Score:5.68|P-value:1.70E-6 ID:SGTC_2964|Compound:9083345|FD-Score:-6.32|P-value:1.01E-7 ID:SGTC_2979|Compound:9012552|FD-Score:3.91|P-value:6.97E-4 ID:SGTC_3102|Compound:9121669|FD-Score:4.13|P-value:3.74E-4 ID:SGTC_3152|Compound:9099253|FD-Score:4.63|P-value:7.57E-5 ID:SGTC_3255|Compound:9139072|FD-Score:4.36|P-value:1.82E-4

Top fitness defect scores for YCR036W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_562 3772-2733 7.68 112.0 µM 1.61E-10 ERG2 16 7.85E-15
2 SGTC_2496 diffractaic acid 6.47 79.8 µM 5.99E-8 2 4.90E-11
3 SGTC_2923 7992654 6.36 58.1 µM 9.70E-8 Golgi 3 9.99E-11
4 SGTC_2762 leflunomide 5.70 42.1 µM 1.59E-6 5 6.16E-9
5 SGTC_2963 9082507 5.68 9.0 µM 1.70E-6 7 6.76E-9
6 SGTC_1152 3909-8331 5.58 15.9 µM 2.52E-6 1 1.21E-8
7 SGTC_2449 5812982 5.38 45.8 µM 5.35E-6 1 3.66E-8
8 SGTC_1176 0848-0131 5.30 83.3 µM 7.28E-6 Golgi 5 5.76E-8
9 SGTC_1107 amlodipine 5.04 47.0 µM 1.91E-5 15 2.38E-7
10 SGTC_737 1950-0117 5.03 57.9 µM 1.98E-5 9 2.51E-7
11 SGTC_753 1322-0200 4.93 289.0 µM 2.74E-5 4 4.03E-7
12 SGTC_2500 5-alpha-androstan-3,17-dione 4.92 61.4 µM 2.90E-5 23 4.37E-7
13 SGTC_838 0109-0203 4.89 71.4 µM 3.16E-5 5 4.98E-7
14 SGTC_1109 tnp00067 4.80 928.3 nM 4.31E-5 6 7.85E-7
15 SGTC_221 trifluoperazine 4.71 10.3 µM 5.91E-5 NEO1-PIK1 174 1.24E-6
16 SGTC_3152 9099253 4.63 49.5 µM 7.57E-5 NEO1-PIK1 95 1.79E-6
17 SGTC_28 pentachloropyridine N-oxide 4.63 1.6 µM 7.59E-5 TSC3-RPN4 39 1.80E-6
18 SGTC_1281 0884-0031 4.49 11.8 µM 1.21E-4 fatty acid desaturase (OLE1) 16 3.55E-6
19 SGTC_1199 1638-0010 4.49 4.5 µM 1.21E-4 endomembrane recycling 9 3.55E-6
20 SGTC_1833 st055984 4.46 71.0 µM 1.34E-4 10 4.13E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.101 3.99E-9 YLR057W MNL2 hom Putative mannosidase involved in ER-associated protein degradation; localizes to the endoplasmic reticulum; sequence similarity with seven-hairpin glycosidase (GH47) family members, such as Mns1p and Mnl1p, that hydrolyze 1,2-linked alpha-D-mannose residues; non-essential gene
0.101 4.54E-9 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.099 7.86E-9 YJL028W YJL028W hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments
0.096 2.24E-8 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.095 3.15E-8 YCL001W-A_p YCL001W-A_p hom Putative protein of unknown function; YCL001W-A gene has similarity to DOM34 and is present in a region duplicated between chromosomes XIV and III
0.095 3.68E-8 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.093 6.80E-8 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.092 9.36E-8 YOL019W-A_p YOL019W-A_p hom Identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.092 9.66E-8 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.090 1.56E-7 YJR087W_d YJR087W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified genes STE18 and ECM2
0.089 2.61E-7 YOR348C PUT4 hom Proline permease, required for high-affinity transport of proline; also transports the toxic proline analog azetidine-2-carboxylate (AzC); PUT4 transcription is repressed in ammonia-grown cells
0.086 6.17E-7 YMR111C YMR111C hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus; YMR111C is not an essential gene; forms nuclear foci upon DNA replication stress
0.086 6.75E-7 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.084 1.14E-6 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.084 1.14E-6 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p