YCR061W_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern; induced by treatment with 8-methoxypsoralen and UVA irradiation

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR061W / YCR061W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:1.39E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.28|P-value:1.33E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.98|P-value:4.69E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.31|P-value:5.80E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.76|P-value:8.08E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:3.48|P-value:3.27E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.71|P-value:1.39E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.27|P-value:1.40E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.95|P-value:5.29E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.47|P-value:3.25E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.26|P-value:6.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.45|P-value:6.45E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:5.62|P-value:1.77E-8 ID:SGTC_773|Compound:4358-1457|FD-Score:3.19|P-value:8.87E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.96|P-value:5.17E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.23|P-value:7.72E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.54|P-value:2.80E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.32|P-value:5.56E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.05|P-value:3.50E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.44|P-value:6.76E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.29|P-value:6.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.61|P-value:1.94E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.28|P-value:6.57E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.25|P-value:1.53E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.78|P-value:1.05E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.96|P-value:5.06E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.54|P-value:2.57E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.35|P-value:5.06E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.75|P-value:1.62E-6 ID:SGTC_1618|Compound:st003135|FD-Score:5.12|P-value:2.57E-7 ID:SGTC_1620|Compound:st003704|FD-Score:-3.56|P-value:2.34E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.20|P-value:8.25E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.57|P-value:2.32E-4 ID:SGTC_1678|Compound:st019265|FD-Score:5.33|P-value:8.70E-8 ID:SGTC_1682|Compound:st012968|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.31|P-value:5.81E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.19|P-value:8.67E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.50|P-value:5.15E-6 ID:SGTC_1867|Compound:st057372|FD-Score:3.29|P-value:6.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.66|P-value:1.65E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.20|P-value:8.28E-4 ID:SGTC_2025|Compound:5147754|FD-Score:4.03|P-value:3.95E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.51|P-value:2.88E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.56|P-value:2.39E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.17|P-value:9.44E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.51|P-value:2.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.57|P-value:2.38E-8 ID:SGTC_2297|Compound:7971671|FD-Score:-3.25|P-value:7.04E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.56|P-value:6.02E-11 ID:SGTC_2310|Compound:7668677|FD-Score:-3.48|P-value:3.18E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.24|P-value:7.53E-4 ID:SGTC_2441|Compound:5730946|FD-Score:6.69|P-value:2.57E-11 ID:SGTC_2442|Compound:5158906|FD-Score:4.97|P-value:5.49E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.04|P-value:3.72E-5 ID:SGTC_2462|Compound:5162487|FD-Score:4.38|P-value:8.64E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.11|P-value:2.80E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.14|P-value:2.44E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.15|P-value:8.01E-10 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.98|P-value:4.74E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.79|P-value:9.98E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.22|P-value:7.98E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.20|P-value:8.39E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.96|P-value:5.21E-5 ID:SGTC_2985|Compound:9022375|FD-Score:5.06|P-value:3.39E-7 ID:SGTC_3026|Compound:9090633|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.23|P-value:7.58E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.12|P-value:2.69E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.16|P-value:9.87E-4 ID:SGTC_3212|Compound:9128307|FD-Score:7.24|P-value:6.34E-13 ID:SGTC_3213|Compound:9129884|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.31|P-value:5.77E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.71|P-value:1.39E-4 ID:SGTC_93|Compound:0109-0045|FD-Score:3.27|P-value:6.75E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:4.28|P-value:1.33E-5 ID:SGTC_164|Compound:4100-3994|FD-Score:-3.98|P-value:4.69E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:3.34|P-value:5.25E-4 ID:SGTC_241|Compound:5hr heat shock (37°C) + cantharidin|FD-Score:3.31|P-value:5.80E-4 ID:SGTC_243|Compound:5hr heat shock (37°C) + splitomicin|FD-Score:5.76|P-value:8.08E-9 ID:SGTC_278|Compound:4092-0821|FD-Score:3.48|P-value:3.27E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.71|P-value:1.39E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:4.27|P-value:1.40E-5 ID:SGTC_610|Compound:4215-0184|FD-Score:3.95|P-value:5.29E-5 ID:SGTC_611|Compound:3453-1652|FD-Score:-3.47|P-value:3.25E-4 ID:SGTC_616|Compound:4092-0450|FD-Score:-3.26|P-value:6.91E-4 ID:SGTC_691|Compound:1548-0686|FD-Score:4.45|P-value:6.45E-6 ID:SGTC_756|Compound:0508-1999|FD-Score:5.62|P-value:1.77E-8 ID:SGTC_773|Compound:4358-1457|FD-Score:3.19|P-value:8.87E-4 ID:SGTC_806|Compound:3966-4455|FD-Score:3.96|P-value:5.17E-5 ID:SGTC_890|Compound:0929-0006|FD-Score:3.23|P-value:7.72E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:5.54|P-value:2.80E-8 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.32|P-value:5.56E-4 ID:SGTC_1106|Compound:tegaserod maleate|FD-Score:4.05|P-value:3.50E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:4.44|P-value:6.76E-6 ID:SGTC_1178|Compound:0988-0033|FD-Score:3.29|P-value:6.25E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:-3.61|P-value:1.94E-4 ID:SGTC_1305|Compound:1181-0477|FD-Score:3.28|P-value:6.57E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:4.25|P-value:1.53E-5 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.41|P-value:4.18E-4 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.78|P-value:1.05E-4 ID:SGTC_1502|Compound:4534-4282|FD-Score:3.96|P-value:5.06E-5 ID:SGTC_1543|Compound:azetidyl-2-carboxylic acid|FD-Score:3.54|P-value:2.57E-4 ID:SGTC_1571|Compound:st070080|FD-Score:3.35|P-value:5.06E-4 ID:SGTC_1604|Compound:st002052|FD-Score:4.75|P-value:1.62E-6 ID:SGTC_1618|Compound:st003135|FD-Score:5.12|P-value:2.57E-7 ID:SGTC_1620|Compound:st003704|FD-Score:-3.56|P-value:2.34E-4 ID:SGTC_1625|Compound:st003711|FD-Score:-3.20|P-value:8.25E-4 ID:SGTC_1649|Compound:st011737|FD-Score:3.57|P-value:2.32E-4 ID:SGTC_1678|Compound:st019265|FD-Score:5.33|P-value:8.70E-8 ID:SGTC_1682|Compound:st012968|FD-Score:3.73|P-value:1.29E-4 ID:SGTC_1796|Compound:st049173|FD-Score:-3.31|P-value:5.81E-4 ID:SGTC_1799|Compound:st045822|FD-Score:-3.19|P-value:8.67E-4 ID:SGTC_1858|Compound:4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione|FD-Score:4.50|P-value:5.15E-6 ID:SGTC_1867|Compound:st057372|FD-Score:3.29|P-value:6.32E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:-3.66|P-value:1.65E-4 ID:SGTC_2002|Compound:4023503|FD-Score:-3.20|P-value:8.28E-4 ID:SGTC_2025|Compound:5147754|FD-Score:4.03|P-value:3.95E-5 ID:SGTC_2088|Compound:5278280|FD-Score:3.51|P-value:2.88E-4 ID:SGTC_2104|Compound:5389443|FD-Score:3.56|P-value:2.39E-4 ID:SGTC_2194|Compound:5927483|FD-Score:3.17|P-value:9.44E-4 ID:SGTC_2265|Compound:7929201|FD-Score:-3.51|P-value:2.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:5.57|P-value:2.38E-8 ID:SGTC_2297|Compound:7971671|FD-Score:-3.25|P-value:7.04E-4 ID:SGTC_2301|Compound:7769476|FD-Score:6.56|P-value:6.02E-11 ID:SGTC_2310|Compound:7668677|FD-Score:-3.48|P-value:3.18E-4 ID:SGTC_2440|Compound:5628896|FD-Score:3.24|P-value:7.53E-4 ID:SGTC_2441|Compound:5730946|FD-Score:6.69|P-value:2.57E-11 ID:SGTC_2442|Compound:5158906|FD-Score:4.97|P-value:5.49E-7 ID:SGTC_2445|Compound:5742597|FD-Score:4.04|P-value:3.72E-5 ID:SGTC_2462|Compound:5162487|FD-Score:4.38|P-value:8.64E-6 ID:SGTC_2526|Compound:patulin|FD-Score:4.11|P-value:2.80E-5 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:4.14|P-value:2.44E-5 ID:SGTC_2543|Compound:pimpinellin|FD-Score:3.49|P-value:3.07E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:6.15|P-value:8.01E-10 ID:SGTC_2630|Compound:antimycin a|FD-Score:3.98|P-value:4.74E-5 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:-3.79|P-value:9.98E-5 ID:SGTC_2950|Compound:9072895|FD-Score:3.22|P-value:7.98E-4 ID:SGTC_2966|Compound:9084041|FD-Score:-3.20|P-value:8.39E-4 ID:SGTC_2967|Compound:9089538|FD-Score:3.96|P-value:5.21E-5 ID:SGTC_2985|Compound:9022375|FD-Score:5.06|P-value:3.39E-7 ID:SGTC_3026|Compound:9090633|FD-Score:3.70|P-value:1.44E-4 ID:SGTC_3030|Compound:9087619|FD-Score:3.68|P-value:1.53E-4 ID:SGTC_3078|Compound:9116413|FD-Score:-3.23|P-value:7.58E-4 ID:SGTC_3180|Compound:9109287|FD-Score:4.12|P-value:2.69E-5 ID:SGTC_3200|Compound:9114385|FD-Score:3.16|P-value:9.87E-4 ID:SGTC_3212|Compound:9128307|FD-Score:7.24|P-value:6.34E-13 ID:SGTC_3213|Compound:9129884|FD-Score:3.39|P-value:4.46E-4 ID:SGTC_3217|Compound:9129673|FD-Score:4.29|P-value:1.32E-5 ID:SGTC_3278|Compound:9139605|FD-Score:3.31|P-value:5.77E-4

Top fitness defect scores for YCR061W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3212 9128307 7.24 49.5 µM 6.34E-13 7 2.32E-13
2 SGTC_2441 5730946 6.69 39.1 µM 2.57E-11 3 1.09E-11
3 SGTC_2301 7769476 6.56 200.0 µM 6.02E-11 7 2.62E-11
4 SGTC_2583 asiatic acid 6.15 100.0 µM 8.01E-10 12 3.85E-10
5 SGTC_243 5hr heat shock (37°C) + splitomicin 5.76 1.0 µM 8.08E-9 heat shock/prefoldin 16 4.23E-9
6 SGTC_756 0508-1999 5.62 28.3 µM 1.77E-8 RPP1 & pyrimidine depletion 4 9.57E-9
7 SGTC_2274 7947094 5.57 46.1 µM 2.38E-8 6 1.30E-8
8 SGTC_1049 3226-0134 5.54 66.0 µM 2.80E-8 6 1.54E-8
9 SGTC_1678 st019265 5.33 80.2 µM 8.70E-8 60S ribosome export 6 4.99E-8
10 SGTC_1618 st003135 5.12 44.5 µM 2.57E-7 5 1.53E-7
11 SGTC_2985 9022375 5.06 71.4 µM 3.39E-7 RPP1 & pyrimidine depletion 11 2.05E-7
12 SGTC_2442 5158906 4.97 48.5 µM 5.49E-7 6 3.38E-7
13 SGTC_1604 st002052 4.75 72.4 µM 1.62E-6 TSC3-RPN4 13 1.04E-6
14 SGTC_1858 4-chloro-8-(diethylamino)pyrano[3,2-c]chromene-2,5-dione 4.50 62.6 µM 5.15E-6 TSC3-RPN4 9 3.44E-6
15 SGTC_691 1548-0686 4.45 185.0 µM 6.45E-6 20 4.35E-6
16 SGTC_1123 mangostin 4.44 811.3 nM 6.76E-6 mitochondrial response to ROS 25 4.56E-6
17 SGTC_2462 5162487 4.38 171.8 µM 8.64E-6 13 5.89E-6
18 SGTC_3217 9129673 4.29 49.5 µM 1.32E-5 28 9.10E-6
19 SGTC_103 0844-0104 4.28 51.8 µM 1.33E-5 ERAD & cell cycle 129 9.21E-6
20 SGTC_404 fumagillin 4.27 50.0 µM 1.40E-5 14 9.69E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.116 1.54E-11 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.097 1.75E-8 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.087 4.46E-7 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.087 4.67E-7 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.087 4.99E-7 YLR027C AAT2 hom Cytosolic aspartate aminotransferase, involved in nitrogen metabolism; localizes to peroxisomes in oleate-grown cells
0.084 1.09E-6 YLR307C-A_p YLR307C-A_p hom Putative protein of unknown function
0.082 1.81E-6 YDR260C SWM1 hom Subunit of the anaphase-promoting complex, which is an E3 ubiquitin ligase that regulates the metaphase-anaphase transition and exit from mitosis; required for activation of the daughter-specific gene expression and spore wall maturation
0.081 2.47E-6 YNL179C_d YNL179C_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; deletion in cyr1 mutant results in loss of stress resistance
0.080 3.41E-6 YOR138C RUP1 hom Protein that regulates Rsp5p, which is a HECT ubiquitin ligase; has a WW domain consensus motif of PPPSY (residues 131-135) that mediates binding of Rsp5p to Ubp2p; contains an UBA domain; relative distribution to the nucleus increases upon DNA replication stress
0.080 3.64E-6 YCR026C NPP1 hom Nucleotide pyrophosphatase/phosphodiesterase; mediates extracellular nucleotide phosphate hydrolysis along with Npp2p and Pho5p; activity and expression enhanced during conditions of phosphate starvation; NPP1 has a paralog, NPP2, that arose from the whole genome duplication
0.078 5.51E-6 YBR058C UBP14 hom Ubiquitin-specific protease that specifically disassembles unanchored ubiquitin chains; involved in fructose-1,6-bisphosphatase (Fbp1p) degradation; similar to human isopeptidase T
0.076 1.03E-5 YER077C_p YER077C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.074 1.72E-5 YBL068W PRS4 hom 5-phospho-ribosyl-1(alpha)-pyrophosphate synthetase, synthesizes PRPP, which is required for nucleotide, histidine, and tryptophan biosynthesis; one of five related enzymes, which are active as heteromultimeric complexes; PRS4 has a paralog, PRS2, that arose from the whole genome duplication
0.074 1.73E-5 YNL115C_p YNL115C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria; YNL115C is not an essential gene
0.073 2.61E-5 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA