YCR092C / MSH3

Mismatch repair protein, forms dimers with Msh2p that mediate repair of insertion or deletion mutations and removal of nonhomologous DNA ends, contains a PCNA (Pol30p) binding motif required for genome stability

Zygosity: Homozygous strain
fixedexpanded
Profile for YCR092C / MSH3

Click on Significant Values for Screen Details ID:SGTC_35|Compound:0133-0054|FD-Score:-3.32|P-value:9.36E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.53|P-value:4.75E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.30|P-value:8.77E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:4.88|P-value:1.93E-6 ID:SGTC_269|Compound:exalamide|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.81|P-value:1.81E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.30|P-value:8.66E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.57|P-value:3.55E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.48|P-value:4.57E-10 ID:SGTC_606|Compound:k015-0008|FD-Score:4.67|P-value:4.93E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.97|P-value:8.59E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.44|P-value:5.47E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.46|P-value:5.13E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:6.34|P-value:1.01E-9 ID:SGTC_799|Compound:1310-0557|FD-Score:3.93|P-value:9.95E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.44|P-value:1.30E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.73|P-value:2.01E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.55|P-value:3.82E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.29|P-value:9.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.69|P-value:2.38E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.06|P-value:6.10E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.43|P-value:5.82E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:5.58|P-value:6.43E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.38|P-value:6.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.59|P-value:3.86E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.38|P-value:6.85E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.06|P-value:8.28E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.60|P-value:6.58E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.28|P-value:2.90E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.26|P-value:9.86E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.63|P-value:5.17E-8 ID:SGTC_1821|Compound:st053465|FD-Score:3.83|P-value:1.41E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.93|P-value:9.80E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.97|P-value:8.39E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.36|P-value:1.86E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.61|P-value:5.70E-8 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.00|P-value:7.58E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.50|P-value:4.57E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.82|P-value:1.50E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.45|P-value:5.34E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.56|P-value:7.76E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.58|P-value:3.98E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.50|P-value:4.03E-10 ID:SGTC_3158|Compound:9100007|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.93|P-value:1.55E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.04|P-value:6.37E-5 ID:SGTC_35|Compound:0133-0054|FD-Score:-3.32|P-value:9.36E-4 ID:SGTC_129|Compound:0088-0017|FD-Score:-3.53|P-value:4.75E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:3.30|P-value:8.77E-4 ID:SGTC_237|Compound:nikkomycin|FD-Score:4.88|P-value:1.93E-6 ID:SGTC_269|Compound:exalamide|FD-Score:-3.83|P-value:1.66E-4 ID:SGTC_278|Compound:4092-0821|FD-Score:-3.81|P-value:1.81E-4 ID:SGTC_332|Compound:4112-0506|FD-Score:3.30|P-value:8.66E-4 ID:SGTC_336|Compound:4111-0029|FD-Score:3.57|P-value:3.55E-4 ID:SGTC_413|Compound:propylparaben|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_594|Compound:1487-1584|FD-Score:6.48|P-value:4.57E-10 ID:SGTC_606|Compound:k015-0008|FD-Score:4.67|P-value:4.93E-6 ID:SGTC_626|Compound:0214-0009|FD-Score:3.97|P-value:8.59E-5 ID:SGTC_724|Compound:3910-0327|FD-Score:3.44|P-value:5.47E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.46|P-value:5.13E-4 ID:SGTC_764|Compound:1951-2361|FD-Score:6.34|P-value:1.01E-9 ID:SGTC_799|Compound:1310-0557|FD-Score:3.93|P-value:9.95E-5 ID:SGTC_811|Compound:0416-0114|FD-Score:3.80|P-value:1.60E-4 ID:SGTC_860|Compound:0443-0016|FD-Score:3.78|P-value:1.73E-4 ID:SGTC_971|Compound:1315-0384|FD-Score:4.44|P-value:1.30E-5 ID:SGTC_1017|Compound:4239-0030|FD-Score:3.73|P-value:2.01E-4 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.55|P-value:3.82E-4 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.29|P-value:9.08E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.69|P-value:2.38E-4 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.06|P-value:6.10E-5 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.66|P-value:2.58E-4 ID:SGTC_1193|Compound:1488-0126|FD-Score:3.56|P-value:3.71E-4 ID:SGTC_1325|Compound:1431-0015|FD-Score:3.43|P-value:5.82E-4 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.49|P-value:4.69E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:5.58|P-value:6.43E-8 ID:SGTC_1367|Compound:1812-0510|FD-Score:3.38|P-value:6.82E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:-3.59|P-value:3.86E-4 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.38|P-value:6.85E-4 ID:SGTC_1381|Compound:2324-0066|FD-Score:5.06|P-value:8.28E-7 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.60|P-value:6.58E-6 ID:SGTC_1484|Compound:3473-2379|FD-Score:5.28|P-value:2.90E-7 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:3.29|P-value:9.10E-4 ID:SGTC_1663|Compound:st014140|FD-Score:3.26|P-value:9.86E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.63|P-value:5.17E-8 ID:SGTC_1821|Compound:st053465|FD-Score:3.83|P-value:1.41E-4 ID:SGTC_1853|Compound:st056710|FD-Score:3.93|P-value:9.80E-5 ID:SGTC_2018|Compound:5133068|FD-Score:3.97|P-value:8.39E-5 ID:SGTC_2154|Compound:5570129|FD-Score:4.36|P-value:1.86E-5 ID:SGTC_2339|Compound:9000433|FD-Score:5.61|P-value:5.70E-8 ID:SGTC_2351|Compound:9026858|FD-Score:3.85|P-value:1.30E-4 ID:SGTC_2561|Compound:acetosyringone|FD-Score:4.00|P-value:7.58E-5 ID:SGTC_2566|Compound:crystal violet carbinol|FD-Score:3.50|P-value:4.57E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:3.82|P-value:1.50E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.45|P-value:5.34E-4 ID:SGTC_2767|Compound:sibutramine|FD-Score:3.87|P-value:1.22E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:4.56|P-value:7.76E-6 ID:SGTC_2896|Compound:9052656|FD-Score:-3.58|P-value:3.98E-4 ID:SGTC_2995|Compound:9067767|FD-Score:6.50|P-value:4.03E-10 ID:SGTC_3158|Compound:9100007|FD-Score:3.54|P-value:3.92E-4 ID:SGTC_3167|Compound:9103034|FD-Score:3.82|P-value:1.49E-4 ID:SGTC_3218|Compound:9131285|FD-Score:4.93|P-value:1.55E-6 ID:SGTC_3233|Compound:9132340|FD-Score:3.66|P-value:2.59E-4 ID:SGTC_3350|Compound:9150499|FD-Score:4.04|P-value:6.37E-5

Top fitness defect scores for YCR092C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2995 9067767 6.50 71.4 µM 4.03E-10 3 4.04E-11
2 SGTC_594 1487-1584 6.48 10.8 µM 4.57E-10 5 4.66E-11
3 SGTC_764 1951-2361 6.34 146.0 µM 1.01E-9 5 1.13E-10
4 SGTC_1785 bathophenanthroline 5.63 24.0 µM 5.17E-8 heme requiring 14 9.25E-9
5 SGTC_2339 9000433 5.61 200.0 µM 5.70E-8 5 1.03E-8
6 SGTC_1330 1469-0054 5.58 61.8 µM 6.43E-8 iron homeostasis 2 1.18E-8
7 SGTC_1484 3473-2379 5.28 286.0 µM 2.90E-7 3 6.37E-8
8 SGTC_1381 2324-0066 5.06 62.1 µM 8.28E-7 12 2.06E-7
9 SGTC_3218 9131285 4.93 49.5 µM 1.55E-6 endomembrane recycling 18 4.14E-7
10 SGTC_237 nikkomycin 4.88 200.0 µM 1.93E-6 RSC complex & mRNA processing 8 5.30E-7
11 SGTC_606 k015-0008 4.67 38.6 µM 4.93E-6 4 1.51E-6
12 SGTC_1446 4239-0190 4.60 62.0 µM 6.58E-6 22 2.08E-6
13 SGTC_2776 terbinafine 4.56 19.9 µM 7.76E-6 cell wall signaling 41 2.50E-6
14 SGTC_971 1315-0384 4.44 26.7 µM 1.30E-5 cell wall signaling 15 4.46E-6
15 SGTC_2154 5570129 4.36 200.0 µM 1.86E-5 6 6.64E-6
16 SGTC_1122 capsaicin 4.06 818.6 nM 6.10E-5 24 2.50E-5
17 SGTC_3350 9150499 4.04 3.6 µM 6.37E-5 cell wall 51 2.62E-5
18 SGTC_2561 acetosyringone 4.00 100.0 µM 7.58E-5 21 3.18E-5
19 SGTC_2018 5133068 3.97 143.0 µM 8.39E-5 22 3.56E-5
20 SGTC_626 0214-0009 3.97 33.0 µM 8.59E-5 copper-dependent oxidative stress 19 3.65E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.099 8.41E-9 YGR175C ERG1 het Squalene epoxidase, catalyzes the epoxidation of squalene to 2,3-oxidosqualene; plays an essential role in the ergosterol-biosynthesis pathway and is the specific target of the antifungal drug terbinafine
0.090 1.96E-7 YDL231C BRE4 hom Zinc finger protein containing five transmembrane domains; null mutant exhibits strongly fragmented vacuoles and sensitivity to brefeldin A, a drug which is known to affect intracellular transport
0.086 5.99E-7 YBR161W CSH1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Sur1p; CSH1 has a paralog, SUR1, that arose from the whole genome duplication
0.081 2.30E-6 YPL097W MSY1 hom Mitochondrial tyrosyl-tRNA synthetase
0.078 6.41E-6 YGL080W FMP37 hom Highly conserved subunit of the mitochondrial pyruvate carrier; a mitochondrial inner membrane complex comprised of Fmp37p/Mpc1p and either Mpc2p or Fmp43p/Mpc3p mediates mitochondrial pyruvate uptake; null mutant displays slow growth that is complemented by expression of human or mouse ortholog; mutation in human ortholog is associated with lactic acidosis and hyperpyruvatemia
0.073 2.11E-5 YKR076W ECM4 hom Omega class glutathione transferase; not essential; similar to Ygr154cp; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.073 2.58E-5 YHR105W YPT35 hom Endosomal protein of unknown function that contains a phox (PX) homology domain and binds to both phosphatidylinositol-3-phosphate (PtdIns(3)P) and proteins involved in ER-Golgi or vesicular transport
0.067 9.47E-5 YPL034W_p YPL034W_p hom Putative protein of unknown function; YPL034W is not essential gene
0.067 9.71E-5 YER021W RPN3 het Essential, non-ATPase regulatory subunit of the 26S proteasome lid, similar to the p58 subunit of the human 26S proteasome; temperature-sensitive alleles cause metaphase arrest, suggesting a role for the proteasome in cell cycle control
0.066 1.32E-4 YNL298W CLA4 hom Cdc42p-activated signal transducing kinase of the PAK (p21-activated kinase) family, along with Ste20p and Skm1p; involved in septin ring assembly, vacuole inheritance, cytokinesis, sterol uptake regulation; phosphorylates Cdc3p and Cdc10p
0.066 1.34E-4 YHR080C YHR080C hom Protein of unknown function; may interact with ribosomes, based on co-purification experiments; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; YHR080C has a paralog, YSP2, that arose from the whole genome duplication
0.065 1.60E-4 YOL115W PAP2 hom Non-canonical poly(A) polymerase, involved in nuclear RNA degradation as a component of the TRAMP complex; catalyzes polyadenylation of hypomodified tRNAs, and snoRNA and rRNA precursors; overlapping but non-redundant functions with Trf5p
0.065 1.64E-4 YER097W_d YER097W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.064 2.27E-4 YDR032C PST2 hom Protein with similarity to a family of flavodoxin-like proteins; induced by oxidative stress in a Yap1p dependent manner; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; protein abundance increases in response to DNA replication stress; PST2 has a paralog, RFS1, that arose from the whole genome duplication
0.063 2.40E-4 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication