YDL080C / THI3

Probable alpha-ketoisocaproate decarboxylase, may have a role in catabolism of amino acids to long-chain and complex alcohols; required for expression of enzymes involved in thiamine biosynthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL080C / THI3

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.31|P-value:2.14E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:7.50|P-value:6.71E-16 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.05|P-value:5.74E-11 ID:SGTC_123|Compound:0083-0120|FD-Score:6.81|P-value:1.99E-13 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.99|P-value:1.07E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.51|P-value:8.70E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.06|P-value:5.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.48|P-value:9.22E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.57|P-value:6.79E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.62|P-value:4.42E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.62|P-value:4.03E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.19|P-value:3.43E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.35|P-value:1.83E-6 ID:SGTC_640|Compound:3381-0960|FD-Score:3.16|P-value:3.90E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.22|P-value:1.32E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.10|P-value:4.80E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.93|P-value:9.09E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.75|P-value:3.09E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:6.23|P-value:1.60E-11 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.48|P-value:9.10E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:8.47|P-value:9.08E-20 ID:SGTC_956|Compound:1185-0240|FD-Score:7.39|P-value:1.70E-15 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.73|P-value:3.41E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.34|P-value:1.92E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:25.50|P-value:4.66E-163 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.61|P-value:5.69E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.98|P-value:5.74E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.02|P-value:6.28E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.65|P-value:5.08E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.40|P-value:1.38E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.85|P-value:2.04E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.33|P-value:2.01E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:2.97|P-value:7.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.02|P-value:6.12E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.19|P-value:3.42E-4 ID:SGTC_2414|Compound:st077232|FD-Score:2.99|P-value:7.19E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.11|P-value:4.59E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.35|P-value:1.80E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.11|P-value:4.36E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.38|P-value:1.51E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.15|P-value:3.94E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.62|P-value:5.53E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.97|P-value:1.14E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-3.72|P-value:3.53E-5 ID:SGTC_3073|Compound:9114972|FD-Score:-3.60|P-value:6.06E-5 ID:SGTC_3147|Compound:9097027|FD-Score:2.96|P-value:8.06E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.31|P-value:2.14E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:7.50|P-value:6.71E-16 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:6.05|P-value:5.74E-11 ID:SGTC_123|Compound:0083-0120|FD-Score:6.81|P-value:1.99E-13 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:3.19|P-value:3.36E-4 ID:SGTC_298|Compound:1391-0729|FD-Score:3.99|P-value:1.07E-5 ID:SGTC_323|Compound:4013-0906|FD-Score:3.48|P-value:1.07E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:-3.51|P-value:8.70E-5 ID:SGTC_347|Compound:4534-1311|FD-Score:-3.06|P-value:5.44E-4 ID:SGTC_352|Compound:k048-0007|FD-Score:4.48|P-value:9.22E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:-3.57|P-value:6.79E-5 ID:SGTC_397|Compound:arbidol|FD-Score:4.62|P-value:4.42E-7 ID:SGTC_407|Compound:eburnamonine|FD-Score:-4.62|P-value:4.03E-7 ID:SGTC_416|Compound:estradiol valerate|FD-Score:3.19|P-value:3.43E-4 ID:SGTC_418|Compound:lividomycin a|FD-Score:3.26|P-value:2.59E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.25|P-value:2.72E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:3.09|P-value:5.06E-4 ID:SGTC_491|Compound:tetrandrine|FD-Score:4.35|P-value:1.83E-6 ID:SGTC_640|Compound:3381-0960|FD-Score:3.16|P-value:3.90E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:5.22|P-value:1.32E-8 ID:SGTC_743|Compound:1275-0778|FD-Score:3.10|P-value:4.80E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.93|P-value:9.09E-4 ID:SGTC_867|Compound:0518-0118|FD-Score:-3.75|P-value:3.09E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:6.23|P-value:1.60E-11 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.48|P-value:9.10E-7 ID:SGTC_923|Compound:1900-2434|FD-Score:8.47|P-value:9.08E-20 ID:SGTC_956|Compound:1185-0240|FD-Score:7.39|P-value:1.70E-15 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.73|P-value:3.41E-5 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.34|P-value:1.92E-6 ID:SGTC_1226|Compound:3909-7979|FD-Score:25.50|P-value:4.66E-163 ID:SGTC_1231|Compound:0242-0792|FD-Score:-3.61|P-value:5.69E-5 ID:SGTC_1240|Compound:0356-0016|FD-Score:4.98|P-value:5.74E-8 ID:SGTC_1340|Compound:1486-1359|FD-Score:-3.02|P-value:6.28E-4 ID:SGTC_1371|Compound:2421-0008|FD-Score:3.03|P-value:6.35E-4 ID:SGTC_1563|Compound:conessine|FD-Score:3.65|P-value:5.08E-5 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:4.40|P-value:1.38E-6 ID:SGTC_1568|Compound:digitonin|FD-Score:4.00|P-value:1.01E-5 ID:SGTC_1569|Compound:carminic acid|FD-Score:3.85|P-value:2.04E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:4.33|P-value:2.01E-6 ID:SGTC_1589|Compound:2',5'-dimethoxyflavone|FD-Score:-3.36|P-value:1.65E-4 ID:SGTC_1975|Compound:st070967|FD-Score:3.24|P-value:2.87E-4 ID:SGTC_2170|Compound:morpholine|FD-Score:2.97|P-value:7.83E-4 ID:SGTC_2176|Compound:5809774|FD-Score:-3.02|P-value:6.12E-4 ID:SGTC_2180|Compound:6301957|FD-Score:3.19|P-value:3.42E-4 ID:SGTC_2414|Compound:st077232|FD-Score:2.99|P-value:7.19E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.11|P-value:4.59E-4 ID:SGTC_2690|Compound:usnic acid|FD-Score:4.35|P-value:1.80E-6 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:3.16|P-value:3.86E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-3.11|P-value:4.36E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.38|P-value:1.51E-4 ID:SGTC_2957|Compound:9076800|FD-Score:3.15|P-value:3.94E-4 ID:SGTC_2999|Compound:9069765|FD-Score:-3.62|P-value:5.53E-5 ID:SGTC_3069|Compound:9117009|FD-Score:-3.97|P-value:1.14E-5 ID:SGTC_3071|Compound:9117417|FD-Score:-3.72|P-value:3.53E-5 ID:SGTC_3073|Compound:9114972|FD-Score:-3.60|P-value:6.06E-5 ID:SGTC_3147|Compound:9097027|FD-Score:2.96|P-value:8.06E-4

Top fitness defect scores for YDL080C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1226 3909-7979 25.50 35.4 µM 4.66E-163 1 1.06E-143
2 SGTC_923 1900-2434 8.47 73.3 µM 9.08E-20 RNA processing & uracil transport 4 1.25E-17
3 SGTC_54 0159-0055 7.50 9.0 µM 6.71E-16 ERG2 15 3.22E-14
4 SGTC_956 1185-0240 7.39 191.0 µM 1.70E-15 3 7.30E-14
5 SGTC_123 0083-0120 6.81 66.7 µM 1.99E-13 13 4.88E-12
6 SGTC_909 3448-9333 6.23 149.0 µM 1.60E-11 2 2.34E-10
7 SGTC_120 rhodamine 6G 6.05 52.3 µM 5.74E-11 mitochondrial processes 8 7.22E-10
8 SGTC_647 0140-0236 5.22 81.0 µM 1.32E-8 3 8.80E-8
9 SGTC_1240 0356-0016 4.98 42.1 µM 5.74E-8 mitochondrial response to ROS 17 3.22E-7
10 SGTC_397 arbidol 4.62 50.0 µM 4.42E-7 cell wall 12 1.96E-6
11 SGTC_915 methyl methanesulfonate (MMS) 4.48 110.0 mM 9.10E-7 DNA damage response 27 3.71E-6
12 SGTC_352 k048-0007 4.48 5.1 µM 9.22E-7 ERAD & cell cycle 61 3.75E-6
13 SGTC_1566 6,7-dimethoxy-4-ethylcoumarin 4.40 85.4 µM 1.38E-6 14 5.38E-6
14 SGTC_2690 usnic acid 4.35 100.0 µM 1.80E-6 20 6.79E-6
15 SGTC_491 tetrandrine 4.35 80.3 µM 1.83E-6 8 6.90E-6
16 SGTC_1223 0764-0573 4.34 147.0 µM 1.92E-6 12 7.20E-6
17 SGTC_1572 epiandrosterone 4.33 68.9 µM 2.01E-6 22 7.47E-6
18 SGTC_1568 digitonin 4.00 820.0 nM 1.01E-5 sphingolipid biosynthesis & PDR1 30 3.12E-5
19 SGTC_298 1391-0729 3.99 10.0 µM 1.07E-5 calcium & mitochondrial duress 19 3.28E-5
20 SGTC_1569 carminic acid 3.85 40.6 µM 2.04E-5 17 5.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.248 2.99E-48 YBR068C BAP2 hom High-affinity leucine permease; functions as a branched-chain amino acid permease involved in uptake of leucine, isoleucine and valine; contains 12 predicted transmembrane domains; BAP2 has a paralog, BAP3, that arose from the whole genome duplication
0.211 3.27E-35 YOR016C ERP4 hom Protein with similarity to Emp24p and Erv25p, member of the p24 family involved in ER to Golgi transport
0.160 1.55E-20 YGR096W TPC1 hom Mitochondrial membrane transporter that mediates uptake of the essential cofactor thiamine pyrophosphate (ThPP) into mitochondria; expression appears to be regulated by carbon source; member of the mitochondrial carrier family
0.140 3.46E-16 YCR095C_p OCA4_p hom Cytoplasmic protein required for replication of Brome mosaic virus in S. cerevisiae, which is a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.137 1.57E-15 YGR071C ENV11 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and fragmented vacuoles; deletion mutant has increased glycogen accumulation and displays elongated buds; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.133 8.71E-15 YJR046W TAH11 het DNA replication licensing factor, required for pre-replication complex assembly
0.132 1.82E-14 YOR297C TIM18 hom Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane; may mediate assembly or stability of the complex
0.130 4.28E-14 YNL032W SIW14 hom Tyrosine phosphatase that plays a role in actin filament organization and endocytosis; localized to the cytoplasm
0.129 5.81E-14 YGR204W ADE3 hom Cytoplasmic trifunctional enzyme C1-tetrahydrofolate synthase, involved in single carbon metabolism and required for biosynthesis of purines, thymidylate, methionine, and histidine; null mutation causes auxotrophy for adenine and histidine
0.124 5.37E-13 YDL119C_p YDL119C_p hom Putative mitochondrial transport protein; GFP-fusion protein is induced in response to the DNA-damaging agent MMS; the authentic, non-tagged protein is detected in purified mitochondria
0.123 1.04E-12 YOR245C DGA1 hom Diacylglycerol acyltransferase, catalyzes the terminal step of triacylglycerol (TAG) formation, acylates diacylglycerol using acyl-CoA as an acyl donor, localized to lipid particles
0.119 5.57E-12 YML113W DAT1 hom DNA binding protein that recognizes oligo(dA).oligo(dT) tracts; Arg side chain in its N-terminal pentad Gly-Arg-Lys-Pro-Gly repeat is required for DNA-binding; not essential for viability
0.116 1.69E-11 YDR306C_p YDR306C_p hom F-box protein of unknown function; interacts with Sgt1p via a Leucine-Rich Repeat (LRR) domain
0.113 6.42E-11 YJL214W HXT8 hom Protein of unknown function with similarity to hexose transporter family members, expression is induced by low levels of glucose and repressed by high levels of glucose
0.112 7.47E-11 YGR201C_p YGR201C_p hom Putative protein of unknown function