YDL082W / RPL13A

Ribosomal 60S subunit protein L13A; not essential for viability; homologous to mammalian ribosomal protein L13, no bacterial homolog; RPL13A has a paralog, RPL13B, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL082W / RPL13A

Click on Significant Values for Screen Details ID:SGTC_12|Compound:0849-0099|FD-Score:-3.99|P-value:3.25E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.88|P-value:5.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.85|P-value:1.95E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:2.94|P-value:9.12E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.34|P-value:4.46E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.46|P-value:2.83E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.30|P-value:2.40E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:6.12|P-value:8.83E-11 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.78|P-value:7.92E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.27|P-value:2.73E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:2.92|P-value:9.57E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.41|P-value:1.88E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.32|P-value:2.25E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.70|P-value:4.75E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.06|P-value:2.50E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.14|P-value:6.88E-6 ID:SGTC_1761|Compound:st044296|FD-Score:4.19|P-value:5.39E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.23|P-value:3.22E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.15|P-value:8.70E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.32|P-value:4.82E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.24|P-value:1.08E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.84|P-value:6.20E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-4.89|P-value:4.51E-7 ID:SGTC_2082|Compound:5219693|FD-Score:2.99|P-value:7.71E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.22|P-value:6.98E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.19|P-value:3.73E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.43|P-value:1.65E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.60|P-value:6.98E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-4.31|P-value:7.83E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.78|P-value:3.40E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.67|P-value:1.27E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.32|P-value:4.75E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.05|P-value:6.23E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.49|P-value:3.35E-15 ID:SGTC_2754|Compound:granisetron|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.21|P-value:7.05E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.11|P-value:7.96E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.72|P-value:4.42E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.63|P-value:6.35E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.39|P-value:3.69E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.01|P-value:3.07E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.01|P-value:3.11E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-4.25|P-value:1.05E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.85|P-value:5.51E-7 ID:SGTC_3040|Compound:9091894|FD-Score:-3.80|P-value:7.45E-5 ID:SGTC_3150|Compound:9097574|FD-Score:2.94|P-value:9.12E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.70|P-value:1.10E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_12|Compound:0849-0099|FD-Score:-3.99|P-value:3.25E-5 ID:SGTC_44|Compound:0929-0055|FD-Score:-3.88|P-value:5.38E-5 ID:SGTC_118|Compound:0083-0097|FD-Score:4.85|P-value:1.95E-7 ID:SGTC_130|Compound:0136-0219|FD-Score:2.94|P-value:9.12E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.22|P-value:3.30E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-3.34|P-value:4.46E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.46|P-value:2.83E-4 ID:SGTC_800|Compound:3448-7362|FD-Score:3.30|P-value:2.40E-4 ID:SGTC_832|Compound:4083-0019|FD-Score:6.12|P-value:8.83E-11 ID:SGTC_984|Compound:1492-0255|FD-Score:-3.78|P-value:7.92E-5 ID:SGTC_1018|Compound:4259-0013|FD-Score:3.05|P-value:6.08E-4 ID:SGTC_1031|Compound:k035-0009|FD-Score:3.27|P-value:2.73E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:2.92|P-value:9.57E-4 ID:SGTC_1338|Compound:1486-1223|FD-Score:4.41|P-value:1.88E-6 ID:SGTC_1339|Compound:1486-1321|FD-Score:3.14|P-value:4.37E-4 ID:SGTC_1569|Compound:carminic acid|FD-Score:-3.52|P-value:2.30E-4 ID:SGTC_1580|Compound:hydrocortisone 21-hemisuccinate|FD-Score:3.32|P-value:2.25E-4 ID:SGTC_1630|Compound:st005209|FD-Score:3.36|P-value:1.89E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-3.71|P-value:1.05E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.70|P-value:4.75E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.06|P-value:2.50E-5 ID:SGTC_1759|Compound:st043059|FD-Score:4.14|P-value:6.88E-6 ID:SGTC_1761|Compound:st044296|FD-Score:4.19|P-value:5.39E-6 ID:SGTC_1769|Compound:st044406|FD-Score:3.23|P-value:3.22E-4 ID:SGTC_1852|Compound:st056254|FD-Score:-3.15|P-value:8.70E-4 ID:SGTC_1856|Compound:st057054|FD-Score:-3.32|P-value:4.82E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.24|P-value:1.08E-5 ID:SGTC_2066|Compound:5222451|FD-Score:-3.84|P-value:6.20E-5 ID:SGTC_2079|Compound:5212404|FD-Score:-4.89|P-value:4.51E-7 ID:SGTC_2082|Compound:5219693|FD-Score:2.99|P-value:7.71E-4 ID:SGTC_2142|Compound:5622915|FD-Score:3.46|P-value:1.30E-4 ID:SGTC_2246|Compound:7293507|FD-Score:3.50|P-value:1.09E-4 ID:SGTC_2336|Compound:9001819|FD-Score:-3.22|P-value:6.98E-4 ID:SGTC_2337|Compound:9009472|FD-Score:3.19|P-value:3.73E-4 ID:SGTC_2403|Compound:6032726|FD-Score:4.43|P-value:1.65E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.60|P-value:6.98E-7 ID:SGTC_2462|Compound:5162487|FD-Score:-4.31|P-value:7.83E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.78|P-value:3.40E-5 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-3.67|P-value:1.27E-4 ID:SGTC_2616|Compound:abietic acid|FD-Score:-3.32|P-value:4.75E-4 ID:SGTC_2654|Compound:protoveratrine a|FD-Score:3.05|P-value:6.23E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:7.49|P-value:3.35E-15 ID:SGTC_2754|Compound:granisetron|FD-Score:3.38|P-value:1.78E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.21|P-value:7.05E-4 ID:SGTC_2829|Compound:7992743|FD-Score:4.11|P-value:7.96E-6 ID:SGTC_2856|Compound:9022925|FD-Score:3.72|P-value:4.42E-5 ID:SGTC_2857|Compound:9024691|FD-Score:3.63|P-value:6.35E-5 ID:SGTC_2878|Compound:9043973|FD-Score:-3.39|P-value:3.69E-4 ID:SGTC_2908|Compound:7930301|FD-Score:3.44|P-value:1.42E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.01|P-value:3.07E-5 ID:SGTC_2928|Compound:9011484|FD-Score:-4.01|P-value:3.11E-5 ID:SGTC_2942|Compound:9052777|FD-Score:-4.25|P-value:1.05E-5 ID:SGTC_3037|Compound:9091026|FD-Score:-4.85|P-value:5.51E-7 ID:SGTC_3040|Compound:9091894|FD-Score:-3.80|P-value:7.45E-5 ID:SGTC_3150|Compound:9097574|FD-Score:2.94|P-value:9.12E-4 ID:SGTC_3152|Compound:9099253|FD-Score:-3.70|P-value:1.10E-4 ID:SGTC_3179|Compound:9107801|FD-Score:3.44|P-value:1.43E-4

Top fitness defect scores for YDL082W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2688 kanamycin b 7.49 96.7 µM 3.35E-15 calcium & mitochondrial duress 86 3.35E-14
2 SGTC_832 4083-0019 6.12 164.0 µM 8.83E-11 translation 16 4.70E-10
3 SGTC_118 0083-0097 4.85 135.3 µM 1.95E-7 translation 68 6.33E-7
4 SGTC_2405 ticlatone 4.60 3.5 µM 6.98E-7 47 2.08E-6
5 SGTC_2403 6032726 4.43 181.2 µM 1.65E-6 25 4.65E-6
6 SGTC_1338 1486-1223 4.41 76.0 µM 1.88E-6 9 5.25E-6
7 SGTC_1761 st044296 4.19 37.0 µM 5.39E-6 10 1.40E-5
8 SGTC_1759 st043059 4.14 70.0 µM 6.88E-6 amide catabolism 24 1.76E-5
9 SGTC_2829 7992743 4.11 58.4 µM 7.96E-6 31 2.01E-5
10 SGTC_2578 7,8-dihydroxyflavone 3.78 64.4 µM 3.40E-5 34 7.77E-5
11 SGTC_2856 9022925 3.72 19.5 µM 4.42E-5 26 9.93E-5
12 SGTC_1735 st034310 3.70 56.8 µM 4.75E-5 Golgi 36 1.06E-4
13 SGTC_2857 9024691 3.63 58.4 µM 6.35E-5 33 1.39E-4
14 SGTC_2246 7293507 3.50 91.6 µM 1.09E-4 40 2.30E-4
15 SGTC_2142 5622915 3.46 118.5 µM 1.30E-4 20 2.70E-4
16 SGTC_2908 7930301 3.44 100.0 µM 1.42E-4 49 2.95E-4
17 SGTC_3179 9107801 3.44 49.5 µM 1.43E-4 22 2.95E-4
18 SGTC_2754 granisetron 3.38 64.0 µM 1.78E-4 52 3.62E-4
19 SGTC_1630 st005209 3.36 31.3 µM 1.89E-4 49 3.83E-4
20 SGTC_1580 hydrocortisone 21-hemisuccinate 3.32 43.2 µM 2.25E-4 38 4.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.191 8.52E-29 YNL227C JJJ1 hom Co-chaperone that stimulates the ATPase activity of Ssa1p, required for a late step of ribosome biogenesis; associated with the cytosolic large ribosomal subunit; contains a J-domain; mutation causes defects in fluid-phase endocytosis
0.187 7.42E-28 YEL054C RPL12A hom Ribosomal 60S subunit protein L12A; rpl12a rpl12b double mutant exhibits slow growth and slow translation; homologous to mammalian ribosomal protein L12 and bacterial L11; RPL12A has a paralog, RPL12B, that arose from the whole genome duplication
0.180 6.18E-26 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.178 2.97E-25 YML073C RPL6A hom Ribosomal 60S subunit protein L6A; N-terminally acetylated; binds 5.8S rRNA; homologous to mammalian ribosomal protein L6, no bacterial homolog; RPL6A has a paralog, RPL6B, that arose from the whole genome duplication
0.178 3.41E-25 YLL045C RPL8B hom Ribosomal 60S subunit protein L8B; mutation results in decreased amounts of free 60S subunits; homologous to mammalian ribosomal protein L7A, no bacterial homolog; RPL8B has a paralog, RPL8A, that arose from the whole genome duplication
0.172 7.72E-24 YJL188C_d BUD19_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 88% of ORF overlaps the verified gene RPL39; diploid mutant displays a weak budding pattern phenotype in a systematic assay
0.169 7.17E-23 YLR068W FYV7 hom Essential protein required for maturation of 18S rRNA; required for survival upon exposure to K1 killer toxin
0.155 1.27E-19 YOR309C_d YOR309C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene NOP58
0.155 1.30E-19 YIR026C YVH1 hom Protein phosphatase involved in vegetative growth at low temperatures, sporulation, and glycogen accumulation; mutants are defective in 60S ribosome assembly; member of the dual-specificity family of protein phosphatases
0.154 2.79E-19 YDR101C ARX1 hom Shuttling pre-60S factor; involved in the biogenesis of ribosomal large subunit biogenesis; interacts directly with Alb1; responsible for Tif6 recycling defects in absence of Rei1; associated with the ribosomal export complex
0.147 1.17E-17 YFR031C-A RPL2A hom Ribosomal 60S subunit protein L2A; homologous to mammalian ribosomal protein L2 and bacterial L2; RPL2A has a paralog, RPL2B, that arose from the whole genome duplication
0.144 5.28E-17 YIL110W HPM1 hom AdoMet-dependent methyltransferase involved in a novel 3-methylhistidine modification of ribosomal protein Rpl3p; seven beta-strand MTase family member; null mutant exhibits a weak vacuolar protein sorting defect and caspofungin resistance
0.142 1.33E-16 YBR191W RPL21A hom Ribosomal 60S subunit protein L21A; homologous to mammalian ribosomal protein L21, no bacterial homolog; RPL21A has a paralog, RPL21B, that arose from the whole genome duplication
0.142 1.66E-16 YJR145C RPS4A hom Protein component of the small (40S) ribosomal subunit; mutation affects 20S pre-rRNA processing; homologous to mammalian ribosomal protein S4, no bacterial homolog; RPS4A has a paralog, RPS4B, that arose from the whole genome duplication
0.141 3.07E-16 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C