YDL114W_p

Putative short-chain dehydrogenase/reductase; YDL114W is not an essential gene

Zygosity: Homozygous strain
fixedexpanded
Profile for YDL114W / YDL114W

Click on Significant Values for Screen Details ID:SGTC_578|Compound:3460-0051|FD-Score:-3.63|P-value:1.27E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.48|P-value:2.57E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.79|P-value:7.80E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.24|P-value:6.12E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.23|P-value:7.15E-8 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.44|P-value:2.93E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.20|P-value:6.42E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-4.24|P-value:9.82E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.01|P-value:2.78E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.12|P-value:1.70E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.74|P-value:1.08E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.27|P-value:4.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.17|P-value:1.56E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.43|P-value:4.77E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-5.38|P-value:3.17E-8 ID:SGTC_1979|Compound:st071809|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.88|P-value:4.78E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-5.97|P-value:9.78E-10 ID:SGTC_2006|Compound:4011487|FD-Score:3.10|P-value:9.87E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-4.56|P-value:2.25E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-4.48|P-value:3.39E-6 ID:SGTC_2366|Compound:9070441|FD-Score:-3.35|P-value:3.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.08|P-value:2.32E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.39|P-value:5.70E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.29|P-value:9.10E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.22|P-value:5.89E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.29|P-value:5.19E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.10|P-value:9.93E-4 ID:SGTC_578|Compound:3460-0051|FD-Score:-3.63|P-value:1.27E-4 ID:SGTC_913|Compound:3487-1245|FD-Score:3.48|P-value:2.57E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.79|P-value:7.80E-5 ID:SGTC_943|Compound:3253-1379|FD-Score:3.24|P-value:6.12E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:-5.23|P-value:7.15E-8 ID:SGTC_1249|Compound:0481-0015|FD-Score:3.62|P-value:1.53E-4 ID:SGTC_1283|Compound:0922-0125|FD-Score:3.44|P-value:2.93E-4 ID:SGTC_1392|Compound:3455-1037|FD-Score:-3.20|P-value:6.42E-4 ID:SGTC_1603|Compound:st002045|FD-Score:3.30|P-value:4.88E-4 ID:SGTC_1612|Compound:st002233|FD-Score:-4.24|P-value:9.82E-6 ID:SGTC_1629|Compound:st005085|FD-Score:-4.01|P-value:2.78E-5 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-4.12|P-value:1.70E-5 ID:SGTC_1636|Compound:st007707|FD-Score:4.74|P-value:1.08E-6 ID:SGTC_1739|Compound:st037196|FD-Score:-3.27|P-value:4.96E-4 ID:SGTC_1741|Compound:st038134|FD-Score:4.17|P-value:1.56E-5 ID:SGTC_1744|Compound:st037937|FD-Score:4.43|P-value:4.77E-6 ID:SGTC_1770|Compound:st043884|FD-Score:-5.38|P-value:3.17E-8 ID:SGTC_1979|Compound:st071809|FD-Score:4.20|P-value:1.35E-5 ID:SGTC_1985|Compound:st071382|FD-Score:3.40|P-value:3.40E-4 ID:SGTC_1992|Compound:st073643|FD-Score:-3.88|P-value:4.78E-5 ID:SGTC_1999|Compound:st074831|FD-Score:-5.97|P-value:9.78E-10 ID:SGTC_2006|Compound:4011487|FD-Score:3.10|P-value:9.87E-4 ID:SGTC_2178|Compound:5812956|FD-Score:-4.56|P-value:2.25E-6 ID:SGTC_2351|Compound:9026858|FD-Score:-4.48|P-value:3.39E-6 ID:SGTC_2366|Compound:9070441|FD-Score:-3.35|P-value:3.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.08|P-value:2.32E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.14|P-value:8.73E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.68|P-value:1.18E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:4.39|P-value:5.70E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.29|P-value:9.10E-6 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:-3.22|P-value:5.89E-4 ID:SGTC_2754|Compound:granisetron|FD-Score:3.29|P-value:5.19E-4 ID:SGTC_3002|Compound:9075603|FD-Score:3.10|P-value:9.93E-4

Top fitness defect scores for YDL114W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1636 st007707 4.74 68.9 µM 1.08E-6 34 1.08E-6
2 SGTC_1744 st037937 4.43 38.9 µM 4.77E-6 17 4.72E-6
3 SGTC_2564 betulinic acid 4.39 100.0 µM 5.70E-6 24 5.64E-6
4 SGTC_2567 aureobasidin a 4.29 60.0 nM 9.10E-6 77 9.00E-6
5 SGTC_1979 st071809 4.20 45.3 µM 1.35E-5 RPP1 & pyrimidine depletion 8 1.33E-5
6 SGTC_1741 st038134 4.17 10.2 µM 1.56E-5 26 1.54E-5
7 SGTC_2449 5812982 4.08 45.8 µM 2.32E-5 8 2.29E-5
8 SGTC_940 3232-1287 3.79 54.8 µM 7.80E-5 NEO1 46 7.68E-5
9 SGTC_2516 gossypol 3.68 71.5 µM 1.18E-4 18 1.16E-4
10 SGTC_1249 0481-0015 3.62 10.2 µM 1.53E-4 34 1.50E-4
11 SGTC_913 3487-1245 3.48 167.0 µM 2.57E-4 49 2.53E-4
12 SGTC_1283 0922-0125 3.44 16.4 µM 2.93E-4 40 2.88E-4
13 SGTC_1985 st071382 3.40 65.5 µM 3.40E-4 32 3.34E-4
14 SGTC_1603 st002045 3.30 67.8 µM 4.88E-4 TSC3-RPN4 36 4.79E-4
15 SGTC_2754 granisetron 3.29 64.0 µM 5.19E-4 63 5.10E-4
16 SGTC_943 3253-1379 3.24 105.0 µM 6.12E-4 47 6.01E-4
17 SGTC_2453 5731132 3.14 22.2 µM 8.73E-4 61 8.56E-4
18 SGTC_2006 4011487 3.10 200.0 µM 9.87E-4 endomembrane recycling 131 9.68E-4
19 SGTC_3002 9075603 3.10 71.4 µM 9.93E-4 63 9.74E-4
20 SGTC_3188 9110789 3.05 49.5 µM 0.00116 iron homeostasis 65 0.00114

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.170 4.53E-23 YKL004W AUR1 het Phosphatidylinositol:ceramide phosphoinositol transferase (IPC synthase), required for sphingolipid synthesis; can mutate to confer aureobasidin A resistance
0.134 8.68E-15 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.118 6.84E-12 YGL217C_d YGL217C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF KIP3/YGL216W
0.114 4.18E-11 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.108 4.03E-10 YDR436W PPZ2 hom Serine/threonine protein phosphatase Z, isoform of Ppz1p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.104 1.52E-9 YJL058C BIT61 hom Subunit of TORC2 membrane-associated complex; involved in regulation of cell cycle-dependent actin cytoskeletal dynamics during polarized growth and cell wall integrity; BIT61 has a paralog, BIT2, that arose from the whole genome duplication
0.099 9.54E-9 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.098 1.43E-8 YBR110W ALG1 het Mannosyltransferase, involved in asparagine-linked glycosylation in the endoplasmic reticulum (ER); essential for viability, mutation is functionally complemented by human ortholog
0.096 2.24E-8 YBR071W YBR071W hom Protein of unknown function found in the cytoplasm and bud neck; mRNA expression may be regulated by the cell cycle and/or cell wall stress; overexpression of YBR071W affects endocytic protein trafficking
0.091 1.12E-7 YDL236W PHO13 hom Alkaline phosphatase specific for p-nitrophenyl phosphate; also has protein phosphatase activity
0.091 1.37E-7 YIL086C_d YIL086C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.091 1.40E-7 YDL192W ARF1 hom ADP-ribosylation factor; GTPase of the Ras superfamily involved in regulation of coated vesicle formation in intracellular trafficking within the Golgi; ARF1 has a paralog, ARF2, that arose from the whole genome duplication
0.090 1.64E-7 YFL055W AGP3 hom Low-affinity amino acid permease, may act to supply the cell with amino acids as nitrogen source in nitrogen-poor conditions; transcription is induced under conditions of sulfur limitation; plays a role in regulating Ty1 transposition
0.088 2.95E-7 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.088 3.65E-7 YGR170W PSD2 hom Phosphatidylserine decarboxylase of the Golgi and vacuolar membranes, converts phosphatidylserine to phosphatidylethanolamine