YDL209C / CWC2

Member of the NineTeen Complex (NTC) that contains Prp19p and stabilizes U6 snRNA in catalytic forms of the spliceosome containing U2, U5, and U6 snRNAs; binds directly to U6 snRNA; similar to S. pombe Cwf2

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDL209C / CWC2

Click on Significant Values for Screen Details ID:SGTC_62|Compound:0180-0423|FD-Score:3.53|P-value:9.11E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.63|P-value:2.33E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.53|P-value:3.28E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.80|P-value:4.11E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.73|P-value:5.15E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.62|P-value:6.98E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:6.24|P-value:1.86E-8 ID:SGTC_600|Compound:1495-0418|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:5.07|P-value:3.85E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.85|P-value:3.44E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-15.40|P-value:5.32E-42 ID:SGTC_907|Compound:3448-6986|FD-Score:4.70|P-value:1.69E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.23|P-value:9.40E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.19|P-value:1.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.71|P-value:5.32E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.81|P-value:3.83E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.43|P-value:4.68E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.38|P-value:9.22E-9 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.13|P-value:1.35E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.33|P-value:6.61E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-3.96|P-value:2.47E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.79|P-value:4.27E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.78|P-value:4.29E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.61|P-value:7.24E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.59|P-value:4.13E-7 ID:SGTC_2289|Compound:7946404|FD-Score:3.52|P-value:9.39E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.66|P-value:3.01E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.55|P-value:9.07E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.65|P-value:2.06E-5 ID:SGTC_2384|Compound:9036245|FD-Score:4.76|P-value:1.36E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.12|P-value:1.72E-10 ID:SGTC_2413|Compound:inermin|FD-Score:4.79|P-value:1.20E-5 ID:SGTC_2468|Compound:5987765|FD-Score:4.03|P-value:1.88E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.57|P-value:8.40E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.82|P-value:1.11E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.55|P-value:8.56E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.55|P-value:9.01E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.68|P-value:5.76E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.87|P-value:3.18E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.79|P-value:1.64E-7 ID:SGTC_2714|Compound:st079313|FD-Score:3.77|P-value:4.43E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.14|P-value:3.06E-8 ID:SGTC_2823|Compound:7987624|FD-Score:4.39|P-value:5.37E-5 ID:SGTC_2897|Compound:9048598|FD-Score:3.98|P-value:2.25E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.49|P-value:3.78E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.37|P-value:5.91E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-4.04|P-value:1.87E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.26|P-value:8.62E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.20|P-value:1.07E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.43|P-value:4.85E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.65|P-value:6.44E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-3.85|P-value:3.54E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-5.02|P-value:4.93E-6 ID:SGTC_62|Compound:0180-0423|FD-Score:3.53|P-value:9.11E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-4.63|P-value:2.33E-5 ID:SGTC_160|Compound:3453-0671|FD-Score:4.53|P-value:3.28E-5 ID:SGTC_186|Compound:3455-3465|FD-Score:-3.80|P-value:4.11E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:-3.73|P-value:5.15E-4 ID:SGTC_229|Compound:benomyl|FD-Score:3.62|P-value:6.98E-4 ID:SGTC_464|Compound:bw-b 70c|FD-Score:6.24|P-value:1.86E-8 ID:SGTC_600|Compound:1495-0418|FD-Score:4.20|P-value:1.04E-4 ID:SGTC_774|Compound:k060-0086|FD-Score:5.07|P-value:3.85E-6 ID:SGTC_777|Compound:1315-0167|FD-Score:3.85|P-value:3.44E-4 ID:SGTC_778|Compound:3456-2434|FD-Score:-15.40|P-value:5.32E-42 ID:SGTC_907|Compound:3448-6986|FD-Score:4.70|P-value:1.69E-5 ID:SGTC_909|Compound:3448-9333|FD-Score:4.23|P-value:9.40E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:-4.19|P-value:1.14E-4 ID:SGTC_1133|Compound:3473-0247|FD-Score:3.71|P-value:5.32E-4 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.81|P-value:3.83E-4 ID:SGTC_1342|Compound:1486-1464|FD-Score:4.43|P-value:4.68E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:6.38|P-value:9.22E-9 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.13|P-value:1.35E-4 ID:SGTC_1836|Compound:st055642|FD-Score:4.33|P-value:6.61E-5 ID:SGTC_1856|Compound:st057054|FD-Score:-3.96|P-value:2.47E-4 ID:SGTC_1892|Compound:st058411|FD-Score:-4.09|P-value:1.61E-4 ID:SGTC_1904|Compound:st060225|FD-Score:-3.79|P-value:4.27E-4 ID:SGTC_1967|Compound:st070177|FD-Score:3.78|P-value:4.29E-4 ID:SGTC_2022|Compound:5136654|FD-Score:3.61|P-value:7.24E-4 ID:SGTC_2028|Compound:5153890|FD-Score:5.59|P-value:4.13E-7 ID:SGTC_2289|Compound:7946404|FD-Score:3.52|P-value:9.39E-4 ID:SGTC_2292|Compound:7671323|FD-Score:5.66|P-value:3.01E-7 ID:SGTC_2302|Compound:7771753|FD-Score:-3.55|P-value:9.07E-4 ID:SGTC_2310|Compound:7668677|FD-Score:4.65|P-value:2.06E-5 ID:SGTC_2384|Compound:9036245|FD-Score:4.76|P-value:1.36E-5 ID:SGTC_2405|Compound:ticlatone|FD-Score:7.12|P-value:1.72E-10 ID:SGTC_2413|Compound:inermin|FD-Score:4.79|P-value:1.20E-5 ID:SGTC_2468|Compound:5987765|FD-Score:4.03|P-value:1.88E-4 ID:SGTC_2522|Compound:biochanin a|FD-Score:-3.57|P-value:8.40E-4 ID:SGTC_2536|Compound:dehydroabietamide|FD-Score:-4.82|P-value:1.11E-5 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:3.55|P-value:8.56E-4 ID:SGTC_2602|Compound:kawain|FD-Score:-3.55|P-value:9.01E-4 ID:SGTC_2642|Compound:cholecalciferol|FD-Score:4.58|P-value:2.70E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.68|P-value:5.76E-4 ID:SGTC_2698|Compound:st077697|FD-Score:3.87|P-value:3.18E-4 ID:SGTC_2701|Compound:st077767|FD-Score:5.79|P-value:1.64E-7 ID:SGTC_2714|Compound:st079313|FD-Score:3.77|P-value:4.43E-4 ID:SGTC_2725|Compound:haloperidol|FD-Score:6.14|P-value:3.06E-8 ID:SGTC_2823|Compound:7987624|FD-Score:4.39|P-value:5.37E-5 ID:SGTC_2897|Compound:9048598|FD-Score:3.98|P-value:2.25E-4 ID:SGTC_2921|Compound:7974240|FD-Score:4.49|P-value:3.78E-5 ID:SGTC_2924|Compound:9010168|FD-Score:4.37|P-value:5.91E-5 ID:SGTC_2964|Compound:9083345|FD-Score:-4.04|P-value:1.87E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.26|P-value:8.62E-5 ID:SGTC_3112|Compound:9123419|FD-Score:4.20|P-value:1.07E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.43|P-value:4.85E-5 ID:SGTC_3202|Compound:9113761|FD-Score:3.65|P-value:6.44E-4 ID:SGTC_3260|Compound:9137109|FD-Score:-3.85|P-value:3.54E-4 ID:SGTC_3271|Compound:9137798|FD-Score:-5.02|P-value:4.93E-6

Top fitness defect scores for YDL209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2405 ticlatone 7.12 3.5 µM 1.72E-10 5 5.38E-13 1.16
2 SGTC_1369 1866-0067 6.38 208.0 µM 9.22E-9 RPP1 & pyrimidine depletion 2 8.80E-11 0.39
3 SGTC_464 bw-b 70c 6.24 158.0 µM 1.86E-8 1 2.16E-10 1.30
4 SGTC_2725 haloperidol 6.14 53.2 µM 3.06E-8 plasma membrane duress 7 4.08E-10 0.48
5 SGTC_2701 st077767 5.79 14.7 µM 1.64E-7 3 3.48E-9 0.39
6 SGTC_2292 7671323 5.66 168.1 µM 3.01E-7 RNA processing & uracil transport 4 7.59E-9 0.58
7 SGTC_2028 5153890 5.59 36.4 µM 4.13E-7 cell wall signaling 4 1.13E-8 0.23
8 SGTC_774 k060-0086 5.07 136.0 µM 3.85E-6 1 1.96E-7 0.56
9 SGTC_2413 inermin 4.79 26.1 µM 1.20E-5 12 8.34E-7 0.35
10 SGTC_2384 9036245 4.76 200.0 µM 1.36E-5 1 9.83E-7 0.72
11 SGTC_907 3448-6986 4.70 75.5 µM 1.69E-5 3 1.30E-6 0.34
12 SGTC_2310 7668677 4.65 200.0 µM 2.06E-5 3 1.66E-6 0.38
13 SGTC_2642 cholecalciferol 4.58 100.0 µM 2.70E-5 1 2.35E-6 0.67
14 SGTC_160 3453-0671 4.53 289.7 µM 3.28E-5 4 3.00E-6 1.04
15 SGTC_2921 7974240 4.49 10.7 µM 3.78E-5 12 3.60E-6 0.26
16 SGTC_1342 1486-1464 4.43 234.0 µM 4.68E-5 2 4.72E-6 0.88
17 SGTC_2823 7987624 4.39 58.4 µM 5.37E-5 8 5.63E-6 0.19
18 SGTC_2924 9010168 4.37 62.8 µM 5.91E-5 cell wall signaling 3 6.35E-6 0.09
19 SGTC_1836 st055642 4.33 81.0 µM 6.61E-5 3 7.33E-6 0.07
20 SGTC_3027 9089541 4.26 49.5 µM 8.62E-5 fatty acid desaturase (OLE1) 13 1.03E-5 0.18

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.177 5.95E-25 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.151 2.20E-18 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.137 2.12E-15 YNL132W KRE33 het Essential protein, required for biogenesis of the small ribosomal subunit; heterozygous mutant shows haploinsufficiency in K1 killer toxin resistance
0.126 2.38E-13 YER136W GDI1 het GDP dissociation inhibitor, regulates vesicle traffic in secretory pathways by regulating the dissociation of GDP from the Sec4/Ypt/rab family of GTP binding proteins
0.125 4.77E-13 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.121 1.96E-12 YLL035W GRC3 het Polynucleotide kinase present on rDNA that is required for efficient transcription termination by RNA polymerase I; required for cell growth; mRNA is cell-cycle regulated
0.121 2.59E-12 YPL146C NOP53 het Nucleolar protein; involved in biogenesis of the 60S subunit of the ribosome; interacts with rRNA processing factors Cbf5p and Nop2p; null mutant is viable but growth is severely impaired
0.115 2.97E-11 YKL153W_d YKL153W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; transcription of both YLK153W and the overlapping essential gene GPM1 is reduced in the gcr1 null mutant
0.106 7.19E-10 YGL018C JAC1 het Specialized J-protein that functions with Hsp70 in Fe-S cluster biogenesis in mitochondria, involved in iron metabolism; contains a J domain typical to J-type chaperones; localizes to the mitochondrial matrix
0.106 7.64E-10 YGL097W SRM1 het Nucleotide exchange factor for Gsp1p, localizes to the nucleus, required for nucleocytoplasmic trafficking of macromolecules; suppressor of the pheromone response pathway; potentially phosphorylated by Cdc28p
0.103 2.00E-9 YMR270C RRN9 het Protein involved in promoting high level transcription of rDNA, subunit of UAF (upstream activation factor) for RNA polymerase I
0.103 2.15E-9 YBR256C RIB5 het Riboflavin synthase; catalyzes the last step of the riboflavin biosynthesis pathway
0.103 2.74E-9 YCR054C CTR86 het Essential protein of unknown function; with orthologs in Ashbya gossypii and Candida albicans; similar to human ATXN10, mutations in which cause spinocerebellar ataxia type 10; codon usage corresponds to that observed for yeast genes expressed at low levels; relative distribution to the nucleus increases upon DNA replication stress
0.102 4.06E-9 YDR478W SNM1 het Subunit of RNase MRP, which cleaves pre-rRNA and has a role in cell cycle-regulated degradation of daughter cell-specific mRNAs; binds to the NME1 RNA subunit of RNase MRP
0.101 4.78E-9 YOR020C HSP10 het Mitochondrial matrix co-chaperonin that inhibits the ATPase activity of Hsp60p, a mitochondrial chaperonin; involved in protein folding and sorting in the mitochondria; 10 kD heat shock protein with similarity to E. coli groES