YDR028C / REG1

Regulatory subunit of type 1 protein phosphatase Glc7p; involved in negative regulation of glucose-repressible genes; involved in regulation of the nucleocytoplasmic shuttling of Hxk2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR028C / REG1

Click on Significant Values for Screen Details ID:SGTC_29|Compound:0299-0004|FD-Score:6.65|P-value:2.05E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.14|P-value:1.96E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:5.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.14|P-value:1.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-8.02|P-value:5.44E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:2.63E-14 ID:SGTC_227|Compound:fluconazole|FD-Score:7.37|P-value:1.56E-7 ID:SGTC_232|Compound:clozapine|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.87|P-value:2.47E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.49|P-value:7.50E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.18|P-value:3.18E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:4.73|P-value:5.56E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.46|P-value:1.96E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:5.76|P-value:3.44E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.10|P-value:3.34E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:5.55|P-value:6.31E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.80|P-value:4.78E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:5.19|P-value:1.73E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.96|P-value:9.89E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:-5.66|P-value:2.52E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.92|P-value:2.12E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-6.42|P-value:2.22E-6 ID:SGTC_394|Compound:menadione|FD-Score:4.95|P-value:3.24E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.59|P-value:2.45E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.57|P-value:2.67E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.03|P-value:1.51E-4 ID:SGTC_470|Compound:aa-861|FD-Score:10.00|P-value:1.65E-12 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.28|P-value:1.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.70|P-value:7.17E-10 ID:SGTC_505|Compound:gw-5074|FD-Score:7.72|P-value:4.18E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.87|P-value:2.34E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:6.13|P-value:1.10E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:4.49|P-value:9.95E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.96|P-value:3.11E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-5.79|P-value:1.68E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:5.05|P-value:2.45E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.79|P-value:3.18E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.44|P-value:4.12E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:8.21|P-value:5.77E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:6.04|P-value:1.45E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:6.30|P-value:6.40E-6 ID:SGTC_781|Compound:4335-2806|FD-Score:13.00|P-value:6.35E-20 ID:SGTC_804|Compound:1595-0054|FD-Score:6.49|P-value:3.49E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:4.59|P-value:8.01E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.47|P-value:7.91E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.15|P-value:1.91E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.31|P-value:9.53E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.84|P-value:2.60E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.30|P-value:6.51E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.47|P-value:7.94E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:10.10|P-value:1.13E-12 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.37|P-value:1.05E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:7.36|P-value:1.60E-7 ID:SGTC_1547|Compound:harmine|FD-Score:-4.77|P-value:3.05E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:11.60|P-value:3.82E-16 ID:SGTC_1556|Compound:plumbagin|FD-Score:14.60|P-value:1.07E-24 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.47|P-value:8.00E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.72|P-value:5.80E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.57|P-value:8.36E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.80|P-value:4.35E-12 ID:SGTC_1700|Compound:st030840|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_1724|Compound:st037281|FD-Score:5.14|P-value:1.98E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.55|P-value:8.78E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.65|P-value:8.89E-10 ID:SGTC_1760|Compound:st045453|FD-Score:11.00|P-value:8.76E-15 ID:SGTC_1766|Compound:st045414|FD-Score:5.21|P-value:1.61E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.88|P-value:3.86E-4 ID:SGTC_1801|Compound:st050089|FD-Score:9.04|P-value:1.56E-10 ID:SGTC_1803|Compound:st050068|FD-Score:9.99|P-value:1.68E-12 ID:SGTC_1827|Compound:berberine|FD-Score:-5.60|P-value:3.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.48|P-value:3.60E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.49|P-value:1.76E-9 ID:SGTC_1884|Compound:5633444|FD-Score:15.70|P-value:2.17E-28 ID:SGTC_1917|Compound:st066507|FD-Score:5.91|P-value:2.18E-5 ID:SGTC_1934|Compound:st074720|FD-Score:6.39|P-value:4.77E-6 ID:SGTC_1941|Compound:st076221|FD-Score:9.67|P-value:8.42E-12 ID:SGTC_1950|Compound:st077106|FD-Score:-4.64|P-value:4.25E-4 ID:SGTC_2055|Compound:5235184|FD-Score:5.03|P-value:2.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-6.80|P-value:6.00E-7 ID:SGTC_2128|Compound:5255449|FD-Score:-8.14|P-value:3.25E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.00|P-value:2.81E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.72|P-value:5.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.22|P-value:7.05E-11 ID:SGTC_2352|Compound:9027995|FD-Score:5.07|P-value:2.37E-4 ID:SGTC_2356|Compound:9061756|FD-Score:5.37|P-value:1.04E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.91|P-value:2.17E-5 ID:SGTC_2436|Compound:5633522|FD-Score:5.16|P-value:1.84E-4 ID:SGTC_2453|Compound:5731132|FD-Score:5.51|P-value:7.11E-5 ID:SGTC_2485|Compound:5633444|FD-Score:10.80|P-value:2.86E-14 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.70|P-value:6.05E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.49|P-value:6.13E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.61|P-value:7.54E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.16|P-value:1.02E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.14|P-value:1.98E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.48|P-value:3.59E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.35|P-value:3.86E-11 ID:SGTC_2681|Compound:menadione|FD-Score:5.48|P-value:7.75E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.79|P-value:3.14E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.90|P-value:1.55E-14 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.33|P-value:9.14E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.21|P-value:1.61E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.42|P-value:9.22E-5 ID:SGTC_2781|Compound:5567276|FD-Score:6.04|P-value:1.46E-5 ID:SGTC_2801|Compound:7907800|FD-Score:7.30|P-value:2.04E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.86|P-value:4.10E-4 ID:SGTC_2833|Compound:9001315|FD-Score:9.53|P-value:1.59E-11 ID:SGTC_2845|Compound:9003024|FD-Score:5.07|P-value:2.34E-4 ID:SGTC_2851|Compound:9015922|FD-Score:7.91|P-value:1.98E-8 ID:SGTC_2858|Compound:9025781|FD-Score:15.30|P-value:7.03E-27 ID:SGTC_2908|Compound:7930301|FD-Score:-4.74|P-value:3.24E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.90|P-value:8.60E-7 ID:SGTC_3062|Compound:9077494|FD-Score:6.63|P-value:2.15E-6 ID:SGTC_3077|Compound:9117319|FD-Score:7.24|P-value:2.49E-7 ID:SGTC_3078|Compound:9116413|FD-Score:8.89|P-value:3.04E-10 ID:SGTC_3098|Compound:9119039|FD-Score:9.41|P-value:2.81E-11 ID:SGTC_3126|Compound:9127922|FD-Score:7.58|P-value:7.03E-8 ID:SGTC_3148|Compound:9097893|FD-Score:5.62|P-value:5.11E-5 ID:SGTC_3166|Compound:9102297|FD-Score:6.91|P-value:8.17E-7 ID:SGTC_3170|Compound:9103054|FD-Score:-4.46|P-value:6.56E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.60|P-value:4.72E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.50|P-value:9.83E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.64|P-value:2.67E-5 ID:SGTC_3279|Compound:9140807|FD-Score:7.28|P-value:2.20E-7 ID:SGTC_3284|Compound:9108171|FD-Score:4.59|P-value:7.89E-4 ID:SGTC_3296|Compound:9122258|FD-Score:6.54|P-value:2.92E-6 ID:SGTC_29|Compound:0299-0004|FD-Score:6.65|P-value:2.05E-6 ID:SGTC_56|Compound:0957-0365|FD-Score:5.14|P-value:1.96E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.54|P-value:5.37E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.14|P-value:1.12E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-8.02|P-value:5.44E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.80|P-value:2.63E-14 ID:SGTC_227|Compound:fluconazole|FD-Score:7.37|P-value:1.56E-7 ID:SGTC_232|Compound:clozapine|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_252|Compound:miconazole|FD-Score:5.87|P-value:2.47E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:5.49|P-value:7.50E-5 ID:SGTC_257|Compound:daunorubicin|FD-Score:7.18|P-value:3.18E-7 ID:SGTC_283|Compound:0987-0079|FD-Score:4.73|P-value:5.56E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-6.46|P-value:1.96E-6 ID:SGTC_301|Compound:4119-0100|FD-Score:5.76|P-value:3.44E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.10|P-value:3.34E-13 ID:SGTC_313|Compound:3474-0040|FD-Score:5.55|P-value:6.31E-5 ID:SGTC_315|Compound:k915-0449|FD-Score:4.80|P-value:4.78E-4 ID:SGTC_328|Compound:k915-0120|FD-Score:5.19|P-value:1.73E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-5.96|P-value:9.89E-6 ID:SGTC_386|Compound:1509-0011|FD-Score:-5.66|P-value:2.52E-5 ID:SGTC_389|Compound:tpck|FD-Score:5.92|P-value:2.12E-5 ID:SGTC_393|Compound:acivicin|FD-Score:-6.42|P-value:2.22E-6 ID:SGTC_394|Compound:menadione|FD-Score:4.95|P-value:3.24E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:6.59|P-value:2.45E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:6.57|P-value:2.67E-6 ID:SGTC_467|Compound:ro 31-8220|FD-Score:-5.03|P-value:1.51E-4 ID:SGTC_470|Compound:aa-861|FD-Score:10.00|P-value:1.65E-12 ID:SGTC_481|Compound:bay k-8644|FD-Score:5.28|P-value:1.36E-4 ID:SGTC_488|Compound:nitrendipine|FD-Score:8.70|P-value:7.17E-10 ID:SGTC_505|Compound:gw-5074|FD-Score:7.72|P-value:4.18E-8 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.87|P-value:2.34E-4 ID:SGTC_515|Compound:4092-1064|FD-Score:6.13|P-value:1.10E-5 ID:SGTC_592|Compound:k241-0073|FD-Score:4.49|P-value:9.95E-4 ID:SGTC_608|Compound:k048-0125|FD-Score:4.96|P-value:3.11E-4 ID:SGTC_617|Compound:3770-0098|FD-Score:-5.79|P-value:1.68E-5 ID:SGTC_639|Compound:0833-0042|FD-Score:5.05|P-value:2.45E-4 ID:SGTC_664|Compound:1222-0054|FD-Score:7.79|P-value:3.18E-8 ID:SGTC_682|Compound:0kpi-0099|FD-Score:6.44|P-value:4.12E-6 ID:SGTC_754|Compound:3474-0146|FD-Score:8.21|P-value:5.77E-9 ID:SGTC_768|Compound:0384-0033|FD-Score:6.04|P-value:1.45E-5 ID:SGTC_773|Compound:4358-1457|FD-Score:6.30|P-value:6.40E-6 ID:SGTC_781|Compound:4335-2806|FD-Score:13.00|P-value:6.35E-20 ID:SGTC_804|Compound:1595-0054|FD-Score:6.49|P-value:3.49E-6 ID:SGTC_813|Compound:k007-0158|FD-Score:4.59|P-value:8.01E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:5.47|P-value:7.91E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:5.15|P-value:1.91E-4 ID:SGTC_917|Compound:harmaline|FD-Score:-4.31|P-value:9.53E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:7.84|P-value:2.60E-8 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.30|P-value:6.51E-6 ID:SGTC_1035|Compound:k081-0041|FD-Score:5.47|P-value:7.94E-5 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:10.10|P-value:1.13E-12 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:5.37|P-value:1.05E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:7.36|P-value:1.60E-7 ID:SGTC_1547|Compound:harmine|FD-Score:-4.77|P-value:3.05E-4 ID:SGTC_1552|Compound:6-methylflavone|FD-Score:11.60|P-value:3.82E-16 ID:SGTC_1556|Compound:plumbagin|FD-Score:14.60|P-value:1.07E-24 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:5.47|P-value:8.00E-5 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:4.72|P-value:5.80E-4 ID:SGTC_1603|Compound:st002045|FD-Score:4.57|P-value:8.36E-4 ID:SGTC_1687|Compound:st020778|FD-Score:9.80|P-value:4.35E-12 ID:SGTC_1700|Compound:st030840|FD-Score:6.05|P-value:1.41E-5 ID:SGTC_1724|Compound:st037281|FD-Score:5.14|P-value:1.98E-4 ID:SGTC_1752|Compound:st044819|FD-Score:4.55|P-value:8.78E-4 ID:SGTC_1754|Compound:st042065|FD-Score:8.65|P-value:8.89E-10 ID:SGTC_1760|Compound:st045453|FD-Score:11.00|P-value:8.76E-15 ID:SGTC_1766|Compound:st045414|FD-Score:5.21|P-value:1.61E-4 ID:SGTC_1800|Compound:st050079|FD-Score:4.88|P-value:3.86E-4 ID:SGTC_1801|Compound:st050089|FD-Score:9.04|P-value:1.56E-10 ID:SGTC_1803|Compound:st050068|FD-Score:9.99|P-value:1.68E-12 ID:SGTC_1827|Compound:berberine|FD-Score:-5.60|P-value:3.01E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:6.48|P-value:3.60E-6 ID:SGTC_1875|Compound:nocodazole|FD-Score:8.49|P-value:1.76E-9 ID:SGTC_1884|Compound:5633444|FD-Score:15.70|P-value:2.17E-28 ID:SGTC_1917|Compound:st066507|FD-Score:5.91|P-value:2.18E-5 ID:SGTC_1934|Compound:st074720|FD-Score:6.39|P-value:4.77E-6 ID:SGTC_1941|Compound:st076221|FD-Score:9.67|P-value:8.42E-12 ID:SGTC_1950|Compound:st077106|FD-Score:-4.64|P-value:4.25E-4 ID:SGTC_2055|Compound:5235184|FD-Score:5.03|P-value:2.62E-4 ID:SGTC_2082|Compound:5219693|FD-Score:-6.80|P-value:6.00E-7 ID:SGTC_2128|Compound:5255449|FD-Score:-8.14|P-value:3.25E-9 ID:SGTC_2249|Compound:haloperidol|FD-Score:5.00|P-value:2.81E-4 ID:SGTC_2296|Compound:7971656|FD-Score:4.72|P-value:5.79E-4 ID:SGTC_2322|Compound:7413319|FD-Score:9.22|P-value:7.05E-11 ID:SGTC_2352|Compound:9027995|FD-Score:5.07|P-value:2.37E-4 ID:SGTC_2356|Compound:9061756|FD-Score:5.37|P-value:1.04E-4 ID:SGTC_2385|Compound:9074692|FD-Score:5.91|P-value:2.17E-5 ID:SGTC_2436|Compound:5633522|FD-Score:5.16|P-value:1.84E-4 ID:SGTC_2453|Compound:5731132|FD-Score:5.51|P-value:7.11E-5 ID:SGTC_2485|Compound:5633444|FD-Score:10.80|P-value:2.86E-14 ID:SGTC_2494|Compound:18-aminoabieta-8,11,13-triene sulfate|FD-Score:4.70|P-value:6.05E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:-4.49|P-value:6.13E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:4.61|P-value:7.54E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:6.16|P-value:1.02E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:5.14|P-value:1.98E-4 ID:SGTC_2630|Compound:antimycin a|FD-Score:6.48|P-value:3.59E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.35|P-value:3.86E-11 ID:SGTC_2681|Compound:menadione|FD-Score:5.48|P-value:7.75E-5 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:5.79|P-value:3.14E-5 ID:SGTC_2752|Compound:diclazuril|FD-Score:10.90|P-value:1.55E-14 ID:SGTC_2759|Compound:disulfiram|FD-Score:-4.33|P-value:9.14E-4 ID:SGTC_2766|Compound:oltipraz|FD-Score:5.21|P-value:1.61E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.42|P-value:9.22E-5 ID:SGTC_2781|Compound:5567276|FD-Score:6.04|P-value:1.46E-5 ID:SGTC_2801|Compound:7907800|FD-Score:7.30|P-value:2.04E-7 ID:SGTC_2814|Compound:7977482|FD-Score:4.86|P-value:4.10E-4 ID:SGTC_2833|Compound:9001315|FD-Score:9.53|P-value:1.59E-11 ID:SGTC_2845|Compound:9003024|FD-Score:5.07|P-value:2.34E-4 ID:SGTC_2851|Compound:9015922|FD-Score:7.91|P-value:1.98E-8 ID:SGTC_2858|Compound:9025781|FD-Score:15.30|P-value:7.03E-27 ID:SGTC_2908|Compound:7930301|FD-Score:-4.74|P-value:3.24E-4 ID:SGTC_2997|Compound:9067075|FD-Score:6.90|P-value:8.60E-7 ID:SGTC_3062|Compound:9077494|FD-Score:6.63|P-value:2.15E-6 ID:SGTC_3077|Compound:9117319|FD-Score:7.24|P-value:2.49E-7 ID:SGTC_3078|Compound:9116413|FD-Score:8.89|P-value:3.04E-10 ID:SGTC_3098|Compound:9119039|FD-Score:9.41|P-value:2.81E-11 ID:SGTC_3126|Compound:9127922|FD-Score:7.58|P-value:7.03E-8 ID:SGTC_3148|Compound:9097893|FD-Score:5.62|P-value:5.11E-5 ID:SGTC_3166|Compound:9102297|FD-Score:6.91|P-value:8.17E-7 ID:SGTC_3170|Compound:9103054|FD-Score:-4.46|P-value:6.56E-4 ID:SGTC_3204|Compound:9114183|FD-Score:-4.60|P-value:4.72E-4 ID:SGTC_3237|Compound:9133362|FD-Score:4.50|P-value:9.83E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-5.64|P-value:2.67E-5 ID:SGTC_3279|Compound:9140807|FD-Score:7.28|P-value:2.20E-7 ID:SGTC_3284|Compound:9108171|FD-Score:4.59|P-value:7.89E-4 ID:SGTC_3296|Compound:9122258|FD-Score:6.54|P-value:2.92E-6

Top fitness defect scores for YDR028C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1884 5633444 15.70 25.0 µM 2.17E-28 redox potentiating 5 5.99E-56
2 SGTC_2858 9025781 15.30 9.0 µM 7.03E-27 sphingolipid biosynthesis & PDR1 11 6.84E-53
3 SGTC_1556 plumbagin 14.60 1.5 µM 1.07E-24 superoxide 3 1.77E-48
4 SGTC_781 4335-2806 13.00 94.4 µM 6.35E-20 1 8.08E-39
5 SGTC_1552 6-methylflavone 11.60 10.6 µM 3.82E-16 superoxide 2 3.55E-31
6 SGTC_1760 st045453 11.00 10.4 µM 8.76E-15 NEO1-PIK1 27 1.99E-28
7 SGTC_2752 diclazuril 10.90 33.1 µM 1.55E-14 20 6.34E-28
8 SGTC_221 trifluoperazine 10.80 10.3 µM 2.63E-14 NEO1-PIK1 47 1.84E-27
9 SGTC_2485 5633444 10.80 17.8 µM 2.86E-14 redox potentiating 3 2.18E-27
10 SGTC_1083 didemethylchlorpromazine sulfoxide 10.10 707.4 nM 1.13E-12 redox potentiating 5 3.66E-24
11 SGTC_470 aa-861 10.00 153.0 µM 1.65E-12 sphingolipid biosynthesis & PDR1 10 7.82E-24
12 SGTC_1803 st050068 9.99 52.4 µM 1.68E-12 NEO1-PIK1 25 8.12E-24
13 SGTC_1687 st020778 9.80 55.4 µM 4.35E-12 52 5.56E-23
14 SGTC_1941 st076221 9.67 61.8 µM 8.42E-12 sphingolipid biosynthesis & PDR1 14 2.11E-22
15 SGTC_2833 9001315 9.53 45.5 µM 1.59E-11 amide catabolism 3 7.59E-22
16 SGTC_3098 9119039 9.41 49.5 µM 2.81E-11 Golgi 1 2.41E-21
17 SGTC_2662 daunorubicin 9.35 22.4 µM 3.86E-11 anthracycline transcription coupled DNA repair 2 4.57E-21
18 SGTC_2322 7413319 9.22 38.2 µM 7.05E-11 ERAD & cell cycle 25 1.54E-20
19 SGTC_1801 st050089 9.04 28.4 µM 1.56E-10 NEO1-PIK1 18 7.67E-20
20 SGTC_3078 9116413 8.89 49.5 µM 3.04E-10 unfolded protein response 5 2.93E-19

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.279 4.59E-61 YDR392W SPT3 hom Subunit of the SAGA and SAGA-like transcriptional regulatory complexes, interacts with Spt15p to activate transcription of some RNA polymerase II-dependent genes, also functions to inhibit transcription at some promoters
0.252 6.04E-50 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.252 1.24E-49 YGR164W_d YGR164W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.251 2.22E-49 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.245 3.31E-47 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.237 4.98E-44 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.236 8.86E-44 YLR087C CSF1 hom Protein required for fermentation at low temperature; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.229 4.15E-41 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.228 9.00E-41 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.228 1.15E-40 YLR417W VPS36 hom Component of the ESCRT-II complex; contains the GLUE (GRAM Like Ubiquitin binding in EAP45) domain which is involved in interactions with ESCRT-I and ubiquitin-dependent sorting of proteins into the endosome
0.224 2.52E-39 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.221 2.21E-38 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes
0.220 4.99E-38 YLR055C SPT8 hom Subunit of the SAGA transcriptional regulatory complex but not present in SAGA-like complex SLIK/SALSA, required for SAGA-mediated inhibition at some promoters
0.218 2.79E-37 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.215 2.44E-36 YDR159W SAC3 hom Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)