YDR076W / RAD55

Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR076W / RAD55

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:6.51|P-value:1.71E-10 ID:SGTC_93|Compound:0109-0045|FD-Score:6.16|P-value:1.50E-9 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:7.69|P-value:5.84E-14 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.57|P-value:5.83E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:6.06|P-value:2.62E-9 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.38|P-value:3.91E-10 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.53|P-value:5.04E-8 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:10.30|P-value:7.43E-24 ID:SGTC_268|Compound:camptothecin|FD-Score:11.50|P-value:2.93E-29 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.36|P-value:4.48E-10 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.12|P-value:3.98E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:5.39|P-value:1.07E-7 ID:SGTC_419|Compound:nsc-638432|FD-Score:5.14|P-value:3.92E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:7.04|P-value:5.43E-12 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.59|P-value:1.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.85|P-value:8.86E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:3.30|P-value:8.12E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.86|P-value:1.82E-11 ID:SGTC_550|Compound:4123-0385|FD-Score:8.52|P-value:9.19E-17 ID:SGTC_558|Compound:k064-0027|FD-Score:14.40|P-value:1.82E-44 ID:SGTC_698|Compound:k064-0052|FD-Score:3.58|P-value:3.06E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.25|P-value:2.32E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.41|P-value:5.64E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.12|P-value:3.85E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:18.10|P-value:1.14E-69 ID:SGTC_864|Compound:0469-0573|FD-Score:3.80|P-value:1.38E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:8.98|P-value:1.96E-18 ID:SGTC_962|Compound:1254-0300|FD-Score:3.63|P-value:2.56E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.55|P-value:6.22E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:9.37|P-value:6.35E-20 ID:SGTC_1082|Compound:camptothecin|FD-Score:16.40|P-value:2.41E-57 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.02|P-value:6.93E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.07|P-value:4.87E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.50|P-value:4.18E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.13|P-value:3.85E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-4.34|P-value:9.26E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.58|P-value:5.50E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:8.49|P-value:1.17E-16 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.54|P-value:3.61E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:9.33|P-value:9.08E-20 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.81|P-value:1.14E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.04|P-value:3.05E-9 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.21|P-value:2.73E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.63|P-value:4.42E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:5.57|P-value:4.11E-8 ID:SGTC_1707|Compound:st032323|FD-Score:12.60|P-value:2.46E-34 ID:SGTC_1718|Compound:roemerine|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.43|P-value:1.05E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.13|P-value:1.79E-9 ID:SGTC_1859|Compound:st055998|FD-Score:3.24|P-value:9.86E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.10|P-value:4.71E-7 ID:SGTC_1915|Compound:st067105|FD-Score:4.04|P-value:5.39E-5 ID:SGTC_1930|Compound:st074634|FD-Score:9.18|P-value:3.49E-19 ID:SGTC_1936|Compound:st074407|FD-Score:5.88|P-value:7.45E-9 ID:SGTC_1958|Compound:st076513|FD-Score:3.55|P-value:3.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.76|P-value:1.00E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.31|P-value:5.04E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.57|P-value:3.25E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.90|P-value:9.30E-5 ID:SGTC_2266|Compound:7929956|FD-Score:8.09|P-value:2.79E-15 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:5.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.57|P-value:3.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:9.36|P-value:7.09E-20 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.91|P-value:1.22E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.63|P-value:6.26E-21 ID:SGTC_2671|Compound:danthron|FD-Score:9.39|P-value:5.72E-20 ID:SGTC_2677|Compound:mitomycin C|FD-Score:7.21|P-value:1.75E-12 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.47|P-value:7.00E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.75|P-value:1.65E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:4.63|P-value:4.48E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-5.10|P-value:2.49E-7 ID:SGTC_2846|Compound:9008642|FD-Score:-3.15|P-value:8.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.14|P-value:9.13E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.12|P-value:3.97E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.27|P-value:5.84E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_3218|Compound:9131285|FD-Score:5.12|P-value:4.21E-7 ID:SGTC_3247|Compound:9135149|FD-Score:12.40|P-value:2.04E-33 ID:SGTC_3254|Compound:9136651|FD-Score:7.56|P-value:1.49E-13 ID:SGTC_3277|Compound:9138724|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.62|P-value:2.60E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.31|P-value:7.95E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:6.51|P-value:1.71E-10 ID:SGTC_93|Compound:0109-0045|FD-Score:6.16|P-value:1.50E-9 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:7.69|P-value:5.84E-14 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:4.57|P-value:5.83E-6 ID:SGTC_244|Compound:nsc-207895|FD-Score:6.06|P-value:2.62E-9 ID:SGTC_248|Compound:streptozotocin|FD-Score:6.38|P-value:3.91E-10 ID:SGTC_257|Compound:daunorubicin|FD-Score:5.53|P-value:5.04E-8 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:10.30|P-value:7.43E-24 ID:SGTC_268|Compound:camptothecin|FD-Score:11.50|P-value:2.93E-29 ID:SGTC_272|Compound:doxorubicin|FD-Score:6.36|P-value:4.48E-10 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.12|P-value:3.98E-5 ID:SGTC_411|Compound:enrofloxacin|FD-Score:5.39|P-value:1.07E-7 ID:SGTC_419|Compound:nsc-638432|FD-Score:5.14|P-value:3.92E-7 ID:SGTC_429|Compound:1112-0049|FD-Score:7.04|P-value:5.43E-12 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-3.59|P-value:1.89E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:5.85|P-value:8.86E-9 ID:SGTC_521|Compound:r062-0005|FD-Score:3.30|P-value:8.12E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:6.86|P-value:1.82E-11 ID:SGTC_550|Compound:4123-0385|FD-Score:8.52|P-value:9.19E-17 ID:SGTC_558|Compound:k064-0027|FD-Score:14.40|P-value:1.82E-44 ID:SGTC_698|Compound:k064-0052|FD-Score:3.58|P-value:3.06E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:4.25|P-value:2.32E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.41|P-value:5.64E-4 ID:SGTC_824|Compound:1304-0008|FD-Score:4.12|P-value:3.85E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:18.10|P-value:1.14E-69 ID:SGTC_864|Compound:0469-0573|FD-Score:3.80|P-value:1.38E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:8.98|P-value:1.96E-18 ID:SGTC_962|Compound:1254-0300|FD-Score:3.63|P-value:2.56E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:3.71|P-value:1.91E-4 ID:SGTC_1036|Compound:k216-0215|FD-Score:3.88|P-value:1.03E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.55|P-value:6.22E-6 ID:SGTC_1079|Compound:idarubicin|FD-Score:9.37|P-value:6.35E-20 ID:SGTC_1082|Compound:camptothecin|FD-Score:16.40|P-value:2.41E-57 ID:SGTC_1085|Compound:doxorubicin|FD-Score:5.02|P-value:6.93E-7 ID:SGTC_1105|Compound:epirubicin|FD-Score:4.07|P-value:4.87E-5 ID:SGTC_1147|Compound:3809-1045|FD-Score:3.50|P-value:4.18E-4 ID:SGTC_1165|Compound:k072-0275|FD-Score:4.13|P-value:3.85E-5 ID:SGTC_1166|Compound:k206-0078|FD-Score:-4.34|P-value:9.26E-6 ID:SGTC_1170|Compound:0310-0127|FD-Score:4.58|P-value:5.50E-6 ID:SGTC_1185|Compound:1319-0113|FD-Score:8.49|P-value:1.17E-16 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.54|P-value:3.61E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:9.33|P-value:9.08E-20 ID:SGTC_1357|Compound:1503-1303|FD-Score:5.81|P-value:1.14E-8 ID:SGTC_1425|Compound:4048-4433|FD-Score:6.04|P-value:3.05E-9 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.21|P-value:2.73E-5 ID:SGTC_1489|Compound:4065-0444|FD-Score:4.63|P-value:4.42E-6 ID:SGTC_1532|Compound:4',5'-dihydroxyflavone|FD-Score:3.46|P-value:4.72E-4 ID:SGTC_1584|Compound:6-fluoro-dl-tryptophan|FD-Score:5.57|P-value:4.11E-8 ID:SGTC_1707|Compound:st032323|FD-Score:12.60|P-value:2.46E-34 ID:SGTC_1718|Compound:roemerine|FD-Score:4.26|P-value:2.17E-5 ID:SGTC_1775|Compound:st081588|FD-Score:4.43|P-value:1.05E-5 ID:SGTC_1834|Compound:st055981|FD-Score:6.13|P-value:1.79E-9 ID:SGTC_1859|Compound:st055998|FD-Score:3.24|P-value:9.86E-4 ID:SGTC_1913|Compound:st060213|FD-Score:5.10|P-value:4.71E-7 ID:SGTC_1915|Compound:st067105|FD-Score:4.04|P-value:5.39E-5 ID:SGTC_1930|Compound:st074634|FD-Score:9.18|P-value:3.49E-19 ID:SGTC_1936|Compound:st074407|FD-Score:5.88|P-value:7.45E-9 ID:SGTC_1958|Compound:st076513|FD-Score:3.55|P-value:3.43E-4 ID:SGTC_2062|Compound:5245942|FD-Score:3.48|P-value:4.45E-4 ID:SGTC_2069|Compound:5228469|FD-Score:-3.76|P-value:1.00E-4 ID:SGTC_2095|Compound:5432005|FD-Score:-3.31|P-value:5.04E-4 ID:SGTC_2128|Compound:5255449|FD-Score:3.57|P-value:3.25E-4 ID:SGTC_2152|Compound:5568786|FD-Score:3.90|P-value:9.30E-5 ID:SGTC_2266|Compound:7929956|FD-Score:8.09|P-value:2.79E-15 ID:SGTC_2303|Compound:7774051|FD-Score:3.41|P-value:5.70E-4 ID:SGTC_2544|Compound:sphondin|FD-Score:3.57|P-value:3.27E-4 ID:SGTC_2612|Compound:dictamnine|FD-Score:9.36|P-value:7.09E-20 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:4.91|P-value:1.22E-6 ID:SGTC_2662|Compound:daunorubicin|FD-Score:9.63|P-value:6.26E-21 ID:SGTC_2671|Compound:danthron|FD-Score:9.39|P-value:5.72E-20 ID:SGTC_2677|Compound:mitomycin C|FD-Score:7.21|P-value:1.75E-12 ID:SGTC_2682|Compound:pyrogallin|FD-Score:5.47|P-value:7.00E-8 ID:SGTC_2737|Compound:bleomycin|FD-Score:3.75|P-value:1.65E-4 ID:SGTC_2738|Compound:aclarubicin|FD-Score:4.63|P-value:4.48E-6 ID:SGTC_2842|Compound:9000675|FD-Score:-5.10|P-value:2.49E-7 ID:SGTC_2846|Compound:9008642|FD-Score:-3.15|P-value:8.75E-4 ID:SGTC_2874|Compound:9043904|FD-Score:-3.14|P-value:9.13E-4 ID:SGTC_2934|Compound:9036370|FD-Score:4.12|P-value:3.97E-5 ID:SGTC_2939|Compound:9044578|FD-Score:-3.29|P-value:5.53E-4 ID:SGTC_2986|Compound:9022445|FD-Score:-3.27|P-value:5.84E-4 ID:SGTC_3106|Compound:9121286|FD-Score:-3.59|P-value:1.85E-4 ID:SGTC_3218|Compound:9131285|FD-Score:5.12|P-value:4.21E-7 ID:SGTC_3247|Compound:9135149|FD-Score:12.40|P-value:2.04E-33 ID:SGTC_3254|Compound:9136651|FD-Score:7.56|P-value:1.49E-13 ID:SGTC_3277|Compound:9138724|FD-Score:3.63|P-value:2.62E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-4.62|P-value:2.60E-6 ID:SGTC_3321|Compound:9137793|FD-Score:3.31|P-value:7.95E-4

Top fitness defect scores for YDR076W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_829 1635-0120 18.10 117.0 µM 1.14E-69 DNA damage response 2 6.55E-74
2 SGTC_1082 camptothecin 16.40 424.9 nM 2.41E-57 DNA damage response 4 7.39E-61
3 SGTC_558 k064-0027 14.40 21.3 µM 1.82E-44 DNA damage response 1 3.26E-47
4 SGTC_1707 st032323 12.60 6.3 µM 2.46E-34 DNA damage response 4 1.79E-36
5 SGTC_3247 9135149 12.40 49.5 µM 2.04E-33 DNA damage response 2 1.68E-35
6 SGTC_268 camptothecin 11.50 39.6 µM 2.93E-29 DNA damage response 6 4.31E-31
7 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 10.30 44.4 nM 7.43E-24 DNA damage response 12 2.34E-25
8 SGTC_2662 daunorubicin 9.63 22.4 µM 6.26E-21 anthracycline transcription coupled DNA repair 1 2.98E-22
9 SGTC_2671 danthron 9.39 100.0 µM 5.72E-20 DNA damage response 3 3.12E-21
10 SGTC_1079 idarubicin 9.37 2.4 µM 6.35E-20 DNA damage response 3 3.49E-21
11 SGTC_2612 dictamnine 9.36 15.5 µM 7.09E-20 RNA pol III & RNase P/MRP 3 3.92E-21
12 SGTC_1290 0986-0249 9.33 10.2 µM 9.08E-20 DNA intercalators 2 5.10E-21
13 SGTC_1930 st074634 9.18 34.3 µM 3.49E-19 RNA pol III & RNase P/MRP 3 2.13E-20
14 SGTC_915 methyl methanesulfonate (MMS) 8.98 110.0 mM 1.96E-18 DNA damage response 3 1.33E-19
15 SGTC_550 4123-0385 8.52 25.7 µM 9.19E-17 TSC3-RPN4 3 7.93E-18
16 SGTC_1185 1319-0113 8.49 81.3 µM 1.17E-16 DNA damage response 1 1.02E-17
17 SGTC_2266 7929956 8.09 200.0 µM 2.79E-15 3 2.98E-16
18 SGTC_219 mitoxanthrone 7.69 164.4 µM 5.84E-14 DNA intercalators 15 7.55E-15
19 SGTC_3254 9136651 7.56 49.5 µM 1.49E-13 DNA damage response 2 2.04E-14
20 SGTC_2677 mitomycin C 7.21 100.0 µM 1.75E-12 DNA damage response 1 2.80E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.648 0 YDR004W RAD57 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad55p
0.608 0 YDL059C RAD59 hom Protein involved DNA double-strand break repair; repairs breaks in DNA during vegetative growth via recombination and single-strand annealing; anneals complementary single-stranded DNA; forms nuclear foci upon DNA replication stress; required for loading of Rad52p to DSBs; paralog of Rad52p
0.589 1.50E-312 YGL163C RAD54 hom DNA-dependent ATPase that stimulates strand exchange; modifies the topology of double-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; member of the SWI/SNF family; forms nuclear foci upon DNA replication stress
0.468 3.32E-182 YGL175C SAE2 hom Endonuclease that processes hairpin DNA structures with the MRX complex; involved in meiotic and mitotic double-strand break repair; phosphorylated in response to DNA damage and required for normal resistance to DNA-damaging agents
0.453 1.75E-169 YDR386W MUS81 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in DNA repair, replication fork stability, and joint molecule formation/resolution during meiotic recombination; helix-hairpin-helix protein; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.436 5.88E-156 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.432 1.02E-152 YBR099C_d YBR099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified gene MMS4
0.415 4.47E-140 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.382 1.07E-116 YER095W RAD51 hom Strand exchange protein, forms a helical filament with DNA that searches for homology; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; homolog of Dmc1p and bacterial RecA protein
0.357 9.25E-102 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability
0.269 9.64E-57 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.258 4.89E-52 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.252 6.22E-50 YDR369C XRS2 hom Protein required for DNA repair; component of the Mre11 complex, which is involved in double strand breaks, meiotic recombination, telomere maintenance, and checkpoint signaling
0.248 4.11E-48 YMR048W CSM3 hom Replication fork associated factor; required for stable replication fork pausing; component of the DNA replication checkpoint pathway; required for accurate chromosome segregation during meiosis; forms nuclear foci upon DNA replication stress
0.239 5.34E-45 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G