YDR142C / PEX7

Peroxisomal signal receptor for the N-terminal nonapeptide signal (PTS2) of peroxisomal matrix proteins; WD repeat protein; defects in human homolog cause lethal rhizomelic chondrodysplasia punctata (RCDP)

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR142C / PEX7

Click on Significant Values for Screen Details ID:SGTC_82|Compound:0054-0107|FD-Score:3.23|P-value:8.73E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.26|P-value:1.68E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:5.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.20|P-value:1.24E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-6.88|P-value:3.26E-12 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.10|P-value:8.90E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.18|P-value:6.78E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.68|P-value:1.76E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.28|P-value:7.41E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.21|P-value:5.94E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:5.27|P-value:1.35E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.80|P-value:6.62E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.64|P-value:2.09E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.64|P-value:2.10E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.84|P-value:9.58E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.18|P-value:1.07E-12 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.26|P-value:7.93E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.29|P-value:4.54E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.20|P-value:9.78E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.49|P-value:3.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.24|P-value:5.48E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.37|P-value:5.56E-4 ID:SGTC_2228|Compound:7354201|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.29|P-value:7.14E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.37|P-value:3.44E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.98|P-value:3.26E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.28|P-value:7.36E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-4.59|P-value:2.11E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.86|P-value:9.03E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.08|P-value:9.53E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.28|P-value:7.44E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.12|P-value:8.33E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.29|P-value:8.23E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-4.03|P-value:2.60E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.29|P-value:7.21E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.48|P-value:6.41E-6 ID:SGTC_2963|Compound:9082507|FD-Score:4.29|P-value:1.47E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:3.23|P-value:8.73E-4 ID:SGTC_267|Compound:4-Nitroquinoline-1-oxide  (4-NQO)|FD-Score:4.26|P-value:1.68E-5 ID:SGTC_358|Compound:0075-0058|FD-Score:3.39|P-value:5.13E-4 ID:SGTC_426|Compound:0988-0037|FD-Score:-4.20|P-value:1.24E-5 ID:SGTC_429|Compound:1112-0049|FD-Score:-6.88|P-value:3.26E-12 ID:SGTC_432|Compound:NS 1619|FD-Score:-3.10|P-value:8.90E-4 ID:SGTC_458|Compound:nppb|FD-Score:-3.18|P-value:6.78E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:3.68|P-value:1.76E-4 ID:SGTC_757|Compound:1066-0008|FD-Score:3.28|P-value:7.41E-4 ID:SGTC_813|Compound:k007-0158|FD-Score:-3.21|P-value:5.94E-4 ID:SGTC_821|Compound:1114-0266|FD-Score:4.37|P-value:1.03E-5 ID:SGTC_824|Compound:1304-0008|FD-Score:5.27|P-value:1.35E-7 ID:SGTC_946|Compound:3434-1334|FD-Score:-3.80|P-value:6.62E-5 ID:SGTC_1032|Compound:k061-1018|FD-Score:3.64|P-value:2.09E-4 ID:SGTC_1102|Compound:cgs 12066b|FD-Score:3.64|P-value:2.10E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.84|P-value:9.58E-5 ID:SGTC_1369|Compound:1866-0067|FD-Score:7.18|P-value:1.07E-12 ID:SGTC_1443|Compound:4112-3303|FD-Score:3.26|P-value:7.93E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:-3.29|P-value:4.54E-4 ID:SGTC_1605|Compound:st000082|FD-Score:3.20|P-value:9.78E-4 ID:SGTC_1976|Compound:st070609|FD-Score:3.49|P-value:3.57E-4 ID:SGTC_2148|Compound:5546263|FD-Score:-3.24|P-value:5.48E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.37|P-value:5.56E-4 ID:SGTC_2228|Compound:7354201|FD-Score:3.71|P-value:1.61E-4 ID:SGTC_2448|Compound:5185112|FD-Score:3.29|P-value:7.14E-4 ID:SGTC_2516|Compound:gossypol|FD-Score:3.48|P-value:3.75E-4 ID:SGTC_2524|Compound:avocatin b|FD-Score:-3.37|P-value:3.44E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.98|P-value:3.26E-5 ID:SGTC_2673|Compound:kobusone|FD-Score:3.28|P-value:7.36E-4 ID:SGTC_2773|Compound:thioridazine|FD-Score:-4.59|P-value:2.11E-6 ID:SGTC_2795|Compound:7780010|FD-Score:3.58|P-value:2.59E-4 ID:SGTC_2811|Compound:7967822|FD-Score:3.86|P-value:9.03E-5 ID:SGTC_2831|Compound:7999036|FD-Score:-3.08|P-value:9.53E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.28|P-value:7.44E-4 ID:SGTC_2859|Compound:9028643|FD-Score:-3.12|P-value:8.33E-4 ID:SGTC_2932|Compound:9016711|FD-Score:-4.29|P-value:8.23E-6 ID:SGTC_2936|Compound:9038235|FD-Score:-4.03|P-value:2.60E-5 ID:SGTC_2938|Compound:9059746|FD-Score:3.29|P-value:7.21E-4 ID:SGTC_2940|Compound:9060638|FD-Score:4.48|P-value:6.41E-6 ID:SGTC_2963|Compound:9082507|FD-Score:4.29|P-value:1.47E-5

Top fitness defect scores for YDR142C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1369 1866-0067 7.18 208.0 µM 1.07E-12 RPP1 & pyrimidine depletion 6 3.61E-13
2 SGTC_824 1304-0008 5.27 100.0 µM 1.35E-7 DNA damage response 16 6.80E-8
3 SGTC_2940 9060638 4.48 45.9 µM 6.41E-6 amide catabolism 13 3.70E-6
4 SGTC_821 1114-0266 4.37 29.2 µM 1.03E-5 14 6.09E-6
5 SGTC_2963 9082507 4.29 9.0 µM 1.47E-5 18 8.75E-6
6 SGTC_267 4-Nitroquinoline-1-oxide (4-NQO) 4.26 44.4 nM 1.68E-5 DNA damage response 24 1.01E-5
7 SGTC_2811 7967822 3.86 32.5 µM 9.03E-5 23 5.77E-5
8 SGTC_1277 0873-0036 3.84 22.0 µM 9.58E-5 PDR1 28 6.13E-5
9 SGTC_2228 7354201 3.71 200.0 µM 1.61E-4 endomembrane recycling 4 1.05E-4
10 SGTC_669 0108-0021 3.68 26.2 µM 1.76E-4 fatty acid desaturase (OLE1) 94 1.16E-4
11 SGTC_1032 k061-1018 3.64 98.7 µM 2.09E-4 34 1.38E-4
12 SGTC_1102 cgs 12066b 3.64 26.1 µM 2.10E-4 endomembrane recycling 12 1.38E-4
13 SGTC_2795 7780010 3.58 54.5 µM 2.59E-4 47 1.72E-4
14 SGTC_1976 st070609 3.49 63.5 µM 3.57E-4 22 2.41E-4
15 SGTC_2516 gossypol 3.48 71.5 µM 3.75E-4 26 2.54E-4
16 SGTC_358 0075-0058 3.39 9.4 µM 5.13E-4 95 3.51E-4
17 SGTC_2214 7179297 3.37 48.3 µM 5.56E-4 superoxide 11 3.82E-4
18 SGTC_2448 5185112 3.29 27.2 µM 7.14E-4 26 4.95E-4
19 SGTC_2938 9059746 3.29 27.3 µM 7.21E-4 fatty acid desaturase (OLE1) 61 5.00E-4
20 SGTC_2673 kobusone 3.28 100.0 µM 7.36E-4 16 5.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.142 1.46E-16 YML095C RAD10 hom Single-stranded DNA endonuclease (with Rad1p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human ERCC1 protein
0.137 1.90E-15 YDR528W HLR1 hom Protein involved in regulation of cell wall composition and integrity and response to osmotic stress; overproduction suppresses a lysis sensitive PKC mutation; similar to Lre1p, which functions antagonistically to protein kinase A;
HLR1 has a paralog, LRE1, that arose from the whole genome duplication
0.137 1.98E-15 YMR201C RAD14 hom Protein that recognizes and binds damaged DNA during nucleotide excision repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); contains zinc finger motif; homolog of human XPA protein
0.135 4.72E-15 YGR258C RAD2 hom Single-stranded DNA endonuclease, cleaves single-stranded DNA during nucleotide excision repair to excise damaged DNA; subunit of Nucleotide Excision Repair Factor 3 (NEF3); homolog of human XPG protein
0.115 2.83E-11 YAL016C-B_d YAL016C-B_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.112 9.03E-11 YPL022W RAD1 hom Single-stranded DNA endonuclease (with Rad10p), cleaves single-stranded DNA during nucleotide excision repair and double-strand break repair; subunit of Nucleotide Excision Repair Factor 1 (NEF1); homolog of human XPF protein
0.108 4.00E-10 YLL004W ORC3 het Subunit of the origin recognition complex, which directs DNA replication by binding to replication origins and is also involved in transcriptional silencing
0.104 1.62E-9 YDL197C ASF2 hom Anti-silencing protein that causes derepression of silent loci when overexpressed
0.103 2.59E-9 YOR169C_d YOR169C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame overlaps the verified gene GLN4/YOR168W
0.100 6.96E-9 YDR109C_p YDR109C_p hom Putative kinase
0.100 7.05E-9 YDR423C CAD1 hom AP-1-like basic leucine zipper (bZIP) transcriptional activator; involved in stress responses, iron metabolism, and pleiotropic drug resistance; controls a set of genes involved in stabilizing proteins; binds consensus sequence TTACTAA; CAD1 has a paralog, YAP1, that arose from the whole genome duplication
0.093 6.86E-8 YML086C ALO1 hom D-Arabinono-1,4-lactone oxidase, catalyzes the final step in biosynthesis of dehydro-D-arabinono-1,4-lactone, which is protective against oxidative stress
0.090 1.78E-7 YER162C RAD4 hom Protein that recognizes and binds damaged DNA (with Rad23p) during nucleotide excision repair; subunit of Nuclear Excision Repair Factor 2 (NEF2); also involved, with Rad23p, in turnover of ubiquitylated proteins
0.087 4.03E-7 YEL067C_p YEL067C_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.087 5.09E-7 YDR132C YDR132C hom Protein of unknown function; protein increases in abundance and relative distribution to the nucleus increases upon DNA replication stress; YDR132C has a paralog, YLR108C, that arose from the whole genome duplication