YDR146C / SWI5

Transcription factor that recruits Mediator and Swi/Snf complexes; activates transcription of genes expressed at the M/G1 phase boundary and in G1 phase; required for expression of the HO gene controlling mating type switching; localization to nucleus occurs during G1 and appears to be regulated by phosphorylation by Cdc28p kinase; SWI5 has a paralog, ACE2, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR146C / SWI5

Click on Significant Values for Screen Details ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:1.55E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.82|P-value:9.19E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.67|P-value:2.86E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:2.99|P-value:5.29E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.29|P-value:1.54E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.20|P-value:2.10E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:7.31E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.92|P-value:6.80E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.93|P-value:6.22E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.94|P-value:7.62E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-4.72|P-value:1.00E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:6.20E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.27|P-value:1.67E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.24|P-value:1.92E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.86|P-value:7.88E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.97|P-value:5.75E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.52|P-value:5.79E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.58|P-value:2.50E-7 ID:SGTC_1743|Compound:st037606|FD-Score:3.49|P-value:6.43E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.75|P-value:1.99E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.40|P-value:9.69E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-3.39|P-value:9.36E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.32|P-value:1.34E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.97|P-value:5.32E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.01|P-value:4.43E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.45|P-value:4.70E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.71|P-value:2.42E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.02|P-value:4.30E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.87|P-value:5.99E-11 ID:SGTC_2432|Compound:5630864|FD-Score:4.93|P-value:3.05E-8 ID:SGTC_2434|Compound:5670830|FD-Score:-4.05|P-value:3.97E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.44|P-value:1.18E-9 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.89|P-value:7.69E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.04|P-value:4.19E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-4.04|P-value:4.19E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.66|P-value:2.73E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.80|P-value:1.55E-5 ID:SGTC_141|Compound:0443-0274|FD-Score:-2.82|P-value:9.19E-4 ID:SGTC_213|Compound:1246-0773|FD-Score:3.67|P-value:2.86E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.39|P-value:1.02E-4 ID:SGTC_517|Compound:1365-0151|FD-Score:2.99|P-value:5.29E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.29|P-value:1.54E-4 ID:SGTC_724|Compound:3910-0327|FD-Score:-3.20|P-value:2.10E-4 ID:SGTC_734|Compound:2023-0417|FD-Score:3.46|P-value:7.31E-5 ID:SGTC_790|Compound:1575-0012|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_847|Compound:0342-0274|FD-Score:2.92|P-value:6.80E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-2.93|P-value:6.22E-4 ID:SGTC_1008|Compound:4106-0037|FD-Score:3.94|P-value:7.62E-6 ID:SGTC_1011|Compound:4112-3381|FD-Score:3.34|P-value:1.26E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:-4.72|P-value:1.00E-7 ID:SGTC_1107|Compound:amlodipine|FD-Score:-3.96|P-value:6.20E-6 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.27|P-value:1.67E-4 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.24|P-value:1.92E-4 ID:SGTC_1203|Compound:3992-3522|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1223|Compound:0764-0573|FD-Score:-3.23|P-value:1.84E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:-2.86|P-value:7.88E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:2.97|P-value:5.75E-4 ID:SGTC_1297|Compound:1068-0111|FD-Score:3.11|P-value:3.28E-4 ID:SGTC_1455|Compound:4262-0120|FD-Score:3.52|P-value:5.79E-5 ID:SGTC_1491|Compound:4138-0063|FD-Score:4.58|P-value:2.50E-7 ID:SGTC_1743|Compound:st037606|FD-Score:3.49|P-value:6.43E-5 ID:SGTC_1744|Compound:st037937|FD-Score:3.75|P-value:1.99E-5 ID:SGTC_1748|Compound:st037455|FD-Score:4.32|P-value:1.05E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:3.40|P-value:9.69E-5 ID:SGTC_1909|Compound:st060837|FD-Score:-3.39|P-value:9.36E-5 ID:SGTC_2093|Compound:5331342|FD-Score:3.32|P-value:1.34E-4 ID:SGTC_2203|Compound:7227154|FD-Score:-2.97|P-value:5.32E-4 ID:SGTC_2283|Compound:7944793|FD-Score:-3.01|P-value:4.43E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-4.45|P-value:4.70E-7 ID:SGTC_2303|Compound:7774051|FD-Score:3.71|P-value:2.42E-5 ID:SGTC_2336|Compound:9001819|FD-Score:-3.02|P-value:4.30E-4 ID:SGTC_2425|Compound:5628681|FD-Score:5.87|P-value:5.99E-11 ID:SGTC_2432|Compound:5630864|FD-Score:4.93|P-value:3.05E-8 ID:SGTC_2434|Compound:5670830|FD-Score:-4.05|P-value:3.97E-6 ID:SGTC_2581|Compound:avocatin a|FD-Score:5.44|P-value:1.18E-9 ID:SGTC_2687|Compound:chenodiol|FD-Score:2.89|P-value:7.69E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-4.04|P-value:4.19E-6 ID:SGTC_2793|Compound:7325131|FD-Score:-4.04|P-value:4.19E-6 ID:SGTC_2806|Compound:7952793|FD-Score:3.29|P-value:1.53E-4 ID:SGTC_2984|Compound:9022109|FD-Score:-3.66|P-value:2.73E-5

Top fitness defect scores for YDR146C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2425 5628681 5.87 7.8 µM 5.99E-11 3 2.23E-9
2 SGTC_2581 avocatin a 5.44 64.0 µM 1.18E-9 sphingolipid biosynthesis & PDR1 28 2.68E-8
3 SGTC_2432 5630864 4.93 12.2 µM 3.05E-8 10 4.02E-7
4 SGTC_1491 4138-0063 4.58 26.5 µM 2.50E-7 4 2.32E-6
5 SGTC_1203 3992-3522 4.32 103.0 µM 1.05E-6 20 7.69E-6
6 SGTC_1748 st037455 4.32 53.6 µM 1.05E-6 20 7.70E-6
7 SGTC_1008 4106-0037 3.94 6.0 µM 7.62E-6 PDR1 20 4.02E-5
8 SGTC_70 0141-0289 3.80 43.3 µM 1.55E-5 mitochondrial stress 189 7.28E-5
9 SGTC_1744 st037937 3.75 38.9 µM 1.99E-5 35 8.97E-5
10 SGTC_2303 7774051 3.71 200.0 µM 2.42E-5 27 1.06E-4
11 SGTC_213 1246-0773 3.67 967.0 nM 2.86E-5 30 1.22E-4
12 SGTC_1455 4262-0120 3.52 131.0 µM 5.79E-5 plasma membrane duress 36 2.20E-4
13 SGTC_1743 st037606 3.49 46.4 µM 6.43E-5 35 2.40E-4
14 SGTC_734 2023-0417 3.46 80.0 µM 7.31E-5 ergosterol biosynthesis 32 2.67E-4
15 SGTC_1785 bathophenanthroline 3.40 24.0 µM 9.69E-5 heme requiring 77 3.38E-4
16 SGTC_415 dibenzyl ketone 3.39 100.0 µM 1.02E-4 26 3.52E-4
17 SGTC_790 1575-0012 3.35 79.1 µM 1.18E-4 TSC3-RPN4 53 3.99E-4
18 SGTC_1011 4112-3381 3.34 17.4 µM 1.26E-4 64 4.21E-4
19 SGTC_2093 5331342 3.32 194.4 µM 1.34E-4 39 4.43E-4
20 SGTC_2806 7952793 3.29 58.4 µM 1.53E-4 50 4.97E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.175 1.38E-24 YGL164C YRB30 hom RanGTP-binding protein, inhibits RanGAP1 (Rna1p)-mediated GTP hydrolysis of RanGTP (Gsp1p); shares similarity to proteins in other fungi but not in higher eukaryotes
0.139 6.48E-16 YDR036C EHD3 hom 3-hydroxyisobutyryl-CoA hydrolase, member of a family of enoyl-CoA hydratase/isomerases; non-tagged protein is detected in highly purified mitochondria in high-throughput studies; phosphorylated; mutation affects fluid-phase endocytosis
0.122 1.22E-12 YDR104C SPO71 hom Meiosis-specific protein of unknown function, required for spore wall formation during sporulation, in particular for the proper size of the prospore membrane (PSM); interacts with SPO1; dispensable for both nuclear divisions during meiosis; contains two PH domains
0.122 1.51E-12 YBL086C_p YBL086C_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.120 2.75E-12 YML084W_d YML084W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.120 2.89E-12 YDR122W KIN1 hom Serine/threonine protein kinase involved in regulation of exocytosis; localizes to the cytoplasmic face of the plasma membrane; closely related to Kin2p
0.116 1.62E-11 YOR298C-A MBF1 hom Transcriptional coactivator; bridges the DNA-binding region of Gcn4p and TATA-binding protein Spt15p; suppressor of frameshift mutations; protein abundance increases in response to DNA replication stress
0.112 7.30E-11 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.111 1.21E-10 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication
0.110 1.63E-10 YGR251W NOP19 het Ribosome biogenesis factor; nucleolar protein associated with pre-rRNA components of the 90S preribosome, required for cleavage of pre-rRNA at A0, A1 and A2 sites; interacts with RNA helicase Dhr2p and RNA helicase-like protein Utp25p; required for incorporation of Utp25p into preribosomes
0.106 8.02E-10 YGR025W_d YGR025W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.104 1.70E-9 YBL043W ECM13 hom Non-essential protein of unknown function; induced by treatment with 8-methoxypsoralen and UVA irradiation; ECM13 has a paralog, YJR115W, that arose from the whole genome duplication
0.102 3.72E-9 YKL131W_d YKL131W_d hom Dubious ORF unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.098 1.09E-8 YLR191W PEX13 hom Integral peroxisomal membrane protein required for translocation of peroxisomal matrix proteins, interacts with the PTS1 signal recognition factor Pex5p and the PTS2 signal recognition factor Pex7p, forms a complex with Pex14p and Pex17p
0.097 1.84E-8 YDR006C SOK1 hom Protein whose overexpression suppresses the growth defect of mutants lacking protein kinase A activity; involved in cAMP-mediated signaling; localized to the nucleus; similar to the mouse testis-specific protein PBS13