YDR171W / HSP42

Small heat shock protein (sHSP) with chaperone activity; forms barrel-shaped oligomers that suppress unfolded protein aggregation; involved in cytoskeleton reorganization after heat shock; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR171W / HSP42

Click on Significant Values for Screen Details ID:SGTC_432|Compound:NS 1619|FD-Score:3.06|P-value:3.75E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.32|P-value:1.37E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:2.93|P-value:6.25E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.48|P-value:6.28E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.27|P-value:1.70E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.21|P-value:2.06E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.45|P-value:7.75E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.00|P-value:4.66E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.05|P-value:3.80E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.31|P-value:1.31E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.57|P-value:4.62E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.05|P-value:3.81E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.76|P-value:8.96E-8 ID:SGTC_1737|Compound:st035557|FD-Score:-5.38|P-value:1.86E-9 ID:SGTC_1743|Compound:st037606|FD-Score:-3.87|P-value:1.11E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.09|P-value:3.61E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.23|P-value:1.89E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.08|P-value:3.40E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.21|P-value:2.24E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.08|P-value:3.67E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.38|P-value:9.71E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.93|P-value:8.35E-6 ID:SGTC_3119|Compound:9125183|FD-Score:-3.10|P-value:3.49E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.41|P-value:6.02E-7 ID:SGTC_3330|Compound:9141424|FD-Score:4.42|P-value:5.66E-7 ID:SGTC_432|Compound:NS 1619|FD-Score:3.06|P-value:3.75E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.32|P-value:1.37E-4 ID:SGTC_947|Compound:3447-0010|FD-Score:2.93|P-value:6.25E-4 ID:SGTC_972|Compound:1319-0219|FD-Score:3.48|P-value:6.28E-5 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.27|P-value:1.70E-4 ID:SGTC_1057|Compound:3448-5381|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.21|P-value:2.06E-4 ID:SGTC_1082|Compound:camptothecin|FD-Score:-3.45|P-value:7.75E-5 ID:SGTC_1084|Compound:voriconazole|FD-Score:3.00|P-value:4.66E-4 ID:SGTC_1124|Compound:fisetin|FD-Score:3.05|P-value:3.80E-4 ID:SGTC_1207|Compound:2099-0101|FD-Score:3.01|P-value:4.48E-4 ID:SGTC_1210|Compound:3013-0140|FD-Score:3.31|P-value:1.31E-4 ID:SGTC_1220|Compound:1838-0075|FD-Score:-3.57|P-value:4.62E-5 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.05|P-value:3.81E-4 ID:SGTC_1732|Compound:st034308|FD-Score:-4.76|P-value:8.96E-8 ID:SGTC_1737|Compound:st035557|FD-Score:-5.38|P-value:1.86E-9 ID:SGTC_1743|Compound:st037606|FD-Score:-3.87|P-value:1.11E-5 ID:SGTC_1747|Compound:st037496|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:-3.09|P-value:3.61E-4 ID:SGTC_1928|Compound:4'-methoxychalcone|FD-Score:3.23|P-value:1.89E-4 ID:SGTC_1951|Compound:sophoraflavanone G|FD-Score:3.08|P-value:3.40E-4 ID:SGTC_1952|Compound:st077036|FD-Score:-3.21|P-value:2.24E-4 ID:SGTC_1954|Compound:st077032|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_2543|Compound:pimpinellin|FD-Score:-3.08|P-value:3.67E-4 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.38|P-value:9.71E-5 ID:SGTC_2693|Compound:st077581|FD-Score:-3.93|P-value:8.35E-6 ID:SGTC_3119|Compound:9125183|FD-Score:-3.10|P-value:3.49E-4 ID:SGTC_3283|Compound:9109332|FD-Score:-3.20|P-value:2.32E-4 ID:SGTC_3295|Compound:9122362|FD-Score:4.41|P-value:6.02E-7 ID:SGTC_3330|Compound:9141424|FD-Score:4.42|P-value:5.66E-7

Top fitness defect scores for YDR171W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_3330 9141424 4.42 71.4 µM 5.66E-7 amide catabolism 11 4.92E-6
2 SGTC_3295 9122362 4.41 53.6 µM 6.02E-7 9 5.19E-6
3 SGTC_972 1319-0219 3.48 195.0 µM 6.28E-5 50 2.50E-4
4 SGTC_2569 tetrandrine 3.38 100.0 µM 9.71E-5 44 3.60E-4
5 SGTC_1747 st037496 3.32 66.6 µM 1.27E-4 38 4.51E-4
6 SGTC_1057 3448-5381 3.32 134.0 µM 1.27E-4 calcium & mitochondrial duress 44 4.51E-4
7 SGTC_1210 3013-0140 3.31 750.0 nM 1.31E-4 21 4.63E-4
8 SGTC_1954 st077032 3.27 68.9 µM 1.60E-4 47 5.47E-4
9 SGTC_1928 4'-methoxychalcone 3.23 40.3 µM 1.89E-4 35 6.27E-4
10 SGTC_1059 3448-6867 3.21 171.0 µM 2.06E-4 32 6.74E-4
11 SGTC_1951 sophoraflavanone G 3.08 9.2 µM 3.40E-4 RNA processing & uracil transport 72 0.00103
12 SGTC_432 NS 1619 3.06 61.3 µM 3.75E-4 66 0.00111
13 SGTC_1124 fisetin 3.05 1.2 µM 3.80E-4 76 0.00113
14 SGTC_1308 1187-1617 3.05 41.4 µM 3.81E-4 fatty acid desaturase (OLE1) 93 0.00113
15 SGTC_1207 2099-0101 3.01 141.0 µM 4.48E-4 68 0.00129
16 SGTC_1084 voriconazole 3.00 435.0 nM 4.66E-4 azole & statin 66 0.00134
17 SGTC_947 3447-0010 2.93 211.0 µM 6.25E-4 60 0.00171
18 SGTC_1033 k072-0102 2.79 21.3 µM 0.00104 60S ribosome export 87 0.00262
19 SGTC_3229 9132204 2.72 49.5 µM 0.00137 32 0.00330
20 SGTC_646 4092-0839 2.69 27.3 µM 0.00153 plasma membrane duress 80 0.00363

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.214 6.40E-36 YGR067C_p YGR067C_p hom Putative protein of unknown function; contains a zinc finger motif similar to that of Adr1p
0.199 4.88E-31 YBL065W_d YBL065W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF SEF1/YBL066C; YBL065W is a non-essential gene
0.177 4.28E-25 YDR094W_d YDR094W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF DNF2
0.175 2.53E-24 YDR206W EBS1 hom Protein involved in inhibition of translation and nonsense-mediated decay; interacts with cap binding protein Cdc33p and with Nam7p; localizes to P-bodies upon glucose starvation; mRNA abundance regulated by mRNA decay factors
0.174 5.62E-24 YMR119W-A_d YMR119W-A_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.145 2.68E-17 YFL052W_p YFL052W_p hom Putative zinc cluster protein that contains a DNA binding domain; computational analysis suggests a role as a transcription factor; null mutant is sensitive to Calcofluor White, low osmolarity, and heat, suggesting a role for YFL052Wp in cell wall integrity
0.142 1.38E-16 YDR274C_d YDR274C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.131 2.84E-14 YDR124W_p YDR124W_p hom Putative protein of unknown function; non-essential gene; expression is strongly induced by alpha factor
0.131 3.11E-14 YHL006C SHU1 hom Component of the Shu complex, which promotes error-free DNA repair; Shu complex mediates inhibition of Srs2p function
0.125 4.61E-13 YPR058W YMC1 hom Putative mitochondrial inner membrane transporter; proposed role in oleate metabolism and glutamate biosynthesis; member of the mitochondrial carrier (MCF) family; YMC1 has a paralog, YMC2, that arose from the whole genome duplication
0.118 8.09E-12 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.116 1.54E-11 YNR020C ATP23 hom Putative metalloprotease of the mitochondrial inner membrane, required for processing of Atp6p; has an additional role in assembly of the F0 sector of the F1F0 ATP synthase complex; substrate of the Mia40p-Erv1p disulfide relay system, and folding is assisted by Mia40p
0.109 2.41E-10 YOR012W_p YOR012W_p hom Putative protein of unknown function
0.107 4.82E-10 YDR523C SPS1 hom Putative protein serine/threonine kinase expressed at the end of meiosis and localized to the prospore membrane, required for correct localization of enzymes involved in spore wall synthesis
0.103 2.20E-9 YDR336W_p YDR336W_p hom Putative protein of unknown function; sumoylated under stress conditions in a genome wide study; YDR336W is not an essential gene