YDR222W_p

Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR222W / YDR222W

Click on Significant Values for Screen Details ID:SGTC_47|Compound:0149-0135|FD-Score:3.63|P-value:4.54E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.38|P-value:2.00E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:4.05|P-value:1.03E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.46|P-value:5.64E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.41|P-value:9.06E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.75|P-value:2.98E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.12|P-value:7.90E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.40|P-value:9.31E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.41|P-value:9.28E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.95|P-value:1.47E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.73|P-value:3.27E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.28|P-value:9.90E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:6.06|P-value:1.22E-8 ID:SGTC_760|Compound:0568-0725|FD-Score:3.46|P-value:7.95E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.38|P-value:7.24E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.88|P-value:1.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.11|P-value:1.34E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.37|P-value:3.09E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.44|P-value:8.46E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:6.40|P-value:1.93E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.51|P-value:6.77E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.78|P-value:1.94E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.52|P-value:6.45E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.78|P-value:2.70E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.68|P-value:3.82E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:5.16E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.83|P-value:2.24E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.37|P-value:2.09E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.94|P-value:1.54E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.57|P-value:5.46E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.11|P-value:8.47E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.75|P-value:3.02E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.68|P-value:3.81E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.36|P-value:3.17E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.47|P-value:2.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.37|P-value:7.63E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.21|P-value:5.66E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.48|P-value:1.96E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-5.30|P-value:3.42E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.31|P-value:2.63E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.35|P-value:8.19E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.15|P-value:1.11E-6 ID:SGTC_3236|Compound:9132701|FD-Score:-3.39|P-value:6.99E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.75|P-value:2.99E-4 ID:SGTC_47|Compound:0149-0135|FD-Score:3.63|P-value:4.54E-4 ID:SGTC_54|Compound:0159-0055|FD-Score:-4.38|P-value:2.00E-5 ID:SGTC_82|Compound:0054-0107|FD-Score:4.05|P-value:1.03E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:4.05|P-value:1.05E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:-3.46|P-value:5.64E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:3.41|P-value:9.06E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:3.75|P-value:2.98E-4 ID:SGTC_521|Compound:r062-0005|FD-Score:4.12|P-value:7.90E-5 ID:SGTC_533|Compound:1222-0222|FD-Score:3.40|P-value:9.31E-4 ID:SGTC_555|Compound:4296-0685|FD-Score:3.41|P-value:9.28E-4 ID:SGTC_624|Compound:k048-0052|FD-Score:3.95|P-value:1.47E-4 ID:SGTC_627|Compound:1391-0720|FD-Score:3.73|P-value:3.27E-4 ID:SGTC_644|Compound:1498-1197|FD-Score:-3.28|P-value:9.90E-4 ID:SGTC_647|Compound:0140-0236|FD-Score:6.06|P-value:1.22E-8 ID:SGTC_760|Compound:0568-0725|FD-Score:3.46|P-value:7.95E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:-3.38|P-value:7.24E-4 ID:SGTC_897|Compound:1000-0139|FD-Score:3.92|P-value:1.68E-4 ID:SGTC_909|Compound:3448-9333|FD-Score:3.88|P-value:1.89E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:5.11|P-value:1.34E-6 ID:SGTC_1056|Compound:3448-1962|FD-Score:4.37|P-value:3.09E-5 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.44|P-value:8.46E-4 ID:SGTC_1225|Compound:1216-0074|FD-Score:6.40|P-value:1.93E-9 ID:SGTC_1287|Compound:0971-0001|FD-Score:3.51|P-value:6.77E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:-3.78|P-value:1.94E-4 ID:SGTC_1477|Compound:0139-0234|FD-Score:3.52|P-value:6.45E-4 ID:SGTC_1546|Compound:5-methoxyflavanone|FD-Score:3.78|P-value:2.70E-4 ID:SGTC_1566|Compound:6,7-dimethoxy-4-ethylcoumarin|FD-Score:3.68|P-value:3.82E-4 ID:SGTC_1631|Compound:benzylvanillin|FD-Score:-3.49|P-value:5.16E-4 ID:SGTC_1636|Compound:st007707|FD-Score:3.83|P-value:2.24E-4 ID:SGTC_1637|Compound:st007924|FD-Score:-4.37|P-value:2.09E-5 ID:SGTC_1643|Compound:st009866|FD-Score:3.94|P-value:1.54E-4 ID:SGTC_1659|Compound:st012954|FD-Score:3.57|P-value:5.46E-4 ID:SGTC_1715|Compound:st032160|FD-Score:4.11|P-value:8.47E-5 ID:SGTC_1880|Compound:MG-132|FD-Score:3.98|P-value:1.32E-4 ID:SGTC_1919|Compound:st067113|FD-Score:3.75|P-value:3.02E-4 ID:SGTC_2404|Compound:5161160|FD-Score:3.68|P-value:3.81E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:4.36|P-value:3.17E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.47|P-value:2.09E-5 ID:SGTC_2845|Compound:9003024|FD-Score:-3.37|P-value:7.63E-4 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:9.37E-4 ID:SGTC_3141|Compound:9094609|FD-Score:4.21|P-value:5.66E-5 ID:SGTC_3145|Compound:9085516|FD-Score:4.48|P-value:1.96E-5 ID:SGTC_3202|Compound:9113761|FD-Score:-5.30|P-value:3.42E-7 ID:SGTC_3204|Compound:9114183|FD-Score:-4.31|P-value:2.63E-5 ID:SGTC_3205|Compound:9113483|FD-Score:-3.35|P-value:8.19E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.15|P-value:1.11E-6 ID:SGTC_3236|Compound:9132701|FD-Score:-3.39|P-value:6.99E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.75|P-value:2.99E-4

Top fitness defect scores for YDR222W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1225 1216-0074 6.40 20.6 µM 1.93E-9 9 7.70E-11
2 SGTC_647 0140-0236 6.06 81.0 µM 1.22E-8 1 6.62E-10
3 SGTC_3209 9113616 5.15 49.5 µM 1.11E-6 5 1.29E-7
4 SGTC_915 methyl methanesulfonate (MMS) 5.11 110.0 mM 1.34E-6 DNA damage response 17 1.61E-7
5 SGTC_3145 9085516 4.48 49.5 µM 1.96E-5 fatty acid desaturase (OLE1) 15 3.66E-6
6 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.47 100.0 µM 2.09E-5 8 3.95E-6
7 SGTC_1056 3448-1962 4.37 115.0 µM 3.09E-5 amide catabolism 14 6.23E-6
8 SGTC_2419 paclitaxel 4.36 166.5 µM 3.17E-5 26 6.42E-6
9 SGTC_3141 9094609 4.21 49.5 µM 5.66E-5 iron homeostasis 32 1.26E-5
10 SGTC_521 r062-0005 4.12 13.8 µM 7.90E-5 12 1.86E-5
11 SGTC_1715 st032160 4.11 10.2 µM 8.47E-5 41 2.02E-5
12 SGTC_82 0054-0107 4.05 293.8 µM 1.03E-4 7 2.54E-5
13 SGTC_108 0509-0257 4.05 621.1 µM 1.05E-4 50 2.61E-5
14 SGTC_1880 MG-132 3.98 525.0 µM 1.32E-4 16 3.38E-5
15 SGTC_624 k048-0052 3.95 28.0 µM 1.47E-4 Golgi 14 3.84E-5
16 SGTC_1643 st009866 3.94 20.2 µM 1.54E-4 34 4.04E-5
17 SGTC_897 1000-0139 3.92 31.4 µM 1.68E-4 28 4.50E-5
18 SGTC_909 3448-9333 3.88 149.0 µM 1.89E-4 18 5.16E-5
19 SGTC_1636 st007707 3.83 68.9 µM 2.24E-4 51 6.28E-5
20 SGTC_1546 5-methoxyflavanone 3.78 78.7 µM 2.70E-4 12 7.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.151 1.55E-18 YDR234W LYS4 hom Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway
0.147 1.16E-17 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.143 9.53E-17 YPR078C_p YPR078C_p hom Putative protein of unknown function; possible role in DNA metabolism and/or in genome stability; expression is heat-inducible
0.130 3.44E-14 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.127 1.64E-13 YGR099W TEL2 het Subunit of the ASTRA complex, involved in chromatin remodeling; subunit of the telomere cap complex DNA-binding protein specific to single-stranded yeast telomeric DNA repeats, required for telomere length regulation and telomere position effect; involved in the stability or biogenesis of PIKKs such as TORC1
0.123 8.26E-13 YJR061W_p YJR061W_p hom Putative protein of unknown function; non-essential gene; transcription repressed by Rm101p; YJR061W has a paralog, MNN4, that arose from the whole genome duplication
0.117 1.31E-11 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.115 2.65E-11 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.108 3.13E-10 YGL011C SCL1 het Alpha 1 subunit of the 20S proteasome involved in the degradation of ubiquitinated substrates; 20S proteasome is the core complex of the 26S proteasome; essential for growth; detected in the mitochondria
0.105 9.63E-10 YGR145W ENP2 het Essential nucleolar protein, required for biogenesis of the small ribosomal subunit; contains WD repeats, interacts with Mpp10p and Bfr2p, and has homology to Spb1p
0.102 3.25E-9 YGR021W_p YGR021W_p hom Putative protein of unknown function; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.101 5.39E-9 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.099 8.27E-9 YAL033W POP5 het Subunit of both RNase MRP and nuclear RNase P; RNase MRP cleaves pre-rRNA, while nuclear RNase P cleaves tRNA precursors to generate mature 5' ends and facilitates turnover of nuclear RNAs
0.098 1.41E-8 YGR189C CRH1 hom Chitin transglycosylase that functions in the transfer of chitin to beta(1-6) and beta(1-3) glucans in the cell wall; similar and functionally redundant to Utr2; localizes to sites of polarized growth; expression induced by cell wall stress
0.096 2.31E-8 YOR225W_d YOR225W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data